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B4KKM7 (B4KKM7_DROMO) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 43. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length1367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces nitric oxide (NO) By similarity. PIRNR PIRNR000333

Catalytic activity

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O. PIRNR PIRNR000333

Cofactor

Binds 1 FAD By similarity. PIRNR PIRNR000333

Binds 1 FMN By similarity. PIRNR PIRNR000333

Heme group By similarity. PIRNR PIRNR000333

Sequence similarities

Belongs to the NOS family. PIRNR PIRNR000333

Sequences

Sequence LengthMass (Da)Tools
B4KKM7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: A070377BDEDF0DF3

FASTA1,367152,762
        10         20         30         40         50         60 
MSQHFTSIFE NLRFVTIKRT TNTQPQQQQQ QQQQQQQSPL PTPKATPVEP NKIKAKTQAA 

        70         80         90        100        110        120 
LNGNGQLLST NLGGVAATTS HEVDHSKGAS GTTAGAVSAL AGGGGVGVGV GGTPLKHHKR 

       130        140        150        160        170        180 
TSIPTSSPQP GRERRGTNTS IVVELDDGVG SGSGSGSGGG VGGGGGVSGS SVGQSAAGAS 

       190        200        210        220        230        240 
GSGTASSKSS RELSPTPKNA QQPRKMSQDH RSRAGSFMHL DDEGRSLLMR KPMRLKNIEG 

       250        260        270        280        290        300 
RPEVYDTLHS KGREILSCSR ATCTSSIMNI GNAPVEARKV DLVLEHAKDF LDQYFTSIKR 

       310        320        330        340        350        360 
SSSAAHETRW KQVRQSIETT GHYQLTETEL IYGAKLAWRN SSRCIGRIQW SKLQVFDCRY 

       370        380        390        400        410        420 
VTTTSGMFEA ICNHIKYATN KGNLRSAITI FPQRTDARHD YRIWNNQLIS YAGYKQSDGK 

       430        440        450        460        470        480 
IIGDPMNVEF TEVCTKLGWK GKGTEWDILP LVVSANGHDP DYFDYPPELI LEVPLSHPKF 

       490        500        510        520        530        540 
EWFTELSLRW YALPAVSSML FDVGGIQFTA TTFSGWYMST EIGCRNLCDT NRRNMLETVA 

       550        560        570        580        590        600 
LKMNLDTRTP TSLWKDKAVV EMNIAVLHSY QSRNVTIVDH HTASESFMKH FENESKLRNG 

       610        620        630        640        650        660 
CPADWIWIVP PLSGSITPVF HQEMALYYLK PSFEYQDPAW RTHIWKKGRG ESKGKKPRRK 

       670        680        690        700        710        720 
FNFKQIARAV KFTSKLFGRA LSKRIKATVL YATETGKSEQ YAKQLCELLG HAFNAQIYCM 

       730        740        750        760        770        780 
SDYDISSIEH EALLIVVAST FGNGDPPENG ELFSQELYAM RIQESGEHGL HDSSMGVSSS 

       790        800        810        820        830        840 
KSFMKANSRQ DFMKLPLQQV KKIDRWDSLR GSTSDTFTDE TFGPLSNVRF AVFALGSSAY 

       850        860        870        880        890        900 
PNFCAFGQYV DNILGELGGE RLLKIAYGDE MCGQEQSFRK WAPEVFKLAC ETFCLDPDQS 

       910        920        930        940        950        960 
LSDASLALQN ESLTVNNVRL VPSVSKVSLD VALSKYHNKK VHCCKIKEQP HNLTKLSEGA 

       970        980        990       1000       1010       1020 
KTTMLLEICA PGLEYEPGDH VGIFPANRAE LVDGLLQRLV GVDNPDEVLQ LQLLKEKQTS 

      1030       1040       1050       1060       1070       1080 
NGIFKCWEQH DKIPADTLRN LLARFFDLTT PPSRQLLTLL AGFCDDNADT ERLQLLVTDS 

      1090       1100       1110       1120       1130       1140 
SAYEDWRHWR LPHLLDVLEE FPSCRPPASL VLAHLTPLQP RFYSISSSPR RVSDEIHLTV 

      1150       1160       1170       1180       1190       1200 
AIVRYRCEDG QGDERYGVCS NYLAGLKAND ELYMFVRSAL GFHLPADRSR PVVLIGPGTG 

      1210       1220       1230       1240       1250       1260 
IAPFRSFWQE FQVLREVDTA TSLPKLWLFF GCRNRDVDLY AEEKAQLLQD QIMDRVFLAL 

      1270       1280       1290       1300       1310       1320 
SREPDIPKTY VQDLIEQEFD SLYKLIVLER GHVYVCGDVT MAEHVYQTIR KCIAGKEQKT 

      1330       1340       1350       1360 
EAEVETFLLT LRDENRYHED IFGITLRTAE IHTKSRATAR IRMASQP 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH933807 Genomic DNA. Translation: EDW12691.1.
RefSeqXP_002003249.1. XM_002003213.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0168537; FBpp0167029; FBgn0140553.
GeneID6577282.
KEGGdmo:Dmoj_GI17812.

Organism-specific databases

FlyBaseFBgn0140553. Dmoj\GI17812.

Phylogenomic databases

InParanoidB4KKM7.
KOK13253.
OrthoDBEOG79SDW7.
PhylomeDBB4KKM7.

Family and domain databases

Gene3D1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR004030. NO_synthase_oxygenase_dom.
IPR012144. NOS_euk.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view]
PIRSFPIRSF000333. NOS. 1 hit.
PRINTSPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMSSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4KKM7_DROMO
AccessionPrimary (citable) accession number: B4KKM7
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)