SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B4K6T8

- DGKH_DROMO

UniProt

B4K6T8 - DGKH_DROMO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Diacylglycerol kinase eta

Gene
GI24133
Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) By similarity.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1Add
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Gene namesi
ORF Names:GI24133
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
ProteomesiUP000009192: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0146856. Dmoj\GI24133.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19251925Diacylglycerol kinase etaPRO_0000375988Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHAdd
BLAST
Domaini350 – 486137DAGKcAdd
BLAST
Domaini1862 – 192564SAMAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1131 – 118757Thr-richAdd
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiB4K6T8.
KOiK00901.
OrthoDBiEOG7DVD9B.
PhylomeDBiB4K6T8.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4K6T8-1 [UniParc]FASTAAdd to Basket

« Hide

MANLKPNTLH VDNLSPRQRS LSSGLSSACS SGSVSPVPII PIISISRDGE     50
ESETESEIEP EPARIFHRRM STHSKRNNNL SAIIREGYLM KHTWSFQRWR 100
RRYFRLKRSY LYYAKDAKCD VFDEIDLSEL CYFECSIKNV NHSFQIITPT 150
RSLVLCADSR REMEDWLGSL KTATAPQRPR GDSFLIDQHD ILSNHHHWYA 200
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK AIANCKWTTL 250
ATVGKDIIEQ PDGSLIMPHQ WMEGNLPVSA VCAVCKKTCG SVLRLQDWRC 300
LWCRDTVHVA CRPQMPIVCP IGPAKLSVVP PTSVHSISTD DAWDVVSPKG 350
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAITV PKMPKMSITT 500
EQEALLTGMV TSANHHLRFI VETNDTQTLI SSTRSLCDTV DELVSRICEH 550
HKDDEQLAMK CDILRQKLTM LLDALQEEEL GTHSGDDLVA TIRSLISRSG 600
PLTTARPSFL NPNISIEKTE KDNINSKERR NSRSLRSSEK EALQCRANSV 650
KRAIYNVVEH SEPGRPKRYQ RKLSITPFEA LKIPITNSGD STPCGSPLPI 700
IPPINIISPT METSRLTCIS PLPDTRRDSV DENFFNSINL PAPRQFADSR 750
RSSGVPEVIQ EMEEGASGET VYRVGRLSLS GGANIDDAGN RLSPSSEAGE 800
NTPTERKVDF LRVPIMTSEP IVDPLSNYRP IEVFERTYYM AREMDKDKER 850
TASGQVESEK EEADVNEKSE PQEPHRALVH TCNLQVPGIV VTPQSQNVYT 900
SENFTIIDTD AQTNTEQSSS EDLGGEASDV LSAISNEECS VASEIFDKPE 950
SGHSLGDIIQ NLDANNFTHI DSPETSDETE PMPGESLMDD ISSVLGHDIT 1000
NALQDNTITD DTTTLCSEHA GPTKPPRKKS LSALVQSKTH PRRRNSSPPR 1050
KAGLARMDSD DNPQQFGFEN IVFEIDNRCD DQKIREPPRY CSLAQFVEGN 1100
DIARQSFKQL MLDRNSGDNH NDNGKNEEAD TPTNSAPTRT YRNLTTTTTS 1150
DELETAIKIE INNATTNTTT STSSSISTTT TTSTTSTVKP LESAMASSTS 1200
PTKKSGHGQE ISVVVRPPTP LRGDSVKPTA SSASSASLLA TSSSLLGVRT 1250
LNSSEIRRHS SHAPSLAVRD YDKDKDRRHS GFNPNFLTLD PEHARFLSSS 1300
PAASRRISCG SLFKKRNQKL NVKRTYGLFS VRFFVVAEPD IRLATLALIR 1350
PLIPLPNEAL PNLQTLKGSK SSLFMGSTLF GFEHFSAGDK DEKPGKDKER 1400
TPTEETNRKL PIINPIVRLP NWPNLANGTG FISKCLMANA DTLCAAVSPL 1450
MDPDETLLAG YHEKCVMNNY FGIGIDAKIS LDFHNKREEH PEKCRSRARN 1500
YMWYGVLGSK QLLQKTCKNL EQRVQLECDG QRIPLPELQG IVILNIPSFM 1550
GGTNFWGNSS KKEDIFLPPS FDDRVLEVVA VFGSVQMAAS RLINLQHHRI 1600
AQCQSVQINI LGDEEIPIQV DGEAWLQPPG MIRILHKNRV QMLCRNRSLE 1650
VSLKTWQEKQ RQHSISIQRD TSSTASEHAV STDEVISERE CYVLLNFIEA 1700
VSSLVKWVKF LIISHPALQH DLYEVACRAS EALESIHPQG KLLEGPSLRT 1750
KLVEVIDSSR QLYDDACTLL RDRGHSLILR EDLETKLSAA LANMEMELKK 1800
CSVQKCIDGK LRAYFNVLAP NEEPDGRRKS RPFWVRLRSG STAGQQQFKP 1850
PITNTREAAN NWSVNEVVTW LETMQLSEYV DSFLKNDIRG KELLTLGRRD 1900
LKDLGVVKVG HVKRILQAIK DLSEN 1925
Length:1,925
Mass (Da):214,943
Last modified:September 23, 2008 - v1
Checksum:i6D8E3E275A23BCF2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933806 Genomic DNA. Translation: EDW14204.1.
RefSeqiXP_001998743.1. XM_001998707.1.

Genome annotation databases

EnsemblMetazoaiFBtr0174858; FBpp0173350; FBgn0146856.
GeneIDi6572637.
KEGGidmo:Dmoj_GI24133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH933806 Genomic DNA. Translation: EDW14204.1 .
RefSeqi XP_001998743.1. XM_001998707.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0174858 ; FBpp0173350 ; FBgn0146856 .
GeneIDi 6572637.
KEGGi dmo:Dmoj_GI24133.

Organism-specific databases

FlyBasei FBgn0146856. Dmoj\GI24133.

Phylogenomic databases

InParanoidi B4K6T8.
KOi K00901.
OrthoDBi EOG7DVD9B.
PhylomeDBi B4K6T8.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15081-1352.22.

Entry informationi

Entry nameiDGKH_DROMO
AccessioniPrimary (citable) accession number: B4K6T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi