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B4M709

- SWS_DROVI

UniProt

B4M709 - SWS_DROVI

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Protein

Neuropathy target esterase sws

Gene
sws, GJ16892
Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei960 – 9601 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 301128cNMP 1Add
BLAST
Nucleotide bindingi456 – 585130cNMP 2Add
BLAST
Nucleotide bindingi574 – 701128cNMP 3Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GJ16892
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0204071. Dvir\GJ16892.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Topological domaini56 – 14831428Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14831483Neuropathy target esterase swsPRO_0000389227Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei418 – 4181Phosphoserine By similarityBy similarity
Modified residuei424 – 4241Phosphoserine By similarityBy similarity
Modified residuei1174 – 11741Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Protein-protein interaction databases

STRINGi7244.FBpp0231309.

Structurei

3D structure databases

ProteinModelPortaliB4M709.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini927 – 1093167PatatinAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1401 – 147373Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB4M709.
KOiK14676.
OMAiMACDRAR.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4M709.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4M709-1 [UniParc]FASTAAdd to Basket

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MDVLELLRAS ANGCYNTLFS DAWFQYVSKQ IATTMYWYGA LLVIGVLFIA     50
WFLYFKRLAR LRLRDEIARS LSAVTSSGGD HRGLRFRKRD KMLFYGRRML 100
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLQRENRPLE MKTVEPPAEY 150
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLKLCKHT QLLQLMAGDY 200
LFKITDPDDS VYIVQSGMIN VYICNADGST LSLKTVRKGE SVTSLLSFID 250
VLSGNSSYYK TVTAKAMEKS VVIRLPMQAF EEVFEENPDV MIRVIQVIMI 300
RLQRVLFTAL RNYLGLNAEL VQNHMRTKGS SVVPNAVGGA VLAQASQASR 350
PVVRAPTSPN SRLSREEHTL SDPDPNPNAN ALLFAEVHGD APYIDLYHHQ 400
QQQSSAVSVN QAGTRRSSTT YGPSGESPNG NANTAPGTSI DQRLVQSSAV 450
DSLRRELGLS EDDAQIIEPF VEVRELEPNV TLITEGNAED VCVWFVMTGT 500
LAVYQSNADA TRATKQDSKN DVLIHFVHPG EIVGGLAMLT GEASAYTIRA 550
RSNSRVAYIR RAAIYQIMRQ RPRIVLDLGN GVVRRLSPLV RQCDYALDWI 600
FLESGRAVYR QDESSDSTYI VLSGRMRSVI THPGGKKEII GEYGKGDLVG 650
IVEMITETSR TTTVMAVRDS ELAKLPEGLF NAIKLRYPIV VTRLISFLSH 700
RFLGSMQTRG SNAAGGPVEA NPVTHKYSTV ALVPITDDVP LTPFTYELYH 750
SLCAIGPVLR LTSEVVRKQL GINIFEAANE YRLTSWLAQQ EDRNIITLYQ 800
CDSSLSPWTQ RCMRQADVVL IVGLGERSHL VGKFEREIDK LAMRTQKELV 850
LLYPETTNAK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS 900
RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG 950
IPIDMVGGVS IGALMGALWC SERNITTVTQ KAREWSKKMT KWFLQLLDLT 1000
YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG 1050
SLWRYVRSSM SLSGYMPPLC DPQDGHLLLD GGYVNNLPGH LWRYCRASMS 1100
IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT 1150
DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV 1200
KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFD NMAKAGRLGR 1250
FNQWFNKEPP KRGNHASLNE YTFIDLAQIV CKLPETYALN TADIFSEDED 1300
FDGYISEPTT LNMDRRRIQV PRAGNSLSFS ETEMDSDVEI DLELERKVDK 1350
ATQSTPPTPN KQHALSPTSS QTNLLPLPPN SKPKEKQPSY DKLDREHKRR 1400
QKSKQKQQQE RSSMQQRDSM VTLHPATMAE ATTQTAPHSS EEDELNKPEQ 1450
QPEQKPVPET EEQQQKQQDQ QQQENLTKTD TKN 1483
Length:1,483
Mass (Da):167,295
Last modified:September 23, 2008 - v1
Checksum:i33D9FF4D68E8946A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940653 Genomic DNA. Translation: EDW62576.1.
RefSeqiXP_002057090.1. XM_002057054.1.

Genome annotation databases

EnsemblMetazoaiFBtr0232817; FBpp0231309; FBgn0204071.
GeneIDi6633725.
KEGGidvi:Dvir_GJ16892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940653 Genomic DNA. Translation: EDW62576.1 .
RefSeqi XP_002057090.1. XM_002057054.1.

3D structure databases

ProteinModelPortali B4M709.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0231309.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0232817 ; FBpp0231309 ; FBgn0204071 .
GeneIDi 6633725.
KEGGi dvi:Dvir_GJ16892.

Organism-specific databases

FlyBasei FBgn0204071. Dvir\GJ16892.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B4M709.
KOi K14676.
OMAi MACDRAR.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4M709.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiSWS_DROVI
AccessioniPrimary (citable) accession number: B4M709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi