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B4K9L4

- PDE6_DROMO

UniProt

B4K9L4 - PDE6_DROMO

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei717 – 7171Proton donorBy similarity
    Metal bindingi721 – 7211Divalent metal cation 1By similarity
    Metal bindingi757 – 7571Divalent metal cation 1By similarity
    Metal bindingi758 – 7581Divalent metal cation 1By similarity
    Metal bindingi758 – 7581Divalent metal cation 2By similarity
    Metal bindingi868 – 8681Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GI10668
    OrganismiDrosophila mojavensis (Fruit fly)
    Taxonomic identifieri7230 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000009192: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0133432. Dmoj\GI10668.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11131113cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363690Add
    BLAST
    Propeptidei1114 – 11163Removed in mature formBy similarityPRO_0000363691

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1113 – 11131Cysteine methyl esterBy similarity
    Lipidationi1113 – 11131S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB4K9L4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini241 – 393153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini425 – 611187GAF 2Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi44 – 7431Thr-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    InParanoidiB4K9L4.
    KOiK13763.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB4K9L4.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4K9L4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVSATTGR AGDRVSSTSS EVAVETTSQA LTNGAAKEPL AAVTAEATAT     50
    ATVTATTTAT VTATTTAATA TMATAVISKQ AKSECHSQSN NNQHVETAPS 100
    KQSSDSEASA PTTVSIPSAN AKINSSSSGK TTATQQDVDE VARLFEEKPE 150
    AFEKWLTERA PPEALSRLHE FIESRKPHKR PSVTSDLFQQ WMASPTVQQK 200
    SPRKLSNSSV HALPESRRHL MELDEGELFM ELIRDVANEL DIDVLCHKIL 250
    VNVGLLTHAD RGSLFLAKGT PNNRYLVAKL FDVTQTTALK DAVTRARAEE 300
    IIIPFGIGIA GMVAQTKQMI NIKEAYKDAR FNCEIDLKTG YTTNAILCMP 350
    ICNYEGDIIG VAQIINKTNG CMEFDEHDVE IFRRYLTFCG IGIQNAQLFE 400
    MSVQEYRRNQ ILLNLARSIF EEQNNLECLV TKIMTEAREL LKCERCSVFL 450
    VDLDCCEESH LEKIIEKPHQ LQQQRTPRAI MSGDSFEEKQ NMRNRFTVLF 500
    ELGGENHAAN VSRPSINDLS HSTLAQIAQF VATTGQTVNI CDVQDWVREH 550
    NQIRAESEID STQAILCMPI VNAQKTVIGV AQLINKASGL PFTESDASIF 600
    EAFAIFCGLG IHNTQMYENA CKLMAKQKVA LECLSYHATA SQDQTEKLAQ 650
    DVIAEAEAYN LYSFTFTDFD LVDDDTCRAV LRMFMQCNLV SQFHIPYDVL 700
    CRWVLSVRKN YRPVKYHNWR HALNVAQTMF AMLKTGKMER FMTDLEILGL 750
    LVACLCHDLD HRGTNNAFQT KTESPLAILY TTSTMEHHHF DQCVMILNSE 800
    GNNIFQALSP EDYRSVMKTV ESAILSTDLA MYFKKRNAFL ELVENGEFDW 850
    QGEEKKDLLC GMMMTACDVS AIAKPWEVQH RVAKLVADEF FDQGDLEKLQ 900
    LNTQPVAMMD RERKDELPKM QVGFIDVICL PLYRVLCDTF PWITPLYEGT 950
    LENRRNWQDL AEKVEMGLTW IDHDTIDKPV EEFAGCADEE IKDIEFTVTT 1000
    LNCNQHGGSA GGGEDTHTPE HQRSSSRLSI KKTGALGKVV RSKLSKTLYN 1050
    SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPHSGSVGR MSASSSTSSA 1100
    GTVDKSKKRS KLCALL 1116
    Length:1,116
    Mass (Da):124,330
    Last modified:September 23, 2008 - v1
    Checksum:i53186D5E1651993E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933806 Genomic DNA. Translation: EDW16674.1.
    RefSeqiXP_002001213.1. XM_002001177.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0161393; FBpp0159885; FBgn0133432.
    GeneIDi6575197.
    KEGGidmo:Dmoj_GI10668.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933806 Genomic DNA. Translation: EDW16674.1 .
    RefSeqi XP_002001213.1. XM_002001177.1.

    3D structure databases

    ProteinModelPortali B4K9L4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0161393 ; FBpp0159885 ; FBgn0133432 .
    GeneIDi 6575197.
    KEGGi dmo:Dmoj_GI10668.

    Organism-specific databases

    FlyBasei FBgn0133432. Dmoj\GI10668.

    Phylogenomic databases

    InParanoidi B4K9L4.
    KOi K13763.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B4K9L4.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15081-1352.22Imported.

    Entry informationi

    Entry nameiPDE6_DROMO
    AccessioniPrimary (citable) accession number: B4K9L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3