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B4LZS3

- B4LZS3_DROVI

UniProt

B4LZS3 - B4LZS3_DROVI

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
Dvir\GJ24607, Dvir_GJ24607, GJ24607
Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferase
Gene namesi
Name:Dvir\GJ24607Imported
ORF Names:Dvir_GJ24607Imported, GJ24607Imported
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0211685. Dvir\GJ24607.

Subcellular locationi

Nucleus By similarity UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0239024.

Family & Domainsi

Sequence similaritiesi

Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiB4LZS3.
KOiK11427.
OMAiQVSPAKM.
OrthoDBiEOG7W6WJV.
PhylomeDBiB4LZS3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4LZS3-1 [UniParc]FASTAAdd to Basket

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MATPQVKDLV LRSPAGSSDT ITFAWPLQIG HGQDKHDNGI DIIDTIKFVC     50
DELPSISSAF EEINLNHIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP 100
AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV 150
QQMLKHVNVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY 200
AERMDQIFRQ YMSWFGKRYC EYKLIKGDFL VDEHREKITS STLVFVNNFA 250
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 300
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG DHEHVGTVRT 350
TRDRAKREAN IGHQNNNHNN NNNHNNNHQR EQREQQRERE RDLFNGPAQQ 400
RNQSQSPANV SGGGGLAASK TRQQLASAQH QQQQQQQQQQ MQQRSLDMDS 450
STESDGEGEA TNGNGGNTTT ATTSTSNGPM TRKVWSDWCS SKGKSSQSDD 500
EENNNSNSNN SNSHQGRGPR AITTLKKRKK LTRKAAIASK SAAAAQREAE 550
EAAAVAAVTA SATSASASKD SSSKEDQPRA ASAGPGRKGR LKKGQRGRKC 600
LKIAGLDVLH KQTVLSTSLD AMTKKLPAAP GTVDQQLTSL LTGDMSHREL 650
DIPTAPQDTP YALQILLDVF RSQYMTMIEH MRSSAYLPQV QKQIAQEQER 700
MARLKNRANQ LDKQIKVLID DSVTLLKVRM NELGINVNSP NDLIAQAKEI 750
VGRHKDLQHA VSKMRNEVTV YESEQKLLLS KQLKHLPEYQ KLCAVANGGN 800
GKVKLELPHE LSETAAQELV LKEIANTLSQ RKKLYAQVST IEQETSSLQK 850
SAEERSTANV LLAQGTNISL ASSAPTVATN AATTATLANC NKLVNNKSSR 900
RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKILETCRQV EAGKFQPPPS 950
TISAVNFING QKPKMEPKTT PAPYKDSTLM PAPKQQSQPQ QQQQQLQQQQ 1000
QQQHHAVLLP KCELPGLGRK QESPKVANFE DRLKSIITSA LNEDQEQRSK 1050
AMPIMETPAV PLQSPVSKRS KQMGQTTTTT GNSLHNIITV STQGLMHLNA 1100
NTTISPITPP LPGPRAAAAA STAPPPPANL PYGSAYMSSK QQQLQHLSGK 1150
YGQTVSLKES KYSPARPGAS APPPPPPPPP TSSSASSSSS SSSAAHMATL 1200
YAGHGSTAAT APTVADLGFH RRRASVSANS YEHFMVQQQQ QQQHALMLAH 1250
VAQQRLQHQQ QQQQQQQQQQ QQQQQHAQHA PIGHLHHHHH QAAGTSAEFK 1300
APAENLLQRS GSREQLSEQQ QQQQQQQQQL QQQHQHQHQQ SQQQQPHSLD 1350
LLPRASSANS DYAGYRVERL SVRPPSRPSS NSSQPDYTQV SPAKMALRRH 1400
LSQEKLSQPP QALPTPPPMS LAPPVTAGKT IGDLVNGEIE RTLEISHQSI 1450
INAAVNMSTG SSSSSSSAHF MERAFLAERT NDRLLINLNA QRPERVHVRP 1500
LGEDAPDPQP TNYSQAASSS NNNLATLAHV AYAHKTQPGA RASSSSRSGR 1550
DYQPVALPRA EMMGCIEAYF HEEQQQQQQQ QQQHQKSKST VGGASALRAP 1600
RLNGANPPLE GLAASLQDHV RARKYKEENE ERQRRAAAAS SSSSLELAPH 1650
FAHQAPPAHS YHQPQQQPHH HTAASIINGT PHKVELGVKR SSPLAPHQQP 1700
SRPAKLAHFE QQPLAHAHQH LYVNSNGVSG LPPPAHDATT PSPTPSSSSS 1750
SCGRRSKLLV EPPLLMSPEI NSLMGDERPL QLSTSHQQLH HHQQKPHQQQ 1800
LRGSHQSGHS ITPTIVGGQR SNAADDVTDS ATHRTITNYD PRRRLRNPTS 1850
TLSGATKQTA TNCNTHNNGF VVADSSSTKN NNNYNNYNNN NDNNNH 1896
Length:1,896
Mass (Da):208,771
Last modified:September 23, 2008 - v1
Checksum:iD6F55B9E4494259F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940650 Genomic DNA. Translation: EDW68242.1.
RefSeqiXP_002054722.1. XM_002054686.1.

Genome annotation databases

EnsemblMetazoaiFBtr0240532; FBpp0239024; FBgn0211685.
GeneIDi6630054.
KEGGidvi:Dvir_GJ24607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940650 Genomic DNA. Translation: EDW68242.1 .
RefSeqi XP_002054722.1. XM_002054686.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0239024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0240532 ; FBpp0239024 ; FBgn0211685 .
GeneIDi 6630054.
KEGGi dvi:Dvir_GJ24607.

Organism-specific databases

FlyBasei FBgn0211685. Dvir\GJ24607.

Phylogenomic databases

eggNOGi NOG294902.
InParanoidi B4LZS3.
KOi K11427.
OMAi QVSPAKM.
OrthoDBi EOG7W6WJV.
PhylomeDBi B4LZS3.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiB4LZS3_DROVI
AccessioniPrimary (citable) accession number: B4LZS3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi