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B4JLX2 (SWS_DROGR) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese
EC=3.1.1.5
Gene names
Name:sws
ORF Names:GH24540
OrganismDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi) [Complete proteome]
Taxonomic identifier7222 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila

Protein attributes

Sequence length1464 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity. UniProtKB Q9U969

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. UniProtKB Q9U969

Subunit structure

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity. UniProtKB Q9U969

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Sws tethers Pka-C3 to the membrane By similarity. UniProtKB Q9U969

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14641464Neuropathy target esterase sws
PRO_0000389222

Regions

Topological domain1 – 3434Lumenal Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 14641409Cytoplasmic Potential
Domain928 – 1094167Patatin
Nucleotide binding176 – 303128cNMP 1
Nucleotide binding456 – 586131cNMP 2
Nucleotide binding575 – 702128cNMP 3

Sites

Active site9611 By similarity UniProtKB Q9U969

Amino acid modifications

Modified residue4211Phosphoserine By similarity UniProtKB Q9U969
Modified residue11751Phosphoserine By similarity UniProtKB Q9U969

Sequences

Sequence LengthMass (Da)Tools
B4JLX2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 4D2B9897F9EE0930

FASTA1,464165,239
        10         20         30         40         50         60 
MDVLELLRAS ATGCYNTIFS EAWHQYVHKQ IAAAVYWYGA LFLLGVLLFV WFLYFKRLAR 

        70         80         90        100        110        120 
LRLRDEIARS LSAVTSAATG VDHRGLRFRK RDKMLFYGRR MLRKMKNVSG QMYSSGKGYK 

       130        140        150        160        170        180 
RRAVMRFARR ILQLQRENRP LEMKTVEPPA EYLEETIEGS DRVPPDALYM LQSIRIFGHF 

       190        200        210        220        230        240 
EKPIFLKLCK HTQILQLMAG DYLFKITDPD DSVYIVQSGM INVYICNADG STLSLKTVRK 

       250        260        270        280        290        300 
GESVTSLLSF IDVLSGNSSY YKTVTAKAIE KSVVIRLPMQ AFEEVFDENP DVMIRVIQVI 

       310        320        330        340        350        360 
MIRLQRVLFT ALRNYLGLNA ELVQNHMRNK NSSNPMATGQ TTSNVQSQTS QATQSRPSGT 

       370        380        390        400        410        420 
TRTPTSPMLR LSREEHTLSD PDPNPNANNL HYHEMHGDAP YIDLYHYQQQ QQSLNSPRRN 

       430        440        450        460        470        480 
STAHVSEAAA ASTASSPTTI DQRLVQSSAV DSLRRELGLG EEDAHIIEQF VLVRELEPNV 

       490        500        510        520        530        540 
TLITEGNADD VCIWFVMTGN LAVYQSNADA TRASAKQDAK PEMLIHFVHP GEIVGGLAML 

       550        560        570        580        590        600 
TGEASAYTIR SRNNSRVAFI RRAAIYQIMR QRPRIVLGLG NGVVRRLSPL VRQCDYALDW 

       610        620        630        640        650        660 
IFLESGRAVY RQDESSDSTY IVLSGRMRSV ITQPNGKKEI VGEYGKGDLV GIVEMITETS 

       670        680        690        700        710        720 
RTTTVMAVRD SELAKLPEGL FNAIKLRYPI VVTRLISFLS HRFLGSMQTR GSNAYGTPVE 

       730        740        750        760        770        780 
ANPVTHKYST VALVPITDDV PLTPFTYELY HSLCAIGPVL RLTSEVVGKQ LGVNIFDTAN 

       790        800        810        820        830        840 
EYRLTSWLAQ QEDRNIITLY QCDSSLSPWT QRCMRQADVI LIVGLGERSH LVGKFEREID 

       850        860        870        880        890        900 
KLAMRTQKEL VLLYPETTNA KPANTLSWLN ARPWVTKHHH VLCVKRIFTR KSQYRINDLY 

       910        920        930        940        950        960 
SRVLLSEPNM HSDFSRLARW LTGNSIGLVL GGGGARGAAH IGMLKAIQEA GIPIDMVGGV 

       970        980        990       1000       1010       1020 
SIGALMGALW CSERNITTVT QKAREWSKKM TKWFLQLLDL TYPITSMFSG REFNKTIHDT 

      1030       1040       1050       1060       1070       1080 
FGDVTIEDLW IPYFTLTTDI TASCHRIHTN GSLWRFVRSS MSLSGYMPPL CDPQDGHLLL 

      1090       1100       1110       1120       1130       1140 
DGGYVNNLPG HLWRYCRASM SIAGVFPPFC DYRDGHLLLD GCYTNNVPAD VMHNLGAAHI 

      1150       1160       1170       1180       1190       1200 
IAIDVGSQDD TDLTNYGDDL SGWWLLYKKW NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE 

      1210       1220       1230       1240       1250       1260 
VKNSDYCEYI RPPIDKYKTL AFGSFDEIRD VGYVFGKNYF DTMAKAGRLG RFNQWFNKEP 

      1270       1280       1290       1300       1310       1320 
PKRGNHASLN EYTFIDLAQI VCKLPETYVR LGTPDLFSED EDEDFDGYIS EPTTLNTDRR 

      1330       1340       1350       1360       1370       1380 
RIQVHRAGNS LSFSEAELDS DVELDLEMEN KVDKATQSTP TLPDKRSVQT PTPSLFNLTM 

      1390       1400       1410       1420       1430       1440 
PIAVDEIDKS SGRVKRKLEA TNTASIAEPE ASPSIKAEAT TQTTPPTSKR TEQDEHELEH 

      1450       1460 
EQVVEKQQVM DKQQGNTTNN DTKN 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15287-2541.00.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH916371 Genomic DNA. Translation: EDV91733.1.
RefSeqXP_001992026.1. XM_001991990.1.

3D structure databases

ProteinModelPortalB4JLX2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7222.FBpp0158446.

Proteomic databases

PRIDEB4JLX2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0159954; FBpp0158446; FBgn0131996.
GeneID6566307.
KEGGdgr:Dgri_GH24540.

Organism-specific databases

FlyBaseFBgn0131996. Dgri\GH24540.

Phylogenomic databases

eggNOGCOG0664.
InParanoidB4JLX2.
KOK14676.
OMAMACDRAR.
OrthoDBEOG7QRQT1.
PhylomeDBB4JLX2.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSWS_DROGR
AccessionPrimary (citable) accession number: B4JLX2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase