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B4K6T8

- DGKH_DROMO

UniProt

B4K6T8 - DGKH_DROMO

Protein

Diacylglycerol kinase eta

Gene

GI24133

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    3. protein oligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
    Short name:
    DAG kinase etaBy similarity
    Gene namesi
    ORF Names:GI24133
    OrganismiDrosophila mojavensis (Fruit fly)
    Taxonomic identifieri7230 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000009192: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0146856. Dmoj\GI24133.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19251925Diacylglycerol kinase etaPRO_0000375988Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 17594PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Domaini1862 – 192564SAMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1131 – 118757Thr-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    InParanoidiB4K6T8.
    KOiK00901.
    OrthoDBiEOG7DVD9B.
    PhylomeDBiB4K6T8.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4K6T8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MANLKPNTLH VDNLSPRQRS LSSGLSSACS SGSVSPVPII PIISISRDGE     50
    ESETESEIEP EPARIFHRRM STHSKRNNNL SAIIREGYLM KHTWSFQRWR 100
    RRYFRLKRSY LYYAKDAKCD VFDEIDLSEL CYFECSIKNV NHSFQIITPT 150
    RSLVLCADSR REMEDWLGSL KTATAPQRPR GDSFLIDQHD ILSNHHHWYA 200
    TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK AIANCKWTTL 250
    ATVGKDIIEQ PDGSLIMPHQ WMEGNLPVSA VCAVCKKTCG SVLRLQDWRC 300
    LWCRDTVHVA CRPQMPIVCP IGPAKLSVVP PTSVHSISTD DAWDVVSPKG 350
    NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
    HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
    WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAITV PKMPKMSITT 500
    EQEALLTGMV TSANHHLRFI VETNDTQTLI SSTRSLCDTV DELVSRICEH 550
    HKDDEQLAMK CDILRQKLTM LLDALQEEEL GTHSGDDLVA TIRSLISRSG 600
    PLTTARPSFL NPNISIEKTE KDNINSKERR NSRSLRSSEK EALQCRANSV 650
    KRAIYNVVEH SEPGRPKRYQ RKLSITPFEA LKIPITNSGD STPCGSPLPI 700
    IPPINIISPT METSRLTCIS PLPDTRRDSV DENFFNSINL PAPRQFADSR 750
    RSSGVPEVIQ EMEEGASGET VYRVGRLSLS GGANIDDAGN RLSPSSEAGE 800
    NTPTERKVDF LRVPIMTSEP IVDPLSNYRP IEVFERTYYM AREMDKDKER 850
    TASGQVESEK EEADVNEKSE PQEPHRALVH TCNLQVPGIV VTPQSQNVYT 900
    SENFTIIDTD AQTNTEQSSS EDLGGEASDV LSAISNEECS VASEIFDKPE 950
    SGHSLGDIIQ NLDANNFTHI DSPETSDETE PMPGESLMDD ISSVLGHDIT 1000
    NALQDNTITD DTTTLCSEHA GPTKPPRKKS LSALVQSKTH PRRRNSSPPR 1050
    KAGLARMDSD DNPQQFGFEN IVFEIDNRCD DQKIREPPRY CSLAQFVEGN 1100
    DIARQSFKQL MLDRNSGDNH NDNGKNEEAD TPTNSAPTRT YRNLTTTTTS 1150
    DELETAIKIE INNATTNTTT STSSSISTTT TTSTTSTVKP LESAMASSTS 1200
    PTKKSGHGQE ISVVVRPPTP LRGDSVKPTA SSASSASLLA TSSSLLGVRT 1250
    LNSSEIRRHS SHAPSLAVRD YDKDKDRRHS GFNPNFLTLD PEHARFLSSS 1300
    PAASRRISCG SLFKKRNQKL NVKRTYGLFS VRFFVVAEPD IRLATLALIR 1350
    PLIPLPNEAL PNLQTLKGSK SSLFMGSTLF GFEHFSAGDK DEKPGKDKER 1400
    TPTEETNRKL PIINPIVRLP NWPNLANGTG FISKCLMANA DTLCAAVSPL 1450
    MDPDETLLAG YHEKCVMNNY FGIGIDAKIS LDFHNKREEH PEKCRSRARN 1500
    YMWYGVLGSK QLLQKTCKNL EQRVQLECDG QRIPLPELQG IVILNIPSFM 1550
    GGTNFWGNSS KKEDIFLPPS FDDRVLEVVA VFGSVQMAAS RLINLQHHRI 1600
    AQCQSVQINI LGDEEIPIQV DGEAWLQPPG MIRILHKNRV QMLCRNRSLE 1650
    VSLKTWQEKQ RQHSISIQRD TSSTASEHAV STDEVISERE CYVLLNFIEA 1700
    VSSLVKWVKF LIISHPALQH DLYEVACRAS EALESIHPQG KLLEGPSLRT 1750
    KLVEVIDSSR QLYDDACTLL RDRGHSLILR EDLETKLSAA LANMEMELKK 1800
    CSVQKCIDGK LRAYFNVLAP NEEPDGRRKS RPFWVRLRSG STAGQQQFKP 1850
    PITNTREAAN NWSVNEVVTW LETMQLSEYV DSFLKNDIRG KELLTLGRRD 1900
    LKDLGVVKVG HVKRILQAIK DLSEN 1925
    Length:1,925
    Mass (Da):214,943
    Last modified:September 23, 2008 - v1
    Checksum:i6D8E3E275A23BCF2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933806 Genomic DNA. Translation: EDW14204.1.
    RefSeqiXP_001998743.1. XM_001998707.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0174858; FBpp0173350; FBgn0146856.
    GeneIDi6572637.
    KEGGidmo:Dmoj_GI24133.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933806 Genomic DNA. Translation: EDW14204.1 .
    RefSeqi XP_001998743.1. XM_001998707.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0174858 ; FBpp0173350 ; FBgn0146856 .
    GeneIDi 6572637.
    KEGGi dmo:Dmoj_GI24133.

    Organism-specific databases

    FlyBasei FBgn0146856. Dmoj\GI24133.

    Phylogenomic databases

    InParanoidi B4K6T8.
    KOi K00901.
    OrthoDBi EOG7DVD9B.
    PhylomeDBi B4K6T8.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15081-1352.22Imported.

    Entry informationi

    Entry nameiDGKH_DROMO
    AccessioniPrimary (citable) accession number: B4K6T8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3