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B4KXJ5

- UBP36_DROMO

UniProt

B4KXJ5 - UBP36_DROMO

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Protein
Ubiquitin carboxyl-terminal hydrolase 36
Gene
Usp36, scny, GI13361
Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei208 – 2081Nucleophile By similarity
Active sitei468 – 4681Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GI13361
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0136118. Dmoj\GI13361.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11851185Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei552 – 5521Phosphoserine By similarity
Modified residuei554 – 5541Phosphoserine By similarity
Modified residuei716 – 7161Phosphothreonine By similarity
Modified residuei726 – 7261Phosphoserine By similarity
Modified residuei728 – 7281Phosphoserine By similarity
Modified residuei867 – 8671Phosphoserine By similarity
Modified residuei870 – 8701Phosphothreonine By similarity
Modified residuei873 – 8731Phosphoserine By similarity
Modified residuei925 – 9251Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 509311USP
Add
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

InParanoidiB4KXJ5.
KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4KXJ5.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4KXJ5-1 [UniParc]FASTAAdd to Basket

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MPVSLAVCET ANVVNAALRE SLGGGGGSGC VAAAAASGRS GSGSSSTAAA     50
AASADEAKIG DPSATDNLQS QIVANAKRVL LAKIEYEEVE NYHESVLAKL 100
KSKYIVIKPD NSGAANCSYK TNGASTGKAL SSNGHDNTNG VNGSSAATVN 150
GNRKQTVEQS NQNSTTNPNE LPKPKRVLYP RENIRIGWKQ SDRKWQVGAG 200
MLNVGNTCYL NSTLQALFHI PALANWLVSE TAHVENCNIS ESCGSGGCII 250
CAMAKTLQTT QSNQTAVRPF LIYTKLRQIC KHMVVGRQED AHEFLRFLVE 300
AMEKAYLMRF RNYKELDQLV KETTPLSQIF GGYLRSEVRC LSCNHVSITF 350
QHFQDLLLDI RKADTLEEAF DGYFSRERLE DMGYKCEGCK KKVSATKQFS 400
LERAPITLCI QLKRFSMMGN KLTKQISFKP RIDLSRFAAR SPAASTQPLS 450
YRLVSMVTHL GVSQHCGHYT AIGLTESGSY YNFDDSYVRP IAMQSVCNTN 500
AYIMFYELDV ASSSINSSSS CSTSVPKLNG LRLNGQHSPS VATTAVAATA 550
TSTSASAVSP RFIGPQLPNG YANNNGHVLG AAKTSIQFKS SPQKQPQQQQ 600
HNGLLMGANK FQESAQSKHS LVGSLHKGET AANASANAIS NANSNKSSCN 650
NNTLTTNSQH QQQHILPISS DEEDEDEDSD DDVDVKANTA PQLPSMPKMF 700
EDAESVAQTA KLKPKTPLKS LVPYESASEE EQEQQQQQQQ LLVSPQLQPA 750
NPRKRRSGAD SSESEDEPPS IMRNGHAKSN GSGNESSTST SIKSNNNKQK 800
TDAIDEIFKS LNNYKNKHRA TAAGTTTADA DEDEQQQQQV TKKPSNSSSS 850
LISKNGWQSQ NGKAPASPKT PPSPAVIKSK TGIWQITRTD DDNDDDDEDA 900
DEEDDADADA EQEEYDDEVV VVETTPSITT KNLNNPFASK PSSADAMPGA 950
KRQKLLNGSA KSAQTPRVGN GYQSEATANG NAVSELLKQT HRGYGTSVLS 1000
WTGKTSDLDK QSFDLVCAKR IAGYGDMDGS VGVSSDSNIN NSKNIDSNSN 1050
IKSLTAPTLL AEAREQRKRD AEDDEENEMD RGRQRKVKSA SVKSNNGIPG 1100
YNPFQEFESQ KRWNGNKSGS FPRFYQNYRQ NFQQRNKFKY NRFGGGGAKF 1150
QQQRALQRHL AAGGGFTRRQ HQSTGHQQQQ QQQQS 1185
Length:1,185
Mass (Da):128,969
Last modified:September 23, 2008 - v1
Checksum:iE42B490B122CB5A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933809 Genomic DNA. Translation: EDW18681.1.
RefSeqiXP_002008205.1. XM_002008169.1.

Genome annotation databases

EnsemblMetazoaiFBtr0164086; FBpp0162578; FBgn0136118.
GeneIDi6582504.
KEGGidmo:Dmoj_GI13361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933809 Genomic DNA. Translation: EDW18681.1 .
RefSeqi XP_002008205.1. XM_002008169.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0164086 ; FBpp0162578 ; FBgn0136118 .
GeneIDi 6582504.
KEGGi dmo:Dmoj_GI13361.

Organism-specific databases

FlyBasei FBgn0136118. Dmoj\GI13361.

Phylogenomic databases

InParanoidi B4KXJ5.
KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4KXJ5.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22.

Entry informationi

Entry nameiUBP36_DROMO
AccessioniPrimary (citable) accession number: B4KXJ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3