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Protein

Diacylglycerol kinase eta

Gene

GH18973

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 256Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri279 – 330Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GH18973
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
Proteomesi
  • UP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0126440 Dgri\GH18973

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003759861 – 1941Diacylglycerol kinase etaAdd BLAST1941

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiB4JHJ7

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0152879

Structurei

3D structure databases

SMRiB4JHJ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 186PHPROSITE-ProRule annotationAdd BLAST94
Domaini361 – 497DAGKcPROSITE-ProRule annotationAdd BLAST137
Domaini1878 – 1941SAMPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1133 – 1157Asn-richSequence analysisAdd BLAST25

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri206 – 256Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri279 – 330Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd BLAST52

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1170 Eukaryota
ENOG410XSJR LUCA
InParanoidiB4JHJ7
KOiK00901
OMAiEYYTEKC
OrthoDBiEOG091G07HR
PhylomeDBiB4JHJ7

Family and domain databases

CDDicd00029 C1, 2 hits
Gene3Di2.30.29.30, 1 hit
3.40.50.10330, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR037607 DGK
IPR000756 Diacylglycerol_kin_accessory
IPR001206 Diacylglycerol_kinase_cat_dom
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR11255 PTHR11255, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 2 hits
PF00609 DAGK_acc, 1 hit
PF00781 DAGK_cat, 1 hit
PF00169 PH, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM00109 C1, 2 hits
SM00045 DAGKa, 1 hit
SM00046 DAGKc, 1 hit
SM00233 PH, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF111331 SSF111331, 2 hits
SSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS50146 DAGK, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50105 SAM_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 2 hits
PS50081 ZF_DAG_PE_2, 2 hits

Sequencei

Sequence statusi: Complete.

