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B4KKM7

- B4KKM7_DROMO

UniProt

B4KKM7 - B4KKM7_DROMO

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Protein

Nitric oxide synthase

Gene
Dmoj\GI17812, Dmoj_GI17812, GI17812
Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Produces nitric oxide (NO) By similarity.UniRule annotation

Catalytic activityi

2 L-arginine + 3 NADPH + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O.UniRule annotation

Cofactori

Binds 1 FAD By similarity.UniRule annotation
Binds 1 FMN By similarity.UniRule annotation
Heme group By similarity.UniRule annotation

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. FMN binding Source: InterPro
  3. heme binding Source: InterPro
  4. iron ion binding Source: InterPro
  5. NADP binding Source: InterPro
  6. nitric-oxide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. nitric oxide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

Calmodulin-bindingUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, HemeUniRule annotation, Iron, Metal-binding, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Nitric oxide synthaseUniRule annotation (EC:1.14.13.39UniRule annotation)
Gene namesi
Name:Dmoj\GI17812Imported
ORF Names:Dmoj_GI17812Imported, GI17812Imported
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0140553. Dmoj\GI17812.

Family & Domainsi

Sequence similaritiesi

Belongs to the NOS family.UniRule annotation

Phylogenomic databases

InParanoidiB4KKM7.
KOiK13253.
OrthoDBiEOG79SDW7.
PhylomeDBiB4KKM7.

Family and domain databases

Gene3Di1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProiIPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view]
PfamiPF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view]
PIRSFiPIRSF000333. NOS. 1 hit.
PRINTSiPR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMiSSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEiPS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4KKM7-1 [UniParc]FASTAAdd to Basket

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MSQHFTSIFE NLRFVTIKRT TNTQPQQQQQ QQQQQQQSPL PTPKATPVEP     50
NKIKAKTQAA LNGNGQLLST NLGGVAATTS HEVDHSKGAS GTTAGAVSAL 100
AGGGGVGVGV GGTPLKHHKR TSIPTSSPQP GRERRGTNTS IVVELDDGVG 150
SGSGSGSGGG VGGGGGVSGS SVGQSAAGAS GSGTASSKSS RELSPTPKNA 200
QQPRKMSQDH RSRAGSFMHL DDEGRSLLMR KPMRLKNIEG RPEVYDTLHS 250
KGREILSCSR ATCTSSIMNI GNAPVEARKV DLVLEHAKDF LDQYFTSIKR 300
SSSAAHETRW KQVRQSIETT GHYQLTETEL IYGAKLAWRN SSRCIGRIQW 350
SKLQVFDCRY VTTTSGMFEA ICNHIKYATN KGNLRSAITI FPQRTDARHD 400
YRIWNNQLIS YAGYKQSDGK IIGDPMNVEF TEVCTKLGWK GKGTEWDILP 450
LVVSANGHDP DYFDYPPELI LEVPLSHPKF EWFTELSLRW YALPAVSSML 500
FDVGGIQFTA TTFSGWYMST EIGCRNLCDT NRRNMLETVA LKMNLDTRTP 550
TSLWKDKAVV EMNIAVLHSY QSRNVTIVDH HTASESFMKH FENESKLRNG 600
CPADWIWIVP PLSGSITPVF HQEMALYYLK PSFEYQDPAW RTHIWKKGRG 650
ESKGKKPRRK FNFKQIARAV KFTSKLFGRA LSKRIKATVL YATETGKSEQ 700
YAKQLCELLG HAFNAQIYCM SDYDISSIEH EALLIVVAST FGNGDPPENG 750
ELFSQELYAM RIQESGEHGL HDSSMGVSSS KSFMKANSRQ DFMKLPLQQV 800
KKIDRWDSLR GSTSDTFTDE TFGPLSNVRF AVFALGSSAY PNFCAFGQYV 850
DNILGELGGE RLLKIAYGDE MCGQEQSFRK WAPEVFKLAC ETFCLDPDQS 900
LSDASLALQN ESLTVNNVRL VPSVSKVSLD VALSKYHNKK VHCCKIKEQP 950
HNLTKLSEGA KTTMLLEICA PGLEYEPGDH VGIFPANRAE LVDGLLQRLV 1000
GVDNPDEVLQ LQLLKEKQTS NGIFKCWEQH DKIPADTLRN LLARFFDLTT 1050
PPSRQLLTLL AGFCDDNADT ERLQLLVTDS SAYEDWRHWR LPHLLDVLEE 1100
FPSCRPPASL VLAHLTPLQP RFYSISSSPR RVSDEIHLTV AIVRYRCEDG 1150
QGDERYGVCS NYLAGLKAND ELYMFVRSAL GFHLPADRSR PVVLIGPGTG 1200
IAPFRSFWQE FQVLREVDTA TSLPKLWLFF GCRNRDVDLY AEEKAQLLQD 1250
QIMDRVFLAL SREPDIPKTY VQDLIEQEFD SLYKLIVLER GHVYVCGDVT 1300
MAEHVYQTIR KCIAGKEQKT EAEVETFLLT LRDENRYHED IFGITLRTAE 1350
IHTKSRATAR IRMASQP 1367
Length:1,367
Mass (Da):152,762
Last modified:September 23, 2008 - v1
Checksum:iA070377BDEDF0DF3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933807 Genomic DNA. Translation: EDW12691.1.
RefSeqiXP_002003249.1. XM_002003213.1.

Genome annotation databases

EnsemblMetazoaiFBtr0168537; FBpp0167029; FBgn0140553.
GeneIDi6577282.
KEGGidmo:Dmoj_GI17812.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933807 Genomic DNA. Translation: EDW12691.1 .
RefSeqi XP_002003249.1. XM_002003213.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0168537 ; FBpp0167029 ; FBgn0140553 .
GeneIDi 6577282.
KEGGi dmo:Dmoj_GI17812.

Organism-specific databases

FlyBasei FBgn0140553. Dmoj\GI17812.

Phylogenomic databases

InParanoidi B4KKM7.
KOi K13253.
OrthoDBi EOG79SDW7.
PhylomeDBi B4KKM7.

Family and domain databases

Gene3Di 1.20.990.10. 1 hit.
3.40.50.360. 2 hits.
3.90.340.10. 1 hit.
InterProi IPR003097. FAD-binding_1.
IPR017927. Fd_Rdtase_FAD-bd.
IPR001094. Flavdoxin.
IPR008254. Flavodoxin/NO_synth.
IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase.
IPR029039. Flavoprotein-like.
IPR023173. NADPH_Cyt_P450_Rdtase_dom3.
IPR012144. NOS_euk.
IPR004030. NOS_N.
IPR001433. OxRdtase_FAD/NAD-bd.
IPR017938. Riboflavin_synthase-like_b-brl.
[Graphical view ]
Pfami PF00667. FAD_binding_1. 1 hit.
PF00258. Flavodoxin_1. 1 hit.
PF00175. NAD_binding_1. 1 hit.
PF02898. NO_synthase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000333. NOS. 1 hit.
PRINTSi PR00369. FLAVODOXIN.
PR00371. FPNCR.
SUPFAMi SSF52218. SSF52218. 1 hit.
SSF56512. SSF56512. 1 hit.
SSF63380. SSF63380. 1 hit.
PROSITEi PS51384. FAD_FR. 1 hit.
PS50902. FLAVODOXIN_LIKE. 1 hit.
PS60001. NOS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22.

Entry informationi

Entry nameiB4KKM7_DROMO
AccessioniPrimary (citable) accession number: B4KKM7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

Similar proteinsi