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B4L6S9

- PGAM5_DROMO

UniProt

B4L6S9 - PGAM5_DROMO

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Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity (By similarity).By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homologBy similarity
Gene namesi
Name:Pgam5By similarity
ORF Names:GI16420
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0139168. Dmoj\GI16420.

Subcellular locationi

Mitochondrion outer membrane By similarity

GO - Cellular componenti

  1. mitochondrial outer membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390706Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4L6S9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiB4L6S9.
KOiK15637.
OrthoDBiEOG7966H1.
PhylomeDBiB4L6S9.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

B4L6S9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRKFAAFACG TGAGFAAYYF QKLRDPLQVV HNSWTNSERH ISECALWDSN
60 70 80 90 100
WDYRDPKSLA RPMKNDKPQE QNRYNADLEK NVSKYARHII LIRHGEYLDV
110 120 130 140 150
GETDETHHLT DRGRLQAKYT GKRLHELGIK WDKVIASNMV RAQETAEIIL
160 170 180 190 200
NEIDFDKTKV KSCSYLREGA PIPPQPPVGH WKPEASQFFR DGARIEAAFR
210 220 230 240 250
RYFHRALPDQ EKDSYTLIVG HGNVIRYFVC RALQFPAEGW LRININHASI
260 270 280
TWLTISPSGN VSIKYLGDTG FIPAKHLTNR IPREAKNVV
Length:289
Mass (Da):33,293
Last modified:September 23, 2008 - v1
Checksum:i8258DE2CBA9AA030
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933812 Genomic DNA. Translation: EDW06075.1.
RefSeqiXP_002011233.1. XM_002011197.1.

Genome annotation databases

EnsemblMetazoaiFBtr0167145; FBpp0165637; FBgn0139168.
GeneIDi6585605.
KEGGidmo:Dmoj_GI16420.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933812 Genomic DNA. Translation: EDW06075.1 .
RefSeqi XP_002011233.1. XM_002011197.1.

3D structure databases

ProteinModelPortali B4L6S9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0167145 ; FBpp0165637 ; FBgn0139168 .
GeneIDi 6585605.
KEGGi dmo:Dmoj_GI16420.

Organism-specific databases

FlyBasei FBgn0139168. Dmoj\GI16420.

Phylogenomic databases

InParanoidi B4L6S9.
KOi K15637.
OrthoDBi EOG7966H1.
PhylomeDBi B4L6S9.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22Imported.

Entry informationi

Entry nameiPGAM5_DROMO
AccessioniPrimary (citable) accession number: B4L6S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3