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B4L7V4 (UBE2S_DROMO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin-conjugating enzyme E2 S

EC=6.3.2.19
Alternative name(s):
Ubiquitin carrier protein S
Ubiquitin-protein ligase S
Gene names
ORF Names:GI11085
OrganismDrosophila mojavensis (Fruit fly) [Complete proteome]
Taxonomic identifier7230 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit By similarity.

Catalytic activity

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 206206Ubiquitin-conjugating enzyme E2 S
PRO_0000390441

Sites

Active site981Glycyl thioester intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
B4L7V4 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 9D53212068B8939F

FASTA20623,213
        10         20         30         40         50         60 
MSSQYSNVEN LSPQTIRQVM KELQDMETTP PEGIKVLINE SDVTDIQALI DGPAGTPYAV 

        70         80         90        100        110        120 
GIFRVKLTLS KDFPQTPPKA YFLTKIFHPN VAANGEICVN TLKKDWKPDL GIKHILLTIK 

       130        140        150        160        170        180 
CLLIVPNPES ALNEEAGKML LERYDDYSQR ARMMTEIHAQ PVKCGVSDAK DDDGPSNKKH 

       190        200 
AGLDKKLQDK KKEKLLKEKK RMLKRL 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH933814 Genomic DNA. Translation: EDW05529.1.
RefSeqXP_002011539.1. XM_002011503.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0161810; FBpp0160302; FBgn0133847.
GeneID6585915.
KEGGdmo:Dmoj_GI11085.

Organism-specific databases

FlyBaseFBgn0133847. Dmoj\GI11085.

Phylogenomic databases

InParanoidB4L7V4.
KOK10583.
OrthoDBEOG73JKXD.

Enzyme and pathway databases

UniPathwayUPA00143.

Family and domain databases

Gene3D3.10.110.10. 1 hit.
InterProIPR000608. UBQ-conjugat_E2.
IPR023313. UBQ-conjugating_AS.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMSSF54495. SSF54495. 1 hit.
PROSITEPS00183. UBIQUITIN_CONJUGAT_1. 1 hit.
PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBE2S_DROMO
AccessionPrimary (citable) accession number: B4L7V4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase