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B4JXX2

- PDE6_DROGR

UniProt

B4JXX2 - PDE6_DROGR

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Protein

cGMP-specific 3',5'-cyclic phosphodiesterase

Gene

Pde6

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei670 – 6701Proton donorBy similarity
Metal bindingi674 – 6741Divalent metal cation 1By similarity
Metal bindingi710 – 7101Divalent metal cation 1By similarity
Metal bindingi711 – 7111Divalent metal cation 1By similarity
Metal bindingi711 – 7111Divalent metal cation 2By similarity
Metal bindingi821 – 8211Divalent metal cation 1By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity (EC:3.1.4.35)
Gene namesi
Name:Pde6By similarity
ORF Names:GH14135
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0121611. Dgri\GH14135.

Subcellular locationi

Cell membrane By similarity; Lipid-anchor By similarity; Cytoplasmic side By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10751075cGMP-specific 3',5'-cyclic phosphodiesterasePRO_0000363688Add
BLAST
Propeptidei1076 – 10783Removed in mature formBy similarityPRO_0000363689

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1075 – 10751Cysteine methyl esterBy similarity
Lipidationi1075 – 10751S-farnesyl cysteineBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP.By similarity

Protein-protein interaction databases

STRINGi7222.FBpp0148041.

Structurei

3D structure databases

ProteinModelPortaliB4JXX2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 348153GAF 1Sequence AnalysisAdd
BLAST
Domaini380 – 564185GAF 2Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 13384Asn-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the cyclic nucleotide phosphodiesterase family.Sequence Analysis
Contains 2 GAF domains.Sequence Analysis

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiB4JXX2.
KOiK13763.
OMAiDDNPSNP.
OrthoDBiEOG7RRF69.
PhylomeDBiB4JXX2.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4JXX2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRIQTMILGC AFLAICIIGS SNAACDEPDK CTPEECEDPA NAAEESCAEN
60 70 80 90 100
PDDNPSNPDD DPSNPDDNPS NPDDNPSNPD DNPSNPDDNP SNPDDNPSNP
110 120 130 140 150
DDNPSNPDDN PSNPDDNPTN PDDNPNNPSN PSNPSGGVEA TTAANNGGSG
160 170 180 190 200
SNAQKSPRRL SNSSVQALPE GRRHLMDLDE GDLFMELIRD VANELDIDVL
210 220 230 240 250
CHKILVNVGL LTHADRGSLF LAKGTPNNKY LVAKLFDVTQ KTALKDAVTR
260 270 280 290 300
ARAEEIIIPF GIGIAGMVAQ TKEMINIKEA YQDVRFNCEI DQKTGYKTNA
310 320 330 340 350
ILCMPICNYE GDIIGVAQII NKTNGCMEFD EHDVEIFRRY LTFCGIGIQN
360 370 380 390 400
AQLFEMSVQE YRRNQILLNL ARSIFEEQNN LECLVTKIMT EARELLKCER
410 420 430 440 450
CSVFLVDLDC CEESHLEKII EKPHQQEQRT MRAIKGGDSF EEQQKMRNRF
460 470 480 490 500
TVLFELGGEY QAANVSRPSI NELSHSTLAQ IAQFVSTTGQ TVNICDVHEW
510 520 530 540 550
VRDHNQIRDS EIDSTHAILC MPIVNAQKTV IGVAQLINKA NGLPFSESDV
560 570 580 590 600
SIFEAFAIFC GLGIHNTQMY ENACKLMAKQ KVALECLSYH ATASQDQTEK
610 620 630 640 650
LTQDPIAEAE SYNLYSFTFT DFDLVDDDTC RAVLRMFMQC NLVSQFHIPY
660 670 680 690 700
DVLCRWVLSV RKNYRPVKYH NWRHALNVAQ TMFAMLKTGK MERFMTDLEI
710 720 730 740 750
LGLLVACLCH DLDHRGTNNA FQTKTESPLA ILYTTSTMEH HHFDQCVMIL
760 770 780 790 800
NSEGNNIFQA LSPEDYRCVM KTVESAILST DLAMYFKKRN AFLELVENGE
810 820 830 840 850
FDWQGEEKKD LLCGMMMTAC DVSAIAKPWE VQHRVAKLVA DEFFDQGDLE
860 870 880 890 900
KLQLNTQPVA MMDRERKDEL PKMQVGFIDV ICLPLYRVLC DTFPWITPLY
910 920 930 940 950
EGTLENRRNW QDLAEKVEMG LTWIDHDTID KPVEEFAGCA DEEIKDIEFT
960 970 980 990 1000
VTTLNCNQQS QSQSQSQSQS QHGGDDIHTP EHQRSSGSRL SIKKTGALGK
1010 1020 1030 1040 1050
VVRSKLSKTL YNSMDGSKPK TSLKLLESHV SEDMDDKSPT SPSQPHSGSV
1060 1070
GRMSASSSTS SAGTVDKTKK RSKLCALL
Length:1,078
Mass (Da):120,555
Last modified:September 23, 2008 - v1
Checksum:i4193E7C8A5FB672E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916377 Genomic DNA. Translation: EDV90534.1.
RefSeqiXP_001995876.1. XM_001995840.1.

Genome annotation databases

EnsemblMetazoaiFBtr0149549; FBpp0148041; FBgn0121611.
GeneIDi6569905.
KEGGidgr:Dgri_GH14135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916377 Genomic DNA. Translation: EDV90534.1 .
RefSeqi XP_001995876.1. XM_001995840.1.

3D structure databases

ProteinModelPortali B4JXX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0148041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0149549 ; FBpp0148041 ; FBgn0121611 .
GeneIDi 6569905.
KEGGi dgr:Dgri_GH14135.

Organism-specific databases

FlyBasei FBgn0121611. Dgri\GH14135.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi B4JXX2.
KOi K13763.
OMAi DDNPSNP.
OrthoDBi EOG7RRF69.
PhylomeDBi B4JXX2.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiPDE6_DROGR
AccessioniPrimary (citable) accession number: B4JXX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3