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Protein

DNA ligase

Gene

Dgri\GH20153

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA biosynthetic process Source: InterPro
  2. DNA ligation involved in DNA repair Source: InterPro
  3. DNA recombination Source: UniProtKB-KW
  4. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotation

Keywords - Biological processi

DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Gene namesi
Name:Dgri\GH20153Imported
ORF Names:Dgri_GH20153Imported, GH20153Imported
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)Imported
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0127617. Dgri\GH20153.

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0154059.

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiB4JRF5.
KOiK10776.
OMAiMILDSEI.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4JRF5.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4JRF5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKQAQNED NKLDTFRHIC DEIAGESSYL RKVEKLEHFF KKGSSGSGFQ
60 70 80 90 100
GDTLQWVQFL IPGATQRVYN LQNKALLKLF ARILHVDQQQ MNLDLEQDGD
110 120 130 140 150
ISETLRKHFA GSSKLKPQAQ SKLYLHEVET LLCQLEQRTK EDEQTEVLHA
160 170 180 190 200
LCKQATDLDL RTFIRLIKQD LRINARARHI LDAFGPQAYP AYQSSRDLTA
210 220 230 240 250
IVENFAGSQD TSTAPKTPAK AAGGKKMKVA SSGIQVMTPV SPMLANACKS
260 270 280 290 300
VEEAFKKNPD GLYSEIKYDG ERVQIHKQGD EFKFFSRNLK PVMDHKIKDL
310 320 330 340 350
KDYIPRAFPG ADDMILDSEI ILVDTETGSL LPFGTLGAHK KHTFENASVC
360 370 380 390 400
LFVFDCLLYD GDDLTQVEFR KRREILEKNI KPIKSHVQLS ESEFLKTKKE
410 420 430 440 450
LALMTAKVLQ ANLEGVVLKN PAGTYQPGKR NWLKVKKDYL FGGKMADTAD
460 470 480 490 500
LVVLGAWYGS GKKGGVLSIF LMGCFDARDH LWKTVTKVHS GLDDVTNDDV
510 520 530 540 550
HEALMKLTDR ADANKIPSWL LCKKALVPDV LAKVPEQMPV WEITGAEFTQ
560 570 580 590 600
SEAHTAAGIS IRFPRITRLR SDKSAMQAND LEHLEQLYAA SKQNVNVDLL
610 620 630 640 650
LANSEPDSND TLENKLKVEK TPTKSKTIKA SLTSSSKKAK RSKNDTDDEE
660 670 680 690 700
AAPSKGRSTR KMSKLEAPSS ASQGNLKDFF KPKAIKTEVK NEPTSNSSKS
710 720 730 740 750
PELLKSESSK LFSGLLANFS VDAAQSKYMD EFVRHGGTLT MNTQKASLVF
760 770 780 790
HDVTRSVDLT QLRPLYHRSC RHLSVKWLET SIRAKTLQPY PLYALILKS
Length:799
Mass (Da):89,446
Last modified:September 23, 2008 - v1
Checksum:i0B8C04D429E52EE5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916373 Genomic DNA. Translation: EDV94345.1.
RefSeqiXP_001993609.1. XM_001993573.1.

Genome annotation databases

EnsemblMetazoaiFBtr0155567; FBpp0154059; FBgn0127617.
GeneIDi6567229.
KEGGidgr:Dgri_GH20153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916373 Genomic DNA. Translation: EDV94345.1.
RefSeqiXP_001993609.1. XM_001993573.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0154059.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0155567; FBpp0154059; FBgn0127617.
GeneIDi6567229.
KEGGidgr:Dgri_GH20153.

Organism-specific databases

FlyBaseiFBgn0127617. Dgri\GH20153.

Phylogenomic databases

eggNOGiCOG1793.
InParanoidiB4JRF5.
KOiK10776.
OMAiMILDSEI.
OrthoDBiEOG7BKCT2.
PhylomeDBiB4JRF5.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
InterProiIPR001357. BRCT_dom.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS50172. BRCT. 1 hit.
PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiB4JRF5_DROGR
AccessioniPrimary (citable) accession number: B4JRF5
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: January 7, 2015
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.