B4JRF5 (B4JRF5_DROGR) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
DNA ligase RuleBase RU000617
EC=6.5.1.1 RuleBase RU000617

Gene names

Name:	GH20153 FlyBase FBgn0127617
Synonyms:	Dgri\GH20153 EMBL EDV94345.1
ORF Names:	Dgri_GH20153 EMBL EDV94345.1

Organism

Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) [Complete proteome]

Taxonomic identifier

7222 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Hawaiian Drosophila › picture wing clade › grimshawi clade › grimshawi group › grimshawi subgroup

Protein attributes

Sequence length	799 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). RuleBase RU000617
Sequence similarities	Belongs to the ATP-dependent DNA ligase family. RuleBase RU004196

Ontologies

Keywords
Biological process	DNA damage DNA recombination RuleBase RU000617 DNA repair RuleBase RU000617 DNA replication RuleBase RU000617
Ligand	ATP-binding RuleBase RU000617 Nucleotide-binding
Molecular function	Ligase RuleBase RU000617
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA ligation involved in DNA repair Inferred from electronic annotation. Source: InterPro DNA recombination Inferred from electronic annotation. Source: UniProtKB-KW DNA replication Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA binding Inferred from electronic annotation. Source: InterPro DNA ligase (ATP) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	B4JRF5 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 0B8C04D429E52EE5	FASTA	799	89,446
	10 20 30 40 50 60 MGSKQAQNED NKLDTFRHIC DEIAGESSYL RKVEKLEHFF KKGSSGSGFQ GDTLQWVQFL 70 80 90 100 110 120 IPGATQRVYN LQNKALLKLF ARILHVDQQQ MNLDLEQDGD ISETLRKHFA GSSKLKPQAQ 130 140 150 160 170 180 SKLYLHEVET LLCQLEQRTK EDEQTEVLHA LCKQATDLDL RTFIRLIKQD LRINARARHI 190 200 210 220 230 240 LDAFGPQAYP AYQSSRDLTA IVENFAGSQD TSTAPKTPAK AAGGKKMKVA SSGIQVMTPV 250 260 270 280 290 300 SPMLANACKS VEEAFKKNPD GLYSEIKYDG ERVQIHKQGD EFKFFSRNLK PVMDHKIKDL 310 320 330 340 350 360 KDYIPRAFPG ADDMILDSEI ILVDTETGSL LPFGTLGAHK KHTFENASVC LFVFDCLLYD 370 380 390 400 410 420 GDDLTQVEFR KRREILEKNI KPIKSHVQLS ESEFLKTKKE LALMTAKVLQ ANLEGVVLKN 430 440 450 460 470 480 PAGTYQPGKR NWLKVKKDYL FGGKMADTAD LVVLGAWYGS GKKGGVLSIF LMGCFDARDH 490 500 510 520 530 540 LWKTVTKVHS GLDDVTNDDV HEALMKLTDR ADANKIPSWL LCKKALVPDV LAKVPEQMPV 550 560 570 580 590 600 WEITGAEFTQ SEAHTAAGIS IRFPRITRLR SDKSAMQAND LEHLEQLYAA SKQNVNVDLL 610 620 630 640 650 660 LANSEPDSND TLENKLKVEK TPTKSKTIKA SLTSSSKKAK RSKNDTDDEE AAPSKGRSTR 670 680 690 700 710 720 KMSKLEAPSS ASQGNLKDFF KPKAIKTEVK NEPTSNSSKS PELLKSESSK LFSGLLANFS 730 740 750 760 770 780 VDAAQSKYMD EFVRHGGTLT MNTQKASLVF HDVTRSVDLT QLRPLYHRSC RHLSVKWLET 790 SIRAKTLQPY PLYALILKS

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15287-2541.00.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH916373 Genomic DNA. Translation: EDV94345.1.
RefSeq	XP_001993609.1. XM_001993573.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	7222.FBpp0154059.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0155567; FBpp0154059; FBgn0127617.
GeneID	6567229.
KEGG	dgr:Dgri_GH20153.
Organism-specific databases
FlyBase	FBgn0127617. Dgri\GH20153.
Phylogenomic databases
eggNOG	COG1793.
InParanoid	B4JRF5.
KO	K10776.
OMA	NEDNKLD.
OrthoDB	EOG4BNZSZ.
Family and domain databases
Gene3D	1.10.3260.10. 1 hit. 2.40.50.140. 1 hit.
InterPro	IPR001357. BRCT_dom. IPR000977. DNA_ligase_ATP-dep. IPR012309. DNA_ligase_ATP-dep_C. IPR012310. DNA_ligase_ATP-dep_cent. IPR016059. DNA_ligase_ATP-dep_CS. IPR012308. DNA_ligase_ATP-dep_N. IPR012340. NA-bd_OB-fold. [Graphical view]
Pfam	PF04679. DNA_ligase_A_C. 1 hit. PF01068. DNA_ligase_A_M. 1 hit. PF04675. DNA_ligase_A_N. 1 hit. [Graphical view]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
TIGRFAMs	TIGR00574. dnl1. 1 hit.
PROSITE	PS50172. BRCT. 1 hit. PS00697. DNA_LIGASE_A1. 1 hit. PS00333. DNA_LIGASE_A2. 1 hit. PS50160. DNA_LIGASE_A3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B4JRF5_DROGR

Accession

Primary (citable) accession number: B4JRF5

Entry history

Integrated into UniProtKB/TrEMBL:	September 23, 2008
Last sequence update:	September 23, 2008
Last modified:	April 3, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)