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B4L535

- SWS_DROMO

UniProt

B4L535 - SWS_DROMO

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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei962 – 9621By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi175 – 302128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi458 – 587130cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi576 – 703128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GI21654
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0144384. Dmoj\GI21654.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14881488Neuropathy target esterase swsPRO_0000389223Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1176 – 11761PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4L535.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence AnalysisAdd
BLAST
Topological domaini56 – 14881433CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini929 – 1095167PatatinSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB4L535.
KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4L535.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4L535 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLELLRAS VNGCYNTLFS DAWSQYVSKQ IATTTYWYGA LLAIGALFIA
60 70 80 90 100
WFLYFKRLAS LRLRDESART LSALTAASGG DHRGLRFRKR DKMLFYGRRM
110 120 130 140 150
LRKMKNVSGQ MYSSGKGYKR RAVMRFARRI LQLQRENRPL EMKTVEPPAE
160 170 180 190 200
YLEETIDGSD RVPPDALYML QSIRIFGHFE KPIFLKLCKH TQLLQLMAGD
210 220 230 240 250
YLFKITDPDD SVYIVQSGMI NVYICNADGS TLSLKTVRKG ESVTSLLSFI
260 270 280 290 300
DVLSGNSSYY KTVTAKAMEK SVVIRLPMQA FEEVFNENPD VMIRVIQVIM
310 320 330 340 350
IRLQRVLFTA LRNYLGLNAE LVQNHMRIKG SNPVPVTVPG PVLSQASQAS
360 370 380 390 400
RAMASRPATS PVTRMSREEH TLSDPDPNPN ASAMLFAEVH GDAPYIDLYH
410 420 430 440 450
HQQQQSSGVS VGGTHRSSGA CTPTGSGGES PDGTGNATIT NIDQRLVQSS
460 470 480 490 500
AVDSLRRELG LSEEDTSIIE PFVEVRELEP NVTLITEGNA EDVCIWFVMT
510 520 530 540 550
GTLAVYQSNA DATRAAKQDS KNDMLIHFVH PGEIVGGLAM LTGEASAYTI
560 570 580 590 600
RARSNSRIAY IRRAAIYQIM RQRPRIVLDL GNGVVRRLSP LVRQCDYALD
610 620 630 640 650
WIFLESGRAV YRQDESSDST YIVLSGRMRS VITHPGGKKE IVGEYGKGDL
660 670 680 690 700
VGIVEMITET SRTTTVLAVR DSELAKLPEG LFNAIKLRYP IVVTRLISFL
710 720 730 740 750
SHRFLGSMQT RGANASSAPV EANPVTHKYS TVALVPITDD VPITPFTYEL
760 770 780 790 800
YHSLCAIGPV LRLTSEVVRK QLGNNIFEAA NEYRLTSWLA QQEDRNIITL
810 820 830 840 850
YQCDSALSPW TQRCMRQADV VLIVGLGERS HMVGKFEREI DKLAMRTQKE
860 870 880 890 900
LVLLYPETTN ARPANTLSWL NARPWVTKHH HVLCVKRIFT RKSQYRINDL
910 920 930 940 950
YSRVLLSEPN MHSDFSRLAR WLTGNSIGLV LGGGGARGAA HIGMLKAIQE
960 970 980 990 1000
AGIPIDMVGG VSIGALMGAL WCSERNITTV TQKAREWSKK MTKWFLQLLD
1010 1020 1030 1040 1050
LTYPITSMFS GREFNKTIHD TFGDVSIEDL WIPYFTLTTD ITASCHRIHT
1060 1070 1080 1090 1100
NGSLWRYVRS SMSLSGYMPP LCDPQDGHLL LDGGYVNNLP GHLWRYCRAS
1110 1120 1130 1140 1150
MSIAGVFPPF CDYRDGHLLL DGCYTNNVPA DVMHNLGAAH IIAIDVGSQD
1160 1170 1180 1190 1200
DTDLTNYGDD LSGWWLLYKK WNPFTSPVKV PDLPDIQSRL AYVSCVRQLE
1210 1220 1230 1240 1250
EVKNSDYCEY IRPPIDKYKT LAFGSFDEIR DVGYVFGKNY FDNMAKAGRL
1260 1270 1280 1290 1300
GRFNQWFNKE PPKRGNHASL NEYTFIDLAQ IVCKLPETYA LNAVDIFSED
1310 1320 1330 1340 1350
EDFDGYISEP TTLNMDRHRI QVPRAGNSLS FSETELDSDV EIDLELERKV
1360 1370 1380 1390 1400
DKSTQSTPPT PNKKHPSTPT SSQGNLMHLP LSMKAKDKMQ ILDKLEREHK
1410 1420 1430 1440 1450
RRQKSKHKRD RSMQRDSKAT LHPAPMAEAT TQTPSSDVDI DAKLDQLRKL
1460 1470 1480
QQELEQGNES EQEQEQEQEQ EQGHIQEPEN VTEADTKN
Length:1,488
Mass (Da):167,474
Last modified:September 23, 2008 - v1
Checksum:i9118C9BA05DC5A56
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933811 Genomic DNA. Translation: EDW06294.1.
RefSeqiXP_002010639.1. XM_002010603.1.

Genome annotation databases

EnsemblMetazoaiFBtr0172379; FBpp0170871; FBgn0144384.
GeneIDi6584999.
KEGGidmo:Dmoj_GI21654.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933811 Genomic DNA. Translation: EDW06294.1 .
RefSeqi XP_002010639.1. XM_002010603.1.

3D structure databases

ProteinModelPortali B4L535.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0172379 ; FBpp0170871 ; FBgn0144384 .
GeneIDi 6584999.
KEGGi dmo:Dmoj_GI21654.

Organism-specific databases

FlyBasei FBgn0144384. Dmoj\GI21654.

Phylogenomic databases

InParanoidi B4L535.
KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4L535.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22Imported.

Entry informationi

Entry nameiSWS_DROMO
AccessioniPrimary (citable) accession number: B4L535
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3