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B4LVU6

- PDE6_DROVI

UniProt

B4LVU6 - PDE6_DROVI

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei496 – 4961Proton donorBy similarity
    Metal bindingi500 – 5001Divalent metal cation 1By similarity
    Metal bindingi536 – 5361Divalent metal cation 1By similarity
    Metal bindingi537 – 5371Divalent metal cation 1By similarity
    Metal bindingi537 – 5371Divalent metal cation 2By similarity
    Metal bindingi647 – 6471Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GJ23019
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0210121. Dvir\GJ23019.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 890890cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363700Add
    BLAST
    Propeptidei891 – 8933Removed in mature formBy similarityPRO_0000363701

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei890 – 8901Cysteine methyl esterBy similarity
    Lipidationi890 – 8901S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Protein-protein interaction databases

    STRINGi7244.FBpp0237436.

    Structurei

    3D structure databases

    ProteinModelPortaliB4LVU6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini21 – 173153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini205 – 390186GAF 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG270709.
    InParanoidiB4LVU6.
    KOiK13763.
    OMAiDDNPSNP.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB4LVU6.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4LVU6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MELDEGELFM ELIRDVANEL DIDVLCHKIL VNVGLLTHAD RGSLFLAKGT    50
    PNNKYLVAKL FDVTQKTALK DAVTRARAEE IIIPFGIGIA GMVAQTKEMI 100
    NIKEAYMDAR FNCEIDLKTG YKTNAILCMP ICNYEGDIIG VAQIINKTNG 150
    CMEFDEHDVE IFRRYLTFCG IGIQNAQLFE MSVQEYRRNQ ILLNLARSIF 200
    EEQNNLECLV TKIMTEAREL LKCERCSVFL VDLDCCEESH LEKIIEKPHQ 250
    LEQRATRAIK GGDSFEEKQK MRNRFTVLFE LGGESQAANV SRPSINDLSH 300
    STLAQIAQFV ATTGQTVNIC DVHDWVREHN QIRAEGEIDS THAILCMPIV 350
    NAQKTVIGVA QLINKASGLP FTESDASIFE AFAIFCGLGI HNTQMYENAC 400
    KLMAKQKVAL ECLSYHATAG QDQTEKLIQD PIAEAETYNL YSFTFTDFDL 450
    VDDDTCRAVL RMFMQCNLVS QFHIPYDVLC RWVLSVRKNY RPVKYHNWRH 500
    ALNVAQTMFA MLKTGKMERF MTDLEILGLL VACLCHDLDH RGTNNAFQTK 550
    TESPLAILYT TSTMEHHHFD QCVMILNSEG NNIFQALSPE DYRSVMKTVE 600
    SAILSTDLAM YFKKRNAFLE LVENGEFDWQ GEEKKDLLCG MMMTACDVSA 650
    IAKPWEVQHR VAKLVADEFF DQGDLEKLQL NTQPVAMMDR ERKDELPKMQ 700
    VGFIDVICLP LYRVLCDTFP WITPLYEGTL ENRRNWQDLA EKVEMGLTWI 750
    DHDTIDKPVE EFAGCADEEI KDIEFTVTTL NCNQQSQHGG DDSHTPEHQR 800
    SGSRLSIKKT GALGKVVRSK LSKTLYNSMD GSKPKTSLKL LESHVSEDMD 850
    DKSPTSPSQP HLGSVGRMSA SSSTSSAGTV DKSKKRSKLC ALL 893
    Length:893
    Mass (Da):100,943
    Last modified:September 23, 2008 - v1
    Checksum:i2CD8AD4CCE687DDE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW67551.1.
    RefSeqiXP_002054031.1. XM_002053995.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0238944; FBpp0237436; FBgn0210121.
    GeneIDi6630351.
    KEGGidvi:Dvir_GJ23019.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940650 Genomic DNA. Translation: EDW67551.1 .
    RefSeqi XP_002054031.1. XM_002053995.1.

    3D structure databases

    ProteinModelPortali B4LVU6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0237436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0238944 ; FBpp0237436 ; FBgn0210121 .
    GeneIDi 6630351.
    KEGGi dvi:Dvir_GJ23019.

    Organism-specific databases

    FlyBasei FBgn0210121. Dvir\GJ23019.

    Phylogenomic databases

    eggNOGi NOG270709.
    InParanoidi B4LVU6.
    KOi K13763.
    OMAi DDNPSNP.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B4LVU6.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87Imported.

    Entry informationi

    Entry nameiPDE6_DROVI
    AccessioniPrimary (citable) accession number: B4LVU6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3