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B4M059

- B4M059_DROVI

UniProt

B4M059 - B4M059_DROVI

Protein
Submitted name:

Trx

Gene

trx

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

    GO - Molecular functioni

    1. histone methyltransferase activity (H3-K4 specific) Source: InterPro
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro
    4. zinc ion binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    MethyltransferaseUniRule annotationSAAS annotation, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation, Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TrxImported
    Gene namesi
    Name:trxImported
    Synonyms:Dvir\trxImported
    ORF Names:Dvir_GJ22599Imported, GJ22599Imported
    OrganismiDrosophila virilis (Fruit fly)Imported
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0014844. Dvir\trx.

    Subcellular locationi

    GO - Cellular componenti

    1. histone methyltransferase complex Source: InterPro

    Keywords - Cellular componenti

    NucleusSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi7244.FBpp0237016.

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 SET domain.
    Contains 1 post-SET domain.UniRule annotation
    Contains SET domain.SAAS annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation
    Contains post-SET domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerSAAS annotation

    Phylogenomic databases

    KOiK09186.
    OMAiARCEPYS.
    PhylomeDBiB4M059.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR003889. FYrich_C.
    IPR003888. FYrich_N.
    IPR016569. MeTrfase_trithorax.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR011011. Znf_FYVE_PHD.
    IPR001628. Znf_hrmn_rcpt.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view]
    PfamiPF05965. FYRC. 1 hit.
    PF05964. FYRN. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    PIRSFiPIRSF010354. Methyltransferase_trithorax. 1 hit.
    SMARTiSM00542. FYRC. 1 hit.
    SM00541. FYRN. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00184. RING. 4 hits.
    SM00317. SET. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF57903. SSF57903. 2 hits.
    PROSITEiPS51543. FYRC. 1 hit.
    PS51542. FYRN. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS50016. ZF_PHD_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4M059-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGRSKFPGKP SKSINRKRIS VLQLEDEAAS AAAAAATAAT TEQHQQSEQS     50
    AGSSASREKG NNCDNDDDDN APSGAATSGN RGASSGASDA AATEGGNSTG 100
    NGSSTGGKTT NGGNVNGGSH HKSATAPAEL KECKNQGNQI EPNNCIAAEP 150
    DGTEDTNNDD DDDSSNDKKP TAAAAAAAAA AFVPGPSALQ RARKGGNKKF 200
    KNLNLARPEV MLPSTSKLKQ QQQQQLQLNC PSASASSLSS SAAAAAAAAA 250
    PTTTTTTASA SATLTATATS TSTSSLPGTP LSVIAGGGGG AAAAGLLLAN 300
    PFASVETKVV EVNAAATAAA GAGEDVAMLH ALLIGQEASS GTFMTYLTFM 350
    FLQLKASIEM ANEAGLEAPA VAVKSSGSSP NPNHNPNAVA GSTSAAAPGA 400
    PTATKQKKTV TFKNILETSD DKSVVKRFYN PDNRVPLVSI MKKDSLNRPL 450
    NYCRGSEFIV RPSILSKILN KNSNIDKLNS LKFRSVHASS NSIQESSSST 500
    TNLFGSGLSR AFGAPIDDED AVSGGVTFRK QEPQHKTPED NDDDGSASSD 550
    AIEDDEDIDD DDAEDNEEAA SEKSAETTAS VDEKEADDRQ LVMDKHFVLP 600
    KRSTRSSRII KPNKRLLEVG GICSKRSPSD ANGKPKPKNY FGLGDFASEV 650
    HASSSSSSST SAATALSQKL GKETFTSFAT AKVNSSFVLR QPRLQFQTDK 700
    SGSFVSAKPT LPTTTLLPAS SSAITSANVL SFGALNNANS AVAAASTCAV 750
    CSAPVNNKDA PLARKYGVIA CEVCRKFNSR MTKISKLSTP MHSNPSTSTA 800
    QSGQQLKCTD GGNCSILSLK SQLKNFKKLY KERCKACWLK KCLATLQLPA 850
    GHRSRLSAIL PASMREEVAP KDDKCPELLS PTASLRFTAP TSSASSGTTI 900
    KWKSSAETAV NSIKSNPLAE NNVTFGGTPL LRPAILEKPL FLKIGSDNKK 950
    AKESKEALGL SPVPSTSEAA VAPGKTTRKA KQDKEKAREQ EAEKPLSPNA 1000
    KKTTEANTPE TQKDEQPAST TTTVSAASSS TPHTSSAATN SSQLETTEAA 1050
    NASTVPDNLK RQRIDLKGPR VKHVCRSASI VLGQPLATFG DEEEELAAAE 1100
    AGPAPTTTTT TTSPEVIIKK PKSPQPMQMI IDENDNCASC ILTPTEAPAE 1150
    AQPAVKSVLE SKSSKSNTQT EAKKTPATSG SSKGKVTTRN ATATVTSVAS 1200
    SLVATKKQRN IEVSSSISSS QAAATQSRRA LAKEVNRLKA LISIDFWENY 1250
