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B4LG38

- UBP36_DROVI

UniProt

B4LG38 - UBP36_DROVI

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila virilis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei201 – 2011NucleophilePROSITE-ProRule annotation
    Active sitei461 – 4611Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GJ13192
    OrganismiDrosophila virilis (Fruit fly)
    Taxonomic identifieri7244 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000008792: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0200418. Dvir\GJ13192.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12141214Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378503Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei553 – 5531PhosphoserineBy similarity
    Modified residuei555 – 5551PhosphoserineBy similarity
    Modified residuei717 – 7171PhosphothreonineBy similarity
    Modified residuei727 – 7271PhosphoserineBy similarity
    Modified residuei729 – 7291PhosphoserineBy similarity
    Modified residuei891 – 8911PhosphoserineBy similarity
    Modified residuei894 – 8941PhosphothreonineBy similarity
    Modified residuei897 – 8971PhosphoserineBy similarity
    Modified residuei951 – 9511PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Protein-protein interaction databases

    STRINGi7244.FBpp0227609.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 502311USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    InParanoidiB4LG38.
    KOiK11855.
    OMAiENEMDRG.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB4LG38.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4LG38-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSLAVCET ANVVNAALRE SLGSGIGGGG GCVAAAASRS SAGSGSGSVA     50
    GVDEAKIGDV SGTDNLQSQI VANAKRVLLA KIEYEEVENY HESVLAKLKS 100
    KYIVIKPDNN NGAANCNYKT NGKAVGSNGH DNNTVNGGTV NGNRKQTVDS 150
    GQSNQNSSAN PNELPKPKRV LYPRENIRIG WKQSERKWQV GAGMLNVGNT 200
    CYLNSTLQAL FHIPALANWL VSETSHVENC NISESCGSGG CIICAMAKTL 250
    QTTQSNQSAV RPFLIYTKLR QICKHMVVGR QEDAHEFLRF LVEAMEKAYL 300
    MRFRNFKELD QLVKETTPIS QIFGGYLRSE VRCLSCNHVS ITFQHFQDLL 350
    LDIRKADTLE EAFDGYFSRE RLEDMGYKCE GCKKKVSATK QFSLERAPIT 400
    LCIQLKRFSM MGNKLTKQIS FKPRIDLSRF AARSPTAAAQ PLSYRLVSMV 450
    THLGVSQHCG HYTAIGLTEA GSYYNFDDSY VKPIAMQSVC NTNAYIMFYE 500
    LDVANSSSSS TINNNSSSSS NNSVAPKLNG LRLSNGAHSP AAATVAVAAT 550
    ATSTSASAVS PRFIGPQLPN GYANSNGHAL GGAKTTIQFK TTPQKQLQQQ 600
    QQQQNGLLMG ANKFQESSQS KHSLAGTLHK GEAAPNANTN ANANKSSCNN 650
    NITSQHQQQH ILPISSDEDE DEDDSDDDDD DDDDDVKANT APQLPSMPKM 700
    FEDSESVAQT AKLKPKTPLK SLVPYESASE EEQEQQQQQQ QQQLLQTPQQ 750
    LAANPRKRRS GSDSSESEEE APPPLPSILR NGHAKTNGSV SNTSNSSHSK 800
    AKSASNASSA NVNSSKQKTD AIDEIFKSLN NYKNKHRIAA DDDEDGDGDG 850
    DGHGNEQVQT EQGTKKLNSA SSASASKSNG WQSQNGKAPS SPKTPPSPAV 900
    IKSKTGIWQI TRTNDDDDEE DEEEDDVEAD ADQEDDDDEV VVVEEPQVSV 950
    TPKNPKNPFA ASKSAEANAT IAGAKRQKLL NGSAKSAATT RPGNGYQSES 1000
    VANGSAVSEL LKQNHRGYGT SVLSWNGKPS ELDKESFDLV CAKRIAGHGD 1050
    TDVHSDVNSS SNNSSNINSN SNSNSNGNGK RKNSTLLAEA REQRKRDAED 1100
    EEENEMDRGR QRKVKSASVK SNNSTPGYNP FQEFENQKRW HSNKSGTFPR 1150
    FYHQNNRPNF QQRNKFKFNR FGGGAKFQQQ RALQRHLAAG GGFTRRQQQS 1200
    TGQQQQQQQQ QQQS 1214
    Length:1,214
    Mass (Da):132,000
    Last modified:September 23, 2008 - v1
    Checksum:iBC3028B949547093
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940647 Genomic DNA. Translation: EDW69346.1.
    RefSeqiXP_002047004.1. XM_002046968.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0229117; FBpp0227609; FBgn0200418.
    GeneIDi6622549.
    KEGGidvi:Dvir_GJ13192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH940647 Genomic DNA. Translation: EDW69346.1 .
    RefSeqi XP_002047004.1. XM_002046968.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7244.FBpp0227609.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0229117 ; FBpp0227609 ; FBgn0200418 .
    GeneIDi 6622549.
    KEGGi dvi:Dvir_GJ13192.

    Organism-specific databases

    FlyBasei FBgn0200418. Dvir\GJ13192.

    Phylogenomic databases

    eggNOGi COG5533.
    InParanoidi B4LG38.
    KOi K11855.
    OMAi ENEMDRG.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B4LG38.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15010-1051.87.

    Entry informationi

    Entry nameiUBP36_DROVI
    AccessioniPrimary (citable) accession number: B4LG38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3