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B4JXX2

- PDE6_DROGR

UniProt

B4JXX2 - PDE6_DROGR

Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

    Catalytic activityi

    Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei670 – 6701Proton donorBy similarity
    Metal bindingi674 – 6741Divalent metal cation 1By similarity
    Metal bindingi710 – 7101Divalent metal cation 1By similarity
    Metal bindingi711 – 7111Divalent metal cation 1By similarity
    Metal bindingi711 – 7111Divalent metal cation 2By similarity
    Metal bindingi821 – 8211Divalent metal cation 1By similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cGMP metabolic process Source: UniProtKB
    2. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cGMP, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
    Gene namesi
    Name:Pde6By similarity
    ORF Names:GH14135
    OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
    Taxonomic identifieri7222 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
    ProteomesiUP000001070: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0121611. Dgri\GH14135.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

    GO - Cellular componenti

    1. membrane Source: UniProtKB
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10751075cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363688Add
    BLAST
    Propeptidei1076 – 10783Removed in mature formBy similarityPRO_0000363689

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1075 – 10751Cysteine methyl esterBy similarity
    Lipidationi1075 – 10751S-farnesyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Methylation, Prenylation

    Interactioni

    Subunit structurei

    Interacts with PrBP.By similarity

    Protein-protein interaction databases

    STRINGi7222.FBpp0148041.

    Structurei

    3D structure databases

    ProteinModelPortaliB4JXX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini196 – 348153GAF 1Sequence AnalysisAdd
    BLAST
    Domaini380 – 564185GAF 2Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi50 – 13384Asn-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
    Contains 2 GAF domains.Sequence Analysis

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG270709.
    InParanoidiB4JXX2.
    KOiK13763.
    OMAiDDNPSNP.
    OrthoDBiEOG7RRF69.
    PhylomeDBiB4JXX2.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProiIPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF55781. SSF55781. 3 hits.
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B4JXX2-1 [UniParc]FASTAAdd to Basket

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    MRIQTMILGC AFLAICIIGS SNAACDEPDK CTPEECEDPA NAAEESCAEN     50
    PDDNPSNPDD DPSNPDDNPS NPDDNPSNPD DNPSNPDDNP SNPDDNPSNP 100
    DDNPSNPDDN PSNPDDNPTN PDDNPNNPSN PSNPSGGVEA TTAANNGGSG 150
    SNAQKSPRRL SNSSVQALPE GRRHLMDLDE GDLFMELIRD VANELDIDVL 200
    CHKILVNVGL LTHADRGSLF LAKGTPNNKY LVAKLFDVTQ KTALKDAVTR 250
    ARAEEIIIPF GIGIAGMVAQ TKEMINIKEA YQDVRFNCEI DQKTGYKTNA 300
    ILCMPICNYE GDIIGVAQII NKTNGCMEFD EHDVEIFRRY LTFCGIGIQN 350
    AQLFEMSVQE YRRNQILLNL ARSIFEEQNN LECLVTKIMT EARELLKCER 400
    CSVFLVDLDC CEESHLEKII EKPHQQEQRT MRAIKGGDSF EEQQKMRNRF 450
    TVLFELGGEY QAANVSRPSI NELSHSTLAQ IAQFVSTTGQ TVNICDVHEW 500
    VRDHNQIRDS EIDSTHAILC MPIVNAQKTV IGVAQLINKA NGLPFSESDV 550
    SIFEAFAIFC GLGIHNTQMY ENACKLMAKQ KVALECLSYH ATASQDQTEK 600
    LTQDPIAEAE SYNLYSFTFT DFDLVDDDTC RAVLRMFMQC NLVSQFHIPY 650
    DVLCRWVLSV RKNYRPVKYH NWRHALNVAQ TMFAMLKTGK MERFMTDLEI 700
    LGLLVACLCH DLDHRGTNNA FQTKTESPLA ILYTTSTMEH HHFDQCVMIL 750
    NSEGNNIFQA LSPEDYRCVM KTVESAILST DLAMYFKKRN AFLELVENGE 800
    FDWQGEEKKD LLCGMMMTAC DVSAIAKPWE VQHRVAKLVA DEFFDQGDLE 850
    KLQLNTQPVA MMDRERKDEL PKMQVGFIDV ICLPLYRVLC DTFPWITPLY 900
    EGTLENRRNW QDLAEKVEMG LTWIDHDTID KPVEEFAGCA DEEIKDIEFT 950
    VTTLNCNQQS QSQSQSQSQS QHGGDDIHTP EHQRSSGSRL SIKKTGALGK 1000
    VVRSKLSKTL YNSMDGSKPK TSLKLLESHV SEDMDDKSPT SPSQPHSGSV 1050
    GRMSASSSTS SAGTVDKTKK RSKLCALL 1078
    Length:1,078
    Mass (Da):120,555
    Last modified:September 23, 2008 - v1
    Checksum:i4193E7C8A5FB672E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916377 Genomic DNA. Translation: EDV90534.1.
    RefSeqiXP_001995876.1. XM_001995840.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0149549; FBpp0148041; FBgn0121611.
    GeneIDi6569905.
    KEGGidgr:Dgri_GH14135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916377 Genomic DNA. Translation: EDV90534.1 .
    RefSeqi XP_001995876.1. XM_001995840.1.

    3D structure databases

    ProteinModelPortali B4JXX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7222.FBpp0148041.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0149549 ; FBpp0148041 ; FBgn0121611 .
    GeneIDi 6569905.
    KEGGi dgr:Dgri_GH14135.

    Organism-specific databases

    FlyBasei FBgn0121611. Dgri\GH14135.

    Phylogenomic databases

    eggNOGi NOG270709.
    InParanoidi B4JXX2.
    KOi K13763.
    OMAi DDNPSNP.
    OrthoDBi EOG7RRF69.
    PhylomeDBi B4JXX2.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    3.30.450.40. 3 hits.
    InterProi IPR003018. GAF.
    IPR029016. GAF_dom_like.
    IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF01590. GAF. 2 hits.
    PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00065. GAF. 2 hits.
    SM00471. HDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55781. SSF55781. 3 hits.
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15287-2541.00Imported.

    Entry informationi

    Entry nameiPDE6_DROGR
    AccessioniPrimary (citable) accession number: B4JXX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3