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Protein

L-lactate dehydrogenase

Gene

Dmoj\GI13222

Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (Dmoj\GI13222), L-lactate dehydrogenase (Dmoj\GI26993)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei106SubstrateUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Binding sitei169SubstrateUniRule annotation1
Active sitei193Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationImported
LigandNADUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Gene namesi
Name:Dmoj\GI13222Imported
ORF Names:Dmoj_GI13222Imported, GI13222Imported
OrganismiDrosophila mojavensis (Fruit fly)Imported
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0135979. Dmoj\GI13222.

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0135979.

Structurei

3D structure databases

ProteinModelPortaliB4KVP9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 160Ldh_1_NInterPro annotationAdd BLAST139
Domaini163 – 324Ldh_1_CInterPro annotationAdd BLAST162

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

InParanoidiB4KVP9.
KOiK00016.
OMAiMDLMQTA.
OrthoDBiEOG091G0HME.
PhylomeDBiB4KVP9.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

B4KVP9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVKDSLLA PVAETLPSSG HKVTVVGIGM VGMASAFSIL AQNVSKEVCL
60 70 80 90 100
IDVCADKLQG ELMDLQHGSN FLKNPQITAS TDYAASANSR LCIVTAGVRQ
110 120 130 140 150
KEGESRLSLV QRNTDILKNI IPKLVEYSPD TILLMVSNPV DIMTYVAWKL
160 170 180 190 200
SGLPKNRVIG SGTNLDSSRF RFLMSQRLGV APTSCHGWII GEHGDSSVPV
210 220 230 240 250
WSGVNIAGVR LRELNPTIGT GEDPEKWNEL HKQVVDSAYE VIRLKGYTSW
260 270 280 290 300
AIGLSTASLA SAILRNTSSV AAVSTSVLGE HGIDKDVFLS LPCVLNANGV
310 320 330
TSVVKQILTD DEVQQLQKSA NIMADVQAGL KF
Length:332
Mass (Da):35,546
Last modified:September 23, 2008 - v1
Checksum:iF145EFE594C3E8E7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933809 Genomic DNA. Translation: EDW18423.1.
CH933809 Genomic DNA. Translation: KRG06187.1.
RefSeqiXP_002007947.1. XM_002007911.2.
XP_015017839.1. XM_015162353.1.

Genome annotation databases

EnsemblMetazoaiFBtr0163947; FBpp0162439; FBgn0135979.
GeneIDi6582243.
KEGGidmo:Dmoj_GI13222.

Similar proteinsi

Entry informationi

Entry nameiB4KVP9_DROMO
AccessioniPrimary (citable) accession number: B4KVP9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 22, 2017
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported