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B4KXJ5

- UBP36_DROMO

UniProt

B4KXJ5 - UBP36_DROMO

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 27 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei208 – 2081NucleophilePROSITE-ProRule annotation
    Active sitei468 – 4681Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GI13361
    OrganismiDrosophila mojavensis (Fruit fly)
    Taxonomic identifieri7230 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000009192: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0136118. Dmoj\GI13361.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11851185Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378499Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei552 – 5521PhosphoserineBy similarity
    Modified residuei554 – 5541PhosphoserineBy similarity
    Modified residuei716 – 7161PhosphothreonineBy similarity
    Modified residuei726 – 7261PhosphoserineBy similarity
    Modified residuei728 – 7281PhosphoserineBy similarity
    Modified residuei867 – 8671PhosphoserineBy similarity
    Modified residuei870 – 8701PhosphothreonineBy similarity
    Modified residuei873 – 8731PhosphoserineBy similarity
    Modified residuei925 – 9251PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini199 – 509311USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    InParanoidiB4KXJ5.
    KOiK11855.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB4KXJ5.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4KXJ5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSLAVCET ANVVNAALRE SLGGGGGSGC VAAAAASGRS GSGSSSTAAA     50
    AASADEAKIG DPSATDNLQS QIVANAKRVL LAKIEYEEVE NYHESVLAKL 100
    KSKYIVIKPD NSGAANCSYK TNGASTGKAL SSNGHDNTNG VNGSSAATVN 150
    GNRKQTVEQS NQNSTTNPNE LPKPKRVLYP RENIRIGWKQ SDRKWQVGAG 200
    MLNVGNTCYL NSTLQALFHI PALANWLVSE TAHVENCNIS ESCGSGGCII 250
    CAMAKTLQTT QSNQTAVRPF LIYTKLRQIC KHMVVGRQED AHEFLRFLVE 300
    AMEKAYLMRF RNYKELDQLV KETTPLSQIF GGYLRSEVRC LSCNHVSITF 350
    QHFQDLLLDI RKADTLEEAF DGYFSRERLE DMGYKCEGCK KKVSATKQFS 400
    LERAPITLCI QLKRFSMMGN KLTKQISFKP RIDLSRFAAR SPAASTQPLS 450
    YRLVSMVTHL GVSQHCGHYT AIGLTESGSY YNFDDSYVRP IAMQSVCNTN 500
    AYIMFYELDV ASSSINSSSS CSTSVPKLNG LRLNGQHSPS VATTAVAATA 550
    TSTSASAVSP RFIGPQLPNG YANNNGHVLG AAKTSIQFKS SPQKQPQQQQ 600
    HNGLLMGANK FQESAQSKHS LVGSLHKGET AANASANAIS NANSNKSSCN 650
    NNTLTTNSQH QQQHILPISS DEEDEDEDSD DDVDVKANTA PQLPSMPKMF 700
    EDAESVAQTA KLKPKTPLKS LVPYESASEE EQEQQQQQQQ LLVSPQLQPA 750
    NPRKRRSGAD SSESEDEPPS IMRNGHAKSN GSGNESSTST SIKSNNNKQK 800
    TDAIDEIFKS LNNYKNKHRA TAAGTTTADA DEDEQQQQQV TKKPSNSSSS 850
    LISKNGWQSQ NGKAPASPKT PPSPAVIKSK TGIWQITRTD DDNDDDDEDA 900
    DEEDDADADA EQEEYDDEVV VVETTPSITT KNLNNPFASK PSSADAMPGA 950
    KRQKLLNGSA KSAQTPRVGN GYQSEATANG NAVSELLKQT HRGYGTSVLS 1000
    WTGKTSDLDK QSFDLVCAKR IAGYGDMDGS VGVSSDSNIN NSKNIDSNSN 1050
    IKSLTAPTLL AEAREQRKRD AEDDEENEMD RGRQRKVKSA SVKSNNGIPG 1100
    YNPFQEFESQ KRWNGNKSGS FPRFYQNYRQ NFQQRNKFKY NRFGGGGAKF 1150
    QQQRALQRHL AAGGGFTRRQ HQSTGHQQQQ QQQQS 1185
    Length:1,185
    Mass (Da):128,969
    Last modified:September 23, 2008 - v1
    Checksum:iE42B490B122CB5A1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933809 Genomic DNA. Translation: EDW18681.1.
    RefSeqiXP_002008205.1. XM_002008169.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0164086; FBpp0162578; FBgn0136118.
    GeneIDi6582504.
    KEGGidmo:Dmoj_GI13361.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933809 Genomic DNA. Translation: EDW18681.1 .
    RefSeqi XP_002008205.1. XM_002008169.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0164086 ; FBpp0162578 ; FBgn0136118 .
    GeneIDi 6582504.
    KEGGi dmo:Dmoj_GI13361.

    Organism-specific databases

    FlyBasei FBgn0136118. Dmoj\GI13361.

    Phylogenomic databases

    InParanoidi B4KXJ5.
    KOi K11855.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B4KXJ5.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15081-1352.22.

    Entry informationi

    Entry nameiUBP36_DROMO
    AccessioniPrimary (citable) accession number: B4KXJ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 27 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3