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B4K9L4

- PDE6_DROMO

UniProt

B4K9L4 - PDE6_DROMO

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei717 – 7171Proton donorBy similarity
Metal bindingi721 – 7211Divalent metal cation 1By similarity
Metal bindingi757 – 7571Divalent metal cation 1By similarity
Metal bindingi758 – 7581Divalent metal cation 1By similarity
Metal bindingi758 – 7581Divalent metal cation 2By similarity
Metal bindingi868 – 8681Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GI10668
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0133432. Dmoj\GI10668.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11131113cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363690Add
BLAST
Propeptidei1114 – 11163Removed in mature formBy similarityPRO_0000363691

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1113 – 11131Cysteine methyl esterBy similarity
Lipidationi1113 – 11131S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4K9L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini241 – 393153GAF 1Sequence AnalysisAdd
BLAST
Domaini425 – 611187GAF 2Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 7431Thr-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiB4K9L4.
KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4K9L4.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4K9L4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVSATTGR AGDRVSSTSS EVAVETTSQA LTNGAAKEPL AAVTAEATAT
60 70 80 90 100
ATVTATTTAT VTATTTAATA TMATAVISKQ AKSECHSQSN NNQHVETAPS
110 120 130 140 150
KQSSDSEASA PTTVSIPSAN AKINSSSSGK TTATQQDVDE VARLFEEKPE
160 170 180 190 200
AFEKWLTERA PPEALSRLHE FIESRKPHKR PSVTSDLFQQ WMASPTVQQK
210 220 230 240 250
SPRKLSNSSV HALPESRRHL MELDEGELFM ELIRDVANEL DIDVLCHKIL
260 270 280 290 300
VNVGLLTHAD RGSLFLAKGT PNNRYLVAKL FDVTQTTALK DAVTRARAEE
310 320 330 340 350
IIIPFGIGIA GMVAQTKQMI NIKEAYKDAR FNCEIDLKTG YTTNAILCMP
360 370 380 390 400
ICNYEGDIIG VAQIINKTNG CMEFDEHDVE IFRRYLTFCG IGIQNAQLFE
410 420 430 440 450
MSVQEYRRNQ ILLNLARSIF EEQNNLECLV TKIMTEAREL LKCERCSVFL
460 470 480 490 500
VDLDCCEESH LEKIIEKPHQ LQQQRTPRAI MSGDSFEEKQ NMRNRFTVLF
510 520 530 540 550
ELGGENHAAN VSRPSINDLS HSTLAQIAQF VATTGQTVNI CDVQDWVREH
560 570 580 590 600
NQIRAESEID STQAILCMPI VNAQKTVIGV AQLINKASGL PFTESDASIF
610 620 630 640 650
EAFAIFCGLG IHNTQMYENA CKLMAKQKVA LECLSYHATA SQDQTEKLAQ
660 670 680 690 700
DVIAEAEAYN LYSFTFTDFD LVDDDTCRAV LRMFMQCNLV SQFHIPYDVL
710 720 730 740 750
CRWVLSVRKN YRPVKYHNWR HALNVAQTMF AMLKTGKMER FMTDLEILGL
760 770 780 790 800
LVACLCHDLD HRGTNNAFQT KTESPLAILY TTSTMEHHHF DQCVMILNSE
810 820 830 840 850
GNNIFQALSP EDYRSVMKTV ESAILSTDLA MYFKKRNAFL ELVENGEFDW
860 870 880 890 900
QGEEKKDLLC GMMMTACDVS AIAKPWEVQH RVAKLVADEF FDQGDLEKLQ
910 920 930 940 950
LNTQPVAMMD RERKDELPKM QVGFIDVICL PLYRVLCDTF PWITPLYEGT
960 970 980 990 1000
LENRRNWQDL AEKVEMGLTW IDHDTIDKPV EEFAGCADEE IKDIEFTVTT
1010 1020 1030 1040 1050
LNCNQHGGSA GGGEDTHTPE HQRSSSRLSI KKTGALGKVV RSKLSKTLYN
1060 1070 1080 1090 1100
SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPHSGSVGR MSASSSTSSA
1110
GTVDKSKKRS KLCALL
Length:1,116
Mass (Da):124,330
Last modified:September 23, 2008 - v1
Checksum:i53186D5E1651993E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933806 Genomic DNA. Translation: EDW16674.1.
RefSeqiXP_002001213.1. XM_002001177.1.

Genome annotation databases

EnsemblMetazoaiFBtr0161393; FBpp0159885; FBgn0133432.
GeneIDi6575197.
KEGGidmo:Dmoj_GI10668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933806 Genomic DNA. Translation: EDW16674.1 .
RefSeqi XP_002001213.1. XM_002001177.1.

3D structure databases

ProteinModelPortali B4K9L4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0161393 ; FBpp0159885 ; FBgn0133432 .
GeneIDi 6575197.
KEGGi dmo:Dmoj_GI10668.

Organism-specific databases

FlyBasei FBgn0133432. Dmoj\GI10668.

Phylogenomic databases

InParanoidi B4K9L4.
KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4K9L4.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22Imported.

Entry informationi

Entry nameiPDE6_DROMO
AccessioniPrimary (citable) accession number: B4K9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3