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B4K5R6 (ARMET_DROMO) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mesencephalic astrocyte-derived neurotrophic factor homolog
Alternative name(s):
MANF/CDNF-like protein
Gene names
Name:Manf
ORF Names:GI22948
OrganismDrosophila mojavensis (Fruit fly) [Complete proteome]
Taxonomic identifier7230 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels By similarity. UniProtKB Q9XZ63

Subcellular location

Secreted By similarity UniProtKB Q9XZ63.

Sequence similarities

Belongs to the ARMET family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 173151Mesencephalic astrocyte-derived neurotrophic factor homolog
PRO_0000390941

Amino acid modifications

Disulfide bond28 ↔ 114 By similarity UniProtKB P55145
Disulfide bond31 ↔ 103 By similarity UniProtKB P55145
Disulfide bond61 ↔ 72 By similarity UniProtKB P55145
Disulfide bond148 ↔ 151 By similarity UniProtKB P55145

Sequences

Sequence LengthMass (Da)Tools
B4K5R6 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 296E39A4774A38D0

FASTA17320,105
        10         20         30         40         50         60 
MNTSQIVVML CFIVGVAQTA LAIKEDDCEV CVKTVKRFAD TLDDTTKKDY KLIETAFKKF 

        70         80         90        100        110        120 
CKTQKNKEHR FCYYLGGLEE SATGILNEMS KPLSWSMPAE KVCEKLKKKD AQICDLRYEK 

       130        140        150        160        170 
QIDLNNVDLK KLKVRDLKKI LNDWDESCDG CLEKTDFIKR IEELKPKYSR NEL 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH933806 Genomic DNA. Translation: EDW15128.1.
RefSeqXP_001999667.1. XM_001999631.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0173673; FBpp0172165; FBgn0145675.
GeneID6573599.
KEGGdmo:Dmoj_GI22948.

Organism-specific databases

FlyBaseFBgn0145675. Dmoj\GI22948.

Phylogenomic databases

InParanoidB4K5R6.
OrthoDBEOG7PZS02.
PhylomeDBB4K5R6.

Family and domain databases

Gene3D1.10.225.10. 1 hit.
InterProIPR019345. Armet_prot.
IPR018247. EF_Hand_1_Ca_BS.
IPR011001. Saposin-like.
[Graphical view]
PfamPF10208. Armet. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARMET_DROMO
AccessionPrimary (citable) accession number: B4K5R6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase