B4K5R6 (ARMET_DROMO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mesencephalic astrocyte-derived neurotrophic factor homolog

Alternative name(s):
MANF/CDNF-like protein

Gene names

Name:	Manf
ORF Names:	GI22948

Organism

Drosophila mojavensis (Fruit fly) [Complete proteome]

Taxonomic identifier

7230 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Drosophila › repleta group › mulleri subgroup › mojavensis species complex

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels By similarity. UniProtKB Q9XZ63
Subcellular location	Secreted By similarity UniProtKB Q9XZ63.
Sequence similarities	Belongs to the ARMET family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Developmental protein
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 173	151	Mesencephalic astrocyte-derived neurotrophic factor homolog		PRO_0000390941
Amino acid modifications
	Disulfide bond	28 ↔ 114		By similarity UniProtKB P55145
	Disulfide bond	31 ↔ 103		By similarity UniProtKB P55145
	Disulfide bond	61 ↔ 72		By similarity UniProtKB P55145
	Disulfide bond	148 ↔ 151		By similarity UniProtKB P55145

Sequences

	Sequence		Length	Mass (Da)
	B4K5R6 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 296E39A4774A38D0	FASTA	173	20,105
	10 20 30 40 50 60 MNTSQIVVML CFIVGVAQTA LAIKEDDCEV CVKTVKRFAD TLDDTTKKDY KLIETAFKKF 70 80 90 100 110 120 CKTQKNKEHR FCYYLGGLEE SATGILNEMS KPLSWSMPAE KVCEKLKKKD AQICDLRYEK 130 140 150 160 170 QIDLNNVDLK KLKVRDLKKI LNDWDESCDG CLEKTDFIKR IEELKPKYSR NEL

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15081-1352.22.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH933806 Genomic DNA. Translation: EDW15128.1.
RefSeq	XP_001999667.1. XM_001999631.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0173673; FBpp0172165; FBgn0145675.
GeneID	6573599.
KEGG	dmo:Dmoj_GI22948.
Organism-specific databases
FlyBase	FBgn0145675. Dmoj\GI22948.
Phylogenomic databases
InParanoid	B4K5R6.
OrthoDB	EOG45HQDT.
Family and domain databases
Gene3D	1.10.225.10. 1 hit.
InterPro	IPR019345. Armet_prot. IPR018247. EF_Hand_1_Ca_BS. IPR011001. Saposin-like. [Graphical view]
Pfam	PF10208. Armet. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARMET_DROMO

Accession

Primary (citable) accession number: B4K5R6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 19, 2010
Last sequence update:	September 23, 2008
Last modified:	March 6, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project