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B4K6T8

- DGKH_DROMO

UniProt

B4K6T8 - DGKH_DROMO

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Protein

Diacylglycerol kinase eta

Gene

GI24133

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GI24133
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0146856. Dmoj\GI24133.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19251925Diacylglycerol kinase etaPRO_0000375988Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHPROSITE-ProRule annotationAdd
BLAST
Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
BLAST
Domaini1862 – 192564SAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1131 – 118757Thr-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiB4K6T8.
KOiK00901.
OrthoDBiEOG7DVD9B.
PhylomeDBiB4K6T8.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4K6T8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MANLKPNTLH VDNLSPRQRS LSSGLSSACS SGSVSPVPII PIISISRDGE
60 70 80 90 100
ESETESEIEP EPARIFHRRM STHSKRNNNL SAIIREGYLM KHTWSFQRWR
110 120 130 140 150
RRYFRLKRSY LYYAKDAKCD VFDEIDLSEL CYFECSIKNV NHSFQIITPT
160 170 180 190 200
RSLVLCADSR REMEDWLGSL KTATAPQRPR GDSFLIDQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK AIANCKWTTL
260 270 280 290 300
ATVGKDIIEQ PDGSLIMPHQ WMEGNLPVSA VCAVCKKTCG SVLRLQDWRC
310 320 330 340 350
LWCRDTVHVA CRPQMPIVCP IGPAKLSVVP PTSVHSISTD DAWDVVSPKG
360 370 380 390 400
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR
410 420 430 440 450
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG
460 470 480 490 500
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAITV PKMPKMSITT
510 520 530 540 550
EQEALLTGMV TSANHHLRFI VETNDTQTLI SSTRSLCDTV DELVSRICEH
560 570 580 590 600
HKDDEQLAMK CDILRQKLTM LLDALQEEEL GTHSGDDLVA TIRSLISRSG
610 620 630 640 650
PLTTARPSFL NPNISIEKTE KDNINSKERR NSRSLRSSEK EALQCRANSV
660 670 680 690 700
KRAIYNVVEH SEPGRPKRYQ RKLSITPFEA LKIPITNSGD STPCGSPLPI
710 720 730 740 750
IPPINIISPT METSRLTCIS PLPDTRRDSV DENFFNSINL PAPRQFADSR
760 770 780 790 800
RSSGVPEVIQ EMEEGASGET VYRVGRLSLS GGANIDDAGN RLSPSSEAGE
810 820 830 840 850
NTPTERKVDF LRVPIMTSEP IVDPLSNYRP IEVFERTYYM AREMDKDKER
860 870 880 890 900
TASGQVESEK EEADVNEKSE PQEPHRALVH TCNLQVPGIV VTPQSQNVYT
910 920 930 940 950
SENFTIIDTD AQTNTEQSSS EDLGGEASDV LSAISNEECS VASEIFDKPE
960 970 980 990 1000
SGHSLGDIIQ NLDANNFTHI DSPETSDETE PMPGESLMDD ISSVLGHDIT
1010 1020 1030 1040 1050
NALQDNTITD DTTTLCSEHA GPTKPPRKKS LSALVQSKTH PRRRNSSPPR
1060 1070 1080 1090 1100
KAGLARMDSD DNPQQFGFEN IVFEIDNRCD DQKIREPPRY CSLAQFVEGN
1110 1120 1130 1140 1150
DIARQSFKQL MLDRNSGDNH NDNGKNEEAD TPTNSAPTRT YRNLTTTTTS
1160 1170 1180 1190 1200
DELETAIKIE INNATTNTTT STSSSISTTT TTSTTSTVKP LESAMASSTS
1210 1220 1230 1240 1250
PTKKSGHGQE ISVVVRPPTP LRGDSVKPTA SSASSASLLA TSSSLLGVRT
1260 1270 1280 1290 1300
LNSSEIRRHS SHAPSLAVRD YDKDKDRRHS GFNPNFLTLD PEHARFLSSS
1310 1320 1330 1340 1350
PAASRRISCG SLFKKRNQKL NVKRTYGLFS VRFFVVAEPD IRLATLALIR
1360 1370 1380 1390 1400
PLIPLPNEAL PNLQTLKGSK SSLFMGSTLF GFEHFSAGDK DEKPGKDKER
1410 1420 1430 1440 1450
TPTEETNRKL PIINPIVRLP NWPNLANGTG FISKCLMANA DTLCAAVSPL
1460 1470 1480 1490 1500
MDPDETLLAG YHEKCVMNNY FGIGIDAKIS LDFHNKREEH PEKCRSRARN
1510 1520 1530 1540 1550
YMWYGVLGSK QLLQKTCKNL EQRVQLECDG QRIPLPELQG IVILNIPSFM
1560 1570 1580 1590 1600
GGTNFWGNSS KKEDIFLPPS FDDRVLEVVA VFGSVQMAAS RLINLQHHRI
1610 1620 1630 1640 1650
AQCQSVQINI LGDEEIPIQV DGEAWLQPPG MIRILHKNRV QMLCRNRSLE
1660 1670 1680 1690 1700
VSLKTWQEKQ RQHSISIQRD TSSTASEHAV STDEVISERE CYVLLNFIEA
1710 1720 1730 1740 1750
VSSLVKWVKF LIISHPALQH DLYEVACRAS EALESIHPQG KLLEGPSLRT
1760 1770 1780 1790 1800
KLVEVIDSSR QLYDDACTLL RDRGHSLILR EDLETKLSAA LANMEMELKK
1810 1820 1830 1840 1850
CSVQKCIDGK LRAYFNVLAP NEEPDGRRKS RPFWVRLRSG STAGQQQFKP
1860 1870 1880 1890 1900
PITNTREAAN NWSVNEVVTW LETMQLSEYV DSFLKNDIRG KELLTLGRRD
1910 1920
LKDLGVVKVG HVKRILQAIK DLSEN
Length:1,925
Mass (Da):214,943
Last modified:September 23, 2008 - v1
Checksum:i6D8E3E275A23BCF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW14204.1.
RefSeqiXP_001998743.1. XM_001998707.1.

Genome annotation databases

EnsemblMetazoaiFBtr0174858; FBpp0173350; FBgn0146856.
GeneIDi6572637.
KEGGidmo:Dmoj_GI24133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW14204.1 .
RefSeqi XP_001998743.1. XM_001998707.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0174858 ; FBpp0173350 ; FBgn0146856 .
GeneIDi 6572637.
KEGGi dmo:Dmoj_GI24133.

Organism-specific databases

FlyBasei FBgn0146856. Dmoj\GI24133.

Phylogenomic databases

InParanoidi B4K6T8.
KOi K00901.
OrthoDBi EOG7DVD9B.
PhylomeDBi B4K6T8.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22Imported.

Entry informationi

Entry nameiDGKH_DROMO
AccessioniPrimary (citable) accession number: B4K6T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3