ID B4M6G3_DROVI Unreviewed; 1453 AA. AC B4M6G3; DT 23-SEP-2008, integrated into UniProtKB/TrEMBL. DT 20-JAN-2016, sequence version 2. DT 27-MAR-2024, entry version 113. DE RecName: Full=Histone-lysine N-methyltransferase Mes-4 {ECO:0008006|Google:ProtNLM}; GN Name=Dvir\GJ10771 {ECO:0000313|EMBL:EDW59239.2}; GN ORFNames=Dvir_GJ10771 {ECO:0000313|EMBL:EDW59239.2}; OS Drosophila virilis (Fruit fly). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; OC Drosophilidae; Drosophila. OX NCBI_TaxID=7244 {ECO:0000313|EMBL:EDW59239.2, ECO:0000313|Proteomes:UP000008792}; RN [1] {ECO:0000313|EMBL:EDW59239.2, ECO:0000313|Proteomes:UP000008792} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Tucson 15010-1051.87 {ECO:0000313|Proteomes:UP000008792}; RX PubMed=17994087; DOI=10.1038/nature06341; RG Drosophila 12 genomes consortium; RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M., RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.; RT "Evolution of genes and genomes on the Drosophila phylogeny."; RL Nature 450:203-218(2007). CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CH940652; EDW59239.2; -; Genomic_DNA. DR RefSeq; XP_002056127.2; XM_002056091.2. DR SMR; B4M6G3; -. DR STRING; 7244.B4M6G3; -. DR EnsemblMetazoa; FBtr0433689; FBpp0390808; FBgn0198045. DR GeneID; 6632940; -. DR KEGG; dvi:6632940; -. DR eggNOG; KOG1081; Eukaryota. DR HOGENOM; CLU_252531_0_0_1; -. DR InParanoid; B4M6G3; -. DR OrthoDB; 950362at2759; -. DR Proteomes; UP000008792; Unassembled WGS sequence. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005721; C:pericentric heterochromatin; IEA:EnsemblMetazoa. DR GO; GO:0005700; C:polytene chromosome; IEA:EnsemblMetazoa. DR GO; GO:0031490; F:chromatin DNA binding; IEA:EnsemblMetazoa. DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd15566; PHD3_NSD; 1. DR CDD; cd15567; PHD4_NSD; 1. DR CDD; cd20144; PWWP_NSD_rpt1; 1. DR CDD; cd05838; PWWP_NSD_rpt2; 1. DR Gene3D; 2.30.30.140; -; 2. DR Gene3D; 2.170.270.10; SET domain; 1. DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1. DR InterPro; IPR006560; AWS_dom. DR InterPro; IPR003616; Post-SET_dom. DR InterPro; IPR000313; PWWP_dom. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR InterPro; IPR019786; Zinc_finger_PHD-type_CS. DR InterPro; IPR011011; Znf_FYVE_PHD. DR InterPro; IPR001965; Znf_PHD. DR InterPro; IPR019787; Znf_PHD-finger. DR InterPro; IPR013083; Znf_RING/FYVE/PHD. DR PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1. DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1. DR Pfam; PF17907; AWS; 1. DR Pfam; PF00855; PWWP; 2. DR Pfam; PF00856; SET; 1. DR SMART; SM00570; AWS; 1. DR SMART; SM00249; PHD; 3. DR SMART; SM00293; PWWP; 2. DR SMART; SM00317; SET; 1. DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1. DR SUPFAM; SSF82199; SET domain; 1. DR SUPFAM; SSF63748; Tudor/PWWP/MBT; 2. DR PROSITE; PS51215; AWS; 1. DR PROSITE; PS50868; POST_SET; 1. DR PROSITE; PS50812; PWWP; 2. DR PROSITE; PS50280; SET; 1. DR PROSITE; PS01359; ZF_PHD_1; 1. DR PROSITE; PS50016; ZF_PHD_2; 1. PE 4: Predicted; KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Reference proteome {ECO:0000313|Proteomes:UP000008792}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}; KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE- KW ProRule:PRU00146}. FT DOMAIN 374..450 FT /note="PWWP" FT /evidence="ECO:0000259|PROSITE:PS50812" FT DOMAIN 1014..1059 FT /note="PHD-type" FT /evidence="ECO:0000259|PROSITE:PS50016" FT DOMAIN 1064..1126 FT /note="PWWP" FT /evidence="ECO:0000259|PROSITE:PS50812" FT DOMAIN 1197..1247 FT /note="AWS" FT /evidence="ECO:0000259|PROSITE:PS51215" FT DOMAIN 1241..1366 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT DOMAIN 1374..1390 FT /note="Post-SET" FT /evidence="ECO:0000259|PROSITE:PS50868" FT REGION 71..100 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 213..255 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 329..355 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 550..596 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 711..738 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 809..849 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 1406..1453 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 214..228 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 229..255 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 338..355 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 711..727 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 824..845 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1408..1428 FT /note="Basic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1453 AA; 162777 MW; E56E877E530CF62A CRC64; MKLSANNTHT EMQDAGVVHT PTEATDNATA GTVVPSVVKT DAGGTLSQLN AIQRFPGNLL LRNCINDAES ATDSSEQFTE YEHHNTTDQQ QTPPAARGRH RVKTLNRKRD LINLQSNLSP KYIGYPNANS PTVPDSVDKV RTTRRRNHVL TPNRDGDSDV ASPKTLLAGM HMLASGAYLS PIDKLLIKNG ANSPNSTGFE ADAEDVAMMQ PTRKQLKRKL KRDSKPKKKH PKETPAEVTA KETSDHLTKD EQSHQKQAIF KIGQTLATDK PEISIKVELT EEDAPHKIFE ADEQIHVKTE LKTAEQKDIE GGQVDSILAL PTATSTEMEA LKSPPDIEPA NNSEQSMKSP SSISLDSAKG SSIVTDSGWP TYQVGDLYWG KLFTYCYWPC MVCPDQLGQI VGNPHTHPQR KSTDSAPGAP VPIQVHVRFF ADNGRHNWIK SENLLPFAGL KAFEELREEA RIKYGPRSLK YRQMTAKQNK QIVWRQAIEE ANIVGQLPYA ERMQKFYEIY ENTVIHNKEK RKYTKSVRQD TSDVGSSLYD STDNLLAKTQ HAQPLKRERS SSPFSPAFSP VKHNHQKRAK RRKLSGSLEA PVGYTPLSEP HGEKLVSPDL VNYKNPEFGQ LFDAIKEYVM VHRQEEKVEK VLLAVVRNIW SLKQLQLREL ERDLASGESE LLGSARLGSE RGRGVGTIKR LSNRLKTMML RRSITPVVTP STAAPAQIST PESMQTERHL SENPKVRKPI GRPIDEVIED ILQLDRKYLF RGLNREPVCK YCYEPGGDIQ RCSLNCNSWL HATCLDQQIT VNTKAKKGLK AVGPAPSKPP EPLTSSSPVS EVEPTTTTST LTKHITGDEI KQEQNKEPLV CHECASGKSN ACCICHQEQL PVNSPPPSPH KESVASATAI SEVEEPPISN KLILCCQPMC SNKFHASCCK YWPQASISNS STRCPMHVCH TCVSDDPSGK YQQLGSAKLT KCVKCPATYH QDSRCIPAGS RMLTVTHLIC PRHNIAKADA NLNVLWCYIC VRGGELVCCE TCPIAVHAHC RNIPIKTNES YICEECESGR LPLYGEIVWA KFNNFRWWPS IILPPTEIPS NILKKPHGAN DFVVRFFGTN DHGWISRRRV YLYIEGDTGD GYKSKSLMSK RYTAGVEEAT RFLKIIKDKR QEQAIGRFSG NKLYPPPYIK IKANKPVPPV RFVYNEEDLN ICECKPGSEH PCGPESGCLN RMLYHECHPD YCHAGRQCEN QLFELRKSPR LEVVYMNERG FGLVCREPIA EGDFIIEYVG EVINHAEFQR RMAQKTRDRD ENFYFLGVEK DFIIDAGPKG NLARFMNHSC EPNCATQKWT VNCINRVGLF AIKDIPENTE LTFNYLWDDL MNNGKKACFC GAKRCSGEIG GKLKDEEVKE TKIKQLPRHK GIRIHVGAPK KKAAKRSKSK HMGADNVPPT EQPLDAAPAS KEP //