UniProtKB - B4LRB8 (B4LRB8_DROVI)
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Protein
Angiotensin-converting enzyme
Gene
Dvir\GJ21681
Organism
Drosophila virilis (Fruit fly)
Status
Functioni
Cofactori
Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation
GO - Molecular functioni
- carboxypeptidase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- metallopeptidase activity Source: UniProtKB-KW
- peptidyl-dipeptidase activity Source: EnsemblMetazoa
GO - Biological processi
- heart morphogenesis Source: EnsemblMetazoa
- positive regulation of circadian sleep/wake cycle, sleep Source: EnsemblMetazoa
- regulation of heart rate Source: EnsemblMetazoa
- sleep Source: EnsemblMetazoa
Keywordsi
Molecular function | CarboxypeptidaseUniRule annotationImported, Hydrolase, MetalloproteaseUniRule annotation, Protease |
Ligand | Metal-bindingUniRule annotation, ZincUniRule annotation |
Protein family/group databases
MEROPSi | M02.002 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Dvir\GJ21681Imported ORF Names:Dvir_GJ21681Imported, GJ21681Imported |
Organismi | Drosophila virilis (Fruit fly)Imported |
Taxonomic identifieri | 7244 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0208800 Dvir\GJ21681 |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | Sequence analysisAdd BLAST | 25 | |
ChainiPRO_5002816591 | 26 – 633 | Angiotensin-converting enzymeSequence analysisAdd BLAST | 608 |
Keywords - PTMi
GlycoproteinUniRule annotationFamily & Domainsi
Sequence similaritiesi
Belongs to the peptidase M2 family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
eggNOGi | KOG3690 Eukaryota ENOG410XPJ3 LUCA |
InParanoidi | B4LRB8 |
KOi | K01283 |
OMAi | NCDIFGS |
OrthoDBi | EOG091G033S |
PhylomeDBi | B4LRB8 |
Family and domain databases
CDDi | cd06461 M2_ACE, 1 hit |
InterProi | View protein in InterPro IPR001548 Peptidase_M2 |
PANTHERi | PTHR10514 PTHR10514, 1 hit |
Pfami | View protein in Pfam PF01401 Peptidase_M2, 1 hit |
PRINTSi | PR00791 PEPDIPTASEA |
i Sequence
Sequence statusi: Complete.
B4LRB8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNGSNLSLLL AFAFAFALWL PYGSADDNSC SASVLQAQRF FEQENSKLRE
60 70 80 90 100
RYHAEYSAAY TYNTNVTEEN RRAMIVVYAE SASQNKLLAQ AVRAGDYAKS
110 120 130 140 150
ADANIRRQAR MLQDLGADAL DPSDYLELKN AISSMQSNYA TTSVCSYTNR
160 170 180 190 200
TDCSLTLEPH IQERLANSRD PAELAWYWRE WYDKAGTPMR GNFEKYVRLT
210 220 230 240 250
RKAAHLNDYR SYADYWVHFY EDADFERQLD ATYKALLPFY RQIHGYVRYR
260 270 280 290 300
LRQHYGPEVV PAEGNIPMHL LGNMWAQSWN DVIDLFTPYP EKPFVDVKLE
310 320 330 340 350
MERQEYSVRK LFELGDQFFQ SLGMRALPAS FWNLSVLERP TDREVVCHAS
360 370 380 390 400
AWDFYQDSDV RIKMCTELNT HYLYVVHHEL GHIQYYLQYE QQPAVFRGAP
410 420 430 440 450
NPGFHEAVGD VIALSAMSAK HLKSLNLTRS GRLDEKSRIN ELFKQALSKI
460 470 480 490 500
VFLPFGYTMD KYRYAVFRGE LDESQWNCAF WQMRSEFGGL EPPLTRSNSD
510 520 530 540 550
FDPPAKYHID ADVEYLRYFA AHIFQFQFHR ALCRLAGQYA PGDSQQTLDN
560 570 580 590 600
CDIFGSKKAG QAFKTFLSAG NSKHWKIVLE EFTGETEMDP AALLEYFDPL
610 620 630
YQWLKQENSR LGVPLGWGNT NKIPSSCCGL FST
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH940649 Genomic DNA Translation: EDW64588.1 |
RefSeqi | XP_002052433.1, XM_002052397.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0237606; FBpp0236098; FBgn0208800 |
GeneIDi | 6628146 |
KEGGi | dvi:Dvir_GJ21681 |
Similar proteinsi
Entry informationi
Entry namei | B4LRB8_DROVI | |
Accessioni | B4LRB8Primary (citable) accession number: B4LRB8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | September 23, 2008 |
Last sequence update: | September 23, 2008 | |
Last modified: | March 28, 2018 | |
This is version 56 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |