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B4L6S9 (PGAM5_DROMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene names
Name:Pgam5
ORF Names:GI16420
OrganismDrosophila mojavensis (Fruit fly) [Complete proteome]
Taxonomic identifier7230 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity. UniProtKB O46084

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with Pk92B/ASK1 By similarity. UniProtKB O46084

Subcellular location

Mitochondrion outer membrane By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
   Cellular componentMembrane
Mitochondrion
Mitochondrion outer membrane
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein dephosphorylation

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentmitochondrial outer membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphoprotein phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000390706

Sequences

Sequence LengthMass (Da)Tools
B4L6S9 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 8258DE2CBA9AA030

FASTA28933,293
        10         20         30         40         50         60 
MRKFAAFACG TGAGFAAYYF QKLRDPLQVV HNSWTNSERH ISECALWDSN WDYRDPKSLA 

        70         80         90        100        110        120 
RPMKNDKPQE QNRYNADLEK NVSKYARHII LIRHGEYLDV GETDETHHLT DRGRLQAKYT 

       130        140        150        160        170        180 
GKRLHELGIK WDKVIASNMV RAQETAEIIL NEIDFDKTKV KSCSYLREGA PIPPQPPVGH 

       190        200        210        220        230        240 
WKPEASQFFR DGARIEAAFR RYFHRALPDQ EKDSYTLIVG HGNVIRYFVC RALQFPAEGW 

       250        260        270        280 
LRININHASI TWLTISPSGN VSIKYLGDTG FIPAKHLTNR IPREAKNVV 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH933812 Genomic DNA. Translation: EDW06075.1.
RefSeqXP_002011233.1. XM_002011197.1.

3D structure databases

ProteinModelPortalB4L6S9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0167145; FBpp0165637; FBgn0139168.
GeneID6585605.
KEGGdmo:Dmoj_GI16420.

Organism-specific databases

FlyBaseFBgn0139168. Dmoj\GI16420.

Phylogenomic databases

InParanoidB4L6S9.
KOK15637.
OrthoDBEOG7966H1.
PhylomeDBB4L6S9.

Family and domain databases

Gene3D3.40.50.1240. 1 hit.
InterProIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMSSF53254. SSF53254. 1 hit.
ProtoNetSearch...

Entry information

Entry namePGAM5_DROMO
AccessionPrimary (citable) accession number: B4L6S9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase