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B4JW98

- CALYP_DROGR

UniProt

B4JW98 - CALYP_DROGR

Protein

Ubiquitin carboxyl-terminal hydrolase calypso

Gene

calypso

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei115 – 1151NucleophileBy similarity
    Active sitei197 – 1971Proton donorBy similarity
    Sitei212 – 2121Important for enzyme activityBy similarity

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. ubiquitin-specific protease activity Source: UniProtKB
    3. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. chromatin silencing Source: UniProtKB
    2. monoubiquitinated histone H2A deubiquitination Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC12.A09.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase calypso (EC:3.4.19.12)
    Alternative name(s):
    BAP1 homolog
    Gene namesi
    Name:calypso
    ORF Names:GH22997
    OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
    Taxonomic identifieri7222 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
    ProteomesiUP000001070: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0130454. Dgri\GH22997.

    Subcellular locationi

    Nucleus By similarity
    Note: Localizes to PcG response elements (PREs).By similarity

    GO - Cellular componenti

    1. nuclear chromatin Source: UniProtKB
    2. PR-DUB complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462Ubiquitin carboxyl-terminal hydrolase calypsoPRO_0000395828Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the PR-DUB complex, at least composed of calypso and Asx.By similarity

    Protein-protein interaction databases

    STRINGi7222.FBpp0156903.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase C12 family. BAP1 subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG249036.
    InParanoidiB4JW98.
    KOiK08588.
    OMAiTDKFRRV.
    OrthoDBiEOG7GN2M2.
    PhylomeDBiB4JW98.

    Family and domain databases

    Gene3Di3.40.532.10. 1 hit.
    InterProiIPR001578. Peptidase_C12_UCH.
    [Graphical view]
    PANTHERiPTHR10589. PTHR10589. 1 hit.
    PfamiPF01088. Peptidase_C12. 1 hit.
    [Graphical view]
    PRINTSiPR00707. UBCTHYDRLASE.

    Sequencei

    Sequence statusi: Complete.

    B4JW98-1 [UniParc]FASTAAdd to Basket

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    MSVAGGSIST AAGNAGKNNA LPMAQLADGW LELESDPGLF TLLLEDFGCH    50
    DVQVEEVYDL QKPIESPYGF IFLFRWIEER RARRKIVETT AEIFVKDEEA 100
    ISSIFFAQQV VPNSCATHAL LSVLLNCNEN NLQLGETLGR LKAHTKGMSP 150
    ENKGLAIGNT PELACAHNSH AMPQARRRLE RTGAGVASCR FTGEAFHFVS 200
    FVPINGQLFE LDGLKPYPMN HGCWEEHEDW TDKFRRVMAE RLGIATGEQD 250
    IRFNLMAVVP DRRIAITHKL KMLRTNQAIV SGTLQKLLKA DEQGERDEQQ 300
    RPDTPTTLLE PSAFTARDLQ SLLKNLDTEI AINEQHLADE NDRRQMFKVD 350
    ASRRTHNYDK FICTFLSMLA HQGVLGELVS QHLLPSKKIA NRLNRQTNAA 400
    TAAANAANTN VAGTNAAGSK SQQQQQQTQQ QPQQTQTAKN GKSPGKTPGR 450
    RRKGRNKCRK RK 462
    Length:462
    Mass (Da):51,491
    Last modified:September 23, 2008 - v1
    Checksum:i21954C62113F766C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916375 Genomic DNA. Translation: EDV98236.1.
    RefSeqiXP_001995164.1. XM_001995128.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0158411; FBpp0156903; FBgn0130454.
    GeneIDi6568805.
    KEGGidgr:Dgri_GH22997.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916375 Genomic DNA. Translation: EDV98236.1 .
    RefSeqi XP_001995164.1. XM_001995128.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7222.FBpp0156903.

    Protein family/group databases

    MEROPSi C12.A09.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0158411 ; FBpp0156903 ; FBgn0130454 .
    GeneIDi 6568805.
    KEGGi dgr:Dgri_GH22997.

    Organism-specific databases

    FlyBasei FBgn0130454. Dgri\GH22997.

    Phylogenomic databases

    eggNOGi NOG249036.
    InParanoidi B4JW98.
    KOi K08588.
    OMAi TDKFRRV.
    OrthoDBi EOG7GN2M2.
    PhylomeDBi B4JW98.

    Family and domain databases

    Gene3Di 3.40.532.10. 1 hit.
    InterProi IPR001578. Peptidase_C12_UCH.
    [Graphical view ]
    PANTHERi PTHR10589. PTHR10589. 1 hit.
    Pfami PF01088. Peptidase_C12. 1 hit.
    [Graphical view ]
    PRINTSi PR00707. UBCTHYDRLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15287-2541.00.

    Entry informationi

    Entry nameiCALYP_DROGR
    AccessioniPrimary (citable) accession number: B4JW98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3