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Protein

Histone-lysine N-methyltransferase

Gene

Dmoj\GI22805

Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei624S-adenosyl-L-methioninePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationImported, Transferase
LigandS-adenosyl-L-methioninePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:Dmoj\GI22805Imported
ORF Names:Dmoj_GI22805Imported, GI22805Imported
OrganismiDrosophila mojavensis (Fruit fly)Imported
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0145532 Dmoj\GI22805

Subcellular locationi

Expressioni

Gene expression databases

BgeeiFBgn0145532

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini569 – 690SETInterPro annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni579 – 581S-adenosyl-L-methionine bindingPROSITE-ProRule annotation3
Regioni651 – 652S-adenosyl-L-methionine bindingPROSITE-ProRule annotation2

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. PR/SET subfamily.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiB4K849
KOiK11428
OrthoDBiEOG091G0UBI

Family and domain databases

InterProiView protein in InterPro
IPR016858 Hist_H4-K20_MeTrfase
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS51571 SAM_MT43_PR_SET, 1 hit
PS50280 SET, 1 hit

Sequencei

Sequence statusi: Complete.

B4K849-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMVRRRARP VKEAALVVVT SDRVASNSDS ALALPFNGEP ISAVAAAATN
60 70 80 90 100
NLLDDQYFAS PKRKDCRLMK AHENLSKDKN GKANGGNSTK SETDRIIGVQ
110 120 130 140 150
LATRSQTRTI ENFFKASAAA KSKKKNGALS ETSVGKETIA EKKTITLIDE
160 170 180 190 200
LEVDEEEELL LYDQHSIASP STSTSSPAYQ NDDLEVENSY DPGCNYTPTD
210 220 230 240 250
IDTHIQIDAH TQTETGIPTD THTQTEQRDE SPTNTTAFQT HRSALRDSHS
260 270 280 290 300
SSHSSSSAAT SDNIFLQEPV LTLDIDRTPT KASSIRINKS FELANAVFSS
310 320 330 340 350
PPSVLSACVL NGRFNQIVTL NGHGHGHGEE VEHEQEQHQM QQPLGGYELD
360 370 380 390 400
QHDSSSCDSG VACSLTTGTS PAVAANRRRK PATPHRILCP SPIKTMPRDT
410 420 430 440 450
ALVKGETLSP RKSPRKLQMQ LAASGASKSR RRLNQPKPQA PYQQQQQQQQ
460 470 480 490 500
QHNHISNEDV VLVDDEDEED DVHALLKAAE ERENLNKTKA MLKPAAVTAT
510 520 530 540 550
AAAKPKASST KPAKAKTMAA KSVPLAATNG NREMTEFFPV RRSVRKTKTA
560 570 580 590 600
VKEEMMRNLE QAVLEERCDG LQVRHFMGKG RGVVAIRRFK RNEFVVEYVG
610 620 630 640 650
DLISISEATE RERRYALDEN AGCYMYYFKH KNQQYCIDAT IDTGKLGRLI
660 670 680 690 700
NHSRNGNLVT KVVVIKQRPH LVLLAKDDIE IGEELTYDYG DRSKESLLHH

PWLAF
Length:705
Mass (Da):78,014
Last modified:January 20, 2016 - v2
Checksum:iDE892DA928C18652
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA Translation: EDW15403.2
CH933806 Genomic DNA Translation: KRG01541.1
RefSeqiXP_001999942.2, XM_001999906.2
XP_015022647.1, XM_015167161.1

Genome annotation databases

EnsemblMetazoaiFBtr0173530; FBpp0172022; FBgn0145532
FBtr0424059; FBpp0381945; FBgn0145532
GeneIDi6573883
KEGGidmo:Dmoj_GI22805

Similar proteinsi

Entry informationi

Entry nameiB4K849_DROMO
AccessioniPrimary (citable) accession number: B4K849
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: February 28, 2018
This is version 50 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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