Reviewed, UniProtKB/Swiss-Prot B4JKK1 (T23O_DROGR)

Names and origin

Protein names

Recommended name:
    Tryptophan 2,3-dioxygenase
      Short name=TDO
    EC=1.13.11.11
Alternative name(s):
    Tryptophan pyrrolase
      Short name=Tryptophanase
    Tryptophan oxygenase
      Short name=TRPO
      Short name=TO
    Tryptamin 2,3-dioxygenase
    Protein vermilion

Gene names

Name:	v
ORF Names:	GH12679

Organism

Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)

Taxonomic identifier

7222 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Hawaiian Drosophila

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring By similarity.
Catalytic activity	L-tryptophan + O2 = N-formyl-L-kynurenine.
Cofactor	Binds 2 heme groups per tetramer By similarity.
Pathway	Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. Pigment biosynthesis; ommochrome biosynthesis.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the tryptophan 2,3-dioxygenase family.

Ontologies

Keywords
Biological process	Tryptophan catabolism
Ligand	Heme Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tryptophan catabolic process to kynurenine Inferred from sequence or structural similarity. Source: UniProtKB
Molecular function	heme binding Inferred from sequence or structural similarity. Source: UniProtKB tryptophan 2,3-dioxygenase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Tryptophan 2,3-dioxygenase		PRO_0000360876
Regions
	Region	27 – 31	5	Substrate binding By similarity
	Region	57 – 61	5	Substrate binding By similarity
Sites
	Metal binding	313	1	Iron (heme axial ligand) By similarity
	Binding site	128	1	Substrate By similarity
	Binding site	135	1	Heme By similarity
	Binding site	328	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	B4JKK1-1 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 85054B06A5729877	FASTA	377	43,939
	10 20 30 40 50 60 MSCPYAGNSN EHDDAAVPLS NDVGKIYGEY LMLDKLLDAQ CMLSMEDKRP VHDEHLFIIT 70 80 90 100 110 120 HQAYELWFKQ IIFEFDSIRD MLDAEVIDET KTLEIVKRLN RVVLILKLLV DQVPILETMT 130 140 150 160 170 180 PLDFMDFRKY LAPASGFQSL QFRLIENKLG VLTEQRVKYN QKYSDVFGND ERALNAIRSS 190 200 210 220 230 240 EDNPSLLELV QRWLERTPGL EADGFNFWEK FQHSVDQFLA AQVHSALLEP VEQAKNYRLM 250 260 270 280 290 300 DIEKRREVYR SIFDPALHEA LVKRGDRRFS HGALQGAIMI TFYRDEPRFS QPHQLLTLLM 310 320 330 340 350 360 DIDSLITKWR YNHVIMVQRM IGSQQLGTGG SSGYQYLRST LSDRYKVFLD LFNLSTFLIP 370 REAIPPLDES IRQKLIH

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed: 17994087] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tucson 15287-2541.00.

Cross-references

Sequence databases
EMBLGenBankDDBJ	CH916370 Genomic DNA. Translation: EDW00104.1.
RefSeq	XP_001991479.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	6564497.
KEGG	dgr:Dgri_GH12679.
Organism-specific databases
FlyBase	FBgn0120158. Dgri\GH12679.
Family and domain databases
InterPro	IPR004981. Trp_2_3_dOase. [Graphical view]
PANTHER	PTHR10138. Trp_2_3_dOase. 1 hit.
Pfam	PF03301. Trp_dioxygenase. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

T23O_DROGR

Accession

Primary (citable) accession number: B4JKK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	September 23, 2008
Last modified:	June 16, 2009
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project