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Protein

Delta-like protein

Gene

Dmoj\GI10494

Organism
Drosophila mojavensis (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:Dmoj\GI10494Imported
ORF Names:Dmoj_GI10494Imported, GI10494Imported
OrganismiDrosophila mojavensis (Fruit fly)Imported
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0133258. Dmoj\GI10494.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1197 – 122024HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini198 – 24245DSLInterPro annotationAdd
BLAST
Domaini243 – 27634EGF-likeInterPro annotationAdd
BLAST
Domaini310 – 34839EGF-likeInterPro annotationAdd
BLAST
Domaini465 – 50137EGF-likeInterPro annotationAdd
BLAST
Domaini549 – 58638EGF-likeInterPro annotationAdd
BLAST
Domaini588 – 62336EGF-likeInterPro annotationAdd
BLAST
Domaini625 – 66137EGF-likeInterPro annotationAdd
BLAST
Domaini663 – 69836EGF-likeInterPro annotationAdd
BLAST
Domaini733 – 76836EGF-likeInterPro annotationAdd
BLAST
Domaini770 – 80637EGF-likeInterPro annotationAdd
BLAST
Domaini808 – 84841EGF-likeInterPro annotationAdd
BLAST
Domaini850 – 88637EGF-likeInterPro annotationAdd
BLAST
Domaini888 – 92437EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.UniRule annotation
Contains 14 EGF-like domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

InParanoidiB4K756.
KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4K756-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAARQRQRQ RLRSLIDDCR SLKSACNLIA LILILLVHKI SAAGNFELEI
60 70 80 90 100
LEISNTNSHL LSGYCCGMPS ELRATKTTGC SPCTTAFRLC LKEYQTTEQG
110 120 130 140 150
VSISTGCSFG NSTTKILGGS SFVLSDPGVG AIVLPFTFRW TKSFTLILQA
160 170 180 190 200
LDMYNTSYPD AERLIEETSY SGVILPSPEW KTLDHIGRNA RITYRVRVQC
210 220 230 240 250
AVTYYNTTCT TFCRPRDDQF GHYACGSEGQ KLCLNGWQGV NCEKAICKPG
260 270 280 290 300
CDPIHGKCDR PGECECRPGW RGPLCNECMV YPGCKHGSCN GSAWKCVCDT
310 320 330 340 350
NWGGILCDQD LNYCGTHEPC KHGGTCENTA PDQYRCTCAE GLSGEQCEIV
360 370 380 390 400
EHPCATQPCR NGGTCTLKLT NATRQPPTYR AMRGMSSSMG KPISRRNSIR
410 420 430 440 450
SLVGLFPEAQ NASSTASSSS SNISSSSSNG NDSQQQQQQQ QLPPLAAEFT
460 470 480 490 500
CGCVAGWTGP TCEINIDECA GGPCEHGGTC VDLIGGFRCE CPPEWRGDVC
510 520 530 540 550
QMDVNECEAS YAAALPANAL LTTTASAIIG SNLSSSAALL AALTSAVAAS
560 570 580 590 600
NSVATHGPCI NARECLNLPG SFSCLCLEGW GGATCAENLD DCVGQCKNGA
610 620 630 640 650
SCIDLVNDYR CACAAGYTGR DCETDIDECA NSPCRNGGEC VDMIGKFNCI
660 670 680 690 700
CPLGYSGSLC EEAKDHCTPS PCLQGRCLNT PGSYYCHCPP DRAGKHCEQL
710 720 730 740 750
RPLCSQPPCN EGCFANVSTV ATTTITKTTK TKTTTPGGQP CSGHGSCEMS
760 770 780 790 800
DVGTFCKCHV GHTGTFCEHN LNECSPNPCR NAGICLDGDG DFTCECMSGW
810 820 830 840 850
TGKRCSERAT VCYAGQCQNG GTCMPGAPDK ALQPHCRCAP GWTGLFCAEA
860 870 880 890 900
IDQCRGQPCH NGGTCESGAG WFRCLCAQGF SGPDCRINVN ECSPQPCQGG
910 920 930 940 950
ATCIDGIGGY TCICPPGRHG LRCEILLSDP KSACLNASNT ISPYMALNQS
960 970 980 990 1000
QSWLDVALSG RSEEDEHCNA CVCENGTSRC TNLWCGLPNC FKLDPLSKSS
1010 1020 1030 1040 1050
NLSGVCKQHE VCVPALGETC LSPPCTVRGD CRALEPSRRV APPRLPAKAS
1060 1070 1080 1090 1100
CWPNQALVNE NCARLTILLD LERVGKGATI EGLCSLVRVL LAARLIKQPQ
1110 1120 1130 1140 1150
MSPSGLVEEE GMLMVLCDLK TGTNDTIELT VSSSKLNDQQ LPVAVSLLGE
1160 1170 1180 1190 1200
LLSSRQLSGI QRRNELQLQH AKLAVLTSIL EVKLETARVA DGNSHSLLIG
1210 1220 1230 1240 1250
VLCGIFIVLV GFSIFITLYW KQRLAYRSSS GMNLTPPMDA LRHEEEKSNN
1260 1270 1280 1290 1300
LQNEENLRRY TNPLKGSTSS LRAGTGMELS LNPAPELAAT AASSSALHRS
1310 1320 1330 1340 1350
QPLFPPCDFE RELDVSTGLK QAHKRSSQIL LQKTQNLDMK KNTVGSLESP
1360 1370 1380
RKDFGKRSIN CKSLPPPASD ESGDVLTTVV V
Length:1,381
Mass (Da):147,860
Last modified:January 20, 2016 - v2
Checksum:i15AD9E85451B877E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW16369.2.
RefSeqiXP_002000908.2. XM_002000872.2.

Genome annotation databases

EnsemblMetazoaiFBtr0161219; FBpp0159711; FBgn0133258.
GeneIDi6574880.
KEGGidmo:Dmoj_GI10494.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW16369.2.
RefSeqiXP_002000908.2. XM_002000872.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0161219; FBpp0159711; FBgn0133258.
GeneIDi6574880.
KEGGidmo:Dmoj_GI10494.

Organism-specific databases

FlyBaseiFBgn0133258. Dmoj\GI10494.

Phylogenomic databases

InParanoidiB4K756.
KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 7 hits.
PF12661. hEGF. 1 hit.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 12 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 Genomes Consortium
    Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.
    , Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22Imported.

Entry informationi

Entry nameiB4K756_DROMO
AccessioniPrimary (citable) accession number: B4K756
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: January 20, 2016
Last modified: June 8, 2016
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.