Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4M709

- SWS_DROVI

UniProt

B4M709 - SWS_DROVI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei960 – 9601By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 301128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi456 – 585130cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi574 – 701128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GJ16892
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0204071. Dvir\GJ16892.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14831483Neuropathy target esterase swsPRO_0000389227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei418 – 4181PhosphoserineBy similarity
Modified residuei424 – 4241PhosphoserineBy similarity
Modified residuei1174 – 11741PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7244.FBpp0231309.

Structurei

3D structure databases

ProteinModelPortaliB4M709.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence AnalysisAdd
BLAST
Topological domaini56 – 14831428CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini927 – 1093167PatatinSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1401 – 147373Gln-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB4M709.
KOiK14676.
OMAiMACDRAR.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4M709.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4M709-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLELLRAS ANGCYNTLFS DAWFQYVSKQ IATTMYWYGA LLVIGVLFIA
60 70 80 90 100
WFLYFKRLAR LRLRDEIARS LSAVTSSGGD HRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLQRENRPLE MKTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLKLCKHT QLLQLMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYICNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNSSYYK TVTAKAMEKS VVIRLPMQAF EEVFEENPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRTKGS SVVPNAVGGA VLAQASQASR
360 370 380 390 400
PVVRAPTSPN SRLSREEHTL SDPDPNPNAN ALLFAEVHGD APYIDLYHHQ
410 420 430 440 450
QQQSSAVSVN QAGTRRSSTT YGPSGESPNG NANTAPGTSI DQRLVQSSAV
460 470 480 490 500
DSLRRELGLS EDDAQIIEPF VEVRELEPNV TLITEGNAED VCVWFVMTGT
510 520 530 540 550
LAVYQSNADA TRATKQDSKN DVLIHFVHPG EIVGGLAMLT GEASAYTIRA
560 570 580 590 600
RSNSRVAYIR RAAIYQIMRQ RPRIVLDLGN GVVRRLSPLV RQCDYALDWI
610 620 630 640 650
FLESGRAVYR QDESSDSTYI VLSGRMRSVI THPGGKKEII GEYGKGDLVG
660 670 680 690 700
IVEMITETSR TTTVMAVRDS ELAKLPEGLF NAIKLRYPIV VTRLISFLSH
710 720 730 740 750
RFLGSMQTRG SNAAGGPVEA NPVTHKYSTV ALVPITDDVP LTPFTYELYH
760 770 780 790 800
SLCAIGPVLR LTSEVVRKQL GINIFEAANE YRLTSWLAQQ EDRNIITLYQ
810 820 830 840 850
CDSSLSPWTQ RCMRQADVVL IVGLGERSHL VGKFEREIDK LAMRTQKELV
860 870 880 890 900
LLYPETTNAK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS
910 920 930 940 950
RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG
960 970 980 990 1000
IPIDMVGGVS IGALMGALWC SERNITTVTQ KAREWSKKMT KWFLQLLDLT
1010 1020 1030 1040 1050
YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG
1060 1070 1080 1090 1100
SLWRYVRSSM SLSGYMPPLC DPQDGHLLLD GGYVNNLPGH LWRYCRASMS
1110 1120 1130 1140 1150
IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT
1160 1170 1180 1190 1200
DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV
1210 1220 1230 1240 1250
KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFD NMAKAGRLGR
1260 1270 1280 1290 1300
FNQWFNKEPP KRGNHASLNE YTFIDLAQIV CKLPETYALN TADIFSEDED
1310 1320 1330 1340 1350
FDGYISEPTT LNMDRRRIQV PRAGNSLSFS ETEMDSDVEI DLELERKVDK
1360 1370 1380 1390 1400
ATQSTPPTPN KQHALSPTSS QTNLLPLPPN SKPKEKQPSY DKLDREHKRR
1410 1420 1430 1440 1450
QKSKQKQQQE RSSMQQRDSM VTLHPATMAE ATTQTAPHSS EEDELNKPEQ
1460 1470 1480
QPEQKPVPET EEQQQKQQDQ QQQENLTKTD TKN
Length:1,483
Mass (Da):167,295
Last modified:September 23, 2008 - v1
Checksum:i33D9FF4D68E8946A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940653 Genomic DNA. Translation: EDW62576.1.
RefSeqiXP_002057090.1. XM_002057054.1.

Genome annotation databases

EnsemblMetazoaiFBtr0232817; FBpp0231309; FBgn0204071.
GeneIDi6633725.
KEGGidvi:Dvir_GJ16892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940653 Genomic DNA. Translation: EDW62576.1 .
RefSeqi XP_002057090.1. XM_002057054.1.

3D structure databases

ProteinModelPortali B4M709.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0231309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0232817 ; FBpp0231309 ; FBgn0204071 .
GeneIDi 6633725.
KEGGi dvi:Dvir_GJ16892.

Organism-specific databases

FlyBasei FBgn0204071. Dvir\GJ16892.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B4M709.
KOi K14676.
OMAi MACDRAR.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4M709.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87Imported.

Entry informationi

Entry nameiSWS_DROVI
AccessioniPrimary (citable) accession number: B4M709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3