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B4JLX2

- SWS_DROGR

UniProt

B4JLX2 - SWS_DROGR

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei961 – 9611By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi176 – 303128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi456 – 586131cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi575 – 702128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GH24540
    OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
    Taxonomic identifieri7222 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
    ProteomesiUP000001070: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0131996. Dgri\GH24540.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14641464Neuropathy target esterase swsPRO_0000389222Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei421 – 4211PhosphoserineBy similarity
    Modified residuei1175 – 11751PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiB4JLX2.

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Protein-protein interaction databases

    STRINGi7222.FBpp0158446.

    Structurei

    3D structure databases

    ProteinModelPortaliB4JLX2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14641409CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini928 – 1094167PatatinSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0664.
    InParanoidiB4JLX2.
    KOiK14676.
    OMAiMACDRAR.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB4JLX2.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 2 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4JLX2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLELLRAS ATGCYNTIFS EAWHQYVHKQ IAAAVYWYGA LFLLGVLLFV     50
    WFLYFKRLAR LRLRDEIARS LSAVTSAATG VDHRGLRFRK RDKMLFYGRR 100
    MLRKMKNVSG QMYSSGKGYK RRAVMRFARR ILQLQRENRP LEMKTVEPPA 150
    EYLEETIEGS DRVPPDALYM LQSIRIFGHF EKPIFLKLCK HTQILQLMAG 200
    DYLFKITDPD DSVYIVQSGM INVYICNADG STLSLKTVRK GESVTSLLSF 250
    IDVLSGNSSY YKTVTAKAIE KSVVIRLPMQ AFEEVFDENP DVMIRVIQVI 300
    MIRLQRVLFT ALRNYLGLNA ELVQNHMRNK NSSNPMATGQ TTSNVQSQTS 350
    QATQSRPSGT TRTPTSPMLR LSREEHTLSD PDPNPNANNL HYHEMHGDAP 400
    YIDLYHYQQQ QQSLNSPRRN STAHVSEAAA ASTASSPTTI DQRLVQSSAV 450
    DSLRRELGLG EEDAHIIEQF VLVRELEPNV TLITEGNADD VCIWFVMTGN 500
    LAVYQSNADA TRASAKQDAK PEMLIHFVHP GEIVGGLAML TGEASAYTIR 550
    SRNNSRVAFI RRAAIYQIMR QRPRIVLGLG NGVVRRLSPL VRQCDYALDW 600
    IFLESGRAVY RQDESSDSTY IVLSGRMRSV ITQPNGKKEI VGEYGKGDLV 650
    GIVEMITETS RTTTVMAVRD SELAKLPEGL FNAIKLRYPI VVTRLISFLS 700
    HRFLGSMQTR GSNAYGTPVE ANPVTHKYST VALVPITDDV PLTPFTYELY 750
    HSLCAIGPVL RLTSEVVGKQ LGVNIFDTAN EYRLTSWLAQ QEDRNIITLY 800
    QCDSSLSPWT QRCMRQADVI LIVGLGERSH LVGKFEREID KLAMRTQKEL 850
    VLLYPETTNA KPANTLSWLN ARPWVTKHHH VLCVKRIFTR KSQYRINDLY 900
    SRVLLSEPNM HSDFSRLARW LTGNSIGLVL GGGGARGAAH IGMLKAIQEA 950
    GIPIDMVGGV SIGALMGALW CSERNITTVT QKAREWSKKM TKWFLQLLDL 1000
    TYPITSMFSG REFNKTIHDT FGDVTIEDLW IPYFTLTTDI TASCHRIHTN 1050
    GSLWRFVRSS MSLSGYMPPL CDPQDGHLLL DGGYVNNLPG HLWRYCRASM 1100
    SIAGVFPPFC DYRDGHLLLD GCYTNNVPAD VMHNLGAAHI IAIDVGSQDD 1150
    TDLTNYGDDL SGWWLLYKKW NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE 1200
    VKNSDYCEYI RPPIDKYKTL AFGSFDEIRD VGYVFGKNYF DTMAKAGRLG 1250
    RFNQWFNKEP PKRGNHASLN EYTFIDLAQI VCKLPETYVR LGTPDLFSED 1300
    EDEDFDGYIS EPTTLNTDRR RIQVHRAGNS LSFSEAELDS DVELDLEMEN 1350
    KVDKATQSTP TLPDKRSVQT PTPSLFNLTM PIAVDEIDKS SGRVKRKLEA 1400
    TNTASIAEPE ASPSIKAEAT TQTTPPTSKR TEQDEHELEH EQVVEKQQVM 1450
    DKQQGNTTNN DTKN 1464
    Length:1,464
    Mass (Da):165,239
    Last modified:September 23, 2008 - v1
    Checksum:i4D2B9897F9EE0930
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916371 Genomic DNA. Translation: EDV91733.1.
    RefSeqiXP_001992026.1. XM_001991990.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0159954; FBpp0158446; FBgn0131996.
    GeneIDi6566307.
    KEGGidgr:Dgri_GH24540.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916371 Genomic DNA. Translation: EDV91733.1 .
    RefSeqi XP_001992026.1. XM_001991990.1.

    3D structure databases

    ProteinModelPortali B4JLX2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7222.FBpp0158446.

    Proteomic databases

    PRIDEi B4JLX2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0159954 ; FBpp0158446 ; FBgn0131996 .
    GeneIDi 6566307.
    KEGGi dgr:Dgri_GH24540.

    Organism-specific databases

    FlyBasei FBgn0131996. Dgri\GH24540.

    Phylogenomic databases

    eggNOGi COG0664.
    InParanoidi B4JLX2.
    KOi K14676.
    OMAi MACDRAR.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B4JLX2.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 2 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15287-2541.00Imported.

    Entry informationi

    Entry nameiSWS_DROGR
    AccessioniPrimary (citable) accession number: B4JLX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3