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B4L6S9

- PGAM5_DROMO

UniProt

B4L6S9 - PGAM5_DROMO

Protein

Serine/threonine-protein phosphatase Pgam5, mitochondrial

Gene

Pgam5

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein phosphatase Pgam5, mitochondrialBy similarity (EC:3.1.3.16)
    Alternative name(s):
    Phosphoglycerate mutase family member 5 homologBy similarity
    Gene namesi
    Name:Pgam5By similarity
    ORF Names:GI16420
    OrganismiDrosophila mojavensis (Fruit fly)
    Taxonomic identifieri7230 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000009192: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0139168. Dmoj\GI16420.

    Subcellular locationi

    Mitochondrion outer membrane By similarity

    GO - Cellular componenti

    1. mitochondrial outer membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion outer membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrialPRO_0000390706Add
    BLAST

    Interactioni

    Subunit structurei

    Interacts with Pk92B/ASK1.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB4L6S9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    InParanoidiB4L6S9.
    KOiK15637.
    OrthoDBiEOG7966H1.
    PhylomeDBiB4L6S9.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view]
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B4L6S9-1 [UniParc]FASTAAdd to Basket

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    MRKFAAFACG TGAGFAAYYF QKLRDPLQVV HNSWTNSERH ISECALWDSN    50
    WDYRDPKSLA RPMKNDKPQE QNRYNADLEK NVSKYARHII LIRHGEYLDV 100
    GETDETHHLT DRGRLQAKYT GKRLHELGIK WDKVIASNMV RAQETAEIIL 150
    NEIDFDKTKV KSCSYLREGA PIPPQPPVGH WKPEASQFFR DGARIEAAFR 200
    RYFHRALPDQ EKDSYTLIVG HGNVIRYFVC RALQFPAEGW LRININHASI 250
    TWLTISPSGN VSIKYLGDTG FIPAKHLTNR IPREAKNVV 289
    Length:289
    Mass (Da):33,293
    Last modified:September 23, 2008 - v1
    Checksum:i8258DE2CBA9AA030
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933812 Genomic DNA. Translation: EDW06075.1.
    RefSeqiXP_002011233.1. XM_002011197.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0167145; FBpp0165637; FBgn0139168.
    GeneIDi6585605.
    KEGGidmo:Dmoj_GI16420.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933812 Genomic DNA. Translation: EDW06075.1 .
    RefSeqi XP_002011233.1. XM_002011197.1.

    3D structure databases

    ProteinModelPortali B4L6S9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0167145 ; FBpp0165637 ; FBgn0139168 .
    GeneIDi 6585605.
    KEGGi dmo:Dmoj_GI16420.

    Organism-specific databases

    FlyBasei FBgn0139168. Dmoj\GI16420.

    Phylogenomic databases

    InParanoidi B4L6S9.
    KOi K15637.
    OrthoDBi EOG7966H1.
    PhylomeDBi B4L6S9.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    [Graphical view ]
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15081-1352.22Imported.

    Entry informationi

    Entry nameiPGAM5_DROMO
    AccessioniPrimary (citable) accession number: B4L6S9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3