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B4LG38

- UBP36_DROVI

UniProt

B4LG38 - UBP36_DROVI

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Protein
Ubiquitin carboxyl-terminal hydrolase 36
Gene
Usp36, scny, GJ13192
Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011Nucleophile By similarity
Active sitei461 – 4611Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GJ13192
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0200418. Dvir\GJ13192.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12141214Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei553 – 5531Phosphoserine By similarity
Modified residuei555 – 5551Phosphoserine By similarity
Modified residuei717 – 7171Phosphothreonine By similarity
Modified residuei727 – 7271Phosphoserine By similarity
Modified residuei729 – 7291Phosphoserine By similarity
Modified residuei891 – 8911Phosphoserine By similarity
Modified residuei894 – 8941Phosphothreonine By similarity
Modified residuei897 – 8971Phosphoserine By similarity
Modified residuei951 – 9511Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Protein-protein interaction databases

STRINGi7244.FBpp0227609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 502311USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiB4LG38.
KOiK11855.
OMAiENEMDRG.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4LG38.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4LG38-1 [UniParc]FASTAAdd to Basket

« Hide

MPVSLAVCET ANVVNAALRE SLGSGIGGGG GCVAAAASRS SAGSGSGSVA     50
GVDEAKIGDV SGTDNLQSQI VANAKRVLLA KIEYEEVENY HESVLAKLKS 100
KYIVIKPDNN NGAANCNYKT NGKAVGSNGH DNNTVNGGTV NGNRKQTVDS 150
GQSNQNSSAN PNELPKPKRV LYPRENIRIG WKQSERKWQV GAGMLNVGNT 200
CYLNSTLQAL FHIPALANWL VSETSHVENC NISESCGSGG CIICAMAKTL 250
QTTQSNQSAV RPFLIYTKLR QICKHMVVGR QEDAHEFLRF LVEAMEKAYL 300
MRFRNFKELD QLVKETTPIS QIFGGYLRSE VRCLSCNHVS ITFQHFQDLL 350
LDIRKADTLE EAFDGYFSRE RLEDMGYKCE GCKKKVSATK QFSLERAPIT 400
LCIQLKRFSM MGNKLTKQIS FKPRIDLSRF AARSPTAAAQ PLSYRLVSMV 450
THLGVSQHCG HYTAIGLTEA GSYYNFDDSY VKPIAMQSVC NTNAYIMFYE 500
LDVANSSSSS TINNNSSSSS NNSVAPKLNG LRLSNGAHSP AAATVAVAAT 550
ATSTSASAVS PRFIGPQLPN GYANSNGHAL GGAKTTIQFK TTPQKQLQQQ 600
QQQQNGLLMG ANKFQESSQS KHSLAGTLHK GEAAPNANTN ANANKSSCNN 650
NITSQHQQQH ILPISSDEDE DEDDSDDDDD DDDDDVKANT APQLPSMPKM 700
FEDSESVAQT AKLKPKTPLK SLVPYESASE EEQEQQQQQQ QQQLLQTPQQ 750
LAANPRKRRS GSDSSESEEE APPPLPSILR NGHAKTNGSV SNTSNSSHSK 800
AKSASNASSA NVNSSKQKTD AIDEIFKSLN NYKNKHRIAA DDDEDGDGDG 850
DGHGNEQVQT EQGTKKLNSA SSASASKSNG WQSQNGKAPS SPKTPPSPAV 900
IKSKTGIWQI TRTNDDDDEE DEEEDDVEAD ADQEDDDDEV VVVEEPQVSV 950
TPKNPKNPFA ASKSAEANAT IAGAKRQKLL NGSAKSAATT RPGNGYQSES 1000
VANGSAVSEL LKQNHRGYGT SVLSWNGKPS ELDKESFDLV CAKRIAGHGD 1050
TDVHSDVNSS SNNSSNINSN SNSNSNGNGK RKNSTLLAEA REQRKRDAED 1100
EEENEMDRGR QRKVKSASVK SNNSTPGYNP FQEFENQKRW HSNKSGTFPR 1150
FYHQNNRPNF QQRNKFKFNR FGGGAKFQQQ RALQRHLAAG GGFTRRQQQS 1200
TGQQQQQQQQ QQQS 1214
Length:1,214
Mass (Da):132,000
Last modified:September 23, 2008 - v1
Checksum:iBC3028B949547093
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940647 Genomic DNA. Translation: EDW69346.1.
RefSeqiXP_002047004.1. XM_002046968.1.

Genome annotation databases

EnsemblMetazoaiFBtr0229117; FBpp0227609; FBgn0200418.
GeneIDi6622549.
KEGGidvi:Dvir_GJ13192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940647 Genomic DNA. Translation: EDW69346.1 .
RefSeqi XP_002047004.1. XM_002046968.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0227609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0229117 ; FBpp0227609 ; FBgn0200418 .
GeneIDi 6622549.
KEGGi dvi:Dvir_GJ13192.

Organism-specific databases

FlyBasei FBgn0200418. Dvir\GJ13192.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi B4LG38.
KOi K11855.
OMAi ENEMDRG.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4LG38.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiUBP36_DROVI
AccessioniPrimary (citable) accession number: B4LG38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi