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B4KXJ5

- UBP36_DROMO

UniProt

B4KXJ5 - UBP36_DROMO

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei208 – 2081NucleophilePROSITE-ProRule annotation
Active sitei468 – 4681Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GI13361
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0136118. Dmoj\GI13361.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11851185Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei552 – 5521PhosphoserineBy similarity
Modified residuei554 – 5541PhosphoserineBy similarity
Modified residuei716 – 7161PhosphothreonineBy similarity
Modified residuei726 – 7261PhosphoserineBy similarity
Modified residuei728 – 7281PhosphoserineBy similarity
Modified residuei867 – 8671PhosphoserineBy similarity
Modified residuei870 – 8701PhosphothreonineBy similarity
Modified residuei873 – 8731PhosphoserineBy similarity
Modified residuei925 – 9251PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 509311USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

InParanoidiB4KXJ5.
KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4KXJ5.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4KXJ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSLAVCET ANVVNAALRE SLGGGGGSGC VAAAAASGRS GSGSSSTAAA
60 70 80 90 100
AASADEAKIG DPSATDNLQS QIVANAKRVL LAKIEYEEVE NYHESVLAKL
110 120 130 140 150
KSKYIVIKPD NSGAANCSYK TNGASTGKAL SSNGHDNTNG VNGSSAATVN
160 170 180 190 200
GNRKQTVEQS NQNSTTNPNE LPKPKRVLYP RENIRIGWKQ SDRKWQVGAG
210 220 230 240 250
MLNVGNTCYL NSTLQALFHI PALANWLVSE TAHVENCNIS ESCGSGGCII
260 270 280 290 300
CAMAKTLQTT QSNQTAVRPF LIYTKLRQIC KHMVVGRQED AHEFLRFLVE
310 320 330 340 350
AMEKAYLMRF RNYKELDQLV KETTPLSQIF GGYLRSEVRC LSCNHVSITF
360 370 380 390 400
QHFQDLLLDI RKADTLEEAF DGYFSRERLE DMGYKCEGCK KKVSATKQFS
410 420 430 440 450
LERAPITLCI QLKRFSMMGN KLTKQISFKP RIDLSRFAAR SPAASTQPLS
460 470 480 490 500
YRLVSMVTHL GVSQHCGHYT AIGLTESGSY YNFDDSYVRP IAMQSVCNTN
510 520 530 540 550
AYIMFYELDV ASSSINSSSS CSTSVPKLNG LRLNGQHSPS VATTAVAATA
560 570 580 590 600
TSTSASAVSP RFIGPQLPNG YANNNGHVLG AAKTSIQFKS SPQKQPQQQQ
610 620 630 640 650
HNGLLMGANK FQESAQSKHS LVGSLHKGET AANASANAIS NANSNKSSCN
660 670 680 690 700
NNTLTTNSQH QQQHILPISS DEEDEDEDSD DDVDVKANTA PQLPSMPKMF
710 720 730 740 750
EDAESVAQTA KLKPKTPLKS LVPYESASEE EQEQQQQQQQ LLVSPQLQPA
760 770 780 790 800
NPRKRRSGAD SSESEDEPPS IMRNGHAKSN GSGNESSTST SIKSNNNKQK
810 820 830 840 850
TDAIDEIFKS LNNYKNKHRA TAAGTTTADA DEDEQQQQQV TKKPSNSSSS
860 870 880 890 900
LISKNGWQSQ NGKAPASPKT PPSPAVIKSK TGIWQITRTD DDNDDDDEDA
910 920 930 940 950
DEEDDADADA EQEEYDDEVV VVETTPSITT KNLNNPFASK PSSADAMPGA
960 970 980 990 1000
KRQKLLNGSA KSAQTPRVGN GYQSEATANG NAVSELLKQT HRGYGTSVLS
1010 1020 1030 1040 1050
WTGKTSDLDK QSFDLVCAKR IAGYGDMDGS VGVSSDSNIN NSKNIDSNSN
1060 1070 1080 1090 1100
IKSLTAPTLL AEAREQRKRD AEDDEENEMD RGRQRKVKSA SVKSNNGIPG
1110 1120 1130 1140 1150
YNPFQEFESQ KRWNGNKSGS FPRFYQNYRQ NFQQRNKFKY NRFGGGGAKF
1160 1170 1180
QQQRALQRHL AAGGGFTRRQ HQSTGHQQQQ QQQQS
Length:1,185
Mass (Da):128,969
Last modified:September 23, 2008 - v1
Checksum:iE42B490B122CB5A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933809 Genomic DNA. Translation: EDW18681.1.
RefSeqiXP_002008205.1. XM_002008169.1.

Genome annotation databases

EnsemblMetazoaiFBtr0164086; FBpp0162578; FBgn0136118.
GeneIDi6582504.
KEGGidmo:Dmoj_GI13361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933809 Genomic DNA. Translation: EDW18681.1 .
RefSeqi XP_002008205.1. XM_002008169.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0164086 ; FBpp0162578 ; FBgn0136118 .
GeneIDi 6582504.
KEGGi dmo:Dmoj_GI13361.

Organism-specific databases

FlyBasei FBgn0136118. Dmoj\GI13361.

Phylogenomic databases

InParanoidi B4KXJ5.
KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4KXJ5.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22.

Entry informationi

Entry nameiUBP36_DROMO
AccessioniPrimary (citable) accession number: B4KXJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3