Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4LZS3

- B4LZS3_DROVI

UniProt

B4LZS3 - B4LZS3_DROVI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dvir\GJ24607

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:Dvir\GJ24607Imported
ORF Names:Dvir_GJ24607Imported, GJ24607Imported
OrganismiDrosophila virilis (Fruit fly)Imported
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0211685. Dvir\GJ24607.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0239024.

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

eggNOGiNOG294902.
InParanoidiB4LZS3.
KOiK11427.
OMAiQVSPAKM.
OrthoDBiEOG7W6WJV.
PhylomeDBiB4LZS3.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4LZS3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPQVKDLV LRSPAGSSDT ITFAWPLQIG HGQDKHDNGI DIIDTIKFVC
60 70 80 90 100
DELPSISSAF EEINLNHIDT ACYKTMTNLV DRFNKAVDSI VALEKGTSLP
110 120 130 140 150
AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV
160 170 180 190 200
QQMLKHVNVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY
210 220 230 240 250
AERMDQIFRQ YMSWFGKRYC EYKLIKGDFL VDEHREKITS STLVFVNNFA
260 270 280 290 300
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS
310 320 330 340 350
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG DHEHVGTVRT
360 370 380 390 400
TRDRAKREAN IGHQNNNHNN NNNHNNNHQR EQREQQRERE RDLFNGPAQQ
410 420 430 440 450
RNQSQSPANV SGGGGLAASK TRQQLASAQH QQQQQQQQQQ MQQRSLDMDS
460 470 480 490 500
STESDGEGEA TNGNGGNTTT ATTSTSNGPM TRKVWSDWCS SKGKSSQSDD
510 520 530 540 550
EENNNSNSNN SNSHQGRGPR AITTLKKRKK LTRKAAIASK SAAAAQREAE
560 570 580 590 600
EAAAVAAVTA SATSASASKD SSSKEDQPRA ASAGPGRKGR LKKGQRGRKC
610 620 630 640 650
LKIAGLDVLH KQTVLSTSLD AMTKKLPAAP GTVDQQLTSL LTGDMSHREL
660 670 680 690 700
DIPTAPQDTP YALQILLDVF RSQYMTMIEH MRSSAYLPQV QKQIAQEQER
710 720 730 740 750
MARLKNRANQ LDKQIKVLID DSVTLLKVRM NELGINVNSP NDLIAQAKEI
760 770 780 790 800
VGRHKDLQHA VSKMRNEVTV YESEQKLLLS KQLKHLPEYQ KLCAVANGGN
810 820 830 840 850
GKVKLELPHE LSETAAQELV LKEIANTLSQ RKKLYAQVST IEQETSSLQK
860 870 880 890 900
SAEERSTANV LLAQGTNISL ASSAPTVATN AATTATLANC NKLVNNKSSR
910 920 930 940 950
RSREHRARSQ EWPEVPEVGK IQESNPEVLA QKILETCRQV EAGKFQPPPS
960 970 980 990 1000
TISAVNFING QKPKMEPKTT PAPYKDSTLM PAPKQQSQPQ QQQQQLQQQQ
1010 1020 1030 1040 1050
QQQHHAVLLP KCELPGLGRK QESPKVANFE DRLKSIITSA LNEDQEQRSK
1060 1070 1080 1090 1100
AMPIMETPAV PLQSPVSKRS KQMGQTTTTT GNSLHNIITV STQGLMHLNA
1110 1120 1130 1140 1150
NTTISPITPP LPGPRAAAAA STAPPPPANL PYGSAYMSSK QQQLQHLSGK
1160 1170 1180 1190 1200
YGQTVSLKES KYSPARPGAS APPPPPPPPP TSSSASSSSS SSSAAHMATL
1210 1220 1230 1240 1250
YAGHGSTAAT APTVADLGFH RRRASVSANS YEHFMVQQQQ QQQHALMLAH
1260 1270 1280 1290 1300
VAQQRLQHQQ QQQQQQQQQQ QQQQQHAQHA PIGHLHHHHH QAAGTSAEFK
1310 1320 1330 1340 1350
APAENLLQRS GSREQLSEQQ QQQQQQQQQL QQQHQHQHQQ SQQQQPHSLD
1360 1370 1380 1390 1400
LLPRASSANS DYAGYRVERL SVRPPSRPSS NSSQPDYTQV SPAKMALRRH
1410 1420 1430 1440 1450
LSQEKLSQPP QALPTPPPMS LAPPVTAGKT IGDLVNGEIE RTLEISHQSI
1460 1470 1480 1490 1500
INAAVNMSTG SSSSSSSAHF MERAFLAERT NDRLLINLNA QRPERVHVRP
1510 1520 1530 1540 1550
LGEDAPDPQP TNYSQAASSS NNNLATLAHV AYAHKTQPGA RASSSSRSGR
1560 1570 1580 1590 1600
DYQPVALPRA EMMGCIEAYF HEEQQQQQQQ QQQHQKSKST VGGASALRAP
1610 1620 1630 1640 1650
RLNGANPPLE GLAASLQDHV RARKYKEENE ERQRRAAAAS SSSSLELAPH
1660 1670 1680 1690 1700
FAHQAPPAHS YHQPQQQPHH HTAASIINGT PHKVELGVKR SSPLAPHQQP
1710 1720 1730 1740 1750
SRPAKLAHFE QQPLAHAHQH LYVNSNGVSG LPPPAHDATT PSPTPSSSSS
1760 1770 1780 1790 1800
SCGRRSKLLV EPPLLMSPEI NSLMGDERPL QLSTSHQQLH HHQQKPHQQQ
1810 1820 1830 1840 1850
LRGSHQSGHS ITPTIVGGQR SNAADDVTDS ATHRTITNYD PRRRLRNPTS
1860 1870 1880 1890
TLSGATKQTA TNCNTHNNGF VVADSSSTKN NNNYNNYNNN NDNNNH
Length:1,896
Mass (Da):208,771
Last modified:September 23, 2008 - v1
Checksum:iD6F55B9E4494259F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940650 Genomic DNA. Translation: EDW68242.1.
RefSeqiXP_002054722.1. XM_002054686.1.

Genome annotation databases

EnsemblMetazoaiFBtr0240532; FBpp0239024; FBgn0211685.
GeneIDi6630054.
KEGGidvi:Dvir_GJ24607.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940650 Genomic DNA. Translation: EDW68242.1 .
RefSeqi XP_002054722.1. XM_002054686.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0239024.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0240532 ; FBpp0239024 ; FBgn0211685 .
GeneIDi 6630054.
KEGGi dvi:Dvir_GJ24607.

Organism-specific databases

FlyBasei FBgn0211685. Dvir\GJ24607.

Phylogenomic databases

eggNOGi NOG294902.
InParanoidi B4LZS3.
KOi K11427.
OMAi QVSPAKM.
OrthoDBi EOG7W6WJV.
PhylomeDBi B4LZS3.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87Imported.

Entry informationi

Entry nameiB4LZS3_DROVI
AccessioniPrimary (citable) accession number: B4LZS3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3