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B4LVU6

- PDE6_DROVI

UniProt

B4LVU6 - PDE6_DROVI

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene
Pde6, GJ23019
Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei496 – 4961Proton donor By similarity
Metal bindingi500 – 5001Divalent metal cation 1 By similarity
Metal bindingi536 – 5361Divalent metal cation 1 By similarity
Metal bindingi537 – 5371Divalent metal cation 1 By similarity
Metal bindingi537 – 5371Divalent metal cation 2 By similarity
Metal bindingi647 – 6471Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GJ23019
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0210121. Dvir\GJ23019.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 890890cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarityPRO_0000363700Add
BLAST
Propeptidei891 – 8933Removed in mature form By similarityBy similarityPRO_0000363701

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei890 – 8901Cysteine methyl ester By similarityBy similarity
Lipidationi890 – 8901S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Protein-protein interaction databases

STRINGi7244.FBpp0237436.

Structurei

3D structure databases

ProteinModelPortaliB4LVU6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 173153GAF 1Add
BLAST
Domaini205 – 390186GAF 2Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiB4LVU6.
KOiK13763.
OMAiDDNPSNP.
OrthoDBiEOG7RRF69.
PhylomeDBiB4LVU6.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4LVU6-1 [UniParc]FASTAAdd to Basket

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MELDEGELFM ELIRDVANEL DIDVLCHKIL VNVGLLTHAD RGSLFLAKGT    50
PNNKYLVAKL FDVTQKTALK DAVTRARAEE IIIPFGIGIA GMVAQTKEMI 100
NIKEAYMDAR FNCEIDLKTG YKTNAILCMP ICNYEGDIIG VAQIINKTNG 150
CMEFDEHDVE IFRRYLTFCG IGIQNAQLFE MSVQEYRRNQ ILLNLARSIF 200
EEQNNLECLV TKIMTEAREL LKCERCSVFL VDLDCCEESH LEKIIEKPHQ 250
LEQRATRAIK GGDSFEEKQK MRNRFTVLFE LGGESQAANV SRPSINDLSH 300
STLAQIAQFV ATTGQTVNIC DVHDWVREHN QIRAEGEIDS THAILCMPIV 350
NAQKTVIGVA QLINKASGLP FTESDASIFE AFAIFCGLGI HNTQMYENAC 400
KLMAKQKVAL ECLSYHATAG QDQTEKLIQD PIAEAETYNL YSFTFTDFDL 450
VDDDTCRAVL RMFMQCNLVS QFHIPYDVLC RWVLSVRKNY RPVKYHNWRH 500
ALNVAQTMFA MLKTGKMERF MTDLEILGLL VACLCHDLDH RGTNNAFQTK 550
TESPLAILYT TSTMEHHHFD QCVMILNSEG NNIFQALSPE DYRSVMKTVE 600
SAILSTDLAM YFKKRNAFLE LVENGEFDWQ GEEKKDLLCG MMMTACDVSA 650
IAKPWEVQHR VAKLVADEFF DQGDLEKLQL NTQPVAMMDR ERKDELPKMQ 700
VGFIDVICLP LYRVLCDTFP WITPLYEGTL ENRRNWQDLA EKVEMGLTWI 750
DHDTIDKPVE EFAGCADEEI KDIEFTVTTL NCNQQSQHGG DDSHTPEHQR 800
SGSRLSIKKT GALGKVVRSK LSKTLYNSMD GSKPKTSLKL LESHVSEDMD 850
DKSPTSPSQP HLGSVGRMSA SSSTSSAGTV DKSKKRSKLC ALL 893
Length:893
Mass (Da):100,943
Last modified:September 23, 2008 - v1
Checksum:i2CD8AD4CCE687DDE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940650 Genomic DNA. Translation: EDW67551.1.
RefSeqiXP_002054031.1. XM_002053995.1.

Genome annotation databases

EnsemblMetazoaiFBtr0238944; FBpp0237436; FBgn0210121.
GeneIDi6630351.
KEGGidvi:Dvir_GJ23019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940650 Genomic DNA. Translation: EDW67551.1 .
RefSeqi XP_002054031.1. XM_002053995.1.

3D structure databases

ProteinModelPortali B4LVU6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0237436.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0238944 ; FBpp0237436 ; FBgn0210121 .
GeneIDi 6630351.
KEGGi dvi:Dvir_GJ23019.

Organism-specific databases

FlyBasei FBgn0210121. Dvir\GJ23019.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi B4LVU6.
KOi K13763.
OMAi DDNPSNP.
OrthoDBi EOG7RRF69.
PhylomeDBi B4LVU6.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiPDE6_DROVI
AccessioniPrimary (citable) accession number: B4LVU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi