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B4JW98 (CALYP_DROGR) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase calypso

EC=3.4.19.12
Alternative name(s):
BAP1 homolog
Gene names
Name:calypso
ORF Names:GH22997
OrganismDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi) [Complete proteome]
Taxonomic identifier7222 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila

Protein attributes

Sequence length462 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Polycomb group (PcG) protein. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-118' (H2AK118ub1). Does not deubiquitinate monoubiquitinated histone H2B. Required to maintain the transcriptionally repressive state of homeotic genes throughout development. The PR-DUB complex has weak or no activity toward 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Component of the PR-DUB complex, at least composed of calypso and Asx By similarity.

Subcellular location

Nucleus By similarity. Note: Localizes to PcG response elements (PREs) By similarity.

Sequence similarities

Belongs to the peptidase C12 family. BAP1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 462462Ubiquitin carboxyl-terminal hydrolase calypso
PRO_0000395828

Sites

Active site1151Nucleophile By similarity
Active site1971Proton donor By similarity
Site2121Important for enzyme activity By similarity

Sequences

Sequence LengthMass (Da)Tools
B4JW98 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 21954C62113F766C

FASTA46251,491
        10         20         30         40         50         60 
MSVAGGSIST AAGNAGKNNA LPMAQLADGW LELESDPGLF TLLLEDFGCH DVQVEEVYDL 

        70         80         90        100        110        120 
QKPIESPYGF IFLFRWIEER RARRKIVETT AEIFVKDEEA ISSIFFAQQV VPNSCATHAL 

       130        140        150        160        170        180 
LSVLLNCNEN NLQLGETLGR LKAHTKGMSP ENKGLAIGNT PELACAHNSH AMPQARRRLE 

       190        200        210        220        230        240 
RTGAGVASCR FTGEAFHFVS FVPINGQLFE LDGLKPYPMN HGCWEEHEDW TDKFRRVMAE 

       250        260        270        280        290        300 
RLGIATGEQD IRFNLMAVVP DRRIAITHKL KMLRTNQAIV SGTLQKLLKA DEQGERDEQQ 

       310        320        330        340        350        360 
RPDTPTTLLE PSAFTARDLQ SLLKNLDTEI AINEQHLADE NDRRQMFKVD ASRRTHNYDK 

       370        380        390        400        410        420 
FICTFLSMLA HQGVLGELVS QHLLPSKKIA NRLNRQTNAA TAAANAANTN VAGTNAAGSK 

       430        440        450        460 
SQQQQQQTQQ QPQQTQTAKN GKSPGKTPGR RRKGRNKCRK RK 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15287-2541.00.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH916375 Genomic DNA. Translation: EDV98236.1.
RefSeqXP_001995164.1. XM_001995128.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7222.FBpp0156903.

Protein family/group databases

MEROPSC12.A09.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0158411; FBpp0156903; FBgn0130454.
GeneID6568805.
KEGGdgr:Dgri_GH22997.

Organism-specific databases

FlyBaseFBgn0130454. Dgri\GH22997.

Phylogenomic databases

eggNOGNOG249036.
InParanoidB4JW98.
KOK08588.
OMATDKFRRV.
OrthoDBEOG7GN2M2.

Family and domain databases

Gene3D3.40.532.10. 1 hit.
InterProIPR001578. Peptidase_C12_UCH.
[Graphical view]
PANTHERPTHR10589. PTHR10589. 1 hit.
PfamPF01088. Peptidase_C12. 1 hit.
[Graphical view]
PRINTSPR00707. UBCTHYDRLASE.
ProtoNetSearch...

Entry information

Entry nameCALYP_DROGR
AccessionPrimary (citable) accession number: B4JW98
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: September 23, 2008
Last modified: March 19, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase