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Protein

DNA ligase

Gene

Dmoj\GI24375

Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dmoj\GI24375Imported
ORF Names:Dmoj_GI24375Imported, GI24375Imported
OrganismiDrosophila mojavensis (Fruit fly)Imported
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0147098. Dmoj\GI24375.

Structurei

3D structure databases

ProteinModelPortaliB4KAY0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

InParanoidiB4KAY0.
KOiK10776.
OMAiMILDSEI.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4KAY0.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4KAY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKHVENED NKLDTFRRVC DEIAAESSYL RKVEKLELFF KKGSSGAGFE
60 70 80 90 100
GDLLQWVQFL IPDSTQRVYN LQNKALLKLF ARIFHVDQQE MHLDLEQDGD
110 120 130 140 150
ISETLRKHFA TSSKLKPQTQ SKLYLHEVEK MLCQLEQRTK EDEQTEVLQK
160 170 180 190 200
LCKQATDLDL RTFIRLIKQD LRINARARHI LDAFGPQAYP AYQSSRDLAA
210 220 230 240 250
IVQNFAGKEG TSLKTPIKAT AKKAKKDTSA IQVMTPISPM LANACKSVEE
260 270 280 290 300
AFKKNPGGLY SEIKYDGERV QIHKKGAEFK FFSRNLKPVM DHKIKDLKDY
310 320 330 340 350
IPRAFPGAGD MILDSEIILV DTETGALLPF GTLGAHKKHT YANASICLFV
360 370 380 390 400
FDCLLYDGDD LTQLAFCKRR EILEQNIQPI KSHVQLSESE FLKTKNELAL
410 420 430 440 450
MTAKVLQANL EGVVLKSPSS TYQPGKRNWL KVKKDYLFGG KMADTADLVV
460 470 480 490 500
LGAWYGSGKK GGVLSIFLMG CYDARDHLWK TVTKVHSGLD DATNDEIHEE
510 520 530 540 550
LMKLTKRADA NNIPNWLHCK KALIPDVLAK TPEKMPVWEI TGAEFTQSEA
560 570 580 590 600
HTAGGISIRF PRITRLRSDK CAKEANDLAH LEQLYAASKN NVNVDLLLAN
610 620 630 640 650
CNADNDDAQT NGLKLEKTPQ KGKGSKETAS SSKKGKRSKS GGSDDEQATP
660 670 680 690 700
SKGPRKLAKV EPSAAASKGS LMDFFKPKKT TPAVKVESKS SEDVKAEVKG
710 720 730 740 750
EVSNLFRGQV AYFAADAAQS KHKDAFIRNG GILSENSREA NLVFHSTTKN
760 770 780 790
VNLAELRPLY RRSCRHLSVK WLEESLQAKK LQPYPLYAVV LKA
Length:793
Mass (Da):88,615
Last modified:September 23, 2008 - v1
Checksum:i51A29C5F515A547E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW14658.1.
RefSeqiXP_001999197.1. XM_001999161.1.

Genome annotation databases

EnsemblMetazoaiFBtr0175100; FBpp0173592; FBgn0147098.
GeneIDi6573106.
KEGGidmo:Dmoj_GI24375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW14658.1.
RefSeqiXP_001999197.1. XM_001999161.1.

3D structure databases

ProteinModelPortaliB4KAY0.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0175100; FBpp0173592; FBgn0147098.
GeneIDi6573106.
KEGGidmo:Dmoj_GI24375.

Organism-specific databases

FlyBaseiFBgn0147098. Dmoj\GI24375.

Phylogenomic databases

InParanoidiB4KAY0.
KOiK10776.
OMAiMILDSEI.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4KAY0.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF52113. SSF52113. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22Imported.

Entry informationi

Entry nameiB4KAY0_DROMO
AccessioniPrimary (citable) accession number: B4KAY0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: February 4, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.