Nitric oxide synthase - Drosophila mojavensis (Fruit fly)

Contribute

Send feedback

Read comments (?) or add your own

B4KKM7 (B4KKM7_DROMO) Unreviewed, UniProtKB/TrEMBL

Last modified March 6, 2013. Version 36. History...

Clusters with 100%, 90%, 50% identity |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info Customize order

Names and origin

Protein names

Recommended name:
Nitric oxide synthase PIRNR PIRNR000333
EC=1.14.13.39 PIRNR PIRNR000333

Gene names

Name:	GI17812 FlyBase FBgn0140553
Synonyms:	Dmoj\GI17812 EMBL EDW12691.1
ORF Names:	Dmoj_GI17812 EMBL EDW12691.1

Organism

Drosophila mojavensis (Fruit fly) [Complete proteome]

Taxonomic identifier

7230 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila ›

Protein attributes

Sequence length	1367 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Produces nitric oxide (NO) By similarity. PIRNR PIRNR000333
Catalytic activity	2 L-arginine + 3 NADPH + 4 O₂ = 2 L-citrulline + 2 nitric oxide + 3 NADP⁺ + 4 H₂O. PIRNR PIRNR000333
Cofactor	Binds 1 FAD By similarity. PIRNR PIRNR000333 Binds 1 FMN By similarity. PIRNR PIRNR000333 Heme group By similarity. PIRNR PIRNR000333
Sequence similarities	Belongs to the NOS family. PIRNR PIRNR000333

Ontologies

Keywords
Ligand	Calmodulin-binding PIRNR PIRNR000333 FAD PIRNR PIRNR000333 FMN PIRNR PIRNR000333 Heme PIRNR PIRNR000333 Iron Metal-binding NADP PIRNR PIRNR000333
Molecular function	Oxidoreductase PIRNR PIRNR000333
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	nitric oxide biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular_function	FMN binding Inferred from electronic annotation. Source: InterPro NADP binding Inferred from electronic annotation. Source: InterPro flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro nitric-oxide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

Sequence

Length

Mass (Da)

Tools

B4KKM7 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: A070377BDEDF0DF3
Show »

FASTA

1,367

152,762

        10         20         30         40         50         60 
MSQHFTSIFE NLRFVTIKRT TNTQPQQQQQ QQQQQQQSPL PTPKATPVEP NKIKAKTQAA 

        70         80         90        100        110        120 
LNGNGQLLST NLGGVAATTS HEVDHSKGAS GTTAGAVSAL AGGGGVGVGV GGTPLKHHKR 

       130        140        150        160        170        180 
TSIPTSSPQP GRERRGTNTS IVVELDDGVG SGSGSGSGGG VGGGGGVSGS SVGQSAAGAS 

       190        200        210        220        230        240 
GSGTASSKSS RELSPTPKNA QQPRKMSQDH RSRAGSFMHL DDEGRSLLMR KPMRLKNIEG 

       250        260        270        280        290        300 
RPEVYDTLHS KGREILSCSR ATCTSSIMNI GNAPVEARKV DLVLEHAKDF LDQYFTSIKR 

       310        320        330        340        350        360 
SSSAAHETRW KQVRQSIETT GHYQLTETEL IYGAKLAWRN SSRCIGRIQW SKLQVFDCRY 

       370        380        390        400        410        420 
VTTTSGMFEA ICNHIKYATN KGNLRSAITI FPQRTDARHD YRIWNNQLIS YAGYKQSDGK 

       430        440        450        460        470        480 
IIGDPMNVEF TEVCTKLGWK GKGTEWDILP LVVSANGHDP DYFDYPPELI LEVPLSHPKF 

       490        500        510        520        530        540 
EWFTELSLRW YALPAVSSML FDVGGIQFTA TTFSGWYMST EIGCRNLCDT NRRNMLETVA 

       550        560        570        580        590        600 
LKMNLDTRTP TSLWKDKAVV EMNIAVLHSY QSRNVTIVDH HTASESFMKH FENESKLRNG 

       610        620        630        640        650        660 
CPADWIWIVP PLSGSITPVF HQEMALYYLK PSFEYQDPAW RTHIWKKGRG ESKGKKPRRK 

       670        680        690        700        710        720 
FNFKQIARAV KFTSKLFGRA LSKRIKATVL YATETGKSEQ YAKQLCELLG HAFNAQIYCM 

       730        740        750        760        770        780 
SDYDISSIEH EALLIVVAST FGNGDPPENG ELFSQELYAM RIQESGEHGL HDSSMGVSSS 

       790        800        810        820        830        840 
KSFMKANSRQ DFMKLPLQQV KKIDRWDSLR GSTSDTFTDE TFGPLSNVRF AVFALGSSAY 

       850        860        870        880        890        900 
PNFCAFGQYV DNILGELGGE RLLKIAYGDE MCGQEQSFRK WAPEVFKLAC ETFCLDPDQS 

       910        920        930        940        950        960 
LSDASLALQN ESLTVNNVRL VPSVSKVSLD VALSKYHNKK VHCCKIKEQP HNLTKLSEGA 

       970        980        990       1000       1010       1020 
KTTMLLEICA PGLEYEPGDH VGIFPANRAE LVDGLLQRLV GVDNPDEVLQ LQLLKEKQTS 

      1030       1040       1050       1060       1070       1080 
NGIFKCWEQH DKIPADTLRN LLARFFDLTT PPSRQLLTLL AGFCDDNADT ERLQLLVTDS 

      1090       1100       1110       1120       1130       1140 
SAYEDWRHWR LPHLLDVLEE FPSCRPPASL VLAHLTPLQP RFYSISSSPR RVSDEIHLTV 

      1150       1160       1170       1180       1190       1200 
AIVRYRCEDG QGDERYGVCS NYLAGLKAND ELYMFVRSAL GFHLPADRSR PVVLIGPGTG 

      1210       1220       1230       1240       1250       1260 
IAPFRSFWQE FQVLREVDTA TSLPKLWLFF GCRNRDVDLY AEEKAQLLQD QIMDRVFLAL 

      1270       1280       1290       1300       1310       1320 
SREPDIPKTY VQDLIEQEFD SLYKLIVLER GHVYVCGDVT MAEHVYQTIR KCIAGKEQKT 

      1330       1340       1350       1360 
EAEVETFLLT LRDENRYHED IFGITLRTAE IHTKSRATAR IRMASQP

« Hide

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH933807 Genomic DNA. Translation: EDW12691.1.
RefSeq	XP_002003249.1. XM_002003213.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0168537; FBpp0167029; FBgn0140553.
GeneID	6577282.
KEGG	dmo:Dmoj_GI17812.
Organism-specific databases
FlyBase	FBgn0140553. Dmoj\GI17812.
Phylogenomic databases
InParanoid	B4KKM7.
KO	K13253.
OrthoDB	EOG4CC2G5.
Family and domain databases
Gene3D	1.20.990.10. 1 hit. 3.90.340.10. 1 hit.
InterPro	IPR003097. FAD-binding_1. IPR017927. Fd_Rdtase_FAD-bd. IPR001094. Flavdoxin. IPR008254. Flavodoxin/NO_synth. IPR001709. Flavoprot_Pyr_Nucl_cyt_Rdtase. IPR023173. NADPH_Cyt_P450_Rdtase_dom3. IPR004030. NO_synthase_oxygenase_dom. IPR026009. NOS. IPR012144. NOS_met. IPR001433. OxRdtase_FAD/NAD-bd. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view]
PANTHER	PTHR19384:SF5. PTHR19384:SF5. 1 hit.
Pfam	PF00667. FAD_binding_1. 1 hit. PF00258. Flavodoxin_1. 1 hit. PF00175. NAD_binding_1. 1 hit. PF02898. NO_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF000333. NOS. 1 hit.
PRINTS	PR00369. FLAVODOXIN. PR00371. FPNCR.
SUPFAM	SSF56512. NO_synthase_oxygenase_reg. 1 hit. SSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITE	PS51384. FAD_FR. 1 hit. PS50902. FLAVODOXIN_LIKE. 1 hit. PS60001. NOS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4KKM7_DROMO

Accession

Primary (citable) accession number: B4KKM7

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	March 6, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Names·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

Entry information