B4KXJ5 (UBP36_DROMO) Reviewed, UniProtKB/Swiss-Prot
Last modified
October 3, 2012.
Version 22.
History...
Clusters with 
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ubiquitin carboxyl-terminal hydrolase 36 EC=3.4.19.12 Alternative name(s): Deubiquitinating enzyme 36 Protein scrawny Ubiquitin thioesterase 36 Ubiquitin-specific-processing protease 36 | ||||||
| Gene names |
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| Organism | Drosophila mojavensis (Fruit fly) [Complete proteome] | ||||||
| Taxonomic identifier | 7230 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila ›  |
Protein attributes
| Sequence length | 1185 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity. |
| Catalytic activity | Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). |
| Subunit structure | Interacts with atms/PAF1, but not with CycT By similarity. |
| Subcellular location | |
| Sequence similarities | Belongs to the peptidase C19 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Cellular component | Nucleus |
| Molecular function | Hydrolase Protease Thiol protease |
| PTM | Phosphoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological_process | germ-line stem cell maintenance Inferred from sequence or structural similarity. Source: UniProtKB protein deubiquitinationInferred from sequence or structural similarity. Source: UniProtKB somatic stem cell maintenanceInferred from sequence or structural similarity. Source: UniProtKB ubiquitin-dependent protein catabolic processInferred from electronic annotation. Source: InterPro |
| Cellular_component | nucleolus Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular_function | cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activityInferred from sequence or structural similarity. Source: UniProtKB |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1185 | 1185 | Ubiquitin carboxyl-terminal hydrolase 36 | PRO_0000378499 | |||||
Sites | |||||||||
| Active site | 208 | 1 | Nucleophile By similarity | ||||||
| Active site | 468 | 1 | Proton acceptor By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 552 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 554 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 716 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 726 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 728 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 867 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 870 | 1 | Phosphothreonine By similarity | ||||||
| Modified residue | 873 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 925 | 1 | Phosphothreonine By similarity | ||||||
Sequences
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References
| [1] | "Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15081-1352.22. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CH933809 Genomic DNA. Translation: EDW18681.1. |
| RefSeq | XP_002008205.1. XM_002008169.1. |
3D structure databases | |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0164086; FBpp0162578; FBgn0136118. |
| GeneID | 6582504. |
| KEGG | dmo:Dmoj_GI13361. |
Organism-specific databases | |
| FlyBase | FBgn0136118. Dmoj\GI13361. |
Phylogenomic databases | |
| InParanoid | B4KXJ5. |
| KO | K11855. |
| OrthoDB | EOG4VMCZ7. |
Family and domain databases | |
| InterPro | IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view] |
| Pfam | PF00443. UCH. 1 hit. [Graphical view] |
| PROSITE | PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | UBP36_DROMO | ||||||||
| Accession | Primary (citable) accession number: B4KXJ5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Peptidase families Classification of peptidase families and list of entries |
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |