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B4KKM7

- B4KKM7_DROMO

UniProt

B4KKM7 - B4KKM7_DROMO

Protein

Nitric oxide synthase

Gene

Dmoj\GI17812

Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Produces nitric oxide (NO).UniRule annotation

    Catalytic activityi

    2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.UniRule annotation

    Cofactori

    Binds 1 FAD.UniRule annotation
    Binds 1 FMN.UniRule annotation
    Heme group.UniRule annotation

    GO - Molecular functioni

    1. flavin adenine dinucleotide binding Source: InterPro
    2. FMN binding Source: InterPro
    3. heme binding Source: InterPro
    4. iron ion binding Source: InterPro
    5. NADP binding Source: InterPro
    6. nitric-oxide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. nitric oxide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Ligandi

    Calmodulin-bindingUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, HemeUniRule annotation, Iron, Metal-binding, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nitric oxide synthaseUniRule annotation (EC:1.14.13.39UniRule annotation)
    Gene namesi
    Name:Dmoj\GI17812Imported
    ORF Names:Dmoj_GI17812Imported, GI17812Imported
    OrganismiDrosophila mojavensis (Fruit fly)Imported
    Taxonomic identifieri7230 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000009192: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0140553. Dmoj\GI17812.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NOS family.UniRule annotation

    Phylogenomic databases

    InParanoidiB4KKM7.
    KOiK13253.
    OrthoDBiEOG79SDW7.
    PhylomeDBiB4KKM7.

    Family and domain databases

    Gene3Di1.20.990.10. 1 hit.
    3.40.50.360. 2 hits.
    3.90.340.10. 1 hit.
    InterProiIPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR012144. NOS_euk.
    IPR004030. NOS_N.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view]
    PfamiPF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    PF02898. NO_synthase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000333. NOS. 1 hit.
    PRINTSiPR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMiSSF52218. SSF52218. 1 hit.
    SSF56512. SSF56512. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEiPS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    PS60001. NOS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4KKM7-1 [UniParc]FASTAAdd to Basket

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    MSQHFTSIFE NLRFVTIKRT TNTQPQQQQQ QQQQQQQSPL PTPKATPVEP     50
    NKIKAKTQAA LNGNGQLLST NLGGVAATTS HEVDHSKGAS GTTAGAVSAL 100
    AGGGGVGVGV GGTPLKHHKR TSIPTSSPQP GRERRGTNTS IVVELDDGVG 150
    SGSGSGSGGG VGGGGGVSGS SVGQSAAGAS GSGTASSKSS RELSPTPKNA 200
    QQPRKMSQDH RSRAGSFMHL DDEGRSLLMR KPMRLKNIEG RPEVYDTLHS 250
    KGREILSCSR ATCTSSIMNI GNAPVEARKV DLVLEHAKDF LDQYFTSIKR 300
    SSSAAHETRW KQVRQSIETT GHYQLTETEL IYGAKLAWRN SSRCIGRIQW 350
    SKLQVFDCRY VTTTSGMFEA ICNHIKYATN KGNLRSAITI FPQRTDARHD 400
    YRIWNNQLIS YAGYKQSDGK IIGDPMNVEF TEVCTKLGWK GKGTEWDILP 450
    LVVSANGHDP DYFDYPPELI LEVPLSHPKF EWFTELSLRW YALPAVSSML 500
    FDVGGIQFTA TTFSGWYMST EIGCRNLCDT NRRNMLETVA LKMNLDTRTP 550
    TSLWKDKAVV EMNIAVLHSY QSRNVTIVDH HTASESFMKH FENESKLRNG 600
    CPADWIWIVP PLSGSITPVF HQEMALYYLK PSFEYQDPAW RTHIWKKGRG 650
    ESKGKKPRRK FNFKQIARAV KFTSKLFGRA LSKRIKATVL YATETGKSEQ 700
    YAKQLCELLG HAFNAQIYCM SDYDISSIEH EALLIVVAST FGNGDPPENG 750
    ELFSQELYAM RIQESGEHGL HDSSMGVSSS KSFMKANSRQ DFMKLPLQQV 800
    KKIDRWDSLR GSTSDTFTDE TFGPLSNVRF AVFALGSSAY PNFCAFGQYV 850
    DNILGELGGE RLLKIAYGDE MCGQEQSFRK WAPEVFKLAC ETFCLDPDQS 900
    LSDASLALQN ESLTVNNVRL VPSVSKVSLD VALSKYHNKK VHCCKIKEQP 950
    HNLTKLSEGA KTTMLLEICA PGLEYEPGDH VGIFPANRAE LVDGLLQRLV 1000
    GVDNPDEVLQ LQLLKEKQTS NGIFKCWEQH DKIPADTLRN LLARFFDLTT 1050
    PPSRQLLTLL AGFCDDNADT ERLQLLVTDS SAYEDWRHWR LPHLLDVLEE 1100
    FPSCRPPASL VLAHLTPLQP RFYSISSSPR RVSDEIHLTV AIVRYRCEDG 1150
    QGDERYGVCS NYLAGLKAND ELYMFVRSAL GFHLPADRSR PVVLIGPGTG 1200
    IAPFRSFWQE FQVLREVDTA TSLPKLWLFF GCRNRDVDLY AEEKAQLLQD 1250
    QIMDRVFLAL SREPDIPKTY VQDLIEQEFD SLYKLIVLER GHVYVCGDVT 1300
    MAEHVYQTIR KCIAGKEQKT EAEVETFLLT LRDENRYHED IFGITLRTAE 1350
    IHTKSRATAR IRMASQP 1367
    Length:1,367
    Mass (Da):152,762
    Last modified:September 23, 2008 - v1
    Checksum:iA070377BDEDF0DF3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933807 Genomic DNA. Translation: EDW12691.1.
    RefSeqiXP_002003249.1. XM_002003213.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0168537; FBpp0167029; FBgn0140553.
    GeneIDi6577282.
    KEGGidmo:Dmoj_GI17812.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933807 Genomic DNA. Translation: EDW12691.1 .
    RefSeqi XP_002003249.1. XM_002003213.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0168537 ; FBpp0167029 ; FBgn0140553 .
    GeneIDi 6577282.
    KEGGi dmo:Dmoj_GI17812.

    Organism-specific databases

    FlyBasei FBgn0140553. Dmoj\GI17812.

    Phylogenomic databases

    InParanoidi B4KKM7.
    KOi K13253.
    OrthoDBi EOG79SDW7.
    PhylomeDBi B4KKM7.

    Family and domain databases

    Gene3Di 1.20.990.10. 1 hit.
    3.40.50.360. 2 hits.
    3.90.340.10. 1 hit.
    InterProi IPR003097. FAD-binding_1.
    IPR017927. Fd_Rdtase_FAD-bd.
    IPR001094. Flavdoxin.
    IPR008254. Flavodoxin/NO_synth.
    IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
    IPR029039. Flavoprotein-like.
    IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
    IPR012144. NOS_euk.
    IPR004030. NOS_N.
    IPR001433. OxRdtase_FAD/NAD-bd.
    IPR017938. Riboflavin_synthase-like_b-brl.
    [Graphical view ]
    Pfami PF00667. FAD_binding_1. 1 hit.
    PF00258. Flavodoxin_1. 1 hit.
    PF00175. NAD_binding_1. 1 hit.
    PF02898. NO_synthase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000333. NOS. 1 hit.
    PRINTSi PR00369. FLAVODOXIN.
    PR00371. FPNCR.
    SUPFAMi SSF52218. SSF52218. 1 hit.
    SSF56512. SSF56512. 1 hit.
    SSF63380. SSF63380. 1 hit.
    PROSITEi PS51384. FAD_FR. 1 hit.
    PS50902. FLAVODOXIN_LIKE. 1 hit.
    PS60001. NOS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15081-1352.22Imported.

    Entry informationi

    Entry nameiB4KKM7_DROMO
    AccessioniPrimary (citable) accession number: B4KKM7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3