B4JHJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNFLKPNTL HVDSLSPRHR SLSSGLSSGL SSACSSGSVS PVPIIPIIAI
60 70 80 90 100
SRIRDGDESE SESEIELEPA RIFHRRMSIN NSGNNKRSTN LASIIKEGYL
110 120 130 140 150
LKHTWSFQRW RRRYFRLKRN HLYYAKDAKC DVFDEIDLSE LCYFECSIKN
160 170 180 190 200
VNHSFQIITP TRSVVLCADS RRDMEDWLGS LKAATAPQRP RGDSILIDQH
210 220 230 240 250
DILSNHHHWY ATSHARPTYC NVCRDALSGV TSHGLSCEVC KCKVHKRCAA
260 270 280 290 300
KAIANCKWTT LATVGKDIIE QPDGSIIMPH QWMEGNLPVS SICAVCKKTC
310 320 330 340 350
GSVLRLQDWR CLWCRDTVHV ACRPQMAIAC PIGPAKLSVV PPTSVHSIST
360 370 380 390 400
DDAWDVASPK GNFSPLLVFV NSKSGDNQGV KFLRRFKQLL NPAQVFDLIS
410 420 430 440 450
TGPSLGLRLF RHFEMFRILV CSGDGSVGWV LSEIDRFNMH KQCQVAVMPL
460 470 480 490 500
GTGNDLARVL GWGSSCDDDT HLPQILERYE SASTKMLDRW SIMVFEKAIS
510 520 530 540 550
VPKIPKMSIT TEQEAVLTGM VTAANQHLRL IVETNDTQTL ISSTRNLCDT
560 570 580 590 600
IDDLVSRIFE HHKDDEQLAV KCDILKQKLT MLLDALQEEE IGAHSGDDLI
610 620 630 640 650
ATIRSLIARS VPSTNSARPS LLNPNISIEK TEKDHINLKE RRSSRSLRSS
660 670 680 690 700
EKEALQCRAN SVKRAIYNVV EHSEPGRPKR YQRKLSITPF EALKIPTNSG
710 720 730 740 750
ESTPCSSPLP IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN
760 770 780 790 800
LPAPRQFADS RRSSGVPEVI QELEEGANGE TIYRIGRLSL SGGANIDDAG
810 820 830 840 850
NRLSPVSDGG DNSPIDRKLD FLRVPIITSD SIVDPLSDYR PIEVFERTYY
860 870 880 890 900
MARELDKDKD KERKQDVVLD GEKEEDAGVN EKCEEQTLHP QNTLVHTCNL
910 920 930 940 950
QVPGIVVTPQ SQNVYTSDSI TIIDTDQQSN TLQEQSSSEE LGCDASDVLS
960 970 980 990 1000
AISNEECSVA SEIFDKAETG HTLGDIIQNL DASNFTHIDS PETSDETEAM
1010 1020 1030 1040 1050
PGESLMDDIS SVLGHDITNA LQDNTITDDT TTLCSEHMGP PKPPRKKSMS
1060 1070 1080 1090 1100
ALSKSQIHPR RRNSSPPRMA RLARMDSDDN PQQFGFENIV FEIDNRCDDQ
1110 1120 1130 1140 1150
KMREPPRYCS LAQFVEGNDI ARQSFKQLML ECNSNNNSNN NSNSNSNNNN
1160 1170 1180 1190 1200
HNDGNSNDEP ETPTNTVITL AHSQLTTTST SDELDELSTQ TAIKIEIHDA
1210 1220 1230 1240 1250
DSSTMCTTTA TTKPLESAMA SSTSPTKRSG LGQDISVVVR PPTPLRGDSI
1260 1270 1280 1290 1300
KPTPSSSSIL SSSLLGVRSL NSSEIRRHSS HAPSLAVREY DKDKDRRHSG
1310 1320 1330 1340 1350
FNPNYLALDP EHARFLSSSP AASRRISCGS LFKKNQKYYT KRTYGLFRVR
1360 1370 1380 1390 1400
FFVVAEPDIR LATLALIRPL IPLPNEALPN LQTLKGSKSS LFMGSTLFGF
1410 1420 1430 1440 1450
EHFSDKEERQ GKDKERTPPE ETSRKMPIIN PIVRLPNWPN LANGTGFISK
1460 1470 1480 1490 1500
CLLANADTLC AAVSPLMDPD ETLLAGYHEK CVMNNYFGIG IDAKISLDFH
1510 1520 1530 1540 1550
NKREEHPEKC RSRARNYMWY GVLGSKQLLQ KTCKNLEQRV QLECDGQRIP
1560 1570 1580 1590 1600
LPELQGIVIL NIPSFMGGTN FWGSSTKKDD IFLPPSFDDR VLEVVAVFGS
1610 1620 1630 1640 1650
VQMAASRLIN LQHHRIAQCQ SVQINILGDE EIPIQVDGEA WLQPPGMIRI
1660 1670 1680 1690 1700
LHKNRVQMLC RNRSLEVSLK SWQEKQRQHS ISIQRDASST ASEHAVSTDD
1710 1720 1730 1740 1750
VISERECYVL LNFIEAVSSL VKWVKFLIIS HPALQHDLYE VACRASEALE
1760 1770 1780 1790 1800
SIHPQGKLLE GPSLRTKLVE VIDSSRQLYD DACTLLRDRG HSLILREDLE
1810 1820 1830 1840 1850
TKLSAALANM EMELKKCSVQ KCIDGKLRAY FNVLAPNEES DGRRKSRPFW
1860 1870 1880 1890 1900
VRLRSGSTAG QQQFKPPMTN TREAANNWSV NEVVTWLETM QLSEYVDSFL
1910 1920 1930 1940
KNDIRGKELL TLGRRDLKDL GVVKVGHVKR ILQAIKDLSE N
Length:1,941
Mass (Da):216,882
Last modified:September 23, 2008 - v1
Checksum:i3BA4E29CAD1430F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916369 Genomic DNA Translation: EDV92824.1
RefSeqiXP_001989762.1, XM_001989726.1

Genome annotation databases

GeneIDi6563274
KEGGidgr:Dgri_GH18973

Similar proteinsi

Entry informationi

Entry nameiDGKH_DROGR
AccessioniPrimary (citable) accession number: B4JHJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 23, 2008
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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