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B4K5R6

- ARMET_DROMO

UniProt

B4K5R6 - ARMET_DROMO

Protein

Mesencephalic astrocyte-derived neurotrophic factor homolog

Gene

Manf

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels By similarity.By similarity

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mesencephalic astrocyte-derived neurotrophic factor homolog
    Alternative name(s):
    MANF/CDNF-like protein
    Gene namesi
    Name:ManfBy similarity
    ORF Names:GI22948
    OrganismiDrosophila mojavensis (Fruit fly)
    Taxonomic identifieri7230 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
    ProteomesiUP000009192: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0145675. Dmoj\GI22948.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 173151Mesencephalic astrocyte-derived neurotrophic factor homologPRO_0000390941Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 114By similarity
    Disulfide bondi31 ↔ 103By similarity
    Disulfide bondi61 ↔ 72By similarity
    Disulfide bondi148 ↔ 151By similarity

    Keywords - PTMi

    Disulfide bond

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ARMET family.Sequence Analysis

    Keywords - Domaini

    Signal

    Phylogenomic databases

    InParanoidiB4K5R6.
    OrthoDBiEOG7PZS02.
    PhylomeDBiB4K5R6.

    Family and domain databases

    Gene3Di1.10.225.10. 1 hit.
    InterProiIPR019345. Armet_prot.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR011001. Saposin-like.
    [Graphical view]
    PfamiPF10208. Armet. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4K5R6-1 [UniParc]FASTAAdd to Basket

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    MNTSQIVVML CFIVGVAQTA LAIKEDDCEV CVKTVKRFAD TLDDTTKKDY    50
    KLIETAFKKF CKTQKNKEHR FCYYLGGLEE SATGILNEMS KPLSWSMPAE 100
    KVCEKLKKKD AQICDLRYEK QIDLNNVDLK KLKVRDLKKI LNDWDESCDG 150
    CLEKTDFIKR IEELKPKYSR NEL 173
    Length:173
    Mass (Da):20,105
    Last modified:September 23, 2008 - v1
    Checksum:i296E39A4774A38D0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933806 Genomic DNA. Translation: EDW15128.1.
    RefSeqiXP_001999667.1. XM_001999631.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0173673; FBpp0172165; FBgn0145675.
    GeneIDi6573599.
    KEGGidmo:Dmoj_GI22948.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH933806 Genomic DNA. Translation: EDW15128.1 .
    RefSeqi XP_001999667.1. XM_001999631.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0173673 ; FBpp0172165 ; FBgn0145675 .
    GeneIDi 6573599.
    KEGGi dmo:Dmoj_GI22948.

    Organism-specific databases

    FlyBasei FBgn0145675. Dmoj\GI22948.

    Phylogenomic databases

    InParanoidi B4K5R6.
    OrthoDBi EOG7PZS02.
    PhylomeDBi B4K5R6.

    Family and domain databases

    Gene3Di 1.10.225.10. 1 hit.
    InterProi IPR019345. Armet_prot.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR011001. Saposin-like.
    [Graphical view ]
    Pfami PF10208. Armet. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15081-1352.22Imported.

    Entry informationi

    Entry nameiARMET_DROMO
    AccessioniPrimary (citable) accession number: B4K5R6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3