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B4LG38 (UBP36_DROVI) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GJ13192
OrganismDrosophila virilis (Fruit fly) [Complete proteome]
Taxonomic identifier7244 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length1214 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12141214Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378503

Regions

Domain192 – 502311USP

Sites

Active site2011Nucleophile By similarity
Active site4611Proton acceptor By similarity

Amino acid modifications

Modified residue5531Phosphoserine By similarity
Modified residue5551Phosphoserine By similarity
Modified residue7171Phosphothreonine By similarity
Modified residue7271Phosphoserine By similarity
Modified residue7291Phosphoserine By similarity
Modified residue8911Phosphoserine By similarity
Modified residue8941Phosphothreonine By similarity
Modified residue8971Phosphoserine By similarity
Modified residue9511Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4LG38 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: BC3028B949547093

FASTA1,214132,000
        10         20         30         40         50         60 
MPVSLAVCET ANVVNAALRE SLGSGIGGGG GCVAAAASRS SAGSGSGSVA GVDEAKIGDV 

        70         80         90        100        110        120 
SGTDNLQSQI VANAKRVLLA KIEYEEVENY HESVLAKLKS KYIVIKPDNN NGAANCNYKT 

       130        140        150        160        170        180 
NGKAVGSNGH DNNTVNGGTV NGNRKQTVDS GQSNQNSSAN PNELPKPKRV LYPRENIRIG 

       190        200        210        220        230        240 
WKQSERKWQV GAGMLNVGNT CYLNSTLQAL FHIPALANWL VSETSHVENC NISESCGSGG 

       250        260        270        280        290        300 
CIICAMAKTL QTTQSNQSAV RPFLIYTKLR QICKHMVVGR QEDAHEFLRF LVEAMEKAYL 

       310        320        330        340        350        360 
MRFRNFKELD QLVKETTPIS QIFGGYLRSE VRCLSCNHVS ITFQHFQDLL LDIRKADTLE 

       370        380        390        400        410        420 
EAFDGYFSRE RLEDMGYKCE GCKKKVSATK QFSLERAPIT LCIQLKRFSM MGNKLTKQIS 

       430        440        450        460        470        480 
FKPRIDLSRF AARSPTAAAQ PLSYRLVSMV THLGVSQHCG HYTAIGLTEA GSYYNFDDSY 

       490        500        510        520        530        540 
VKPIAMQSVC NTNAYIMFYE LDVANSSSSS TINNNSSSSS NNSVAPKLNG LRLSNGAHSP 

       550        560        570        580        590        600 
AAATVAVAAT ATSTSASAVS PRFIGPQLPN GYANSNGHAL GGAKTTIQFK TTPQKQLQQQ 

       610        620        630        640        650        660 
QQQQNGLLMG ANKFQESSQS KHSLAGTLHK GEAAPNANTN ANANKSSCNN NITSQHQQQH 

       670        680        690        700        710        720 
ILPISSDEDE DEDDSDDDDD DDDDDVKANT APQLPSMPKM FEDSESVAQT AKLKPKTPLK 

       730        740        750        760        770        780 
SLVPYESASE EEQEQQQQQQ QQQLLQTPQQ LAANPRKRRS GSDSSESEEE APPPLPSILR 

       790        800        810        820        830        840 
NGHAKTNGSV SNTSNSSHSK AKSASNASSA NVNSSKQKTD AIDEIFKSLN NYKNKHRIAA 

       850        860        870        880        890        900 
DDDEDGDGDG DGHGNEQVQT EQGTKKLNSA SSASASKSNG WQSQNGKAPS SPKTPPSPAV 

       910        920        930        940        950        960 
IKSKTGIWQI TRTNDDDDEE DEEEDDVEAD ADQEDDDDEV VVVEEPQVSV TPKNPKNPFA 

       970        980        990       1000       1010       1020 
ASKSAEANAT IAGAKRQKLL NGSAKSAATT RPGNGYQSES VANGSAVSEL LKQNHRGYGT 

      1030       1040       1050       1060       1070       1080 
SVLSWNGKPS ELDKESFDLV CAKRIAGHGD TDVHSDVNSS SNNSSNINSN SNSNSNGNGK 

      1090       1100       1110       1120       1130       1140 
RKNSTLLAEA REQRKRDAED EEENEMDRGR QRKVKSASVK SNNSTPGYNP FQEFENQKRW 

      1150       1160       1170       1180       1190       1200 
HSNKSGTFPR FYHQNNRPNF QQRNKFKFNR FGGGAKFQQQ RALQRHLAAG GGFTRRQQQS 

      1210 
TGQQQQQQQQ QQQS 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15010-1051.87.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH940647 Genomic DNA. Translation: EDW69346.1.
RefSeqXP_002047004.1. XM_002046968.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7244.FBpp0227609.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0229117; FBpp0227609; FBgn0200418.
GeneID6622549.
KEGGdvi:Dvir_GJ13192.

Organism-specific databases

FlyBaseFBgn0200418. Dvir\GJ13192.

Phylogenomic databases

eggNOGCOG5533.
InParanoidB4LG38.
KOK11855.
OMAENEMDRG.
OrthoDBEOG7XDBF6.
PhylomeDBB4LG38.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROVI
AccessionPrimary (citable) accession number: B4LG38
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase