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B4M7S0 (PGAM5_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 27. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene names
Name:Pgam5
ORF Names:GJ17041
OrganismDrosophila virilis (Fruit fly) [Complete proteome]
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity. UniProtKB O46084

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with Pk92B/ASK1 By similarity. UniProtKB O46084

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000390710

Regions

Transmembrane7 – 2317Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B4M7S0 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: DA3B0488113D26BC

FASTA28933,194
        10         20         30         40         50         60 
MRKFTAFACG TGAGLAAYYL QKLRDPQLAV HNSWTNSDRP ISECALWDSN WDFRDPKSLV 

        70         80         90        100        110        120 
RPQKNDLPQE QNRYNSDLEK HVAKSARHII LIRHGEYLDV GDSDDTHHLT DRGRLQAKYT 

       130        140        150        160        170        180 
GQRLRELGIK WDKVIASNMV RAQETADIIL NQIDYDKAKL KHCSYLREGA PIPPQPPVGH 

       190        200        210        220        230        240 
WKPEASQFFR DGARIEAAFR RYFHRALPEQ EKESYTLIVG HGNVIRYFVC RALQFPAEAW 

       250        260        270        280 
LRISINHASI TWLTISPSGN VSIKYLGDTG FMPAKYLTHR IPRDAKNVV 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15010-1051.87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH940653 Genomic DNA. Translation: EDW62837.1.
RefSeqXP_002057351.1. XM_002057315.1.

3D structure databases

ProteinModelPortalB4M7S0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7244.FBpp0231458.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0232966; FBpp0231458; FBgn0204218.
GeneID6633492.
KEGGdvi:Dvir_GJ17041.

Organism-specific databases

FlyBaseFBgn0204218. Dvir\GJ17041.

Phylogenomic databases

eggNOGNOG71348.
InParanoidB4M7S0.
KOK15637.
OMAWLRMSLN.
OrthoDBEOG7966H1.

Family and domain databases

InterProIPR013078. His_Pase_superF_clade-1.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGAM5_DROVI
AccessionPrimary (citable) accession number: B4M7S0
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: March 19, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase