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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei960NucleophilePROSITE-ProRule annotation1
Active sitei1080Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi174 – 301cNMP 1Sequence analysisAdd BLAST128
Nucleotide bindingi456 – 585cNMP 2Sequence analysisAdd BLAST130
Nucleotide bindingi574 – 701cNMP 3Sequence analysisAdd BLAST128

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GJ16892
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0204071. Dvir\GJ16892.

Subcellular locationi

  • Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity

  • Note: Sws tethers Pka-C3 to the membrane.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34LumenalSequence analysisAdd BLAST34
Transmembranei35 – 55HelicalSequence analysisAdd BLAST21
Topological domaini56 – 1483CytoplasmicSequence analysisAdd BLAST1428

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003892271 – 1483Neuropathy target esterase swsAdd BLAST1483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei418PhosphoserineBy similarity1
Modified residuei424PhosphoserineBy similarity1
Modified residuei1174PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7244.FBpp0231309.

Structurei

3D structure databases

ProteinModelPortaliB4M709.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini927 – 1093PNPLAPROSITE-ProRule annotationAdd BLAST167

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi931 – 936GXGXXGPROSITE-ProRule annotation6
Motifi958 – 962GXSXGPROSITE-ProRule annotation5
Motifi1080 – 1082DGA/GPROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1401 – 1473Gln-richSequence analysisAdd BLAST73

Sequence similaritiesi

Belongs to the NTE family.Sequence analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 PNPLA (patatin-like phospholipase) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
InParanoidiB4M709.
KOiK14676.
OMAiCAQVGIL.
OrthoDBiEOG091G00XM.
PhylomeDBiB4M709.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4M709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVLELLRAS ANGCYNTLFS DAWFQYVSKQ IATTMYWYGA LLVIGVLFIA
60 70 80 90 100
WFLYFKRLAR LRLRDEIARS LSAVTSSGGD HRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKMKNVSGQM YSSGKGYKRR AVMRFARRIL QLQRENRPLE MKTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PIFLKLCKHT QLLQLMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYICNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNSSYYK TVTAKAMEKS VVIRLPMQAF EEVFEENPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRTKGS SVVPNAVGGA VLAQASQASR
360 370 380 390 400
PVVRAPTSPN SRLSREEHTL SDPDPNPNAN ALLFAEVHGD APYIDLYHHQ
410 420 430 440 450
QQQSSAVSVN QAGTRRSSTT YGPSGESPNG NANTAPGTSI DQRLVQSSAV
460 470 480 490 500
DSLRRELGLS EDDAQIIEPF VEVRELEPNV TLITEGNAED VCVWFVMTGT
510 520 530 540 550
LAVYQSNADA TRATKQDSKN DVLIHFVHPG EIVGGLAMLT GEASAYTIRA
560 570 580 590 600
RSNSRVAYIR RAAIYQIMRQ RPRIVLDLGN GVVRRLSPLV RQCDYALDWI
610 620 630 640 650
FLESGRAVYR QDESSDSTYI VLSGRMRSVI THPGGKKEII GEYGKGDLVG
660 670 680 690 700
IVEMITETSR TTTVMAVRDS ELAKLPEGLF NAIKLRYPIV VTRLISFLSH
710 720 730 740 750
RFLGSMQTRG SNAAGGPVEA NPVTHKYSTV ALVPITDDVP LTPFTYELYH
760 770 780 790 800
SLCAIGPVLR LTSEVVRKQL GINIFEAANE YRLTSWLAQQ EDRNIITLYQ
810 820 830 840 850
CDSSLSPWTQ RCMRQADVVL IVGLGERSHL VGKFEREIDK LAMRTQKELV
860 870 880 890 900
LLYPETTNAK PANTLSWLNA RPWVTKHHHV LCVKRIFTRK SQYRINDLYS
910 920 930 940 950
RVLLSEPNMH SDFSRLARWL TGNSIGLVLG GGGARGAAHI GMLKAIQEAG
960 970 980 990 1000
IPIDMVGGVS IGALMGALWC SERNITTVTQ KAREWSKKMT KWFLQLLDLT
1010 1020 1030 1040 1050
YPITSMFSGR EFNKTIHDTF GDVSIEDLWI PYFTLTTDIT ASCHRIHTNG
1060 1070 1080 1090 1100
SLWRYVRSSM SLSGYMPPLC DPQDGHLLLD GGYVNNLPGH LWRYCRASMS
1110 1120 1130 1140 1150
IAGVFPPFCD YRDGHLLLDG CYTNNVPADV MHNLGAAHII AIDVGSQDDT
1160 1170 1180 1190 1200
DLTNYGDDLS GWWLLYKKWN PFTSPVKVPD LPDIQSRLAY VSCVRQLEEV
1210 1220 1230 1240 1250
KNSDYCEYIR PPIDKYKTLA FGSFDEIRDV GYVFGKNYFD NMAKAGRLGR
1260 1270 1280 1290 1300
FNQWFNKEPP KRGNHASLNE YTFIDLAQIV CKLPETYALN TADIFSEDED
1310 1320 1330 1340 1350
FDGYISEPTT LNMDRRRIQV PRAGNSLSFS ETEMDSDVEI DLELERKVDK
1360 1370 1380 1390 1400
ATQSTPPTPN KQHALSPTSS QTNLLPLPPN SKPKEKQPSY DKLDREHKRR
1410 1420 1430 1440 1450
QKSKQKQQQE RSSMQQRDSM VTLHPATMAE ATTQTAPHSS EEDELNKPEQ
1460 1470 1480
QPEQKPVPET EEQQQKQQDQ QQQENLTKTD TKN
Length:1,483
Mass (Da):167,295
Last modified:September 23, 2008 - v1
Checksum:i33D9FF4D68E8946A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940653 Genomic DNA. Translation: EDW62576.1.
RefSeqiXP_002057090.2. XM_002057054.2.

Genome annotation databases

EnsemblMetazoaiFBtr0232817; FBpp0231309; FBgn0204071.
GeneIDi6633725.
KEGGidvi:Dvir_GJ16892.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940653 Genomic DNA. Translation: EDW62576.1.
RefSeqiXP_002057090.2. XM_002057054.2.

3D structure databases

ProteinModelPortaliB4M709.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0231309.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0232817; FBpp0231309; FBgn0204071.
GeneIDi6633725.
KEGGidvi:Dvir_GJ16892.

Organism-specific databases

FlyBaseiFBgn0204071. Dvir\GJ16892.

Phylogenomic databases

eggNOGiKOG2968. Eukaryota.
COG0664. LUCA.
COG1752. LUCA.
InParanoidiB4M709.
KOiK14676.
OMAiCAQVGIL.
OrthoDBiEOG091G00XM.
PhylomeDBiB4M709.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS51635. PNPLA. 1 hit.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWS_DROVI
AccessioniPrimary (citable) accession number: B4M709
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.