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B4LQ24

- CALYP_DROVI

UniProt

B4LQ24 - CALYP_DROVI

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Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151NucleophileBy similarity
Active sitei197 – 1971Proton donorBy similarity
Sitei212 – 2121Important for enzyme activityBy similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin-specific protease activity Source: UniProtKB
  3. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:GJ20906
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0208042. Dvir\GJ20906.

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs).By similarity

GO - Cellular componenti

  1. nuclear chromatin Source: UniProtKB
  2. PR-DUB complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 462462Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395834Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

Protein-protein interaction databases

STRINGi7244.FBpp0235323.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C12 family. BAP1 subfamily.Curated

Phylogenomic databases

eggNOGiNOG249036.
InParanoidiB4LQ24.
KOiK08588.
OMAiTDKFRRV.
OrthoDBiEOG7GN2M2.
PhylomeDBiB4LQ24.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B4LQ24-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVAGGGTGT TAGSAGNNNT LPMAQLADGW LELESDPGLF TLLLEDFGCH
60 70 80 90 100
DVQVEEVYDL QKPIESPYGF IFLFRWIEER RARRKIVETT AEIFVKDEEA
110 120 130 140 150
ISSIFFAQQV VPNSCATHAL LSVLLNCNEN NLQLGETLSR LKAHTKGMSP
160 170 180 190 200
ENKGLAIGNT PELACAHNSH AMPQARRRLE RTGAGVASCR FTGEAFHFVS
210 220 230 240 250
FVPINGQLFE LDGLKPYPMN HGCWEEHEDW TDKFRRVMAE RLGIATGEQD
260 270 280 290 300
IRFNLMAVVP DRRIAITHKL KMLRTNQAIV SGTLQKLLKA DEQGERDEQQ
310 320 330 340 350
RPDTPNTLLE PSAFTARDLQ SLLKNLDTEI AINEQHLADE NDRRQMFKVD
360 370 380 390 400
ASRRTHNYDK FICTFLTMLA HQGVLGELVS QHLLPSKKIS GQSAANRLNK
410 420 430 440 450
QNSAAASTAN SSAGATAGGA KSQQQQQQQQ QPQQPQTPKN GKSPGKTPGR
460
RRKGRNKCRK RK
Length:462
Mass (Da):51,378
Last modified:September 23, 2008 - v1
Checksum:i8B4F7B38F50D8F2E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940648 Genomic DNA. Translation: EDW60347.1.
RefSeqiXP_002049154.1. XM_002049118.1.

Genome annotation databases

EnsemblMetazoaiFBtr0236831; FBpp0235323; FBgn0208042.
GeneIDi6626878.
KEGGidvi:Dvir_GJ20906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940648 Genomic DNA. Translation: EDW60347.1 .
RefSeqi XP_002049154.1. XM_002049118.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0235323.

Protein family/group databases

MEROPSi C12.A09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0236831 ; FBpp0235323 ; FBgn0208042 .
GeneIDi 6626878.
KEGGi dvi:Dvir_GJ20906.

Organism-specific databases

FlyBasei FBgn0208042. Dvir\GJ20906.

Phylogenomic databases

eggNOGi NOG249036.
InParanoidi B4LQ24.
KOi K08588.
OMAi TDKFRRV.
OrthoDBi EOG7GN2M2.
PhylomeDBi B4LQ24.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiCALYP_DROVI
AccessioniPrimary (citable) accession number: B4LQ24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3