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B4M059

- B4M059_DROVI

UniProt

B4M059 - B4M059_DROVI

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Protein
Submitted name:

Trx

Gene

trx

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. histone methyltransferase activity (H3-K4 specific) Source: InterPro
  2. sequence-specific DNA binding Source: InterPro
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulationSAAS annotation

Keywords - Ligandi

DNA-bindingSAAS annotation, Metal-binding, S-adenosyl-L-methionineSAAS annotation, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
TrxImported
Gene namesi
Name:trxImported
Synonyms:Dvir\trxImported
ORF Names:Dvir_GJ22599Imported, GJ22599Imported
OrganismiDrosophila virilis (Fruit fly)Imported
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0014844. Dvir\trx.

Subcellular locationi

GO - Cellular componenti

  1. histone methyltransferase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

NucleusSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0237016.

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains SET domain.SAAS annotation
Contains nuclear receptor DNA-binding domain.SAAS annotation
Contains post-SET domain.SAAS annotation

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

InParanoidiB4M059.
KOiK09186.
OMAiARCEPYS.
PhylomeDBiB4M059.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR016569. MeTrfase_trithorax.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF010354. Methyltransferase_trithorax. 1 hit.
SMARTiSM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4M059-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRSKFPGKP SKSINRKRIS VLQLEDEAAS AAAAAATAAT TEQHQQSEQS
60 70 80 90 100
AGSSASREKG NNCDNDDDDN APSGAATSGN RGASSGASDA AATEGGNSTG
110 120 130 140 150
NGSSTGGKTT NGGNVNGGSH HKSATAPAEL KECKNQGNQI EPNNCIAAEP
160 170 180 190 200
DGTEDTNNDD DDDSSNDKKP TAAAAAAAAA AFVPGPSALQ RARKGGNKKF
210 220 230 240 250
KNLNLARPEV MLPSTSKLKQ QQQQQLQLNC PSASASSLSS SAAAAAAAAA
260 270 280 290 300
PTTTTTTASA SATLTATATS TSTSSLPGTP LSVIAGGGGG AAAAGLLLAN
310 320 330 340 350
PFASVETKVV EVNAAATAAA GAGEDVAMLH ALLIGQEASS GTFMTYLTFM
360 370 380 390 400
FLQLKASIEM ANEAGLEAPA VAVKSSGSSP NPNHNPNAVA GSTSAAAPGA
410 420 430 440 450
PTATKQKKTV TFKNILETSD DKSVVKRFYN PDNRVPLVSI MKKDSLNRPL
460 470 480 490 500
NYCRGSEFIV RPSILSKILN KNSNIDKLNS LKFRSVHASS NSIQESSSST
510 520 530 540 550
TNLFGSGLSR AFGAPIDDED AVSGGVTFRK QEPQHKTPED NDDDGSASSD
560 570 580 590 600
AIEDDEDIDD DDAEDNEEAA SEKSAETTAS VDEKEADDRQ LVMDKHFVLP
610 620 630 640 650
KRSTRSSRII KPNKRLLEVG GICSKRSPSD ANGKPKPKNY FGLGDFASEV
660 670 680 690 700
HASSSSSSST SAATALSQKL GKETFTSFAT AKVNSSFVLR QPRLQFQTDK
710 720 730 740 750
SGSFVSAKPT LPTTTLLPAS SSAITSANVL SFGALNNANS AVAAASTCAV
760 770 780 790 800
CSAPVNNKDA PLARKYGVIA CEVCRKFNSR MTKISKLSTP MHSNPSTSTA
810 820 830 840 850
QSGQQLKCTD GGNCSILSLK SQLKNFKKLY KERCKACWLK KCLATLQLPA
860 870 880 890 900
GHRSRLSAIL PASMREEVAP KDDKCPELLS PTASLRFTAP TSSASSGTTI
910 920 930 940 950
KWKSSAETAV NSIKSNPLAE NNVTFGGTPL LRPAILEKPL FLKIGSDNKK
960 970 980 990 1000
AKESKEALGL SPVPSTSEAA VAPGKTTRKA KQDKEKAREQ EAEKPLSPNA
1010 1020 1030 1040 1050
KKTTEANTPE TQKDEQPAST TTTVSAASSS TPHTSSAATN SSQLETTEAA
1060 1070 1080 1090 1100
NASTVPDNLK RQRIDLKGPR VKHVCRSASI VLGQPLATFG DEEEELAAAE
1110 1120 1130 1140 1150
AGPAPTTTTT TTSPEVIIKK PKSPQPMQMI IDENDNCASC ILTPTEAPAE
1160 1170 1180 1190 1200
AQPAVKSVLE SKSSKSNTQT EAKKTPATSG SSKGKVTTRN ATATVTSVAS
1210 1220 1230 1240 1250
SLVATKKQRN IEVSSSISSS QAAATQSRRA LAKEVNRLKA LISIDFWENY
1260 1270 1280 1290 1300
DPAEVCQTGF GLIVTETVAQ RALCFLCGST GLDPLIFCAC CCEPYHQYCV
1310 1320 1330 1340 1350
LDEYNLKHSS FEDTLMNSLL ETSNNACAIS AATNTALNQL TQRLNWLCPR
1360 1370 1380 1390 1400
CTVCYTCNMS SGSKVKCQKC QKNYHSTCLG TSKRLLGADR PLICVNCLKC
1410 1420 1430 1440 1450
KSCATTKVSK FVGNLPMCTA CFKLRKKGNF CPICQKCYDD NDFDLKMMEC
1460 1470 1480 1490 1500
GDCNQWVHSK CEGLSDEQYN LLSTLPESIE FICKKCARRC DVSRNKADEW
1510 1520 1530 1540 1550
RQAVMEEFKS SLYSVLKLLS KSRQACALLK LSPRKKLRCS CSAGGAAGKA
1560 1570 1580 1590 1600
HSQGKLQPKA LQFTYNGLGS DGESQNSDDI YEFKEQHSTN RKPSTPVPCS
1610 1620 1630 1640 1650
CLQPLSQSPS FSLVDIKQKI ASNAYVSLAE FNYDMSQVIQ QSNCDELDIA
1660 1670 1680 1690 1700
YKELLSEQFP WFQNETKACT DALEEDMFES CGYEELEESP TTYAEHHTAS
1710 1720 1730 1740 1750
QAPRTGLLDI PLDDVDDLGG CAVKTRLDTR VCLFCRKSGE GLSGEEARLL
1760 1770 1780 1790 1800
YCGHDCWVHI NCAMWSAEVF EEIDGSLQNV HSAVARGRMI KCTVCGNRGA
1810 1820 1830 1840 1850
TVGCNVKSCG EHYHYPCARS IDCAFLTDKS MYCPAHARNA LKANGSPSVT
1860 1870 1880 1890 1900
YESNFEVSRP VYVELDRKRK KLIEPAKVQF HIGSLEVRQL GSIVPRFSDS
1910 1920 1930 1940 1950
FEAIVPINFL CSRLYWSSKE PWKIVEYTVR TTIQNSYSSS LTLDAGRNFT
1960 1970 1980 1990 2000
VDHTNPNCSL VQLGLAQIAR WHSSLARSDL LDTDWAEFPN SYVPADENTE
2010 2020 2030 2040 2050
EEPQQNADLL PPEIKDAIFE DLPHELLDGI SMLDIFMYED LGDKTELFAM
2060 2070 2080 2090 2100
SEQSKDGTTA TSQTGGGSVS ICDEDTRNSN SLSKQLELSN CWPASNPVED
2110 2120 2130 2140 2150
AMLCAARSSS QAKQRGEVLK KTATAPTRSW PKLDGGSVAA FKRRKLSKNI
2160 2170 2180 2190 2200
AEGVLLSLNQ RSKKEMATVA GITRRQSVCG SSELPPEGSA TMRTKSFTWS
2210 2220 2230 2240 2250
AAKCLFEKNE SREEPAKLKI MQMDGVDDSI TEYRIIGSDG NLSTAQFTGQ
2260 2270 2280 2290 2300
VKCERCQCTY RNYDSFQRHL GSCEPMSTSE SESETATGTA QLSAESLNEL
2310 2320 2330 2340 2350
QKQALAAATL SNTGGLNYLQ TSFPQVQNLA TLGQFGVQGL QGLQTLQLQP
2360 2370 2380 2390 2400
QSLGNGFFLS QPNAAQATSN GNDELQLYAN SLQNLAANLG GGFTLTQPTM
2410 2420 2430 2440 2450
STQAQPQLIA LSTNPDGTQQ FIQLPQSNGA TTQLLQTAAP AAMPTATYQT
2460 2470 2480 2490 2500
LQATNSDKKI VLPLRNAGKP LKTVATKAAQ QATAAAKQKQ LKSAHGVKPI
2510 2520 2530 2540 2550
QAKLQPQQQQ QQHQQHQQQQ HQQQQQQQQQ QQQQQTPITV AQHGGTTQLL
2560 2570 2580 2590 2600
GQNLLQPQLL FQSNAQPQTQ QLLLPQTQAQ NIISFVTGDG SQNQPLQYIS
2610 2620 2630 2640 2650
IPTTNDFKPQ QTTSTPTFLT APGGGATFLQ TDASGNLMLT TAPANSGLQM
2660 2670 2680 2690 2700
LTGQLQTQPQ VIGTLIQPQT LQLTTGADGT QSATAQQPLI LGGATGGGTT
2710 2720 2730 2740 2750
GLEFATATPQ VILATQPMYY GLETIVQNTV MSSQQFVSTA MPGVLSQNSS
2760 2770 2780 2790 2800
FSATTTQVFQ ASKIEPIVDL PAGYVVLNNA VDASGNTSWL QQSQTQATDD
2810 2820 2830 2840 2850
ATAQLLQNAG FQFQTTPTTS TQQTMSTDYA PPLVVTAKVP PVAQMKRNTN
2860 2870 2880 2890 2900
ANKSPISVLS KVQPQPQQSQ VVNKVLPTNL TSQFQRQQQA NELKNKQAAG
2910 2920 2930 2940 2950
QQTGSTCGAP PSIASKPLQK KTNLIRPIHK VEVKPKIMKQ APKLATSAAS
2960 2970 2980 2990 3000
MQHHQQQQSP AAINQVAKVA LLQQRLPPAP QPQQQQPQQQ QQQLHQQQQQ
3010 3020 3030 3040 3050
QQQQQQHMQQ HQQQQQQLSM PQLLPAQQPI ISIVNTAEPQ AATQFVITPA
3060 3070 3080 3090 3100
LQAQAQPIQL QEQQSQQQQQ QPAEQLINGN ATRLQHYASN SLPTNVVNPL
3110 3120 3130 3140 3150
QQQPLAASAN NSSNSNVTQQ NSTITINSRP TNRVLPMQQR QEPTPLSNDV
3160 3170 3180 3190 3200
VVQSPTPPKP IEEPVPAGAS TQKPIVKCYA QLEQKSPGYE TELKTNITLD
3210 3220 3230 3240 3250
NLEQTNSITT LQLQQPQQGP IYGEQIFEKQ SEAQVQLEKP KHNDLMLLEA
3260 3270 3280 3290 3300
TSCQQQQQQQ QQHMEMVVDN GFQLTSNESC LLEKHGFNVE AVPMDTEDHY
3310 3320 3330 3340 3350
ASMKNGSGGG AAEGIGQVDD AEEDEDDDDD FSLKMATSAC NDHEMSDSEE
3360 3370 3380 3390 3400
PAVKEKISKI LDNLTNDDCA DSITTATTVE ASAGYQQMVE DVLATTAAGS
3410 3420 3430 3440 3450
VSTDDETFTA TAEAVEAAAS YINEMAEAHE LQLKQLQAGV ELDLKKPKLD
3460 3470 3480 3490 3500
VPQQQPNTVP TNVVPTAAAP QQPPPMRDPK KISGPHLLYE IQSEDGFTYK
3510 3520 3530 3540 3550
SSSIAEIWEK VFEAVQVARR AHGLTPLPEG PLADMSGVQM IGLKTNALKY
3560 3570 3580 3590 3600
LIEQLPGVEK CVKYTPKYHK RNGNVSTAAG GGHAASTAGS NAAALGAGAD
3610 3620 3630 3640 3650
AQALIDYGSD QEELQENAYE CARCEPYVSR SEYDMFSWLA SRHRKQPIQV
3660 3670 3680 3690 3700
FVQPSDNELV PRRGTGSNLP MAMKYRTLKE TYKDYVGVFR SHIHGRGLYC
3710 3720 3730 3740 3750
TKDIEAGEMV IEYAGELIRS TLTDKRERYY DSRGIGCYMF KIDDNLVVDA
3760 3770 3780 3790 3800
TMRGNAARFI NHSCEPNCYS KVVDILGHKH IIIFALRRIV QGEELTYDYK
3810 3820
FPFEDEKIPC SCGSKRCRKY LN
Length:3,822
Mass (Da):412,089
Last modified:September 23, 2008 - v1
Checksum:iFFF3F8E8E459DBAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940650 Genomic DNA. Translation: EDW68309.1.
RefSeqiXP_002054789.1. XM_002054753.1.

Genome annotation databases

EnsemblMetazoaiFBtr0238524; FBpp0237016; FBgn0014844.
GeneIDi6630169.
KEGGidvi:Dvir_GJ22599.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940650 Genomic DNA. Translation: EDW68309.1 .
RefSeqi XP_002054789.1. XM_002054753.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0237016.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0238524 ; FBpp0237016 ; FBgn0014844 .
GeneIDi 6630169.
KEGGi dvi:Dvir_GJ22599.

Organism-specific databases

FlyBasei FBgn0014844. Dvir\trx.

Phylogenomic databases

InParanoidi B4M059.
KOi K09186.
OMAi ARCEPYS.
PhylomeDBi B4M059.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR003889. FYrich_C.
IPR003888. FYrich_N.
IPR016569. MeTrfase_trithorax.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
IPR011011. Znf_FYVE_PHD.
IPR001628. Znf_hrmn_rcpt.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view ]
Pfami PF05965. FYRC. 1 hit.
PF05964. FYRN. 1 hit.
PF00628. PHD. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
PIRSFi PIRSF010354. Methyltransferase_trithorax. 1 hit.
SMARTi SM00542. FYRC. 1 hit.
SM00541. FYRN. 1 hit.
SM00249. PHD. 4 hits.
SM00508. PostSET. 1 hit.
SM00184. RING. 4 hits.
SM00317. SET. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF57903. SSF57903. 2 hits.
PROSITEi PS51543. FYRC. 1 hit.
PS51542. FYRN. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
PS50016. ZF_PHD_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87Imported.

Entry informationi

Entry nameiB4M059_DROVI
AccessioniPrimary (citable) accession number: B4M059
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3