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B4K9L4

- PDE6_DROMO

UniProt

B4K9L4 - PDE6_DROMO

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene
Pde6, GI10668
Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei717 – 7171Proton donor By similarity
Metal bindingi721 – 7211Divalent metal cation 1 By similarity
Metal bindingi757 – 7571Divalent metal cation 1 By similarity
Metal bindingi758 – 7581Divalent metal cation 1 By similarity
Metal bindingi758 – 7581Divalent metal cation 2 By similarity
Metal bindingi868 – 8681Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GI10668
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0133432. Dmoj\GI10668.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11131113cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarityPRO_0000363690Add
BLAST
Propeptidei1114 – 11163Removed in mature form By similarityBy similarityPRO_0000363691

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1113 – 11131Cysteine methyl ester By similarityBy similarity
Lipidationi1113 – 11131S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4K9L4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini241 – 393153GAF 1Add
BLAST
Domaini425 – 611187GAF 2Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi44 – 7431Thr-richAdd
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiB4K9L4.
KOiK13763.
OrthoDBiEOG7RRF69.
PhylomeDBiB4K9L4.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4K9L4-1 [UniParc]FASTAAdd to Basket

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MTDVSATTGR AGDRVSSTSS EVAVETTSQA LTNGAAKEPL AAVTAEATAT     50
ATVTATTTAT VTATTTAATA TMATAVISKQ AKSECHSQSN NNQHVETAPS 100
KQSSDSEASA PTTVSIPSAN AKINSSSSGK TTATQQDVDE VARLFEEKPE 150
AFEKWLTERA PPEALSRLHE FIESRKPHKR PSVTSDLFQQ WMASPTVQQK 200
SPRKLSNSSV HALPESRRHL MELDEGELFM ELIRDVANEL DIDVLCHKIL 250
VNVGLLTHAD RGSLFLAKGT PNNRYLVAKL FDVTQTTALK DAVTRARAEE 300
IIIPFGIGIA GMVAQTKQMI NIKEAYKDAR FNCEIDLKTG YTTNAILCMP 350
ICNYEGDIIG VAQIINKTNG CMEFDEHDVE IFRRYLTFCG IGIQNAQLFE 400
MSVQEYRRNQ ILLNLARSIF EEQNNLECLV TKIMTEAREL LKCERCSVFL 450
VDLDCCEESH LEKIIEKPHQ LQQQRTPRAI MSGDSFEEKQ NMRNRFTVLF 500
ELGGENHAAN VSRPSINDLS HSTLAQIAQF VATTGQTVNI CDVQDWVREH 550
NQIRAESEID STQAILCMPI VNAQKTVIGV AQLINKASGL PFTESDASIF 600
EAFAIFCGLG IHNTQMYENA CKLMAKQKVA LECLSYHATA SQDQTEKLAQ 650
DVIAEAEAYN LYSFTFTDFD LVDDDTCRAV LRMFMQCNLV SQFHIPYDVL 700
CRWVLSVRKN YRPVKYHNWR HALNVAQTMF AMLKTGKMER FMTDLEILGL 750
LVACLCHDLD HRGTNNAFQT KTESPLAILY TTSTMEHHHF DQCVMILNSE 800
GNNIFQALSP EDYRSVMKTV ESAILSTDLA MYFKKRNAFL ELVENGEFDW 850
QGEEKKDLLC GMMMTACDVS AIAKPWEVQH RVAKLVADEF FDQGDLEKLQ 900
LNTQPVAMMD RERKDELPKM QVGFIDVICL PLYRVLCDTF PWITPLYEGT 950
LENRRNWQDL AEKVEMGLTW IDHDTIDKPV EEFAGCADEE IKDIEFTVTT 1000
LNCNQHGGSA GGGEDTHTPE HQRSSSRLSI KKTGALGKVV RSKLSKTLYN 1050
SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPHSGSVGR MSASSSTSSA 1100
GTVDKSKKRS KLCALL 1116
Length:1,116
Mass (Da):124,330
Last modified:September 23, 2008 - v1
Checksum:i53186D5E1651993E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933806 Genomic DNA. Translation: EDW16674.1.
RefSeqiXP_002001213.1. XM_002001177.1.

Genome annotation databases

EnsemblMetazoaiFBtr0161393; FBpp0159885; FBgn0133432.
GeneIDi6575197.
KEGGidmo:Dmoj_GI10668.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933806 Genomic DNA. Translation: EDW16674.1 .
RefSeqi XP_002001213.1. XM_002001177.1.

3D structure databases

ProteinModelPortali B4K9L4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0161393 ; FBpp0159885 ; FBgn0133432 .
GeneIDi 6575197.
KEGGi dmo:Dmoj_GI10668.

Organism-specific databases

FlyBasei FBgn0133432. Dmoj\GI10668.

Phylogenomic databases

InParanoidi B4K9L4.
KOi K13763.
OrthoDBi EOG7RRF69.
PhylomeDBi B4K9L4.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22.

Entry informationi

Entry nameiPDE6_DROMO
AccessioniPrimary (citable) accession number: B4K9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi