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B4JHJ7

- DGKH_DROGR

UniProt

B4JHJ7 - DGKH_DROGR

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Protein
Diacylglycerol kinase eta
Gene
GH18973
Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA) By similarity.By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 25651Phorbol-ester/DAG-type 1
Add
BLAST
Zinc fingeri279 – 33052Phorbol-ester/DAG-type 2
Add
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: InterPro
  3. diacylglycerol kinase activity Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase eta (EC:2.7.1.107)
Short name:
DAG kinase eta
Gene namesi
ORF Names:GH18973
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0126440. Dgri\GH18973.

Subcellular locationi

Cytoplasm By similarity By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19411941Diacylglycerol kinase eta
PRO_0000375986Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0152879.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 18694PH
Add
BLAST
Domaini361 – 497137DAGKc
Add
BLAST
Domaini1878 – 194164SAM
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1133 – 115725Asn-rich
Add
BLAST

Sequence similaritiesi

Contains 1 DAGKc domain.
Contains 1 PH domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
InParanoidiB4JHJ7.
KOiK00901.
OMAiDPFRILV.
OrthoDBiEOG7DVD9B.
PhylomeDBiB4JHJ7.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4JHJ7-1 [UniParc]FASTAAdd to Basket

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MSNFLKPNTL HVDSLSPRHR SLSSGLSSGL SSACSSGSVS PVPIIPIIAI     50
SRIRDGDESE SESEIELEPA RIFHRRMSIN NSGNNKRSTN LASIIKEGYL 100
LKHTWSFQRW RRRYFRLKRN HLYYAKDAKC DVFDEIDLSE LCYFECSIKN 150
VNHSFQIITP TRSVVLCADS RRDMEDWLGS LKAATAPQRP RGDSILIDQH 200
DILSNHHHWY ATSHARPTYC NVCRDALSGV TSHGLSCEVC KCKVHKRCAA 250
KAIANCKWTT LATVGKDIIE QPDGSIIMPH QWMEGNLPVS SICAVCKKTC 300
GSVLRLQDWR CLWCRDTVHV ACRPQMAIAC PIGPAKLSVV PPTSVHSIST 350
DDAWDVASPK GNFSPLLVFV NSKSGDNQGV KFLRRFKQLL NPAQVFDLIS 400
TGPSLGLRLF RHFEMFRILV CSGDGSVGWV LSEIDRFNMH KQCQVAVMPL 450
GTGNDLARVL GWGSSCDDDT HLPQILERYE SASTKMLDRW SIMVFEKAIS 500
VPKIPKMSIT TEQEAVLTGM VTAANQHLRL IVETNDTQTL ISSTRNLCDT 550
IDDLVSRIFE HHKDDEQLAV KCDILKQKLT MLLDALQEEE IGAHSGDDLI 600
ATIRSLIARS VPSTNSARPS LLNPNISIEK TEKDHINLKE RRSSRSLRSS 650
EKEALQCRAN SVKRAIYNVV EHSEPGRPKR YQRKLSITPF EALKIPTNSG 700
ESTPCSSPLP IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN 750
LPAPRQFADS RRSSGVPEVI QELEEGANGE TIYRIGRLSL SGGANIDDAG 800
NRLSPVSDGG DNSPIDRKLD FLRVPIITSD SIVDPLSDYR PIEVFERTYY 850
MARELDKDKD KERKQDVVLD GEKEEDAGVN EKCEEQTLHP QNTLVHTCNL 900
QVPGIVVTPQ SQNVYTSDSI TIIDTDQQSN TLQEQSSSEE LGCDASDVLS 950
AISNEECSVA SEIFDKAETG HTLGDIIQNL DASNFTHIDS PETSDETEAM 1000
PGESLMDDIS SVLGHDITNA LQDNTITDDT TTLCSEHMGP PKPPRKKSMS 1050
ALSKSQIHPR RRNSSPPRMA RLARMDSDDN PQQFGFENIV FEIDNRCDDQ 1100
KMREPPRYCS LAQFVEGNDI ARQSFKQLML ECNSNNNSNN NSNSNSNNNN 1150
HNDGNSNDEP ETPTNTVITL AHSQLTTTST SDELDELSTQ TAIKIEIHDA 1200
DSSTMCTTTA TTKPLESAMA SSTSPTKRSG LGQDISVVVR PPTPLRGDSI 1250
KPTPSSSSIL SSSLLGVRSL NSSEIRRHSS HAPSLAVREY DKDKDRRHSG 1300
FNPNYLALDP EHARFLSSSP AASRRISCGS LFKKNQKYYT KRTYGLFRVR 1350
FFVVAEPDIR LATLALIRPL IPLPNEALPN LQTLKGSKSS LFMGSTLFGF 1400
EHFSDKEERQ GKDKERTPPE ETSRKMPIIN PIVRLPNWPN LANGTGFISK 1450
CLLANADTLC AAVSPLMDPD ETLLAGYHEK CVMNNYFGIG IDAKISLDFH 1500
NKREEHPEKC RSRARNYMWY GVLGSKQLLQ KTCKNLEQRV QLECDGQRIP 1550
LPELQGIVIL NIPSFMGGTN FWGSSTKKDD IFLPPSFDDR VLEVVAVFGS 1600
VQMAASRLIN LQHHRIAQCQ SVQINILGDE EIPIQVDGEA WLQPPGMIRI 1650
LHKNRVQMLC RNRSLEVSLK SWQEKQRQHS ISIQRDASST ASEHAVSTDD 1700
VISERECYVL LNFIEAVSSL VKWVKFLIIS HPALQHDLYE VACRASEALE 1750
SIHPQGKLLE GPSLRTKLVE VIDSSRQLYD DACTLLRDRG HSLILREDLE 1800
TKLSAALANM EMELKKCSVQ KCIDGKLRAY FNVLAPNEES DGRRKSRPFW 1850
VRLRSGSTAG QQQFKPPMTN TREAANNWSV NEVVTWLETM QLSEYVDSFL 1900
KNDIRGKELL TLGRRDLKDL GVVKVGHVKR ILQAIKDLSE N 1941
Length:1,941
Mass (Da):216,882
Last modified:September 23, 2008 - v1
Checksum:i3BA4E29CAD1430F9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916369 Genomic DNA. Translation: EDV92824.1.
RefSeqiXP_001989762.1. XM_001989726.1.

Genome annotation databases

EnsemblMetazoaiFBtr0154387; FBpp0152879; FBgn0126440.
GeneIDi6563274.
KEGGidgr:Dgri_GH18973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916369 Genomic DNA. Translation: EDV92824.1 .
RefSeqi XP_001989762.1. XM_001989726.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0152879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0154387 ; FBpp0152879 ; FBgn0126440 .
GeneIDi 6563274.
KEGGi dgr:Dgri_GH18973.

Organism-specific databases

FlyBasei FBgn0126440. Dgri\GH18973.

Phylogenomic databases

eggNOGi NOG328046.
InParanoidi B4JHJ7.
KOi K00901.
OMAi DPFRILV.
OrthoDBi EOG7DVD9B.
PhylomeDBi B4JHJ7.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00.

Entry informationi

Entry nameiDGKH_DROGR
AccessioniPrimary (citable) accession number: B4JHJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 23, 2008
Last modified: September 3, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi