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Protein

DNA ligase

Gene

Dvir\GJ24382

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dvir\GJ24382Imported
ORF Names:Dvir_GJ24382Imported, GJ24382Imported
OrganismiDrosophila virilis (Fruit fly)Imported
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0211462. Dvir\GJ24382.

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0238799.

Structurei

3D structure databases

ProteinModelPortaliB4LXG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiB4LXG8.
KOiK10776.
OMAiMILDSEI.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4LXG8.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4LXG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKLLRNCRV SHFTRIRSRG MSSKQARNED NKLDTFRRIC DEIAGEASYL
60 70 80 90 100
RKVEKLEHFL KKGSSGSGFK GDLLQWVQFL IPGATQRVYN LQNKALLKLF
110 120 130 140 150
ARIFHVDQQQ MHLDLEQDGD ISETLRKHFA SSSKLKPQAQ SKLYLHEVEN
160 170 180 190 200
MLCQLEQRTK EDEQTEVLQE VCKQATDLDL RTFIRLIKQD LRINARARHI
210 220 230 240 250
LDAFGPEAYP AYQSTRDLKL IVENFAGTQG KPKSLKGLPK AATKSSKKAI
260 270 280 290 300
GAIQVMTPIS PMLANACKSV EEAFKKNPGG LYSEVKYDGE RVQIHKHGSE
310 320 330 340 350
FKFFSRNLKP VVDHKIKELK DYIPRAFPGA NDMILDSEII LVNTKTGELL
360 370 380 390 400
PFGTLGAHKK HTYANASVCL FVFDCLLYDG DDLTQLSFCK RREILEQNIK
410 420 430 440 450
PIKHHVQLSE SQFLKTKNEL AMMTAKVLQA NLEGVVLKSP EGTYQPGKRN
460 470 480 490 500
WLKVKKDYLF GGKMADTADL VVLGAWYGSG KKGGVLSIFL MGCYDARDRL
510 520 530 540 550
WKTVTKVHSG LDDASNDEVH ESLMKLTERA DASKIPNWLL CKKALIPDVL
560 570 580 590 600
AKIPEQMPVW EITGAEFTQS EAHTAAGISI RFPRITRLRS DKSAMQANDL
610 620 630 640 650
EHLEQLYAAS KQNVNVDLLL ANCEADRDDA LKNKLKLEKT PQKSKAPKEA
660 670 680 690 700
TASSSKKPKR SKSASDDEEV TPSKGRSSRK MHKLEAPTVT SQGNLKDFFK
710 720 730 740 750
PKIVIADVKI ENPPLASTSS NYGKGEDRKL FIGLEAHFVA DAAQPKLMDE
760 770 780 790 800
FVRHGGILAK CTQRASLVFH DCNKNKDLSQ LRPLYRRSCR HLNIKWLEET
810
LKMKTLQPYP LYALLLQS
Length:818
Mass (Da):92,379
Last modified:September 23, 2008 - v1
Checksum:iC2AB42793B7BD029
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940650 Genomic DNA. Translation: EDW67846.1.
RefSeqiXP_002054326.1. XM_002054290.1.

Genome annotation databases

EnsemblMetazoaiFBtr0240307; FBpp0238799; FBgn0211462.
GeneIDi6629925.
KEGGidvi:Dvir_GJ24382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940650 Genomic DNA. Translation: EDW67846.1.
RefSeqiXP_002054326.1. XM_002054290.1.

3D structure databases

ProteinModelPortaliB4LXG8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0238799.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0240307; FBpp0238799; FBgn0211462.
GeneIDi6629925.
KEGGidvi:Dvir_GJ24382.

Organism-specific databases

FlyBaseiFBgn0211462. Dvir\GJ24382.

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiB4LXG8.
KOiK10776.
OMAiMILDSEI.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4LXG8.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87Imported.

Entry informationi

Entry nameiB4LXG8_DROVI
AccessioniPrimary (citable) accession number: B4LXG8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.