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B4LXG8

- B4LXG8_DROVI

UniProt

B4LXG8 - B4LXG8_DROVI

Protein

DNA ligase

Gene

Dvir\GJ24382

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA ligation involved in DNA repair Source: InterPro
    2. DNA recombination Source: UniProtKB-KW
    3. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    LigaseUniRule annotation

    Keywords - Biological processi

    DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Gene namesi
    Name:Dvir\GJ24382Imported
    ORF Names:Dvir_GJ24382Imported, GJ24382Imported
    OrganismiDrosophila virilis (Fruit fly)Imported
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0211462. Dvir\GJ24382.

    Interactioni

    Protein-protein interaction databases

    STRINGi7244.FBpp0238799.

    Structurei

    3D structure databases

    ProteinModelPortaliB4LXG8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1793.
    InParanoidiB4LXG8.
    KOiK10776.
    OMAiNEDNKLD.
    OrthoDBiEOG7BKCT2.
    PhylomeDBiB4LXG8.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4LXG8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MIKLLRNCRV SHFTRIRSRG MSSKQARNED NKLDTFRRIC DEIAGEASYL    50
    RKVEKLEHFL KKGSSGSGFK GDLLQWVQFL IPGATQRVYN LQNKALLKLF 100
    ARIFHVDQQQ MHLDLEQDGD ISETLRKHFA SSSKLKPQAQ SKLYLHEVEN 150
    MLCQLEQRTK EDEQTEVLQE VCKQATDLDL RTFIRLIKQD LRINARARHI 200
    LDAFGPEAYP AYQSTRDLKL IVENFAGTQG KPKSLKGLPK AATKSSKKAI 250
    GAIQVMTPIS PMLANACKSV EEAFKKNPGG LYSEVKYDGE RVQIHKHGSE 300
    FKFFSRNLKP VVDHKIKELK DYIPRAFPGA NDMILDSEII LVNTKTGELL 350
    PFGTLGAHKK HTYANASVCL FVFDCLLYDG DDLTQLSFCK RREILEQNIK 400
    PIKHHVQLSE SQFLKTKNEL AMMTAKVLQA NLEGVVLKSP EGTYQPGKRN 450
    WLKVKKDYLF GGKMADTADL VVLGAWYGSG KKGGVLSIFL MGCYDARDRL 500
    WKTVTKVHSG LDDASNDEVH ESLMKLTERA DASKIPNWLL CKKALIPDVL 550
    AKIPEQMPVW EITGAEFTQS EAHTAAGISI RFPRITRLRS DKSAMQANDL 600
    EHLEQLYAAS KQNVNVDLLL ANCEADRDDA LKNKLKLEKT PQKSKAPKEA 650
    TASSSKKPKR SKSASDDEEV TPSKGRSSRK MHKLEAPTVT SQGNLKDFFK 700
    PKIVIADVKI ENPPLASTSS NYGKGEDRKL FIGLEAHFVA DAAQPKLMDE 750
    FVRHGGILAK CTQRASLVFH DCNKNKDLSQ LRPLYRRSCR HLNIKWLEET 800
    LKMKTLQPYP LYALLLQS 818
    Length:818
    Mass (Da):92,379
    Last modified:September 23, 2008 - v1
    Checksum:iC2AB42793B7BD029
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW67846.1.
    RefSeqiXP_002054326.1. XM_002054290.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0240307; FBpp0238799; FBgn0211462.
    GeneIDi6629925.
    KEGGidvi:Dvir_GJ24382.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW67846.1 .
    RefSeqi XP_002054326.1. XM_002054290.1.

    3D structure databases

    ProteinModelPortali B4LXG8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0238799.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0240307 ; FBpp0238799 ; FBgn0211462 .
    GeneIDi 6629925.
    KEGGi dvi:Dvir_GJ24382.

    Organism-specific databases

    FlyBasei FBgn0211462. Dvir\GJ24382.

    Phylogenomic databases

    eggNOGi COG1793.
    InParanoidi B4LXG8.
    KOi K10776.
    OMAi NEDNKLD.
    OrthoDBi EOG7BKCT2.
    PhylomeDBi B4LXG8.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87Imported.

    Entry informationi

    Entry nameiB4LXG8_DROVI
    AccessioniPrimary (citable) accession number: B4LXG8
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3