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B4LG38

- UBP36_DROVI

UniProt

B4LG38 - UBP36_DROVI

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei201 – 2011NucleophilePROSITE-ProRule annotation
Active sitei461 – 4611Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GJ13192
OrganismiDrosophila virilis (Fruit fly)
Taxonomic identifieri7244 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000008792: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0200418. Dvir\GJ13192.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12141214Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378503Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei553 – 5531PhosphoserineBy similarity
Modified residuei555 – 5551PhosphoserineBy similarity
Modified residuei717 – 7171PhosphothreonineBy similarity
Modified residuei727 – 7271PhosphoserineBy similarity
Modified residuei729 – 7291PhosphoserineBy similarity
Modified residuei891 – 8911PhosphoserineBy similarity
Modified residuei894 – 8941PhosphothreonineBy similarity
Modified residuei897 – 8971PhosphoserineBy similarity
Modified residuei951 – 9511PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Protein-protein interaction databases

STRINGi7244.FBpp0227609.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 502311USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiB4LG38.
KOiK11855.
OMAiENEMDRG.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4LG38.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4LG38-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSLAVCET ANVVNAALRE SLGSGIGGGG GCVAAAASRS SAGSGSGSVA
60 70 80 90 100
GVDEAKIGDV SGTDNLQSQI VANAKRVLLA KIEYEEVENY HESVLAKLKS
110 120 130 140 150
KYIVIKPDNN NGAANCNYKT NGKAVGSNGH DNNTVNGGTV NGNRKQTVDS
160 170 180 190 200
GQSNQNSSAN PNELPKPKRV LYPRENIRIG WKQSERKWQV GAGMLNVGNT
210 220 230 240 250
CYLNSTLQAL FHIPALANWL VSETSHVENC NISESCGSGG CIICAMAKTL
260 270 280 290 300
QTTQSNQSAV RPFLIYTKLR QICKHMVVGR QEDAHEFLRF LVEAMEKAYL
310 320 330 340 350
MRFRNFKELD QLVKETTPIS QIFGGYLRSE VRCLSCNHVS ITFQHFQDLL
360 370 380 390 400
LDIRKADTLE EAFDGYFSRE RLEDMGYKCE GCKKKVSATK QFSLERAPIT
410 420 430 440 450
LCIQLKRFSM MGNKLTKQIS FKPRIDLSRF AARSPTAAAQ PLSYRLVSMV
460 470 480 490 500
THLGVSQHCG HYTAIGLTEA GSYYNFDDSY VKPIAMQSVC NTNAYIMFYE
510 520 530 540 550
LDVANSSSSS TINNNSSSSS NNSVAPKLNG LRLSNGAHSP AAATVAVAAT
560 570 580 590 600
ATSTSASAVS PRFIGPQLPN GYANSNGHAL GGAKTTIQFK TTPQKQLQQQ
610 620 630 640 650
QQQQNGLLMG ANKFQESSQS KHSLAGTLHK GEAAPNANTN ANANKSSCNN
660 670 680 690 700
NITSQHQQQH ILPISSDEDE DEDDSDDDDD DDDDDVKANT APQLPSMPKM
710 720 730 740 750
FEDSESVAQT AKLKPKTPLK SLVPYESASE EEQEQQQQQQ QQQLLQTPQQ
760 770 780 790 800
LAANPRKRRS GSDSSESEEE APPPLPSILR NGHAKTNGSV SNTSNSSHSK
810 820 830 840 850
AKSASNASSA NVNSSKQKTD AIDEIFKSLN NYKNKHRIAA DDDEDGDGDG
860 870 880 890 900
DGHGNEQVQT EQGTKKLNSA SSASASKSNG WQSQNGKAPS SPKTPPSPAV
910 920 930 940 950
IKSKTGIWQI TRTNDDDDEE DEEEDDVEAD ADQEDDDDEV VVVEEPQVSV
960 970 980 990 1000
TPKNPKNPFA ASKSAEANAT IAGAKRQKLL NGSAKSAATT RPGNGYQSES
1010 1020 1030 1040 1050
VANGSAVSEL LKQNHRGYGT SVLSWNGKPS ELDKESFDLV CAKRIAGHGD
1060 1070 1080 1090 1100
TDVHSDVNSS SNNSSNINSN SNSNSNGNGK RKNSTLLAEA REQRKRDAED
1110 1120 1130 1140 1150
EEENEMDRGR QRKVKSASVK SNNSTPGYNP FQEFENQKRW HSNKSGTFPR
1160 1170 1180 1190 1200
FYHQNNRPNF QQRNKFKFNR FGGGAKFQQQ RALQRHLAAG GGFTRRQQQS
1210
TGQQQQQQQQ QQQS
Length:1,214
Mass (Da):132,000
Last modified:September 23, 2008 - v1
Checksum:iBC3028B949547093
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940647 Genomic DNA. Translation: EDW69346.1.
RefSeqiXP_002047004.1. XM_002046968.1.

Genome annotation databases

EnsemblMetazoaiFBtr0229117; FBpp0227609; FBgn0200418.
GeneIDi6622549.
KEGGidvi:Dvir_GJ13192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH940647 Genomic DNA. Translation: EDW69346.1 .
RefSeqi XP_002047004.1. XM_002046968.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7244.FBpp0227609.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0229117 ; FBpp0227609 ; FBgn0200418 .
GeneIDi 6622549.
KEGGi dvi:Dvir_GJ13192.

Organism-specific databases

FlyBasei FBgn0200418. Dvir\GJ13192.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi B4LG38.
KOi K11855.
OMAi ENEMDRG.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4LG38.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15010-1051.87.

Entry informationi

Entry nameiUBP36_DROVI
AccessioniPrimary (citable) accession number: B4LG38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3