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B4LXG8

- B4LXG8_DROVI

UniProt

B4LXG8 - B4LXG8_DROVI

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Protein
DNA ligase
Gene
Dvir\GJ24382, Dvir_GJ24382, GJ24382
Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-KW
  3. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dvir\GJ24382Imported
ORF Names:Dvir_GJ24382Imported, GJ24382Imported
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0211462. Dvir\GJ24382.

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0238799.

Structurei

3D structure databases

ProteinModelPortaliB4LXG8.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiB4LXG8.
KOiK10776.
OMAiNEDNKLD.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4LXG8.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4LXG8-1 [UniParc]FASTAAdd to Basket

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MIKLLRNCRV SHFTRIRSRG MSSKQARNED NKLDTFRRIC DEIAGEASYL    50
RKVEKLEHFL KKGSSGSGFK GDLLQWVQFL IPGATQRVYN LQNKALLKLF 100
ARIFHVDQQQ MHLDLEQDGD ISETLRKHFA SSSKLKPQAQ SKLYLHEVEN 150
MLCQLEQRTK EDEQTEVLQE VCKQATDLDL RTFIRLIKQD LRINARARHI 200
LDAFGPEAYP AYQSTRDLKL IVENFAGTQG KPKSLKGLPK AATKSSKKAI 250
GAIQVMTPIS PMLANACKSV EEAFKKNPGG LYSEVKYDGE RVQIHKHGSE 300
FKFFSRNLKP VVDHKIKELK DYIPRAFPGA NDMILDSEII LVNTKTGELL 350
PFGTLGAHKK HTYANASVCL FVFDCLLYDG DDLTQLSFCK RREILEQNIK 400
PIKHHVQLSE SQFLKTKNEL AMMTAKVLQA NLEGVVLKSP EGTYQPGKRN 450
WLKVKKDYLF GGKMADTADL VVLGAWYGSG KKGGVLSIFL MGCYDARDRL 500
WKTVTKVHSG LDDASNDEVH ESLMKLTERA DASKIPNWLL CKKALIPDVL 550
AKIPEQMPVW EITGAEFTQS EAHTAAGISI RFPRITRLRS DKSAMQANDL 600
EHLEQLYAAS KQNVNVDLLL ANCEADRDDA LKNKLKLEKT PQKSKAPKEA 650
TASSSKKPKR SKSASDDEEV TPSKGRSSRK MHKLEAPTVT SQGNLKDFFK 700
PKIVIADVKI ENPPLASTSS NYGKGEDRKL FIGLEAHFVA DAAQPKLMDE 750
FVRHGGILAK CTQRASLVFH DCNKNKDLSQ LRPLYRRSCR HLNIKWLEET 800
LKMKTLQPYP LYALLLQS 818
Length:818
Mass (Da):92,379
Last modified:September 23, 2008 - v1
Checksum:iC2AB42793B7BD029
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940650 Genomic DNA. Translation: EDW67846.1.
RefSeqiXP_002054326.1. XM_002054290.1.

Genome annotation databases

EnsemblMetazoaiFBtr0240307; FBpp0238799; FBgn0211462.
GeneIDi6629925.
KEGGidvi:Dvir_GJ24382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940650 Genomic DNA. Translation: EDW67846.1 .
RefSeqi XP_002054326.1. XM_002054290.1.

3D structure databases

ProteinModelPortali B4LXG8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0238799.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0240307 ; FBpp0238799 ; FBgn0211462 .
GeneIDi 6629925.
KEGGi dvi:Dvir_GJ24382.

Organism-specific databases

FlyBasei FBgn0211462. Dvir\GJ24382.

Phylogenomic databases

eggNOGi COG1793.
InParanoidi B4LXG8.
KOi K10776.
OMAi NEDNKLD.
OrthoDBi EOG7BKCT2.
PhylomeDBi B4LXG8.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProi IPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiB4LXG8_DROVI
AccessioniPrimary (citable) accession number: B4LXG8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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