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B4JLX2

- SWS_DROGR

UniProt

B4JLX2 - SWS_DROGR

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Protein
Neuropathy target esterase sws
Gene
sws, GH24540
Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei961 – 9611 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 303128cNMP 1
Add
BLAST
Nucleotide bindingi456 – 586131cNMP 2
Add
BLAST
Nucleotide bindingi575 – 702128cNMP 3
Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GH24540
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0131996. Dgri\GH24540.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed prediction
Add
BLAST
Transmembranei35 – 5521Helical; Reviewed prediction
Add
BLAST
Topological domaini56 – 14641409Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14641464Neuropathy target esterase sws
PRO_0000389222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei421 – 4211Phosphoserine By similarityBy similarity
Modified residuei1175 – 11751Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB4JLX2.

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Protein-protein interaction databases

STRINGi7222.FBpp0158446.

Structurei

3D structure databases

ProteinModelPortaliB4JLX2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini928 – 1094167Patatin
Add
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB4JLX2.
KOiK14676.
OMAiMACDRAR.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4JLX2.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4JLX2-1 [UniParc]FASTAAdd to Basket

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MDVLELLRAS ATGCYNTIFS EAWHQYVHKQ IAAAVYWYGA LFLLGVLLFV     50
WFLYFKRLAR LRLRDEIARS LSAVTSAATG VDHRGLRFRK RDKMLFYGRR 100
MLRKMKNVSG QMYSSGKGYK RRAVMRFARR ILQLQRENRP LEMKTVEPPA 150
EYLEETIEGS DRVPPDALYM LQSIRIFGHF EKPIFLKLCK HTQILQLMAG 200
DYLFKITDPD DSVYIVQSGM INVYICNADG STLSLKTVRK GESVTSLLSF 250
IDVLSGNSSY YKTVTAKAIE KSVVIRLPMQ AFEEVFDENP DVMIRVIQVI 300
MIRLQRVLFT ALRNYLGLNA ELVQNHMRNK NSSNPMATGQ TTSNVQSQTS 350
QATQSRPSGT TRTPTSPMLR LSREEHTLSD PDPNPNANNL HYHEMHGDAP 400
YIDLYHYQQQ QQSLNSPRRN STAHVSEAAA ASTASSPTTI DQRLVQSSAV 450
DSLRRELGLG EEDAHIIEQF VLVRELEPNV TLITEGNADD VCIWFVMTGN 500
LAVYQSNADA TRASAKQDAK PEMLIHFVHP GEIVGGLAML TGEASAYTIR 550
SRNNSRVAFI RRAAIYQIMR QRPRIVLGLG NGVVRRLSPL VRQCDYALDW 600
IFLESGRAVY RQDESSDSTY IVLSGRMRSV ITQPNGKKEI VGEYGKGDLV 650
GIVEMITETS RTTTVMAVRD SELAKLPEGL FNAIKLRYPI VVTRLISFLS 700
HRFLGSMQTR GSNAYGTPVE ANPVTHKYST VALVPITDDV PLTPFTYELY 750
HSLCAIGPVL RLTSEVVGKQ LGVNIFDTAN EYRLTSWLAQ QEDRNIITLY 800
QCDSSLSPWT QRCMRQADVI LIVGLGERSH LVGKFEREID KLAMRTQKEL 850
VLLYPETTNA KPANTLSWLN ARPWVTKHHH VLCVKRIFTR KSQYRINDLY 900
SRVLLSEPNM HSDFSRLARW LTGNSIGLVL GGGGARGAAH IGMLKAIQEA 950
GIPIDMVGGV SIGALMGALW CSERNITTVT QKAREWSKKM TKWFLQLLDL 1000
TYPITSMFSG REFNKTIHDT FGDVTIEDLW IPYFTLTTDI TASCHRIHTN 1050
GSLWRFVRSS MSLSGYMPPL CDPQDGHLLL DGGYVNNLPG HLWRYCRASM 1100
SIAGVFPPFC DYRDGHLLLD GCYTNNVPAD VMHNLGAAHI IAIDVGSQDD 1150
TDLTNYGDDL SGWWLLYKKW NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE 1200
VKNSDYCEYI RPPIDKYKTL AFGSFDEIRD VGYVFGKNYF DTMAKAGRLG 1250
RFNQWFNKEP PKRGNHASLN EYTFIDLAQI VCKLPETYVR LGTPDLFSED 1300
EDEDFDGYIS EPTTLNTDRR RIQVHRAGNS LSFSEAELDS DVELDLEMEN 1350
KVDKATQSTP TLPDKRSVQT PTPSLFNLTM PIAVDEIDKS SGRVKRKLEA 1400
TNTASIAEPE ASPSIKAEAT TQTTPPTSKR TEQDEHELEH EQVVEKQQVM 1450
DKQQGNTTNN DTKN 1464
Length:1,464
Mass (Da):165,239
Last modified:September 23, 2008 - v1
Checksum:i4D2B9897F9EE0930
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916371 Genomic DNA. Translation: EDV91733.1.
RefSeqiXP_001992026.1. XM_001991990.1.

Genome annotation databases

EnsemblMetazoaiFBtr0159954; FBpp0158446; FBgn0131996.
GeneIDi6566307.
KEGGidgr:Dgri_GH24540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916371 Genomic DNA. Translation: EDV91733.1 .
RefSeqi XP_001992026.1. XM_001991990.1.

3D structure databases

ProteinModelPortali B4JLX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0158446.

Proteomic databases

PRIDEi B4JLX2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0159954 ; FBpp0158446 ; FBgn0131996 .
GeneIDi 6566307.
KEGGi dgr:Dgri_GH24540.

Organism-specific databases

FlyBasei FBgn0131996. Dgri\GH24540.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B4JLX2.
KOi K14676.
OMAi MACDRAR.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4JLX2.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00.

Entry informationi

Entry nameiSWS_DROGR
AccessioniPrimary (citable) accession number: B4JLX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi