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B4JLX2

- SWS_DROGR

UniProt

B4JLX2 - SWS_DROGR

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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei961 – 9611By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi176 – 303128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi456 – 586131cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi575 – 702128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GH24540
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0131996. Dgri\GH24540.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14641464Neuropathy target esterase swsPRO_0000389222Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei421 – 4211PhosphoserineBy similarity
Modified residuei1175 – 11751PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB4JLX2.

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Protein-protein interaction databases

STRINGi7222.FBpp0158446.

Structurei

3D structure databases

ProteinModelPortaliB4JLX2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence AnalysisAdd
BLAST
Topological domaini56 – 14641409CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini928 – 1094167PatatinSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0664.
InParanoidiB4JLX2.
KOiK14676.
OMAiMACDRAR.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4JLX2.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 2 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4JLX2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLELLRAS ATGCYNTIFS EAWHQYVHKQ IAAAVYWYGA LFLLGVLLFV
60 70 80 90 100
WFLYFKRLAR LRLRDEIARS LSAVTSAATG VDHRGLRFRK RDKMLFYGRR
110 120 130 140 150
MLRKMKNVSG QMYSSGKGYK RRAVMRFARR ILQLQRENRP LEMKTVEPPA
160 170 180 190 200
EYLEETIEGS DRVPPDALYM LQSIRIFGHF EKPIFLKLCK HTQILQLMAG
210 220 230 240 250
DYLFKITDPD DSVYIVQSGM INVYICNADG STLSLKTVRK GESVTSLLSF
260 270 280 290 300
IDVLSGNSSY YKTVTAKAIE KSVVIRLPMQ AFEEVFDENP DVMIRVIQVI
310 320 330 340 350
MIRLQRVLFT ALRNYLGLNA ELVQNHMRNK NSSNPMATGQ TTSNVQSQTS
360 370 380 390 400
QATQSRPSGT TRTPTSPMLR LSREEHTLSD PDPNPNANNL HYHEMHGDAP
410 420 430 440 450
YIDLYHYQQQ QQSLNSPRRN STAHVSEAAA ASTASSPTTI DQRLVQSSAV
460 470 480 490 500
DSLRRELGLG EEDAHIIEQF VLVRELEPNV TLITEGNADD VCIWFVMTGN
510 520 530 540 550
LAVYQSNADA TRASAKQDAK PEMLIHFVHP GEIVGGLAML TGEASAYTIR
560 570 580 590 600
SRNNSRVAFI RRAAIYQIMR QRPRIVLGLG NGVVRRLSPL VRQCDYALDW
610 620 630 640 650
IFLESGRAVY RQDESSDSTY IVLSGRMRSV ITQPNGKKEI VGEYGKGDLV
660 670 680 690 700
GIVEMITETS RTTTVMAVRD SELAKLPEGL FNAIKLRYPI VVTRLISFLS
710 720 730 740 750
HRFLGSMQTR GSNAYGTPVE ANPVTHKYST VALVPITDDV PLTPFTYELY
760 770 780 790 800
HSLCAIGPVL RLTSEVVGKQ LGVNIFDTAN EYRLTSWLAQ QEDRNIITLY
810 820 830 840 850
QCDSSLSPWT QRCMRQADVI LIVGLGERSH LVGKFEREID KLAMRTQKEL
860 870 880 890 900
VLLYPETTNA KPANTLSWLN ARPWVTKHHH VLCVKRIFTR KSQYRINDLY
910 920 930 940 950
SRVLLSEPNM HSDFSRLARW LTGNSIGLVL GGGGARGAAH IGMLKAIQEA
960 970 980 990 1000
GIPIDMVGGV SIGALMGALW CSERNITTVT QKAREWSKKM TKWFLQLLDL
1010 1020 1030 1040 1050
TYPITSMFSG REFNKTIHDT FGDVTIEDLW IPYFTLTTDI TASCHRIHTN
1060 1070 1080 1090 1100
GSLWRFVRSS MSLSGYMPPL CDPQDGHLLL DGGYVNNLPG HLWRYCRASM
1110 1120 1130 1140 1150
SIAGVFPPFC DYRDGHLLLD GCYTNNVPAD VMHNLGAAHI IAIDVGSQDD
1160 1170 1180 1190 1200
TDLTNYGDDL SGWWLLYKKW NPFTSPVKVP DLPDIQSRLA YVSCVRQLEE
1210 1220 1230 1240 1250
VKNSDYCEYI RPPIDKYKTL AFGSFDEIRD VGYVFGKNYF DTMAKAGRLG
1260 1270 1280 1290 1300
RFNQWFNKEP PKRGNHASLN EYTFIDLAQI VCKLPETYVR LGTPDLFSED
1310 1320 1330 1340 1350
EDEDFDGYIS EPTTLNTDRR RIQVHRAGNS LSFSEAELDS DVELDLEMEN
1360 1370 1380 1390 1400
KVDKATQSTP TLPDKRSVQT PTPSLFNLTM PIAVDEIDKS SGRVKRKLEA
1410 1420 1430 1440 1450
TNTASIAEPE ASPSIKAEAT TQTTPPTSKR TEQDEHELEH EQVVEKQQVM
1460
DKQQGNTTNN DTKN
Length:1,464
Mass (Da):165,239
Last modified:September 23, 2008 - v1
Checksum:i4D2B9897F9EE0930
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916371 Genomic DNA. Translation: EDV91733.1.
RefSeqiXP_001992026.1. XM_001991990.1.

Genome annotation databases

EnsemblMetazoaiFBtr0159954; FBpp0158446; FBgn0131996.
GeneIDi6566307.
KEGGidgr:Dgri_GH24540.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916371 Genomic DNA. Translation: EDV91733.1 .
RefSeqi XP_001992026.1. XM_001991990.1.

3D structure databases

ProteinModelPortali B4JLX2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0158446.

Proteomic databases

PRIDEi B4JLX2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0159954 ; FBpp0158446 ; FBgn0131996 .
GeneIDi 6566307.
KEGGi dgr:Dgri_GH24540.

Organism-specific databases

FlyBasei FBgn0131996. Dgri\GH24540.

Phylogenomic databases

eggNOGi COG0664.
InParanoidi B4JLX2.
KOi K14676.
OMAi MACDRAR.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4JLX2.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 2 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiSWS_DROGR
AccessioniPrimary (citable) accession number: B4JLX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3