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B4M703

- TRMB_DROVI

UniProt

B4M703 - TRMB_DROVI

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Protein

tRNA (guanine-N(7)-)-methyltransferase

Gene

GJ16889

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei70 – 701S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Binding sitei148 – 1481S-adenosyl-L-methionine; via carbonyl oxygenUniRule annotation
Active sitei151 – 1511UniRule annotation

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
  2. tRNA binding Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine, tRNA-binding

Enzyme and pathway databases

UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation (EC:2.1.1.33UniRule annotation)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferaseUniRule annotation
tRNA(m7G46)-methyltransferaseUniRule annotation
Gene namesi
ORF Names:GJ16889
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0204068. Dvir\GJ16889.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247tRNA (guanine-N(7)-)-methyltransferasePRO_0000370576Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0231306.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni93 – 942S-adenosyl-L-methionine bindingUniRule annotation
Regioni128 – 1292S-adenosyl-L-methionine bindingUniRule annotation
Regioni226 – 2283S-adenosyl-L-methionine bindingUniRule annotation

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0220.
InParanoidiB4M703.
KOiK03439.
OMAiRAHSNPI.
OrthoDBiEOG7PS1GC.
PhylomeDBiB4M703.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_03055. tRNA_methyltr_TrmB_euk.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4M703-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTNSQEGET LPATSSVTGL PQKRFYRQRA HSNPIADHSF DYPARPEDVD
60 70 80 90 100
WRSLYPNIGS EQQVEFADIG CGYGGFLVTL GEMFPDKLAI GMEIRVKVSD
110 120 130 140 150
YVIDRIAALR MKNAETSAYQ NIACIRTNAM KYLPNYFQKS QLEKMFFLYP
160 170 180 190 200
DPHFKRAKHK WRIINQALLS EYAYVLRSGG LVYTMTDVED LHKWIVSHMT
210 220 230 240
QHPLYERLTD EEANADPITP KLYQSSEEGA KVVRNKGDHF LAIFRRI
Length:247
Mass (Da):28,463
Last modified:September 23, 2008 - v1
Checksum:i225A7A97B192FD46
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940653 Genomic DNA. Translation: EDW62570.1.
RefSeqiXP_002057084.1. XM_002057048.1.

Genome annotation databases

EnsemblMetazoaiFBtr0232814; FBpp0231306; FBgn0204068.
GeneIDi6633719.
KEGGidvi:Dvir_GJ16889.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940653 Genomic DNA. Translation: EDW62570.1 .
RefSeqi XP_002057084.1. XM_002057048.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0231306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0232814 ; FBpp0231306 ; FBgn0204068 .
GeneIDi 6633719.
KEGGi dvi:Dvir_GJ16889.

Organism-specific databases

FlyBasei FBgn0204068. Dvir\GJ16889.

Phylogenomic databases

eggNOGi COG0220.
InParanoidi B4M703.
KOi K03439.
OMAi RAHSNPI.
OrthoDBi EOG7PS1GC.
PhylomeDBi B4M703.

Enzyme and pathway databases

UniPathwayi UPA00989 .

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_03055. tRNA_methyltr_TrmB_euk.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR025763. Trm8_euk.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiTRMB_DROVI
AccessioniPrimary (citable) accession number: B4M703
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3