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B4KXJ5 (UBP36_DROMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GI13361
OrganismDrosophila mojavensis (Fruit fly) [Complete proteome]
Taxonomic identifier7230 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length1185 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11851185Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378499

Regions

Domain199 – 509311USP

Sites

Active site2081Nucleophile By similarity
Active site4681Proton acceptor By similarity

Amino acid modifications

Modified residue5521Phosphoserine By similarity
Modified residue5541Phosphoserine By similarity
Modified residue7161Phosphothreonine By similarity
Modified residue7261Phosphoserine By similarity
Modified residue7281Phosphoserine By similarity
Modified residue8671Phosphoserine By similarity
Modified residue8701Phosphothreonine By similarity
Modified residue8731Phosphoserine By similarity
Modified residue9251Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4KXJ5 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: E42B490B122CB5A1

FASTA1,185128,969
        10         20         30         40         50         60 
MPVSLAVCET ANVVNAALRE SLGGGGGSGC VAAAAASGRS GSGSSSTAAA AASADEAKIG 

        70         80         90        100        110        120 
DPSATDNLQS QIVANAKRVL LAKIEYEEVE NYHESVLAKL KSKYIVIKPD NSGAANCSYK 

       130        140        150        160        170        180 
TNGASTGKAL SSNGHDNTNG VNGSSAATVN GNRKQTVEQS NQNSTTNPNE LPKPKRVLYP 

       190        200        210        220        230        240 
RENIRIGWKQ SDRKWQVGAG MLNVGNTCYL NSTLQALFHI PALANWLVSE TAHVENCNIS 

       250        260        270        280        290        300 
ESCGSGGCII CAMAKTLQTT QSNQTAVRPF LIYTKLRQIC KHMVVGRQED AHEFLRFLVE 

       310        320        330        340        350        360 
AMEKAYLMRF RNYKELDQLV KETTPLSQIF GGYLRSEVRC LSCNHVSITF QHFQDLLLDI 

       370        380        390        400        410        420 
RKADTLEEAF DGYFSRERLE DMGYKCEGCK KKVSATKQFS LERAPITLCI QLKRFSMMGN 

       430        440        450        460        470        480 
KLTKQISFKP RIDLSRFAAR SPAASTQPLS YRLVSMVTHL GVSQHCGHYT AIGLTESGSY 

       490        500        510        520        530        540 
YNFDDSYVRP IAMQSVCNTN AYIMFYELDV ASSSINSSSS CSTSVPKLNG LRLNGQHSPS 

       550        560        570        580        590        600 
VATTAVAATA TSTSASAVSP RFIGPQLPNG YANNNGHVLG AAKTSIQFKS SPQKQPQQQQ 

       610        620        630        640        650        660 
HNGLLMGANK FQESAQSKHS LVGSLHKGET AANASANAIS NANSNKSSCN NNTLTTNSQH 

       670        680        690        700        710        720 
QQQHILPISS DEEDEDEDSD DDVDVKANTA PQLPSMPKMF EDAESVAQTA KLKPKTPLKS 

       730        740        750        760        770        780 
LVPYESASEE EQEQQQQQQQ LLVSPQLQPA NPRKRRSGAD SSESEDEPPS IMRNGHAKSN 

       790        800        810        820        830        840 
GSGNESSTST SIKSNNNKQK TDAIDEIFKS LNNYKNKHRA TAAGTTTADA DEDEQQQQQV 

       850        860        870        880        890        900 
TKKPSNSSSS LISKNGWQSQ NGKAPASPKT PPSPAVIKSK TGIWQITRTD DDNDDDDEDA 

       910        920        930        940        950        960 
DEEDDADADA EQEEYDDEVV VVETTPSITT KNLNNPFASK PSSADAMPGA KRQKLLNGSA 

       970        980        990       1000       1010       1020 
KSAQTPRVGN GYQSEATANG NAVSELLKQT HRGYGTSVLS WTGKTSDLDK QSFDLVCAKR 

      1030       1040       1050       1060       1070       1080 
IAGYGDMDGS VGVSSDSNIN NSKNIDSNSN IKSLTAPTLL AEAREQRKRD AEDDEENEMD 

      1090       1100       1110       1120       1130       1140 
RGRQRKVKSA SVKSNNGIPG YNPFQEFESQ KRWNGNKSGS FPRFYQNYRQ NFQQRNKFKY 

      1150       1160       1170       1180 
NRFGGGGAKF QQQRALQRHL AAGGGFTRRQ HQSTGHQQQQ QQQQS 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH933809 Genomic DNA. Translation: EDW18681.1.
RefSeqXP_002008205.1. XM_002008169.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0164086; FBpp0162578; FBgn0136118.
GeneID6582504.
KEGGdmo:Dmoj_GI13361.

Organism-specific databases

FlyBaseFBgn0136118. Dmoj\GI13361.

Phylogenomic databases

InParanoidB4KXJ5.
KOK11855.
OrthoDBEOG7XDBF6.
PhylomeDBB4KXJ5.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROMO
AccessionPrimary (citable) accession number: B4KXJ5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase