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B4LX78

- ARMET_DROVI

UniProt

B4LX78 - ARMET_DROVI

Protein

Mesencephalic astrocyte-derived neurotrophic factor homolog

Gene

Manf

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels By similarity.By similarity

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mesencephalic astrocyte-derived neurotrophic factor homolog
    Alternative name(s):
    MANF/CDNF-like protein
    Gene namesi
    Name:ManfBy similarity
    ORF Names:GJ23764
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0210861. Dvir\GJ23764.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 173151Mesencephalic astrocyte-derived neurotrophic factor homologPRO_0000390946Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 114By similarity
    Disulfide bondi31 ↔ 103By similarity
    Disulfide bondi61 ↔ 72By similarity
    Disulfide bondi148 ↔ 151By similarity

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Protein-protein interaction databases

    STRINGi7244.FBpp0238181.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ARMET family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG301491.
    InParanoidiB4LX78.
    OMAiKDAQICE.
    OrthoDBiEOG7PZS02.
    PhylomeDBiB4LX78.

    Family and domain databases

    Gene3Di1.10.225.10. 1 hit.
    InterProiIPR019345. Armet_prot.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR011001. Saposin-like.
    [Graphical view]
    PfamiPF10208. Armet. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4LX78-1 [UniParc]FASTAAdd to Basket

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    MNTSHIVLMI CFIVGVGQTA LALKEDDCEV CVKTVKRFAD TLDDATKKDY    50
    KLIETAFKKY CKTQKNKEHR FCYYLGGLEE SATGILNELS KPLSWSMPAE 100
    KVCEKLKKKD AQICDLRYEK QIDLNSVDLK KLKVRDLKKI LNDWDESCDG 150
    CLEKSDFIKR IEELKPKYSR NEL 173
    Length:173
    Mass (Da):20,041
    Last modified:September 23, 2008 - v1
    Checksum:i7540A6DD06A62933
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW66730.1.
    RefSeqiXP_002053210.1. XM_002053174.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0239689; FBpp0238181; FBgn0210861.
    GeneIDi6630749.
    KEGGidvi:Dvir_GJ23764.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW66730.1 .
    RefSeqi XP_002053210.1. XM_002053174.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0238181.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0239689 ; FBpp0238181 ; FBgn0210861 .
    GeneIDi 6630749.
    KEGGi dvi:Dvir_GJ23764.

    Organism-specific databases

    FlyBasei FBgn0210861. Dvir\GJ23764.

    Phylogenomic databases

    eggNOGi NOG301491.
    InParanoidi B4LX78.
    OMAi KDAQICE.
    OrthoDBi EOG7PZS02.
    PhylomeDBi B4LX78.

    Family and domain databases

    Gene3Di 1.10.225.10. 1 hit.
    InterProi IPR019345. Armet_prot.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR011001. Saposin-like.
    [Graphical view ]
    Pfami PF10208. Armet. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87Imported.

    Entry informationi

    Entry nameiARMET_DROVI
    AccessioniPrimary (citable) accession number: B4LX78
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3