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Protein

Hexokinase

Gene

Dgri\GH12375

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Dgri\GH12375Imported
ORF Names:Dgri_GH12375Imported, GH12375Imported
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)Imported
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0119854. Dgri\GH12375.

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0146281.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiB4JIX4.
KOiK00844.
OMAiIKPGITF.
OrthoDBiEOG7S21X5.
PhylomeDBiB4JIX4.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4JIX4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQQEQLNGA MRNVSINSNG LATTLNGHNG CDQTDNVRVL RDSSSSGGSG
60 70 80 90 100
ATSKATNATA AVTTTTAAAA IANAIQIQTS AAGASAADKK KMVYELCQQL
110 120 130 140 150
LLTDEQVQEL CYRILHEVRR GLAKDTHPKA NVKCFVTYVQ DLPNGNERGK
160 170 180 190 200
FLALDLGGTN FRVLLIHLQE NNDFQMESRI YAIPQHIMIG SGLQLFDHIA
210 220 230 240 250
ECLSNFMAEH NVYSERLPLG FTFSFPLRQL GLTKGLLETW TKGFDCAGVV
260 270 280 290 300
NEDVVQLLKD AIARRGDVQI DVCAILNDTT GTLMSCAWKN HNCKIGLIVG
310 320 330 340 350
TGSNACYVER VEEAELFDGS ENGKPHVLIN TEWGAFGDNG ALDFVRTEFD
360 370 380 390 400
KDIDSHSINP GKQTFEKMIS GMYMGELVRL VLAKMTQNGI LFNGQGSEVL
410 420 430 440 450
FTRGLFFTKY VSEIEADEPG NFTNCRLVFE ELGLPNASDG DCANVRYICE
460 470 480 490 500
CVSKRAAHLV SAGIATLINK MDEPHVTVGV DGSVYRFHPK FHNLMVEKIT
510 520 530
QLIKPGISFD LMLSEDGSGR GAALVAAVAC REDILNSK
Length:538
Mass (Da):58,681
Last modified:September 22, 2008 - v1
Checksum:i5A3F395D9F170E4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916370 Genomic DNA. Translation: EDV99538.1.
RefSeqiXP_001990914.1. XM_001990878.1.

Genome annotation databases

EnsemblMetazoaiFBtr0147789; FBpp0146281; FBgn0119854.
GeneIDi6565266.
KEGGidgr:Dgri_GH12375.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916370 Genomic DNA. Translation: EDV99538.1.
RefSeqiXP_001990914.1. XM_001990878.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0146281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0147789; FBpp0146281; FBgn0119854.
GeneIDi6565266.
KEGGidgr:Dgri_GH12375.

Organism-specific databases

FlyBaseiFBgn0119854. Dgri\GH12375.

Phylogenomic databases

eggNOGiCOG5026.
InParanoidiB4JIX4.
KOiK00844.
OMAiIKPGITF.
OrthoDBiEOG7S21X5.
PhylomeDBiB4JIX4.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiB4JIX4_DROGR
AccessioniPrimary (citable) accession number: B4JIX4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2008
Last sequence update: September 22, 2008
Last modified: March 31, 2015
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.