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B4LZS3 (B4LZS3_DROVI) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
Name:Dvir\GJ24607 EMBL EDW68242.1
ORF Names:Dvir_GJ24607 EMBL EDW68242.1, GJ24607 FlyBase FBgn0211685
OrganismDrosophila virilis (Fruit fly) [Complete proteome]
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length1896 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU271113
   LigandS-adenosyl-L-methionine RuleBase RU271113
   Molecular functionChromatin regulator RuleBase RU271113
Methyltransferase RuleBase RU271113
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B4LZS3 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: D6F55B9E4494259F

FASTA1,896208,771
        10         20         30         40         50         60 
MATPQVKDLV LRSPAGSSDT ITFAWPLQIG HGQDKHDNGI DIIDTIKFVC DELPSISSAF 

        70         80         90        100        110        120 
EEINLNHIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP AERLNKFAHP SLLRHILQLV 

       130        140        150        160        170        180 
YNAAVLDPDK LNQYEPFSPE VYGETSYELV QQMLKHVNVS KEDTFIDLGS GVGQVVLQMA 

       190        200        210        220        230        240 
GSFPLKTCIG IEKADTPARY AERMDQIFRQ YMSWFGKRYC EYKLIKGDFL VDEHREKITS 

       250        260        270        280        290        300 
STLVFVNNFA FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 

       310        320        330        340        350        360 
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG DHEHVGTVRT TRDRAKREAN 

       370        380        390        400        410        420 
IGHQNNNHNN NNNHNNNHQR EQREQQRERE RDLFNGPAQQ RNQSQSPANV SGGGGLAASK 

       430        440        450        460        470        480 
TRQQLASAQH QQQQQQQQQQ MQQRSLDMDS STESDGEGEA TNGNGGNTTT ATTSTSNGPM 

       490        500        510        520        530        540 
TRKVWSDWCS SKGKSSQSDD EENNNSNSNN SNSHQGRGPR AITTLKKRKK LTRKAAIASK 

       550        560        570        580        590        600 
SAAAAQREAE EAAAVAAVTA SATSASASKD SSSKEDQPRA ASAGPGRKGR LKKGQRGRKC 

       610        620        630        640        650        660 
LKIAGLDVLH KQTVLSTSLD AMTKKLPAAP GTVDQQLTSL LTGDMSHREL DIPTAPQDTP 

       670        680        690        700        710        720 
YALQILLDVF RSQYMTMIEH MRSSAYLPQV QKQIAQEQER MARLKNRANQ LDKQIKVLID 

       730        740        750        760        770        780 
DSVTLLKVRM NELGINVNSP NDLIAQAKEI VGRHKDLQHA VSKMRNEVTV YESEQKLLLS 

       790        800        810        820        830        840 
KQLKHLPEYQ KLCAVANGGN GKVKLELPHE LSETAAQELV LKEIANTLSQ RKKLYAQVST 

       850        860        870        880        890        900 
IEQETSSLQK SAEERSTANV LLAQGTNISL ASSAPTVATN AATTATLANC NKLVNNKSSR 

       910        920        930        940        950        960 
RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKILETCRQV EAGKFQPPPS TISAVNFING 

       970        980        990       1000       1010       1020 
QKPKMEPKTT PAPYKDSTLM PAPKQQSQPQ QQQQQLQQQQ QQQHHAVLLP KCELPGLGRK 

      1030       1040       1050       1060       1070       1080 
QESPKVANFE DRLKSIITSA LNEDQEQRSK AMPIMETPAV PLQSPVSKRS KQMGQTTTTT 

      1090       1100       1110       1120       1130       1140 
GNSLHNIITV STQGLMHLNA NTTISPITPP LPGPRAAAAA STAPPPPANL PYGSAYMSSK 

      1150       1160       1170       1180       1190       1200 
QQQLQHLSGK YGQTVSLKES KYSPARPGAS APPPPPPPPP TSSSASSSSS SSSAAHMATL 

      1210       1220       1230       1240       1250       1260 
YAGHGSTAAT APTVADLGFH RRRASVSANS YEHFMVQQQQ QQQHALMLAH VAQQRLQHQQ 

      1270       1280       1290       1300       1310       1320 
QQQQQQQQQQ QQQQQHAQHA PIGHLHHHHH QAAGTSAEFK APAENLLQRS GSREQLSEQQ 

      1330       1340       1350       1360       1370       1380 
QQQQQQQQQL QQQHQHQHQQ SQQQQPHSLD LLPRASSANS DYAGYRVERL SVRPPSRPSS 

      1390       1400       1410       1420       1430       1440 
NSSQPDYTQV SPAKMALRRH LSQEKLSQPP QALPTPPPMS LAPPVTAGKT IGDLVNGEIE 

      1450       1460       1470       1480       1490       1500 
RTLEISHQSI INAAVNMSTG SSSSSSSAHF MERAFLAERT NDRLLINLNA QRPERVHVRP 

      1510       1520       1530       1540       1550       1560 
LGEDAPDPQP TNYSQAASSS NNNLATLAHV AYAHKTQPGA RASSSSRSGR DYQPVALPRA 

      1570       1580       1590       1600       1610       1620 
EMMGCIEAYF HEEQQQQQQQ QQQHQKSKST VGGASALRAP RLNGANPPLE GLAASLQDHV 

      1630       1640       1650       1660       1670       1680 
RARKYKEENE ERQRRAAAAS SSSSLELAPH FAHQAPPAHS YHQPQQQPHH HTAASIINGT 

      1690       1700       1710       1720       1730       1740 
PHKVELGVKR SSPLAPHQQP SRPAKLAHFE QQPLAHAHQH LYVNSNGVSG LPPPAHDATT 

      1750       1760       1770       1780       1790       1800 
PSPTPSSSSS SCGRRSKLLV EPPLLMSPEI NSLMGDERPL QLSTSHQQLH HHQQKPHQQQ 

      1810       1820       1830       1840       1850       1860 
LRGSHQSGHS ITPTIVGGQR SNAADDVTDS ATHRTITNYD PRRRLRNPTS TLSGATKQTA 

      1870       1880       1890 
TNCNTHNNGF VVADSSSTKN NNNYNNYNNN NDNNNH 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15010-1051.87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH940650 Genomic DNA. Translation: EDW68242.1.
RefSeqXP_002054722.1. XM_002054686.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7244.FBpp0239024.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0240532; FBpp0239024; FBgn0211685.
GeneID6630054.
KEGGdvi:Dvir_GJ24607.

Organism-specific databases

FlyBaseFBgn0211685. Dvir\GJ24607.

Phylogenomic databases

eggNOGNOG294902.
InParanoidB4LZS3.
KOK11427.
OMAQVSPAKM.
OrthoDBEOG7W6WJV.

Family and domain databases

InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4LZS3_DROVI
AccessionPrimary (citable) accession number: B4LZS3
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 16, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)