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B4KT51

- CALYP_DROMO

UniProt

B4KT51 - CALYP_DROMO

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Protein
Ubiquitin carboxyl-terminal hydrolase calypso
Gene
calypso, GI18963
Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei115 – 1151Nucleophile By similarity
Active sitei197 – 1971Proton donor By similarity
Sitei212 – 2121Important for enzyme activity By similarity

GO - Molecular functioni

  1. chromatin binding Source: UniProtKB
  2. ubiquitin thiolesterase activity Source: UniProtKB
  3. ubiquitin-specific protease activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. chromatin silencing Source: UniProtKB
  2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC12.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
Alternative name(s):
BAP1 homolog
Gene namesi
Name:calypso
ORF Names:GI18963
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0141702. Dmoj\GI18963.

Subcellular locationi

Nucleus By similarity
Note: Localizes to PcG response elements (PREs) By similarity.

GO - Cellular componenti

  1. PR-DUB complex Source: UniProtKB
  2. nuclear chromatin Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Ubiquitin carboxyl-terminal hydrolase calypso
PRO_0000395829Add
BLAST

Interactioni

Subunit structurei

Component of the PR-DUB complex, at least composed of calypso and Asx By similarity.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiB4KT51.
KOiK08588.
OrthoDBiEOG7GN2M2.
PhylomeDBiB4KT51.

Family and domain databases

Gene3Di3.40.532.10. 1 hit.
InterProiIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERiPTHR10589. PTHR10589. 1 hit.
PfamiPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSiPR00707. UBCTHYDRLASE.

Sequencei

Sequence statusi: Complete.

B4KT51-1 [UniParc]FASTAAdd to Basket

« Hide

MNVAAGGTSA AAGSASNNNA LPMAQLADGW LELESDPGLF TLLLEDFGCH    50
DVQVEEVYDL QKPIESPYGF IFLFRWIEER RARRKIVETT AEIFVKDEEA 100
ISSIFFAQQV VPNSCATHAL LSVLLNCNEN NLQLGETLSR LKAHTKGMSP 150
ENKGLAIGNT PELACAHNSH AMPQARRRLE RTGAGVASCR FTGEAFHFVS 200
FVPINGQLFE LDGLKPYPMN HGCWEEHEDW TDKFRRVMAD RLGIATGEQD 250
IRFNLMAVVP DRRIAITHKL KMLRTNQAIV SGTLQKLLKA DEQGDDQQRP 300
DTPNTLLEPS AFTARDLQSL LKNLDTEIAI NEQHLADEND RRQMFKVDAS 350
RRTHNYDKFI CTFLSMLAHQ GVLGELVSQH LLPTKKISGQ SAANRLSKQS 400
SAATANTANS AANATAGKSQ PQQQQQQQQQ QPQSQAAKNG KSPGKTPGRR 450
RKGRNKCRKR K 461
Length:461
Mass (Da):51,195
Last modified:September 23, 2008 - v1
Checksum:i12F6203BE0B33A9A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933808 Genomic DNA. Translation: EDW09571.1.
RefSeqiXP_002005636.1. XM_002005600.1.

Genome annotation databases

EnsemblMetazoaiFBtr0169688; FBpp0168180; FBgn0141702.
GeneIDi6579754.
KEGGidmo:Dmoj_GI18963.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933808 Genomic DNA. Translation: EDW09571.1 .
RefSeqi XP_002005636.1. XM_002005600.1.

3D structure databases

ModBasei Search...

Protein family/group databases

MEROPSi C12.A09.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0169688 ; FBpp0168180 ; FBgn0141702 .
GeneIDi 6579754.
KEGGi dmo:Dmoj_GI18963.

Organism-specific databases

FlyBasei FBgn0141702. Dmoj\GI18963.

Phylogenomic databases

InParanoidi B4KT51.
KOi K08588.
OrthoDBi EOG7GN2M2.
PhylomeDBi B4KT51.

Family and domain databases

Gene3Di 3.40.532.10. 1 hit.
InterProi IPR001578. Peptidase_C12_UCH.
[Graphical view ]
PANTHERi PTHR10589. PTHR10589. 1 hit.
Pfami PF01088. Peptidase_C12. 1 hit.
[Graphical view ]
PRINTSi PR00707. UBCTHYDRLASE.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22.

Entry informationi

Entry nameiCALYP_DROMO
AccessioniPrimary (citable) accession number: B4KT51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi