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B4M709

- SWS_DROVI

UniProt

B4M709 - SWS_DROVI

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei960 – 9601By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi174 – 301128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi456 – 585130cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi574 – 701128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GJ16892
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0204071. Dvir\GJ16892.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14831483Neuropathy target esterase swsPRO_0000389227Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei418 – 4181PhosphoserineBy similarity
    Modified residuei424 – 4241PhosphoserineBy similarity
    Modified residuei1174 – 11741PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Protein-protein interaction databases

    STRINGi7244.FBpp0231309.

    Structurei

    3D structure databases

    ProteinModelPortaliB4M709.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14831428CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini927 – 1093167PatatinSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1401 – 147373Gln-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    InParanoidiB4M709.
    KOiK14676.
    OMAiMACDRAR.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB4M709.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4M709-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLELLRAS ANGCYNTLFS DAWFQYVSKQ IATTMYWYGA LLVIGVLFIA     50
    WFLYFKRLAR LRLRDEIARS LSAVTSSGGD HRGLRFRKRD KMLFYGRRML 100
    RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLQRENRPLE MKTVEPPAEY 150
    LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLKLCKHT QLLQLMAGDY 200
    LFKITDPDDS VYIVQSGMIN VYICNADGST LSLKTVRKGE SVTSLLSFID 250
    VLSGNSSYYK TVTAKAMEKS VVIRLPMQAF EEVFEENPDV MIRVIQVIMI 300
    RLQRVLFTAL RNYLGLNAEL VQNHMRTKGS SVVPNAVGGA VLAQASQASR 350
    PVVRAPTSPN SRLSREEHTL SDPDPNPNAN ALLFAEVHGD APYIDLYHHQ 400
    QQQSSAVSVN QAGTRRSSTT YGPSGESPNG NANTAPGTSI DQRLVQSSAV 450
    DSLRRELGLS EDDAQIIEPF VEVRELEPNV TLITEGNAED VCVWFVMTGT 500
    LAVYQSNADA TRATKQDSKN DVLIHFVHPG EIVGGLAMLT GEASAYTIRA 550
    RSNSRVAYIR RAAIYQIMRQ RPRIVLDLGN GVVRRLSPLV RQCDYALDWI 600
    FLESGRAVYR QDESSDSTYI VLSGRMRSVI THPGGKKEII GEYGKGDLVG 650
    IVEMITETSR TTTVMAVRDS ELAKLPEGLF NAIKLRYPIV VTRLISFLSH 700
    RFLGSMQTRG SNAAGGPVEA NPVTHKYSTV ALVPITDDVP LTPFTYELYH 750
    SLCAIGPVLR LTSEVVRKQL GINIFEAANE YRLTSWLAQQ EDRNIITLYQ 800
    CDSSLSPWTQ RCMRQADVVL IVGLGERSHL VGKFEREIDK LAMRTQKELV 850
    LLYPETTNAK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS 900
    RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG 950
    IPIDMVGGVS IGALMGALWC SERNITTVTQ KAREWSKKMT KWFLQLLDLT 1000
    YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG 1050
    SLWRYVRSSM SLSGYMPPLC DPQDGHLLLD GGYVNNLPGH LWRYCRASMS 1100
    IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT 1150
    DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV 1200
    KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFD NMAKAGRLGR 1250
    FNQWFNKEPP KRGNHASLNE YTFIDLAQIV CKLPETYALN TADIFSEDED 1300
    FDGYISEPTT LNMDRRRIQV PRAGNSLSFS ETEMDSDVEI DLELERKVDK 1350
    ATQSTPPTPN KQHALSPTSS QTNLLPLPPN SKPKEKQPSY DKLDREHKRR 1400
    QKSKQKQQQE RSSMQQRDSM VTLHPATMAE ATTQTAPHSS EEDELNKPEQ 1450
    QPEQKPVPET EEQQQKQQDQ QQQENLTKTD TKN 1483
    Length:1,483
    Mass (Da):167,295
    Last modified:September 23, 2008 - v1
    Checksum:i33D9FF4D68E8946A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940653 Genomic DNA. Translation: EDW62576.1.
    RefSeqiXP_002057090.1. XM_002057054.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0232817; FBpp0231309; FBgn0204071.
    GeneIDi6633725.
    KEGGidvi:Dvir_GJ16892.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940653 Genomic DNA. Translation: EDW62576.1 .
    RefSeqi XP_002057090.1. XM_002057054.1.

    3D structure databases

    ProteinModelPortali B4M709.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0231309.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0232817 ; FBpp0231309 ; FBgn0204071 .
    GeneIDi 6633725.
    KEGGi dvi:Dvir_GJ16892.

    Organism-specific databases

    FlyBasei FBgn0204071. Dvir\GJ16892.

    Phylogenomic databases

    eggNOGi COG0664.
    InParanoidi B4M709.
    KOi K14676.
    OMAi MACDRAR.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B4M709.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87Imported.

    Entry informationi

    Entry nameiSWS_DROVI
    AccessioniPrimary (citable) accession number: B4M709
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3