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Protein

Mesencephalic astrocyte-derived neurotrophic factor homolog

Gene

Manf

Organism
Drosophila mojavensis (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required during the maturation of the embryonic nervous system for maintenance of neuronal and cuticular connectivity. Essential for maintenance of dopaminergic neurons and dopamine levels (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Mesencephalic astrocyte-derived neurotrophic factor homolog
Alternative name(s):
MANF/CDNF-like protein
Gene namesi
Name:ManfBy similarity
ORF Names:GI22948
OrganismiDrosophila mojavensis (Fruit fly)
Taxonomic identifieri7230 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophila
Proteomesi
  • UP000009192 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0145675. Dmoj\GI22948.

Subcellular locationi

  • Secreted By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000039094123 – 173Mesencephalic astrocyte-derived neurotrophic factor homologAdd BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 114By similarity
Disulfide bondi31 ↔ 103By similarity
Disulfide bondi61 ↔ 72By similarity
Disulfide bondi148 ↔ 151By similarity

Keywords - PTMi

Disulfide bond

Structurei

3D structure databases

ProteinModelPortaliB4K5R6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ARMET family.Sequence analysis

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiB4K5R6.
OMAiFCKAQKN.
OrthoDBiEOG091G0P3O.
PhylomeDBiB4K5R6.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
InterProiIPR019345. Armet_prot.
IPR018247. EF_Hand_1_Ca_BS.
IPR011001. Saposin-like.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4K5R6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTSQIVVML CFIVGVAQTA LAIKEDDCEV CVKTVKRFAD TLDDTTKKDY
60 70 80 90 100
KLIETAFKKF CKTQKNKEHR FCYYLGGLEE SATGILNEMS KPLSWSMPAE
110 120 130 140 150
KVCEKLKKKD AQICDLRYEK QIDLNNVDLK KLKVRDLKKI LNDWDESCDG
160 170
CLEKTDFIKR IEELKPKYSR NEL
Length:173
Mass (Da):20,105
Last modified:September 23, 2008 - v1
Checksum:i296E39A4774A38D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW15128.1.
RefSeqiXP_001999667.1. XM_001999631.2.

Genome annotation databases

EnsemblMetazoaiFBtr0173673; FBpp0172165; FBgn0145675.
GeneIDi6573599.
KEGGidmo:Dmoj_GI22948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH933806 Genomic DNA. Translation: EDW15128.1.
RefSeqiXP_001999667.1. XM_001999631.2.

3D structure databases

ProteinModelPortaliB4K5R6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0173673; FBpp0172165; FBgn0145675.
GeneIDi6573599.
KEGGidmo:Dmoj_GI22948.

Organism-specific databases

FlyBaseiFBgn0145675. Dmoj\GI22948.

Phylogenomic databases

InParanoidiB4K5R6.
OMAiFCKAQKN.
OrthoDBiEOG091G0P3O.
PhylomeDBiB4K5R6.

Miscellaneous databases

ChiTaRSiManf. fly.

Family and domain databases

Gene3Di1.10.225.10. 1 hit.
InterProiIPR019345. Armet_prot.
IPR018247. EF_Hand_1_Ca_BS.
IPR011001. Saposin-like.
[Graphical view]
PfamiPF10208. Armet. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARMET_DROMO
AccessioniPrimary (citable) accession number: B4K5R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: November 30, 2016
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.