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B4L535 (SWS_DROMO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese
EC=3.1.1.5
Gene names
Name:sws
ORF Names:GI21654
OrganismDrosophila mojavensis (Fruit fly) [Complete proteome]
Taxonomic identifier7230 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length1488 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity. UniProtKB Q9U969

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. UniProtKB Q9U969

Subunit structure

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity. UniProtKB Q9U969

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Sws tethers Pka-C3 to the membrane By similarity. UniProtKB Q9U969

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14881488Neuropathy target esterase sws
PRO_0000389223

Regions

Topological domain1 – 3434Lumenal Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 14881433Cytoplasmic Potential
Domain929 – 1095167Patatin
Nucleotide binding175 – 302128cNMP 1
Nucleotide binding458 – 587130cNMP 2
Nucleotide binding576 – 703128cNMP 3

Sites

Active site9621 By similarity UniProtKB Q9U969

Amino acid modifications

Modified residue11761Phosphoserine By similarity UniProtKB Q9U969

Sequences

Sequence LengthMass (Da)Tools
B4L535 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 9118C9BA05DC5A56

FASTA1,488167,474
        10         20         30         40         50         60 
MDVLELLRAS VNGCYNTLFS DAWSQYVSKQ IATTTYWYGA LLAIGALFIA WFLYFKRLAS 

        70         80         90        100        110        120 
LRLRDESART LSALTAASGG DHRGLRFRKR DKMLFYGRRM LRKMKNVSGQ MYSSGKGYKR 

       130        140        150        160        170        180 
RAVMRFARRI LQLQRENRPL EMKTVEPPAE YLEETIDGSD RVPPDALYML QSIRIFGHFE 

       190        200        210        220        230        240 
KPIFLKLCKH TQLLQLMAGD YLFKITDPDD SVYIVQSGMI NVYICNADGS TLSLKTVRKG 

       250        260        270        280        290        300 
ESVTSLLSFI DVLSGNSSYY KTVTAKAMEK SVVIRLPMQA FEEVFNENPD VMIRVIQVIM 

       310        320        330        340        350        360 
IRLQRVLFTA LRNYLGLNAE LVQNHMRIKG SNPVPVTVPG PVLSQASQAS RAMASRPATS 

       370        380        390        400        410        420 
PVTRMSREEH TLSDPDPNPN ASAMLFAEVH GDAPYIDLYH HQQQQSSGVS VGGTHRSSGA 

       430        440        450        460        470        480 
CTPTGSGGES PDGTGNATIT NIDQRLVQSS AVDSLRRELG LSEEDTSIIE PFVEVRELEP 

       490        500        510        520        530        540 
NVTLITEGNA EDVCIWFVMT GTLAVYQSNA DATRAAKQDS KNDMLIHFVH PGEIVGGLAM 

       550        560        570        580        590        600 
LTGEASAYTI RARSNSRIAY IRRAAIYQIM RQRPRIVLDL GNGVVRRLSP LVRQCDYALD 

       610        620        630        640        650        660 
WIFLESGRAV YRQDESSDST YIVLSGRMRS VITHPGGKKE IVGEYGKGDL VGIVEMITET 

       670        680        690        700        710        720 
SRTTTVLAVR DSELAKLPEG LFNAIKLRYP IVVTRLISFL SHRFLGSMQT RGANASSAPV 

       730        740        750        760        770        780 
EANPVTHKYS TVALVPITDD VPITPFTYEL YHSLCAIGPV LRLTSEVVRK QLGNNIFEAA 

       790        800        810        820        830        840 
NEYRLTSWLA QQEDRNIITL YQCDSALSPW TQRCMRQADV VLIVGLGERS HMVGKFEREI 

       850        860        870        880        890        900 
DKLAMRTQKE LVLLYPETTN ARPANTLSWL NARPWVTKHH HVLCVKRIFT RKSQYRINDL 

       910        920        930        940        950        960 
YSRVLLSEPN MHSDFSRLAR WLTGNSIGLV LGGGGARGAA HIGMLKAIQE AGIPIDMVGG 

       970        980        990       1000       1010       1020 
VSIGALMGAL WCSERNITTV TQKAREWSKK MTKWFLQLLD LTYPITSMFS GREFNKTIHD 

      1030       1040       1050       1060       1070       1080 
TFGDVSIEDL WIPYFTLTTD ITASCHRIHT NGSLWRYVRS SMSLSGYMPP LCDPQDGHLL 

      1090       1100       1110       1120       1130       1140 
LDGGYVNNLP GHLWRYCRAS MSIAGVFPPF CDYRDGHLLL DGCYTNNVPA DVMHNLGAAH 

      1150       1160       1170       1180       1190       1200 
IIAIDVGSQD DTDLTNYGDD LSGWWLLYKK WNPFTSPVKV PDLPDIQSRL AYVSCVRQLE 

      1210       1220       1230       1240       1250       1260 
EVKNSDYCEY IRPPIDKYKT LAFGSFDEIR DVGYVFGKNY FDNMAKAGRL GRFNQWFNKE 

      1270       1280       1290       1300       1310       1320 
PPKRGNHASL NEYTFIDLAQ IVCKLPETYA LNAVDIFSED EDFDGYISEP TTLNMDRHRI 

      1330       1340       1350       1360       1370       1380 
QVPRAGNSLS FSETELDSDV EIDLELERKV DKSTQSTPPT PNKKHPSTPT SSQGNLMHLP 

      1390       1400       1410       1420       1430       1440 
LSMKAKDKMQ ILDKLEREHK RRQKSKHKRD RSMQRDSKAT LHPAPMAEAT TQTPSSDVDI 

      1450       1460       1470       1480 
DAKLDQLRKL QQELEQGNES EQEQEQEQEQ EQGHIQEPEN VTEADTKN 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH933811 Genomic DNA. Translation: EDW06294.1.
RefSeqXP_002010639.1. XM_002010603.1.

3D structure databases

ProteinModelPortalB4L535.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0172379; FBpp0170871; FBgn0144384.
GeneID6584999.
KEGGdmo:Dmoj_GI21654.

Organism-specific databases

FlyBaseFBgn0144384. Dmoj\GI21654.

Phylogenomic databases

InParanoidB4L535.
KOK14676.
OrthoDBEOG7QRQT1.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSWS_DROMO
AccessionPrimary (citable) accession number: B4L535
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase