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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei717Proton donorBy similarity1
Metal bindingi721Divalent metal cation 1By similarity1
Metal bindingi757Divalent metal cation 1By similarity1
Metal bindingi758Divalent metal cation 1By similarity1
Metal bindingi758Divalent metal cation 2By similarity1
Metal bindingi868Divalent metal cation 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandcGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GI10668
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0133432 Dmoj\GI10668

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003636901 – 1113cGMP-specific 3',5'-cyclic phosphodiesteraseAdd BLAST1113
PropeptideiPRO_00003636911114 – 1116Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1113Cysteine methyl esterBy similarity1
Lipidationi1113S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Expressioni

Gene expression databases

BgeeiFBgn0133432

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4K9L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 393GAF 1Sequence analysisAdd BLAST153
Domaini425 – 611GAF 2Sequence analysisAdd BLAST187
Domaini641 – 964PDEasePROSITE-ProRule annotationAdd BLAST324

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 74Thr-richSequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence analysis

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiB4K9L4
KOiK13763
OMAiATIRMFK
OrthoDBiEOG091G04JU
PhylomeDBiB4K9L4

Family and domain databases

CDDicd00077 HDc, 1 hit
Gene3Di1.10.1300.101 hit
3.30.450.401 hit
InterProiView protein in InterPro
IPR003018 GAF
IPR029016 GAF-like_dom_sf
IPR003607 HD/PDEase_dom
IPR023088 PDEase
IPR002073 PDEase_catalytic_dom
IPR036971 PDEase_catalytic_dom_sf
IPR023174 PDEase_CS
PfamiView protein in Pfam
PF01590 GAF, 2 hits
PF00233 PDEase_I, 1 hit
PRINTSiPR00387 PDIESTERASE1
SMARTiView protein in SMART
SM00065 GAF, 2 hits
SM00471 HDc, 1 hit
PROSITEiView protein in PROSITE
PS00126 PDEASE_I_1, 1 hit
PS51845 PDEASE_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4K9L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDVSATTGR AGDRVSSTSS EVAVETTSQA LTNGAAKEPL AAVTAEATAT
60 70 80 90 100
ATVTATTTAT VTATTTAATA TMATAVISKQ AKSECHSQSN NNQHVETAPS
110 120 130 140 150
KQSSDSEASA PTTVSIPSAN AKINSSSSGK TTATQQDVDE VARLFEEKPE
160 170 180 190 200
AFEKWLTERA PPEALSRLHE FIESRKPHKR PSVTSDLFQQ WMASPTVQQK
210 220 230 240 250
SPRKLSNSSV HALPESRRHL MELDEGELFM ELIRDVANEL DIDVLCHKIL
260 270 280 290 300
VNVGLLTHAD RGSLFLAKGT PNNRYLVAKL FDVTQTTALK DAVTRARAEE
310 320 330 340 350
IIIPFGIGIA GMVAQTKQMI NIKEAYKDAR FNCEIDLKTG YTTNAILCMP
360 370 380 390 400
ICNYEGDIIG VAQIINKTNG CMEFDEHDVE IFRRYLTFCG IGIQNAQLFE
410 420 430 440 450
MSVQEYRRNQ ILLNLARSIF EEQNNLECLV TKIMTEAREL LKCERCSVFL
460 470 480 490 500
VDLDCCEESH LEKIIEKPHQ LQQQRTPRAI MSGDSFEEKQ NMRNRFTVLF
510 520 530 540 550
ELGGENHAAN VSRPSINDLS HSTLAQIAQF VATTGQTVNI CDVQDWVREH
560 570 580 590 600
NQIRAESEID STQAILCMPI VNAQKTVIGV AQLINKASGL PFTESDASIF
610 620 630 640 650
EAFAIFCGLG IHNTQMYENA CKLMAKQKVA LECLSYHATA SQDQTEKLAQ
660 670 680 690 700
DVIAEAEAYN LYSFTFTDFD LVDDDTCRAV LRMFMQCNLV SQFHIPYDVL
710 720 730 740 750
CRWVLSVRKN YRPVKYHNWR HALNVAQTMF AMLKTGKMER FMTDLEILGL
760 770 780 790 800
LVACLCHDLD HRGTNNAFQT KTESPLAILY TTSTMEHHHF DQCVMILNSE
810 820 830 840 850
GNNIFQALSP EDYRSVMKTV ESAILSTDLA MYFKKRNAFL ELVENGEFDW
860 870 880 890 900
QGEEKKDLLC GMMMTACDVS AIAKPWEVQH RVAKLVADEF FDQGDLEKLQ
910 920 930 940 950
LNTQPVAMMD RERKDELPKM QVGFIDVICL PLYRVLCDTF PWITPLYEGT
960 970 980 990 1000
LENRRNWQDL AEKVEMGLTW IDHDTIDKPV EEFAGCADEE IKDIEFTVTT
1010 1020 1030 1040 1050
LNCNQHGGSA GGGEDTHTPE HQRSSSRLSI KKTGALGKVV RSKLSKTLYN
1060 1070 1080 1090 1100
SMDGSKPKTS LKLLESHVSE DMDDKSPTSP SQPHSGSVGR MSASSSTSSA
1110
GTVDKSKKRS KLCALL
Length:1,116
Mass (Da):124,330
Last modified:September 23, 2008 - v1
Checksum:i53186D5E1651993E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA Translation: EDW16674.1
RefSeqiXP_002001213.2, XM_002001177.2

Genome annotation databases

EnsemblMetazoaiFBtr0429027; FBpp0386515; FBgn0133432
GeneIDi6575197
KEGGidmo:Dmoj_GI10668

Similar proteinsi

Entry informationi

Entry nameiPDE6_DROMO
AccessioniPrimary (citable) accession number: B4K9L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome