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Protein

Alcohol dehydrogenase

Gene

Adh1

more
Organism
Drosophila virilis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.PROSITE-ProRule annotationCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63NADBy similarity1
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotationBy similarity1
Binding sitei155NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 39NADBy similarityAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh1Imported
Synonyms:Adh-1Imported
ORF Names:GJ18208
AND
Name:Adh2Imported
Synonyms:Adh-2Imported
ORF Names:GJ18209
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0014836. Dvir\Adh1.
FBgn0014837. Dvir\Adh2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003555762 – 254Alcohol dehydrogenaseAdd BLAST253

Expressioni

Gene expression databases

BgeeiFBgn0014836.

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi7244.FBpp0232626.

Structurei

3D structure databases

SMRiB4M8Y0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169. Eukaryota.
COG1028. LUCA.
InParanoidiB4M8Y0.
KOiK00001.
OMAiWSKHWDS.
OrthoDBiEOG091G0OC9.
PhylomeDBiB4M8Y0.

Family and domain databases

InterProiView protein in InterPro
IPR002425. ADH_Drosophila-type.
IPR002424. ADH_insect.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
PfamiView protein in Pfam
PF00106. adh_short. 1 hit.
PRINTSiPR01168. ALCDHDRGNASE.
PR01167. INSADHFAMILY.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00061. ADH_SHORT. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4M8Y0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIANKNIIF VAGLGGIGLD TSREIVKSGP KNLVILDRIE NPTAIAELKA
60 70 80 90 100
INPKVTVTFY PYDVTVPVAE TTKLLKTIFA KLKTVDLLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNFTG TVNTTTAIME FWDKRKGGPG GVIANICSVT GFNAIYQVPV
160 170 180 190 200
YSASKAAALS FTNSLARLAP ITGVTAYSIN PGITRTPLVH KFNSWLDVEP
210 220 230 240 250
RVGELLLEHP TQTTLECAQN FVKAIEANQN GAIWQLDLGR LISVEWTKHW

DSHI
Length:254
Mass (Da):27,608
Last modified:September 23, 2008 - v1
Checksum:i176D48D05518DF17
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140T → S in AAB02632 (PubMed:8583887).Curated1
Sequence conflicti140T → S in AAB02633 (PubMed:8583887).Curated1
Sequence conflicti155K → E in AAB02632 (PubMed:8583887).Curated1
Sequence conflicti155K → E in AAB02633 (PubMed:8583887).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26846 Genomic DNA. Translation: AAB02632.1.
U26846 Genomic DNA. Translation: AAB02633.1.
CH940654 Genomic DNA. Translation: EDW57656.1.
CH940654 Genomic DNA. Translation: EDW57657.1.
DQ471643 Genomic DNA. Translation: ABG56040.1.
DQ471668 Genomic DNA. Translation: ABG56065.1.
AB033640 mRNA. Translation: BAA85906.1.
AJ005667 Genomic DNA. Translation: CAA06663.1.
RefSeqiXP_002057583.1. XM_002057547.2.
XP_002057584.1. XM_002057548.2.

Genome annotation databases

EnsemblMetazoaiFBtr0234133; FBpp0232625; FBgn0014836.
FBtr0234134; FBpp0232626; FBgn0014837.
GeneIDi6633890.
6634390.
KEGGidvi:Dvir_GJ18208.
dvi:Dvir_GJ18209.

Similar proteinsi

Entry informationi

Entry nameiADH_DROVI
AccessioniPrimary (citable) accession number: B4M8Y0
Secondary accession number(s): O96996, Q27431, Q9U8P1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: September 23, 2008
Last modified: August 30, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families