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B4LVU6 (PDE6_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase

EC=3.1.4.35
Gene names
Name:Pde6
ORF Names:GJ23019
OrganismDrosophila virilis (Fruit fly) [Complete proteome]
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length893 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity. UniProtKB Q9VFI9

Catalytic activity

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate. UniProtKB Q9VFI9

Cofactor

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Subunit structure

Interacts with PrBP By similarity. UniProtKB Q9VFI9

Subcellular location

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity UniProtKB Q9VFI9.

Sequence similarities

Belongs to the cyclic nucleotide phosphodiesterase family.

Contains 2 GAF domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 890890cGMP-specific 3',5'-cyclic phosphodiesterase UniProtKB Q9VFI9
PRO_0000363700
Propeptide891 – 8933Removed in mature form By similarity UniProtKB Q9VFI9
PRO_0000363701

Regions

Domain21 – 173153GAF 1
Domain205 – 390186GAF 2

Sites

Active site4961Proton donor By similarity
Metal binding5001Divalent metal cation 1 By similarity
Metal binding5361Divalent metal cation 1 By similarity
Metal binding5371Divalent metal cation 1 By similarity
Metal binding5371Divalent metal cation 2 By similarity
Metal binding6471Divalent metal cation 1 By similarity

Amino acid modifications

Modified residue8901Cysteine methyl ester By similarity UniProtKB Q9VFI9
Lipidation8901S-farnesyl cysteine By similarity UniProtKB Q9VFI9

Sequences

Sequence LengthMass (Da)Tools
B4LVU6 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 2CD8AD4CCE687DDE

FASTA893100,943
        10         20         30         40         50         60 
MELDEGELFM ELIRDVANEL DIDVLCHKIL VNVGLLTHAD RGSLFLAKGT PNNKYLVAKL 

        70         80         90        100        110        120 
FDVTQKTALK DAVTRARAEE IIIPFGIGIA GMVAQTKEMI NIKEAYMDAR FNCEIDLKTG 

       130        140        150        160        170        180 
YKTNAILCMP ICNYEGDIIG VAQIINKTNG CMEFDEHDVE IFRRYLTFCG IGIQNAQLFE 

       190        200        210        220        230        240 
MSVQEYRRNQ ILLNLARSIF EEQNNLECLV TKIMTEAREL LKCERCSVFL VDLDCCEESH 

       250        260        270        280        290        300 
LEKIIEKPHQ LEQRATRAIK GGDSFEEKQK MRNRFTVLFE LGGESQAANV SRPSINDLSH 

       310        320        330        340        350        360 
STLAQIAQFV ATTGQTVNIC DVHDWVREHN QIRAEGEIDS THAILCMPIV NAQKTVIGVA 

       370        380        390        400        410        420 
QLINKASGLP FTESDASIFE AFAIFCGLGI HNTQMYENAC KLMAKQKVAL ECLSYHATAG 

       430        440        450        460        470        480 
QDQTEKLIQD PIAEAETYNL YSFTFTDFDL VDDDTCRAVL RMFMQCNLVS QFHIPYDVLC 

       490        500        510        520        530        540 
RWVLSVRKNY RPVKYHNWRH ALNVAQTMFA MLKTGKMERF MTDLEILGLL VACLCHDLDH 

       550        560        570        580        590        600 
RGTNNAFQTK TESPLAILYT TSTMEHHHFD QCVMILNSEG NNIFQALSPE DYRSVMKTVE 

       610        620        630        640        650        660 
SAILSTDLAM YFKKRNAFLE LVENGEFDWQ GEEKKDLLCG MMMTACDVSA IAKPWEVQHR 

       670        680        690        700        710        720 
VAKLVADEFF DQGDLEKLQL NTQPVAMMDR ERKDELPKMQ VGFIDVICLP LYRVLCDTFP 

       730        740        750        760        770        780 
WITPLYEGTL ENRRNWQDLA EKVEMGLTWI DHDTIDKPVE EFAGCADEEI KDIEFTVTTL 

       790        800        810        820        830        840 
NCNQQSQHGG DDSHTPEHQR SGSRLSIKKT GALGKVVRSK LSKTLYNSMD GSKPKTSLKL 

       850        860        870        880        890 
LESHVSEDMD DKSPTSPSQP HLGSVGRMSA SSSTSSAGTV DKSKKRSKLC ALL 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15010-1051.87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH940650 Genomic DNA. Translation: EDW67551.1.
RefSeqXP_002054031.1. XM_002053995.1.

3D structure databases

ProteinModelPortalB4LVU6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7244.FBpp0237436.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0238944; FBpp0237436; FBgn0210121.
GeneID6630351.
KEGGdvi:Dvir_GJ23019.

Organism-specific databases

FlyBaseFBgn0210121. Dvir\GJ23019.

Phylogenomic databases

eggNOGNOG270709.
InParanoidB4LVU6.
KOK13763.
OMADDNPSNP.
OrthoDBEOG7RRF69.
PhylomeDBB4LVU6.

Family and domain databases

Gene3D1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSPR00387. PDIESTERASE1.
SMARTSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMSSF55781. SSF55781. 3 hits.
PROSITEPS00126. PDEASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePDE6_DROVI
AccessionPrimary (citable) accession number: B4LVU6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase