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Protein

DNA ligase

Gene

Dvir\GJ20456

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dvir\GJ20456Imported
ORF Names:Dvir_GJ20456Imported, GJ20456Imported
OrganismiDrosophila virilis (Fruit fly)Imported
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0207596. Dvir\GJ20456.

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0234873.

Structurei

3D structure databases

ProteinModelPortaliB4LNY6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini461 – 597137DNA_LIGASE_A3InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0967. Eukaryota.
COG1793. LUCA.
InParanoidiB4LNY6.
KOiK10747.
OMAiSQCPNYD.
OrthoDBiEOG7RFTGN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4LNY6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKSITSFFK PKDGLPGPEK SSVPEKTKST ENISKNKIKS EDVVEEPGNE
60 70 80 90 100
NKQPPLEATG AEKPADMPPS KITKMELNPE VTEGEGIEIY DPSLESYHPL
110 120 130 140 150
KHAYWKAERV TPYLALARTF QVIEETSGRL KMIDILSNFF CSVMLVSPED
160 170 180 190 200
LVPCVYLSIN QLAPAYEGLE LGVAETTLMK AICKATGRNL AHIKSQTHLT
210 220 230 240 250
GDLGIVAEQS RVSQRMMFRP KPLNVRGVFT KLKEIAKISG QAKMTLVYDV
260 270 280 290 300
FVACRLSEAR FFIRSLIGKL RIGIAEQSLL TALAIALVKR NHINDCKTNK
310 320 330 340 350
VCDVYKDEIA ETTLILKTTF CQCPNYDIII PAILKYDIKE LQERCPMHPG
360 370 380 390 400
MPLRPMLAQP TKGVLEVLER FSGMHITCEW KYDGERAQIH LNELGEISIF
410 420 430 440 450
SRNSENNTPK YPDLIARSKS FLKTDVQSYI IDSEIVAWDI ERKQILPFQI
460 470 480 490 500
LSTRKRKNVD IEDIKVQVCV YIFDLLFING VSLVTKPLSL RRKMLFEHFQ
510 520 530 540 550
EVEGQWKFAT ALDTNDMDEV QQFLEESIKG NCEGLMVKTL EEEATYEIAK
560 570 580 590 600
RSRNWLKLKK DYLSNVGDSL DLVVIGGYKG KGRRTGTYGG FLLACYDTEN
610 620 630 640 650
EEYQSICKIG TGFTDDDLRL HSEFFNKHVT GSAKSYFRYD PSLEPDVWFE
660 670 680 690 700
PVQVWEVKCA DLSLSPIHRA SIGIVDAERG ISLRFPRFIR IRDDKSPENA
710 720 730
TDANQVAHMY KSQDQVRNNQ KSSSLMDIES DFY
Length:733
Mass (Da):83,294
Last modified:January 20, 2016 - v2
Checksum:iF62B93312EB2771E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940648 Genomic DNA. Translation: EDW61155.2.
CH940648 Genomic DNA. Translation: KRF79818.1.
CH940648 Genomic DNA. Translation: KRF79819.1.
RefSeqiXP_002049962.2. XM_002049926.2.
XP_015029313.1. XM_015173827.1.
XP_015029314.1. XM_015173828.1.

Genome annotation databases

EnsemblMetazoaiFBtr0236381; FBpp0234873; FBgn0207596.
GeneIDi6624981.
KEGGidvi:Dvir_GJ20456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940648 Genomic DNA. Translation: EDW61155.2.
CH940648 Genomic DNA. Translation: KRF79818.1.
CH940648 Genomic DNA. Translation: KRF79819.1.
RefSeqiXP_002049962.2. XM_002049926.2.
XP_015029313.1. XM_015173827.1.
XP_015029314.1. XM_015173828.1.

3D structure databases

ProteinModelPortaliB4LNY6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7244.FBpp0234873.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0236381; FBpp0234873; FBgn0207596.
GeneIDi6624981.
KEGGidvi:Dvir_GJ20456.

Organism-specific databases

FlyBaseiFBgn0207596. Dvir\GJ20456.

Phylogenomic databases

eggNOGiKOG0967. Eukaryota.
COG1793. LUCA.
InParanoidiB4LNY6.
KOiK10747.
OMAiSQCPNYD.
OrthoDBiEOG7RFTGN.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TSC#15010-1051.87Imported and Tucson 15010-1051.87Imported.
  2. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TSC#15010-1051.87Imported.
  3. FlyBase
    Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TSC#15010-1051.87Imported.
  4. FlyBase
    Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: TSC#15010-1051.87Imported.

Entry informationi

Entry nameiB4LNY6_DROVI
AccessioniPrimary (citable) accession number: B4LNY6
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: April 13, 2016
This is version 54 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.