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B4JHJ7

- DGKH_DROGR

UniProt

B4JHJ7 - DGKH_DROGR

Protein

Diacylglycerol kinase eta

Gene

GH18973

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 25651Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 33052Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    3. protein oligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
    Short name:
    DAG kinase etaBy similarity
    Gene namesi
    ORF Names:GH18973
    OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
    Taxonomic identifieri7222 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
    ProteomesiUP000001070: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0126440. Dgri\GH18973.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19411941Diacylglycerol kinase etaPRO_0000375986Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi7222.FBpp0152879.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini93 – 18694PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini361 – 497137DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Domaini1878 – 194164SAMPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1133 – 115725Asn-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri206 – 25651Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri279 – 33052Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG328046.
    InParanoidiB4JHJ7.
    KOiK00901.
    OMAiDPFRILV.
    OrthoDBiEOG7DVD9B.
    PhylomeDBiB4JHJ7.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4JHJ7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNFLKPNTL HVDSLSPRHR SLSSGLSSGL SSACSSGSVS PVPIIPIIAI     50
    SRIRDGDESE SESEIELEPA RIFHRRMSIN NSGNNKRSTN LASIIKEGYL 100
    LKHTWSFQRW RRRYFRLKRN HLYYAKDAKC DVFDEIDLSE LCYFECSIKN 150
    VNHSFQIITP TRSVVLCADS RRDMEDWLGS LKAATAPQRP RGDSILIDQH 200
    DILSNHHHWY ATSHARPTYC NVCRDALSGV TSHGLSCEVC KCKVHKRCAA 250
    KAIANCKWTT LATVGKDIIE QPDGSIIMPH QWMEGNLPVS SICAVCKKTC 300
    GSVLRLQDWR CLWCRDTVHV ACRPQMAIAC PIGPAKLSVV PPTSVHSIST 350
    DDAWDVASPK GNFSPLLVFV NSKSGDNQGV KFLRRFKQLL NPAQVFDLIS 400
    TGPSLGLRLF RHFEMFRILV CSGDGSVGWV LSEIDRFNMH KQCQVAVMPL 450
    GTGNDLARVL GWGSSCDDDT HLPQILERYE SASTKMLDRW SIMVFEKAIS 500
    VPKIPKMSIT TEQEAVLTGM VTAANQHLRL IVETNDTQTL ISSTRNLCDT 550
    IDDLVSRIFE HHKDDEQLAV KCDILKQKLT MLLDALQEEE IGAHSGDDLI 600
    ATIRSLIARS VPSTNSARPS LLNPNISIEK TEKDHINLKE RRSSRSLRSS 650
    EKEALQCRAN SVKRAIYNVV EHSEPGRPKR YQRKLSITPF EALKIPTNSG 700
    ESTPCSSPLP IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN 750
    LPAPRQFADS RRSSGVPEVI QELEEGANGE TIYRIGRLSL SGGANIDDAG 800
    NRLSPVSDGG DNSPIDRKLD FLRVPIITSD SIVDPLSDYR PIEVFERTYY 850
    MARELDKDKD KERKQDVVLD GEKEEDAGVN EKCEEQTLHP QNTLVHTCNL 900
    QVPGIVVTPQ SQNVYTSDSI TIIDTDQQSN TLQEQSSSEE LGCDASDVLS 950
    AISNEECSVA SEIFDKAETG HTLGDIIQNL DASNFTHIDS PETSDETEAM 1000
    PGESLMDDIS SVLGHDITNA LQDNTITDDT TTLCSEHMGP PKPPRKKSMS 1050
    ALSKSQIHPR RRNSSPPRMA RLARMDSDDN PQQFGFENIV FEIDNRCDDQ 1100
    KMREPPRYCS LAQFVEGNDI ARQSFKQLML ECNSNNNSNN NSNSNSNNNN 1150
    HNDGNSNDEP ETPTNTVITL AHSQLTTTST SDELDELSTQ TAIKIEIHDA 1200
    DSSTMCTTTA TTKPLESAMA SSTSPTKRSG LGQDISVVVR PPTPLRGDSI 1250
    KPTPSSSSIL SSSLLGVRSL NSSEIRRHSS HAPSLAVREY DKDKDRRHSG 1300
    FNPNYLALDP EHARFLSSSP AASRRISCGS LFKKNQKYYT KRTYGLFRVR 1350
    FFVVAEPDIR LATLALIRPL IPLPNEALPN LQTLKGSKSS LFMGSTLFGF 1400
    EHFSDKEERQ GKDKERTPPE ETSRKMPIIN PIVRLPNWPN LANGTGFISK 1450
    CLLANADTLC AAVSPLMDPD ETLLAGYHEK CVMNNYFGIG IDAKISLDFH 1500
    NKREEHPEKC RSRARNYMWY GVLGSKQLLQ KTCKNLEQRV QLECDGQRIP 1550
    LPELQGIVIL NIPSFMGGTN FWGSSTKKDD IFLPPSFDDR VLEVVAVFGS 1600
    VQMAASRLIN LQHHRIAQCQ SVQINILGDE EIPIQVDGEA WLQPPGMIRI 1650
    LHKNRVQMLC RNRSLEVSLK SWQEKQRQHS ISIQRDASST ASEHAVSTDD 1700
    VISERECYVL LNFIEAVSSL VKWVKFLIIS HPALQHDLYE VACRASEALE 1750
    SIHPQGKLLE GPSLRTKLVE VIDSSRQLYD DACTLLRDRG HSLILREDLE 1800
    TKLSAALANM EMELKKCSVQ KCIDGKLRAY FNVLAPNEES DGRRKSRPFW 1850
    VRLRSGSTAG QQQFKPPMTN TREAANNWSV NEVVTWLETM QLSEYVDSFL 1900
    KNDIRGKELL TLGRRDLKDL GVVKVGHVKR ILQAIKDLSE N 1941
    Length:1,941
    Mass (Da):216,882
    Last modified:September 23, 2008 - v1
    Checksum:i3BA4E29CAD1430F9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916369 Genomic DNA. Translation: EDV92824.1.
    RefSeqiXP_001989762.1. XM_001989726.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0154387; FBpp0152879; FBgn0126440.
    GeneIDi6563274.
    KEGGidgr:Dgri_GH18973.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916369 Genomic DNA. Translation: EDV92824.1 .
    RefSeqi XP_001989762.1. XM_001989726.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7222.FBpp0152879.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0154387 ; FBpp0152879 ; FBgn0126440 .
    GeneIDi 6563274.
    KEGGi dgr:Dgri_GH18973.

    Organism-specific databases

    FlyBasei FBgn0126440. Dgri\GH18973.

    Phylogenomic databases

    eggNOGi NOG328046.
    InParanoidi B4JHJ7.
    KOi K00901.
    OMAi DPFRILV.
    OrthoDBi EOG7DVD9B.
    PhylomeDBi B4JHJ7.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15287-2541.00Imported.

    Entry informationi

    Entry nameiDGKH_DROGR
    AccessioniPrimary (citable) accession number: B4JHJ7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3