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B4L535

- SWS_DROMO

UniProt

B4L535 - SWS_DROMO

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Protein
Neuropathy target esterase sws
Gene
sws, GI21654
Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei962 – 9621 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 302128cNMP 1
Add
BLAST
Nucleotide bindingi458 – 587130cNMP 2
Add
BLAST
Nucleotide bindingi576 – 703128cNMP 3
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GI21654
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0144384. Dmoj\GI21654.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Topological domaini56 – 14881433Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14881488Neuropathy target esterase sws
PRO_0000389223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1176 – 11761Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4L535.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini929 – 1095167Patatin
Add
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB4L535.
KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4L535.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4L535-1 [UniParc]FASTAAdd to Basket

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MDVLELLRAS VNGCYNTLFS DAWSQYVSKQ IATTTYWYGA LLAIGALFIA     50
WFLYFKRLAS LRLRDESART LSALTAASGG DHRGLRFRKR DKMLFYGRRM 100
LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLQRENRPL EMKTVEPPAE 150
YLEETIDGSD RVPPDALYML QSIRIFGHFE KPIFLKLCKH TQLLQLMAGD 200
YLFKITDPDD SVYIVQSGMI NVYICNADGS TLSLKTVRKG ESVTSLLSFI 250
DVLSGNSSYY KTVTAKAMEK SVVIRLPMQA FEEVFNENPD VMIRVIQVIM 300
IRLQRVLFTA LRNYLGLNAE LVQNHMRIKG SNPVPVTVPG PVLSQASQAS 350
RAMASRPATS PVTRMSREEH TLSDPDPNPN ASAMLFAEVH GDAPYIDLYH 400
HQQQQSSGVS VGGTHRSSGA CTPTGSGGES PDGTGNATIT NIDQRLVQSS 450
AVDSLRRELG LSEEDTSIIE PFVEVRELEP NVTLITEGNA EDVCIWFVMT 500
GTLAVYQSNA DATRAAKQDS KNDMLIHFVH PGEIVGGLAM LTGEASAYTI 550
RARSNSRIAY IRRAAIYQIM RQRPRIVLDL GNGVVRRLSP LVRQCDYALD 600
WIFLESGRAV YRQDESSDST YIVLSGRMRS VITHPGGKKE IVGEYGKGDL 650
VGIVEMITET SRTTTVLAVR DSELAKLPEG LFNAIKLRYP IVVTRLISFL 700
SHRFLGSMQT RGANASSAPV EANPVTHKYS TVALVPITDD VPITPFTYEL 750
YHSLCAIGPV LRLTSEVVRK QLGNNIFEAA NEYRLTSWLA QQEDRNIITL 800
YQCDSALSPW TQRCMRQADV VLIVGLGERS HMVGKFEREI DKLAMRTQKE 850
LVLLYPETTN ARPANTLSWL NARPWVTKHH HVLCVKRIFT RKSQYRINDL 900
YSRVLLSEPN MHSDFSRLAR WLTGNSIGLV LGGGGARGAA HIGMLKAIQE 950
AGIPIDMVGG VSIGALMGAL WCSERNITTV TQKAREWSKK MTKWFLQLLD 1000
LTYPITSMFS GREFNKTIHD TFGDVSIEDL WIPYFTLTTD ITASCHRIHT 1050
NGSLWRYVRS SMSLSGYMPP LCDPQDGHLL LDGGYVNNLP GHLWRYCRAS 1100
MSIAGVFPPF CDYRDGHLLL DGCYTNNVPA DVMHNLGAAH IIAIDVGSQD 1150
DTDLTNYGDD LSGWWLLYKK WNPFTSPVKV PDLPDIQSRL AYVSCVRQLE 1200
EVKNSDYCEY IRPPIDKYKT LAFGSFDEIR DVGYVFGKNY FDNMAKAGRL 1250
GRFNQWFNKE PPKRGNHASL NEYTFIDLAQ IVCKLPETYA LNAVDIFSED 1300
EDFDGYISEP TTLNMDRHRI QVPRAGNSLS FSETELDSDV EIDLELERKV 1350
DKSTQSTPPT PNKKHPSTPT SSQGNLMHLP LSMKAKDKMQ ILDKLEREHK 1400
RRQKSKHKRD RSMQRDSKAT LHPAPMAEAT TQTPSSDVDI DAKLDQLRKL 1450
QQELEQGNES EQEQEQEQEQ EQGHIQEPEN VTEADTKN 1488
Length:1,488
Mass (Da):167,474
Last modified:September 23, 2008 - v1
Checksum:i9118C9BA05DC5A56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933811 Genomic DNA. Translation: EDW06294.1.
RefSeqiXP_002010639.1. XM_002010603.1.

Genome annotation databases

EnsemblMetazoaiFBtr0172379; FBpp0170871; FBgn0144384.
GeneIDi6584999.
KEGGidmo:Dmoj_GI21654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933811 Genomic DNA. Translation: EDW06294.1 .
RefSeqi XP_002010639.1. XM_002010603.1.

3D structure databases

ProteinModelPortali B4L535.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0172379 ; FBpp0170871 ; FBgn0144384 .
GeneIDi 6584999.
KEGGi dmo:Dmoj_GI21654.

Organism-specific databases

FlyBasei FBgn0144384. Dmoj\GI21654.

Phylogenomic databases

InParanoidi B4L535.
KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4L535.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22.

Entry informationi

Entry nameiSWS_DROMO
AccessioniPrimary (citable) accession number: B4L535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3
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