Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B4M709 (SWS_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese
EC=3.1.1.5
Gene names
Name:sws
ORF Names:GJ16892
OrganismDrosophila virilis (Fruit fly) [Complete proteome]
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length1483 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity. UniProtKB Q9U969

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. UniProtKB Q9U969

Subunit structure

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity. UniProtKB Q9U969

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Sws tethers Pka-C3 to the membrane By similarity. UniProtKB Q9U969

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14831483Neuropathy target esterase sws
PRO_0000389227

Regions

Topological domain1 – 3434Lumenal Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 14831428Cytoplasmic Potential
Domain927 – 1093167Patatin
Nucleotide binding174 – 301128cNMP 1
Nucleotide binding456 – 585130cNMP 2
Nucleotide binding574 – 701128cNMP 3
Compositional bias1401 – 147373Gln-rich

Sites

Active site9601 By similarity UniProtKB Q9U969

Amino acid modifications

Modified residue4181Phosphoserine By similarity UniProtKB Q9U969
Modified residue4241Phosphoserine By similarity UniProtKB Q9U969
Modified residue11741Phosphoserine By similarity UniProtKB Q9U969

Sequences

Sequence LengthMass (Da)Tools
B4M709 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 33D9FF4D68E8946A

FASTA1,483167,295
        10         20         30         40         50         60 
MDVLELLRAS ANGCYNTLFS DAWFQYVSKQ IATTMYWYGA LLVIGVLFIA WFLYFKRLAR 

        70         80         90        100        110        120 
LRLRDEIARS LSAVTSSGGD HRGLRFRKRD KMLFYGRRML RKMKNVSGQM YSSGKGYKRR 

       130        140        150        160        170        180 
AVMRFARRIL QLQRENRPLE MKTVEPPAEY LEETIEGSDR VPPDALYMLQ SIRIFGHFEK 

       190        200        210        220        230        240 
PIFLKLCKHT QLLQLMAGDY LFKITDPDDS VYIVQSGMIN VYICNADGST LSLKTVRKGE 

       250        260        270        280        290        300 
SVTSLLSFID VLSGNSSYYK TVTAKAMEKS VVIRLPMQAF EEVFEENPDV MIRVIQVIMI 

       310        320        330        340        350        360 
RLQRVLFTAL RNYLGLNAEL VQNHMRTKGS SVVPNAVGGA VLAQASQASR PVVRAPTSPN 

       370        380        390        400        410        420 
SRLSREEHTL SDPDPNPNAN ALLFAEVHGD APYIDLYHHQ QQQSSAVSVN QAGTRRSSTT 

       430        440        450        460        470        480 
YGPSGESPNG NANTAPGTSI DQRLVQSSAV DSLRRELGLS EDDAQIIEPF VEVRELEPNV 

       490        500        510        520        530        540 
TLITEGNAED VCVWFVMTGT LAVYQSNADA TRATKQDSKN DVLIHFVHPG EIVGGLAMLT 

       550        560        570        580        590        600 
GEASAYTIRA RSNSRVAYIR RAAIYQIMRQ RPRIVLDLGN GVVRRLSPLV RQCDYALDWI 

       610        620        630        640        650        660 
FLESGRAVYR QDESSDSTYI VLSGRMRSVI THPGGKKEII GEYGKGDLVG IVEMITETSR 

       670        680        690        700        710        720 
TTTVMAVRDS ELAKLPEGLF NAIKLRYPIV VTRLISFLSH RFLGSMQTRG SNAAGGPVEA 

       730        740        750        760        770        780 
NPVTHKYSTV ALVPITDDVP LTPFTYELYH SLCAIGPVLR LTSEVVRKQL GINIFEAANE 

       790        800        810        820        830        840 
YRLTSWLAQQ EDRNIITLYQ CDSSLSPWTQ RCMRQADVVL IVGLGERSHL VGKFEREIDK 

       850        860        870        880        890        900 
LAMRTQKELV LLYPETTNAK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS 

       910        920        930        940        950        960 
RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG IPIDMVGGVS 

       970        980        990       1000       1010       1020 
IGALMGALWC SERNITTVTQ KAREWSKKMT KWFLQLLDLT YPITSMFSGR EFNKTIHDTF 

      1030       1040       1050       1060       1070       1080 
GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG SLWRYVRSSM SLSGYMPPLC DPQDGHLLLD 

      1090       1100       1110       1120       1130       1140 
GGYVNNLPGH LWRYCRASMS IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII 

      1150       1160       1170       1180       1190       1200 
AIDVGSQDDT DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV 

      1210       1220       1230       1240       1250       1260 
KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFD NMAKAGRLGR FNQWFNKEPP 

      1270       1280       1290       1300       1310       1320 
KRGNHASLNE YTFIDLAQIV CKLPETYALN TADIFSEDED FDGYISEPTT LNMDRRRIQV 

      1330       1340       1350       1360       1370       1380 
PRAGNSLSFS ETEMDSDVEI DLELERKVDK ATQSTPPTPN KQHALSPTSS QTNLLPLPPN 

      1390       1400       1410       1420       1430       1440 
SKPKEKQPSY DKLDREHKRR QKSKQKQQQE RSSMQQRDSM VTLHPATMAE ATTQTAPHSS 

      1450       1460       1470       1480 
EEDELNKPEQ QPEQKPVPET EEQQQKQQDQ QQQENLTKTD TKN 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15010-1051.87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH940653 Genomic DNA. Translation: EDW62576.1.
RefSeqXP_002057090.1. XM_002057054.1.

3D structure databases

ProteinModelPortalB4M709.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7244.FBpp0231309.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0232817; FBpp0231309; FBgn0204071.
GeneID6633725.
KEGGdvi:Dvir_GJ16892.

Organism-specific databases

FlyBaseFBgn0204071. Dvir\GJ16892.

Phylogenomic databases

eggNOGCOG0664.
InParanoidB4M709.
KOK14676.
OMAMACDRAR.
OrthoDBEOG7QRQT1.
PhylomeDBB4M709.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSWS_DROVI
AccessionPrimary (citable) accession number: B4M709
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase