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B4KKM7

- B4KKM7_DROMO

UniProt

B4KKM7 - B4KKM7_DROMO

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Protein

Nitric oxide synthase

Gene

Dmoj\GI17812

Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Produces nitric oxide (NO).UniRule annotation

Catalytic activityi

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.UniRule annotation

Cofactori

Binds 1 FAD.UniRule annotation
Binds 1 FMN.UniRule annotation
Heme group.UniRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. FMN binding Source: InterPro
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. NADP binding Source: InterPro
  6. nitric-oxide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. nitric oxide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

Calmodulin-bindingUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, HemeUniRule annotation, Iron, Metal-binding, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide synthaseUniRule annotation (EC:1.14.13.39UniRule annotation)
Gene namesi
Name:Dmoj\GI17812Imported
ORF Names:Dmoj_GI17812Imported, GI17812Imported
OrganismiDrosophila mojavensis (Fruit fly)Imported
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0140553. Dmoj\GI17812.

Family & Domainsi

Sequence similaritiesi

Belongs to the NOS family.UniRule annotation

Phylogenomic databases

InParanoidiB4KKM7.
KOiK13253.
OrthoDBiEOG79SDW7.
PhylomeDBiB4KKM7.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000333. NOS. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4KKM7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQHFTSIFE NLRFVTIKRT TNTQPQQQQQ QQQQQQQSPL PTPKATPVEP
60 70 80 90 100
NKIKAKTQAA LNGNGQLLST NLGGVAATTS HEVDHSKGAS GTTAGAVSAL
110 120 130 140 150
AGGGGVGVGV GGTPLKHHKR TSIPTSSPQP GRERRGTNTS IVVELDDGVG
160 170 180 190 200
SGSGSGSGGG VGGGGGVSGS SVGQSAAGAS GSGTASSKSS RELSPTPKNA
210 220 230 240 250
QQPRKMSQDH RSRAGSFMHL DDEGRSLLMR KPMRLKNIEG RPEVYDTLHS
260 270 280 290 300
KGREILSCSR ATCTSSIMNI GNAPVEARKV DLVLEHAKDF LDQYFTSIKR
310 320 330 340 350
SSSAAHETRW KQVRQSIETT GHYQLTETEL IYGAKLAWRN SSRCIGRIQW
360 370 380 390 400
SKLQVFDCRY VTTTSGMFEA ICNHIKYATN KGNLRSAITI FPQRTDARHD
410 420 430 440 450
YRIWNNQLIS YAGYKQSDGK IIGDPMNVEF TEVCTKLGWK GKGTEWDILP
460 470 480 490 500
LVVSANGHDP DYFDYPPELI LEVPLSHPKF EWFTELSLRW YALPAVSSML
510 520 530 540 550
FDVGGIQFTA TTFSGWYMST EIGCRNLCDT NRRNMLETVA LKMNLDTRTP
560 570 580 590 600
TSLWKDKAVV EMNIAVLHSY QSRNVTIVDH HTASESFMKH FENESKLRNG
610 620 630 640 650
CPADWIWIVP PLSGSITPVF HQEMALYYLK PSFEYQDPAW RTHIWKKGRG
660 670 680 690 700
ESKGKKPRRK FNFKQIARAV KFTSKLFGRA LSKRIKATVL YATETGKSEQ
710 720 730 740 750
YAKQLCELLG HAFNAQIYCM SDYDISSIEH EALLIVVAST FGNGDPPENG
760 770 780 790 800
ELFSQELYAM RIQESGEHGL HDSSMGVSSS KSFMKANSRQ DFMKLPLQQV
810 820 830 840 850
KKIDRWDSLR GSTSDTFTDE TFGPLSNVRF AVFALGSSAY PNFCAFGQYV
860 870 880 890 900
DNILGELGGE RLLKIAYGDE MCGQEQSFRK WAPEVFKLAC ETFCLDPDQS
910 920 930 940 950
LSDASLALQN ESLTVNNVRL VPSVSKVSLD VALSKYHNKK VHCCKIKEQP
960 970 980 990 1000
HNLTKLSEGA KTTMLLEICA PGLEYEPGDH VGIFPANRAE LVDGLLQRLV
1010 1020 1030 1040 1050
GVDNPDEVLQ LQLLKEKQTS NGIFKCWEQH DKIPADTLRN LLARFFDLTT
1060 1070 1080 1090 1100
PPSRQLLTLL AGFCDDNADT ERLQLLVTDS SAYEDWRHWR LPHLLDVLEE
1110 1120 1130 1140 1150
FPSCRPPASL VLAHLTPLQP RFYSISSSPR RVSDEIHLTV AIVRYRCEDG
1160 1170 1180 1190 1200
QGDERYGVCS NYLAGLKAND ELYMFVRSAL GFHLPADRSR PVVLIGPGTG
1210 1220 1230 1240 1250
IAPFRSFWQE FQVLREVDTA TSLPKLWLFF GCRNRDVDLY AEEKAQLLQD
1260 1270 1280 1290 1300
QIMDRVFLAL SREPDIPKTY VQDLIEQEFD SLYKLIVLER GHVYVCGDVT
1310 1320 1330 1340 1350
MAEHVYQTIR KCIAGKEQKT EAEVETFLLT LRDENRYHED IFGITLRTAE
1360
IHTKSRATAR IRMASQP
Length:1,367
Mass (Da):152,762
Last modified:September 23, 2008 - v1
Checksum:iA070377BDEDF0DF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933807 Genomic DNA. Translation: EDW12691.1.
RefSeqiXP_002003249.1. XM_002003213.1.

Genome annotation databases

EnsemblMetazoaiFBtr0168537; FBpp0167029; FBgn0140553.
GeneIDi6577282.
KEGGidmo:Dmoj_GI17812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933807 Genomic DNA. Translation: EDW12691.1 .
RefSeqi XP_002003249.1. XM_002003213.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0168537 ; FBpp0167029 ; FBgn0140553 .
GeneIDi 6577282.
KEGGi dmo:Dmoj_GI17812.

Organism-specific databases

FlyBasei FBgn0140553. Dmoj\GI17812.

Phylogenomic databases

InParanoidi B4KKM7.
KOi K13253.
OrthoDBi EOG79SDW7.
PhylomeDBi B4KKM7.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000333. NOS. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22Imported.

Entry informationi

Entry nameiB4KKM7_DROMO
AccessioniPrimary (citable) accession number: B4KKM7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3