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Protein

Diphosphomevalonate decarboxylase

Gene

Dvir\GJ19966

Organism
Drosophila virilis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Performs the first committed step in the biosynthesis of isoprenes.UniRule annotation

Catalytic activityi

ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2.UniRule annotation

Pathwayi: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationImported
Biological processCholesterol biosynthesisUniRule annotation, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00063.

Names & Taxonomyi

Protein namesi
Recommended name:
Diphosphomevalonate decarboxylaseUniRule annotation (EC:4.1.1.33UniRule annotation)
Alternative name(s):
Mevalonate pyrophosphate decarboxylaseUniRule annotation
Gene namesi
Name:Dvir\GJ19966Imported
ORF Names:Dvir_GJ19966Imported, GJ19966Imported
OrganismiDrosophila virilis (Fruit fly)Imported
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000008792 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0207108. Dvir\GJ19966.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiFBgn0207108.

Interactioni

Protein-protein interaction databases

STRINGi7244.FBpp0234383.

Structurei

3D structure databases

ProteinModelPortaliB4LMG1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 157GHMP_kinases_NInterPro annotationAdd BLAST58

Sequence similaritiesi

Belongs to the diphosphomevalonate decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2833. Eukaryota.
COG3407. LUCA.
InParanoidiB4LMG1.
KOiK01597.
OMAiLTLHAMM.
OrthoDBiEOG091G0EUU.
PhylomeDBiB4LMG1.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
InterProiView protein in InterPro
IPR036554. GHMP_kinase_C_sf.
IPR006204. GHMP_kinase_N_dom.
IPR005935. Mev_decarb.
IPR029765. Mev_diP_decarb.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PfamiView protein in Pfam
PF00288. GHMP_kinases_N. 1 hit.
PIRSFiPIRSF015950. Mev_P_decrbx. 1 hit.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR01240. mevDPdecarb. 1 hit.

Sequencei

Sequence statusi: Complete.

B4LMG1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSATCVAPV NMALVKYWGK RNEELILPIN DSVSMTLDAN EMCAKTTITA
60 70 80 90 100
SESFKQNRMW LNGEVVTFEE NARLMRCLAG VQRLALANGA HKFSLSWKLH
110 120 130 140 150
IASYNNFPTA AGLASSAAGY ACLVYTLARL YELPLNEELT TVARQGSGSA
160 170 180 190 200
CRSLYGGFVH WRRGSSADGS DSIAVPLAPA SHWPNMHMLI LVVNDARKKT
210 220 230 240 250
GSTRGMQLGV STSSLIQHRA KEVVPRRVKE LMAAIESRDF QAFAEITIKE
260 270 280 290 300
SNQLHAICLD TYPPCVYMND VSHAIVNFVH DYNETVGSLQ AAYTFDAGPN
310 320 330 340 350
ACIYVLAENV PRLLAAIQLA FPNDAQQSVE YLMGIPVPPV ELKNGLRDAS
360 370 380 390
IGHVNPNNML KYIIHTKIGE GPHQLSDDKS LLIDGFPLPK
Length:390
Mass (Da):42,768
Last modified:September 23, 2008 - v1
Checksum:i8AE61981045EF774
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH940648 Genomic DNA. Translation: EDW62056.1.
RefSeqiXP_002050863.1. XM_002050827.2.

Genome annotation databases

EnsemblMetazoaiFBtr0235891; FBpp0234383; FBgn0207108.
GeneIDi6626360.
KEGGidvi:Dvir_GJ19966.

Similar proteinsi

Entry informationi

Entry nameiB4LMG1_DROVI
AccessioniPrimary (citable) accession number: B4LMG1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 25, 2017
This is version 59 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported