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Protein

DNA ligase

Gene

Dmoj\GI24375

Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dmoj\GI24375Imported
ORF Names:Dmoj_GI24375Imported, GI24375Imported
OrganismiDrosophila mojavensis (Fruit fly)Imported
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0147098. Dmoj\GI24375.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini360 – 494DNA_LIGASE_A3InterPro annotationAdd BLAST135
Domaini722 – 810BRCTInterPro annotationAdd BLAST89

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiB4KAY0.
KOiK10776.
OrthoDBiEOG091G0XBU.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4KAY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLLANNCR IANIPRIWTR TMGSKHVENE DNKLDTFRRV CDEIAAESSY
60 70 80 90 100
LRKVEKLELF FKKGSSGAGF EGDLLQWVQF LIPDSTQRVY NLQNKALLKL
110 120 130 140 150
FARIFHVDQQ EMHLDLEQDG DISETLRKHF ATSSKLKPQT QSKLYLHEVE
160 170 180 190 200
KMLCQLEQRT KEDEQTEVLQ KLCKQATDLD LRTFIRLIKQ DLRINARARH
210 220 230 240 250
ILDAFGPQAY PAYQSSRDLA AIVQNFAGKE GTSLKTPIKA TAKKAKKDTS
260 270 280 290 300
AIQVMTPISP MLANACKSVE EAFKKNPGGL YSEIKYDGER VQIHKKGAEF
310 320 330 340 350
KFFSRNLKPV MDHKIKDLKD YIPRAFPGAG DMILDSEIIL VDTETGALLP
360 370 380 390 400
FGTLGAHKKH TYANASICLF VFDCLLYDGD DLTQLAFCKR REILEQNIQP
410 420 430 440 450
IKSHVQLSES EFLKTKNELA LMTAKVLQAN LEGVVLKSPS STYQPGKRNW
460 470 480 490 500
LKVKKDYLFG GKMADTADLV VLGAWYGSGK KGGVLSIFLM GCYDARDHLW
510 520 530 540 550
KTVTKVHSGL DDATNDEIHE ELMKLTKRAD ANNIPNWLHC KKALIPDVLA
560 570 580 590 600
KTPEKMPVWE ITGAEFTQSE AHTAGGISIR FPRITRLRSD KCAKEANDLA
610 620 630 640 650
HLEQLYAASK NNVNVDLLLA NCNADNDDAQ TNGLKLEKTP QKGKGSKETA
660 670 680 690 700
SSSKKGKRSK SGGSDDEQAT PSKGPRKLAK VEPSAAASKG SLMDFFKPKK
710 720 730 740 750
TTPAVKVESK SSEDVKAEVK GEVSNLFRGQ VAYFAADAAQ SKHKDAFIRN
760 770 780 790 800
GGILSENSRE ANLVFHSTTK NVNLAELRPL YRRSCRHLSV KWLEESLQAK
810
KLQPYPLYAV VLKA
Length:814
Mass (Da):91,095
Last modified:January 20, 2016 - v2
Checksum:iA72AEE879CC9E917
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW14658.2.
RefSeqiXP_001999197.2. XM_001999161.2.

Genome annotation databases

EnsemblMetazoaiFBtr0175100; FBpp0173592; FBgn0147098.
GeneIDi6573106.
KEGGidmo:Dmoj_GI24375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW14658.2.
RefSeqiXP_001999197.2. XM_001999161.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0175100; FBpp0173592; FBgn0147098.
GeneIDi6573106.
KEGGidmo:Dmoj_GI24375.

Organism-specific databases

FlyBaseiFBgn0147098. Dmoj\GI24375.

Phylogenomic databases

InParanoidiB4KAY0.
KOiK10776.
OrthoDBiEOG091G0XBU.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4KAY0_DROMO
AccessioniPrimary (citable) accession number: B4KAY0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: November 2, 2016
This is version 53 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.