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B4JXX2

- PDE6_DROGR

UniProt

B4JXX2 - PDE6_DROGR

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Protein
cGMP-specific 3',5'-cyclic phosphodiesterase
Gene
Pde6, GH14135
Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Has a role regulating cGMP transport in Malpighian tubule principal cells By similarity.By similarity

Catalytic activityi

Guanosine 3',5'-cyclic phosphate + H2O = guanosine 5'-phosphate.By similarity

Cofactori

Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei670 – 6701Proton donor By similarity
Metal bindingi674 – 6741Divalent metal cation 1 By similarity
Metal bindingi710 – 7101Divalent metal cation 1 By similarity
Metal bindingi711 – 7111Divalent metal cation 1 By similarity
Metal bindingi711 – 7111Divalent metal cation 2 By similarity
Metal bindingi821 – 8211Divalent metal cation 1 By similarity

GO - Molecular functioni

  1. 3',5'-cyclic-GMP phosphodiesterase activity Source: UniProtKB
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cGMP metabolic process Source: UniProtKB
  2. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

cGMP, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
cGMP-specific 3',5'-cyclic phosphodiesterase (EC:3.1.4.35)
Gene namesi
Name:Pde6
ORF Names:GH14135
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0121611. Dgri\GH14135.

Subcellular locationi

Cell membrane; Lipid-anchor; Cytoplasmic side By similarity By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10751075cGMP-specific 3',5'-cyclic phosphodiesteraseBy similarity
PRO_0000363688Add
BLAST
Propeptidei1076 – 10783Removed in mature form By similarityBy similarity
PRO_0000363689

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1075 – 10751Cysteine methyl ester By similarityBy similarity
Lipidationi1075 – 10751S-farnesyl cysteine By similarityBy similarity

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Interactioni

Subunit structurei

Interacts with PrBP By similarity.By similarity

Protein-protein interaction databases

STRINGi7222.FBpp0148041.

Structurei

3D structure databases

ProteinModelPortaliB4JXX2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 348153GAF 1
Add
BLAST
Domaini380 – 564185GAF 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 13384Asn-rich
Add
BLAST

Sequence similaritiesi

Contains 2 GAF domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG270709.
InParanoidiB4JXX2.
KOiK13763.
OMAiDDNPSNP.
OrthoDBiEOG7RRF69.
PhylomeDBiB4JXX2.

Family and domain databases

Gene3Di1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProiIPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view]
PfamiPF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view]
PRINTSiPR00387. PDIESTERASE1.
SMARTiSM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view]
SUPFAMiSSF55781. SSF55781. 3 hits.
PROSITEiPS00126. PDEASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B4JXX2-1 [UniParc]FASTAAdd to Basket

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MRIQTMILGC AFLAICIIGS SNAACDEPDK CTPEECEDPA NAAEESCAEN     50
PDDNPSNPDD DPSNPDDNPS NPDDNPSNPD DNPSNPDDNP SNPDDNPSNP 100
DDNPSNPDDN PSNPDDNPTN PDDNPNNPSN PSNPSGGVEA TTAANNGGSG 150
SNAQKSPRRL SNSSVQALPE GRRHLMDLDE GDLFMELIRD VANELDIDVL 200
CHKILVNVGL LTHADRGSLF LAKGTPNNKY LVAKLFDVTQ KTALKDAVTR 250
ARAEEIIIPF GIGIAGMVAQ TKEMINIKEA YQDVRFNCEI DQKTGYKTNA 300
ILCMPICNYE GDIIGVAQII NKTNGCMEFD EHDVEIFRRY LTFCGIGIQN 350
AQLFEMSVQE YRRNQILLNL ARSIFEEQNN LECLVTKIMT EARELLKCER 400
CSVFLVDLDC CEESHLEKII EKPHQQEQRT MRAIKGGDSF EEQQKMRNRF 450
TVLFELGGEY QAANVSRPSI NELSHSTLAQ IAQFVSTTGQ TVNICDVHEW 500
VRDHNQIRDS EIDSTHAILC MPIVNAQKTV IGVAQLINKA NGLPFSESDV 550
SIFEAFAIFC GLGIHNTQMY ENACKLMAKQ KVALECLSYH ATASQDQTEK 600
LTQDPIAEAE SYNLYSFTFT DFDLVDDDTC RAVLRMFMQC NLVSQFHIPY 650
DVLCRWVLSV RKNYRPVKYH NWRHALNVAQ TMFAMLKTGK MERFMTDLEI 700
LGLLVACLCH DLDHRGTNNA FQTKTESPLA ILYTTSTMEH HHFDQCVMIL 750
NSEGNNIFQA LSPEDYRCVM KTVESAILST DLAMYFKKRN AFLELVENGE 800
FDWQGEEKKD LLCGMMMTAC DVSAIAKPWE VQHRVAKLVA DEFFDQGDLE 850
KLQLNTQPVA MMDRERKDEL PKMQVGFIDV ICLPLYRVLC DTFPWITPLY 900
EGTLENRRNW QDLAEKVEMG LTWIDHDTID KPVEEFAGCA DEEIKDIEFT 950
VTTLNCNQQS QSQSQSQSQS QHGGDDIHTP EHQRSSGSRL SIKKTGALGK 1000
VVRSKLSKTL YNSMDGSKPK TSLKLLESHV SEDMDDKSPT SPSQPHSGSV 1050
GRMSASSSTS SAGTVDKTKK RSKLCALL 1078
Length:1,078
Mass (Da):120,555
Last modified:September 23, 2008 - v1
Checksum:i4193E7C8A5FB672E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916377 Genomic DNA. Translation: EDV90534.1.
RefSeqiXP_001995876.1. XM_001995840.1.

Genome annotation databases

EnsemblMetazoaiFBtr0149549; FBpp0148041; FBgn0121611.
GeneIDi6569905.
KEGGidgr:Dgri_GH14135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916377 Genomic DNA. Translation: EDV90534.1 .
RefSeqi XP_001995876.1. XM_001995840.1.

3D structure databases

ProteinModelPortali B4JXX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0148041.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0149549 ; FBpp0148041 ; FBgn0121611 .
GeneIDi 6569905.
KEGGi dgr:Dgri_GH14135.

Organism-specific databases

FlyBasei FBgn0121611. Dgri\GH14135.

Phylogenomic databases

eggNOGi NOG270709.
InParanoidi B4JXX2.
KOi K13763.
OMAi DDNPSNP.
OrthoDBi EOG7RRF69.
PhylomeDBi B4JXX2.

Family and domain databases

Gene3Di 1.10.1300.10. 1 hit.
3.30.450.40. 3 hits.
InterProi IPR003018. GAF.
IPR029016. GAF_dom_like.
IPR003607. HD/PDEase_dom.
IPR023088. PDEase.
IPR002073. PDEase_catalytic_dom.
IPR023174. PDEase_CS.
[Graphical view ]
Pfami PF01590. GAF. 2 hits.
PF00233. PDEase_I. 1 hit.
[Graphical view ]
PRINTSi PR00387. PDIESTERASE1.
SMARTi SM00065. GAF. 2 hits.
SM00471. HDc. 1 hit.
[Graphical view ]
SUPFAMi SSF55781. SSF55781. 3 hits.
PROSITEi PS00126. PDEASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00.

Entry informationi

Entry nameiPDE6_DROGR
AccessioniPrimary (citable) accession number: B4JXX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi