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Protein

Diacylglycerol kinase eta

Gene

GI24133

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 245Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 319Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GI24133
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0146856 Dmoj\GI24133

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003759881 – 1925Diacylglycerol kinase etaAdd BLAST1925

Keywords - PTMi

Phosphoprotein

Expressioni

Gene expression databases

BgeeiFBgn0146856

Structurei

3D structure databases

SMRiB4K6T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini82 – 175PHPROSITE-ProRule annotationAdd BLAST94
Domaini350 – 486DAGKcPROSITE-ProRule annotationAdd BLAST137
Domaini1862 – 1925SAMPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1131 – 1187Thr-richSequence analysisAdd BLAST57

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 245Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri268 – 319Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiB4K6T8
KOiK00901
OMAiEYYTEKC
OrthoDBiEOG091G07HR
PhylomeDBiB4K6T8

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.30.29.301 hit
3.40.50.103301 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
PF00169 PH, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF111331 SSF111331, 2 hits
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

B4K6T8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLKPNTLH VDNLSPRQRS LSSGLSSACS SGSVSPVPII PIISISRDGE
60 70 80 90 100
ESETESEIEP EPARIFHRRM STHSKRNNNL SAIIREGYLM KHTWSFQRWR
110 120 130 140 150
RRYFRLKRSY LYYAKDAKCD VFDEIDLSEL CYFECSIKNV NHSFQIITPT
160 170 180 190 200
RSLVLCADSR REMEDWLGSL KTATAPQRPR GDSFLIDQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK AIANCKWTTL
260 270 280 290 300
ATVGKDIIEQ PDGSLIMPHQ WMEGNLPVSA VCAVCKKTCG SVLRLQDWRC
310 320 330 340 350
LWCRDTVHVA CRPQMPIVCP IGPAKLSVVP PTSVHSISTD DAWDVVSPKG
360 370 380 390 400
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR
410 420 430 440 450
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG
460 470 480 490 500
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAITV PKMPKMSITT
510 520 530 540 550
EQEALLTGMV TSANHHLRFI VETNDTQTLI SSTRSLCDTV DELVSRICEH
560 570 580 590 600
HKDDEQLAMK CDILRQKLTM LLDALQEEEL GTHSGDDLVA TIRSLISRSG
610 620 630 640 650
PLTTARPSFL NPNISIEKTE KDNINSKERR NSRSLRSSEK EALQCRANSV
660 670 680 690 700
KRAIYNVVEH SEPGRPKRYQ RKLSITPFEA LKIPITNSGD STPCGSPLPI
710 720 730 740 750
IPPINIISPT METSRLTCIS PLPDTRRDSV DENFFNSINL PAPRQFADSR
760 770 780 790 800
RSSGVPEVIQ EMEEGASGET VYRVGRLSLS GGANIDDAGN RLSPSSEAGE
810 820 830 840 850
NTPTERKVDF LRVPIMTSEP IVDPLSNYRP IEVFERTYYM AREMDKDKER
860 870 880 890 900
TASGQVESEK EEADVNEKSE PQEPHRALVH TCNLQVPGIV VTPQSQNVYT
910 920 930 940 950
SENFTIIDTD AQTNTEQSSS EDLGGEASDV LSAISNEECS VASEIFDKPE
960 970 980 990 1000
SGHSLGDIIQ NLDANNFTHI DSPETSDETE PMPGESLMDD ISSVLGHDIT
1010 1020 1030 1040 1050
NALQDNTITD DTTTLCSEHA GPTKPPRKKS LSALVQSKTH PRRRNSSPPR
1060 1070 1080 1090 1100
KAGLARMDSD DNPQQFGFEN IVFEIDNRCD DQKIREPPRY CSLAQFVEGN
1110 1120 1130 1140 1150
DIARQSFKQL MLDRNSGDNH NDNGKNEEAD TPTNSAPTRT YRNLTTTTTS
1160 1170 1180 1190 1200
DELETAIKIE INNATTNTTT STSSSISTTT TTSTTSTVKP LESAMASSTS
1210 1220 1230 1240 1250
PTKKSGHGQE ISVVVRPPTP LRGDSVKPTA SSASSASLLA TSSSLLGVRT
1260 1270 1280 1290 1300
LNSSEIRRHS SHAPSLAVRD YDKDKDRRHS GFNPNFLTLD PEHARFLSSS
1310 1320 1330 1340 1350
PAASRRISCG SLFKKRNQKL NVKRTYGLFS VRFFVVAEPD IRLATLALIR
1360 1370 1380 1390 1400
PLIPLPNEAL PNLQTLKGSK SSLFMGSTLF GFEHFSAGDK DEKPGKDKER
1410 1420 1430 1440 1450
TPTEETNRKL PIINPIVRLP NWPNLANGTG FISKCLMANA DTLCAAVSPL
1460 1470 1480 1490 1500
MDPDETLLAG YHEKCVMNNY FGIGIDAKIS LDFHNKREEH PEKCRSRARN
1510 1520 1530 1540 1550
YMWYGVLGSK QLLQKTCKNL EQRVQLECDG QRIPLPELQG IVILNIPSFM
1560 1570 1580 1590 1600
GGTNFWGNSS KKEDIFLPPS FDDRVLEVVA VFGSVQMAAS RLINLQHHRI
1610 1620 1630 1640 1650
AQCQSVQINI LGDEEIPIQV DGEAWLQPPG MIRILHKNRV QMLCRNRSLE
1660 1670 1680 1690 1700
VSLKTWQEKQ RQHSISIQRD TSSTASEHAV STDEVISERE CYVLLNFIEA
1710 1720 1730 1740 1750
VSSLVKWVKF LIISHPALQH DLYEVACRAS EALESIHPQG KLLEGPSLRT
1760 1770 1780 1790 1800
KLVEVIDSSR QLYDDACTLL RDRGHSLILR EDLETKLSAA LANMEMELKK
1810 1820 1830 1840 1850
CSVQKCIDGK LRAYFNVLAP NEEPDGRRKS RPFWVRLRSG STAGQQQFKP
1860 1870 1880 1890 1900
PITNTREAAN NWSVNEVVTW LETMQLSEYV DSFLKNDIRG KELLTLGRRD
1910 1920
LKDLGVVKVG HVKRILQAIK DLSEN
Length:1,925
Mass (Da):214,943
Last modified:September 23, 2008 - v1
Checksum:i6D8E3E275A23BCF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA Translation: EDW14204.1
RefSeqiXP_001998743.2, XM_001998707.2

Genome annotation databases

GeneIDi6572637
KEGGidmo:Dmoj_GI24133

Similar proteinsi

Entry informationi

Entry nameiDGKH_DROMO
AccessioniPrimary (citable) accession number: B4K6T8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome