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B4L535

- SWS_DROMO

UniProt

B4L535 - SWS_DROMO

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei962 – 9621By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi175 – 302128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi458 – 587130cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi576 – 703128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GI21654
    OrganismiDrosophila mojavensis (Fruit fly)
    Taxonomic identifieri7230 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000009192: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0144384. Dmoj\GI21654.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14881488Neuropathy target esterase swsPRO_0000389223Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1176 – 11761PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB4L535.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14881433CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini929 – 1095167PatatinSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    InParanoidiB4L535.
    KOiK14676.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB4L535.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4L535-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLELLRAS VNGCYNTLFS DAWSQYVSKQ IATTTYWYGA LLAIGALFIA     50
    WFLYFKRLAS LRLRDESART LSALTAASGG DHRGLRFRKR DKMLFYGRRM 100
    LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLQRENRPL EMKTVEPPAE 150
    YLEETIDGSD RVPPDALYML QSIRIFGHFE KPIFLKLCKH TQLLQLMAGD 200
    YLFKITDPDD SVYIVQSGMI NVYICNADGS TLSLKTVRKG ESVTSLLSFI 250
    DVLSGNSSYY KTVTAKAMEK SVVIRLPMQA FEEVFNENPD VMIRVIQVIM 300
    IRLQRVLFTA LRNYLGLNAE LVQNHMRIKG SNPVPVTVPG PVLSQASQAS 350
    RAMASRPATS PVTRMSREEH TLSDPDPNPN ASAMLFAEVH GDAPYIDLYH 400
    HQQQQSSGVS VGGTHRSSGA CTPTGSGGES PDGTGNATIT NIDQRLVQSS 450
    AVDSLRRELG LSEEDTSIIE PFVEVRELEP NVTLITEGNA EDVCIWFVMT 500
    GTLAVYQSNA DATRAAKQDS KNDMLIHFVH PGEIVGGLAM LTGEASAYTI 550
    RARSNSRIAY IRRAAIYQIM RQRPRIVLDL GNGVVRRLSP LVRQCDYALD 600
    WIFLESGRAV YRQDESSDST YIVLSGRMRS VITHPGGKKE IVGEYGKGDL 650
    VGIVEMITET SRTTTVLAVR DSELAKLPEG LFNAIKLRYP IVVTRLISFL 700
    SHRFLGSMQT RGANASSAPV EANPVTHKYS TVALVPITDD VPITPFTYEL 750
    YHSLCAIGPV LRLTSEVVRK QLGNNIFEAA NEYRLTSWLA QQEDRNIITL 800
    YQCDSALSPW TQRCMRQADV VLIVGLGERS HMVGKFEREI DKLAMRTQKE 850
    LVLLYPETTN ARPANTLSWL NARPWVTKHH HVLCVKRIFT RKSQYRINDL 900
    YSRVLLSEPN MHSDFSRLAR WLTGNSIGLV LGGGGARGAA HIGMLKAIQE 950
    AGIPIDMVGG VSIGALMGAL WCSERNITTV TQKAREWSKK MTKWFLQLLD 1000
    LTYPITSMFS GREFNKTIHD TFGDVSIEDL WIPYFTLTTD ITASCHRIHT 1050
    NGSLWRYVRS SMSLSGYMPP LCDPQDGHLL LDGGYVNNLP GHLWRYCRAS 1100
    MSIAGVFPPF CDYRDGHLLL DGCYTNNVPA DVMHNLGAAH IIAIDVGSQD 1150
    DTDLTNYGDD LSGWWLLYKK WNPFTSPVKV PDLPDIQSRL AYVSCVRQLE 1200
    EVKNSDYCEY IRPPIDKYKT LAFGSFDEIR DVGYVFGKNY FDNMAKAGRL 1250
    GRFNQWFNKE PPKRGNHASL NEYTFIDLAQ IVCKLPETYA LNAVDIFSED 1300
    EDFDGYISEP TTLNMDRHRI QVPRAGNSLS FSETELDSDV EIDLELERKV 1350
    DKSTQSTPPT PNKKHPSTPT SSQGNLMHLP LSMKAKDKMQ ILDKLEREHK 1400
    RRQKSKHKRD RSMQRDSKAT LHPAPMAEAT TQTPSSDVDI DAKLDQLRKL 1450
    QQELEQGNES EQEQEQEQEQ EQGHIQEPEN VTEADTKN 1488
    Length:1,488
    Mass (Da):167,474
    Last modified:September 23, 2008 - v1
    Checksum:i9118C9BA05DC5A56
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933811 Genomic DNA. Translation: EDW06294.1.
    RefSeqiXP_002010639.1. XM_002010603.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0172379; FBpp0170871; FBgn0144384.
    GeneIDi6584999.
    KEGGidmo:Dmoj_GI21654.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933811 Genomic DNA. Translation: EDW06294.1 .
    RefSeqi XP_002010639.1. XM_002010603.1.

    3D structure databases

    ProteinModelPortali B4L535.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0172379 ; FBpp0170871 ; FBgn0144384 .
    GeneIDi 6584999.
    KEGGi dmo:Dmoj_GI21654.

    Organism-specific databases

    FlyBasei FBgn0144384. Dmoj\GI21654.

    Phylogenomic databases

    InParanoidi B4L535.
    KOi K14676.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B4L535.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15081-1352.22Imported.

    Entry informationi

    Entry nameiSWS_DROMO
    AccessioniPrimary (citable) accession number: B4L535
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3