    DPAEVCQTGF GLIVTETVAQ RALCFLCGST GLDPLIFCAC CCEPYHQYCV 1300
    LDEYNLKHSS FEDTLMNSLL ETSNNACAIS AATNTALNQL TQRLNWLCPR 1350
    CTVCYTCNMS SGSKVKCQKC QKNYHSTCLG TSKRLLGADR PLICVNCLKC 1400
    KSCATTKVSK FVGNLPMCTA CFKLRKKGNF CPICQKCYDD NDFDLKMMEC 1450
    GDCNQWVHSK CEGLSDEQYN LLSTLPESIE FICKKCARRC DVSRNKADEW 1500
    RQAVMEEFKS SLYSVLKLLS KSRQACALLK LSPRKKLRCS CSAGGAAGKA 1550
    HSQGKLQPKA LQFTYNGLGS DGESQNSDDI YEFKEQHSTN RKPSTPVPCS 1600
    CLQPLSQSPS FSLVDIKQKI ASNAYVSLAE FNYDMSQVIQ QSNCDELDIA 1650
    YKELLSEQFP WFQNETKACT DALEEDMFES CGYEELEESP TTYAEHHTAS 1700
    QAPRTGLLDI PLDDVDDLGG CAVKTRLDTR VCLFCRKSGE GLSGEEARLL 1750
    YCGHDCWVHI NCAMWSAEVF EEIDGSLQNV HSAVARGRMI KCTVCGNRGA 1800
    TVGCNVKSCG EHYHYPCARS IDCAFLTDKS MYCPAHARNA LKANGSPSVT 1850
    YESNFEVSRP VYVELDRKRK KLIEPAKVQF HIGSLEVRQL GSIVPRFSDS 1900
    FEAIVPINFL CSRLYWSSKE PWKIVEYTVR TTIQNSYSSS LTLDAGRNFT 1950
    VDHTNPNCSL VQLGLAQIAR WHSSLARSDL LDTDWAEFPN SYVPADENTE 2000
    EEPQQNADLL PPEIKDAIFE DLPHELLDGI SMLDIFMYED LGDKTELFAM 2050
    SEQSKDGTTA TSQTGGGSVS ICDEDTRNSN SLSKQLELSN CWPASNPVED 2100
    AMLCAARSSS QAKQRGEVLK KTATAPTRSW PKLDGGSVAA FKRRKLSKNI 2150
    AEGVLLSLNQ RSKKEMATVA GITRRQSVCG SSELPPEGSA TMRTKSFTWS 2200
    AAKCLFEKNE SREEPAKLKI MQMDGVDDSI TEYRIIGSDG NLSTAQFTGQ 2250
    VKCERCQCTY RNYDSFQRHL GSCEPMSTSE SESETATGTA QLSAESLNEL 2300
    QKQALAAATL SNTGGLNYLQ TSFPQVQNLA TLGQFGVQGL QGLQTLQLQP 2350
    QSLGNGFFLS QPNAAQATSN GNDELQLYAN SLQNLAANLG GGFTLTQPTM 2400
    STQAQPQLIA LSTNPDGTQQ FIQLPQSNGA TTQLLQTAAP AAMPTATYQT 2450
    LQATNSDKKI VLPLRNAGKP LKTVATKAAQ QATAAAKQKQ LKSAHGVKPI 2500
    QAKLQPQQQQ QQHQQHQQQQ HQQQQQQQQQ QQQQQTPITV AQHGGTTQLL 2550
    GQNLLQPQLL FQSNAQPQTQ QLLLPQTQAQ NIISFVTGDG SQNQPLQYIS 2600
    IPTTNDFKPQ QTTSTPTFLT APGGGATFLQ TDASGNLMLT TAPANSGLQM 2650
    LTGQLQTQPQ VIGTLIQPQT LQLTTGADGT QSATAQQPLI LGGATGGGTT 2700
    GLEFATATPQ VILATQPMYY GLETIVQNTV MSSQQFVSTA MPGVLSQNSS 2750
    FSATTTQVFQ ASKIEPIVDL PAGYVVLNNA VDASGNTSWL QQSQTQATDD 2800
    ATAQLLQNAG FQFQTTPTTS TQQTMSTDYA PPLVVTAKVP PVAQMKRNTN 2850
    ANKSPISVLS KVQPQPQQSQ VVNKVLPTNL TSQFQRQQQA NELKNKQAAG 2900
    QQTGSTCGAP PSIASKPLQK KTNLIRPIHK VEVKPKIMKQ APKLATSAAS 2950
    MQHHQQQQSP AAINQVAKVA LLQQRLPPAP QPQQQQPQQQ QQQLHQQQQQ 3000
    QQQQQQHMQQ HQQQQQQLSM PQLLPAQQPI ISIVNTAEPQ AATQFVITPA 3050
    LQAQAQPIQL QEQQSQQQQQ QPAEQLINGN ATRLQHYASN SLPTNVVNPL 3100
    QQQPLAASAN NSSNSNVTQQ NSTITINSRP TNRVLPMQQR QEPTPLSNDV 3150
    VVQSPTPPKP IEEPVPAGAS TQKPIVKCYA QLEQKSPGYE TELKTNITLD 3200
    NLEQTNSITT LQLQQPQQGP IYGEQIFEKQ SEAQVQLEKP KHNDLMLLEA 3250
    TSCQQQQQQQ QQHMEMVVDN GFQLTSNESC LLEKHGFNVE AVPMDTEDHY 3300
    ASMKNGSGGG AAEGIGQVDD AEEDEDDDDD FSLKMATSAC NDHEMSDSEE 3350
    PAVKEKISKI LDNLTNDDCA DSITTATTVE ASAGYQQMVE DVLATTAAGS 3400
    VSTDDETFTA TAEAVEAAAS YINEMAEAHE LQLKQLQAGV ELDLKKPKLD 3450
    VPQQQPNTVP TNVVPTAAAP QQPPPMRDPK KISGPHLLYE IQSEDGFTYK 3500
    SSSIAEIWEK VFEAVQVARR AHGLTPLPEG PLADMSGVQM IGLKTNALKY 3550
    LIEQLPGVEK CVKYTPKYHK RNGNVSTAAG GGHAASTAGS NAAALGAGAD 3600
    AQALIDYGSD QEELQENAYE CARCEPYVSR SEYDMFSWLA SRHRKQPIQV 3650
    FVQPSDNELV PRRGTGSNLP MAMKYRTLKE TYKDYVGVFR SHIHGRGLYC 3700
    TKDIEAGEMV IEYAGELIRS TLTDKRERYY DSRGIGCYMF KIDDNLVVDA 3750
    TMRGNAARFI NHSCEPNCYS KVVDILGHKH IIIFALRRIV QGEELTYDYK 3800
    FPFEDEKIPC SCGSKRCRKY LN 3822
    Length:3,822
    Mass (Da):412,089
    Last modified:September 23, 2008 - v1
    Checksum:iFFF3F8E8E459DBAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW68309.1.
    RefSeqiXP_002054789.1. XM_002054753.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0238524; FBpp0237016; FBgn0014844.
    GeneIDi6630169.
    KEGGidvi:Dvir_GJ22599.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW68309.1 .
    RefSeqi XP_002054789.1. XM_002054753.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0237016.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0238524 ; FBpp0237016 ; FBgn0014844 .
    GeneIDi 6630169.
    KEGGi dvi:Dvir_GJ22599.

    Organism-specific databases

    FlyBasei FBgn0014844. Dvir\trx.

    Phylogenomic databases

    KOi K09186.
    OMAi ARCEPYS.
    PhylomeDBi B4M059.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR003889. FYrich_C.
    IPR003888. FYrich_N.
    IPR016569. MeTrfase_trithorax.
    IPR003616. Post-SET_dom.
    IPR001214. SET_dom.
    IPR011011. Znf_FYVE_PHD.
    IPR001628. Znf_hrmn_rcpt.
    IPR001965. Znf_PHD.
    IPR019787. Znf_PHD-finger.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    [Graphical view ]
    Pfami PF05965. FYRC. 1 hit.
    PF05964. FYRN. 1 hit.
    PF00628. PHD. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF010354. Methyltransferase_trithorax. 1 hit.
    SMARTi SM00542. FYRC. 1 hit.
    SM00541. FYRN. 1 hit.
    SM00249. PHD. 4 hits.
    SM00508. PostSET. 1 hit.
    SM00184. RING. 4 hits.
    SM00317. SET. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57903. SSF57903. 2 hits.
    PROSITEi PS51543. FYRC. 1 hit.
    PS51542. FYRN. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    PS50016. ZF_PHD_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87Imported.

    Entry informationi

    Entry nameiB4M059_DROVI
    AccessioniPrimary (citable) accession number: B4M059
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3