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B4JHJ7

- DGKH_DROGR

UniProt

B4JHJ7 - DGKH_DROGR

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Protein

Diacylglycerol kinase eta

Gene

GH18973

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 25651Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 33052Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GH18973
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0126440. Dgri\GH18973.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19411941Diacylglycerol kinase etaPRO_0000375986Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0152879.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini93 – 18694PHPROSITE-ProRule annotationAdd
BLAST
Domaini361 – 497137DAGKcPROSITE-ProRule annotationAdd
BLAST
Domaini1878 – 194164SAMPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1133 – 115725Asn-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri206 – 25651Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri279 – 33052Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG328046.
InParanoidiB4JHJ7.
KOiK00901.
OMAiDPFRILV.
OrthoDBiEOG7DVD9B.
PhylomeDBiB4JHJ7.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4JHJ7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSNFLKPNTL HVDSLSPRHR SLSSGLSSGL SSACSSGSVS PVPIIPIIAI
60 70 80 90 100
SRIRDGDESE SESEIELEPA RIFHRRMSIN NSGNNKRSTN LASIIKEGYL
110 120 130 140 150
LKHTWSFQRW RRRYFRLKRN HLYYAKDAKC DVFDEIDLSE LCYFECSIKN
160 170 180 190 200
VNHSFQIITP TRSVVLCADS RRDMEDWLGS LKAATAPQRP RGDSILIDQH
210 220 230 240 250
DILSNHHHWY ATSHARPTYC NVCRDALSGV TSHGLSCEVC KCKVHKRCAA
260 270 280 290 300
KAIANCKWTT LATVGKDIIE QPDGSIIMPH QWMEGNLPVS SICAVCKKTC
310 320 330 340 350
GSVLRLQDWR CLWCRDTVHV ACRPQMAIAC PIGPAKLSVV PPTSVHSIST
360 370 380 390 400
DDAWDVASPK GNFSPLLVFV NSKSGDNQGV KFLRRFKQLL NPAQVFDLIS
410 420 430 440 450
TGPSLGLRLF RHFEMFRILV CSGDGSVGWV LSEIDRFNMH KQCQVAVMPL
460 470 480 490 500
GTGNDLARVL GWGSSCDDDT HLPQILERYE SASTKMLDRW SIMVFEKAIS
510 520 530 540 550
VPKIPKMSIT TEQEAVLTGM VTAANQHLRL IVETNDTQTL ISSTRNLCDT
560 570 580 590 600
IDDLVSRIFE HHKDDEQLAV KCDILKQKLT MLLDALQEEE IGAHSGDDLI
610 620 630 640 650
ATIRSLIARS VPSTNSARPS LLNPNISIEK TEKDHINLKE RRSSRSLRSS
660 670 680 690 700
EKEALQCRAN SVKRAIYNVV EHSEPGRPKR YQRKLSITPF EALKIPTNSG
710 720 730 740 750
ESTPCSSPLP IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN
760 770 780 790 800
LPAPRQFADS RRSSGVPEVI QELEEGANGE TIYRIGRLSL SGGANIDDAG
810 820 830 840 850
NRLSPVSDGG DNSPIDRKLD FLRVPIITSD SIVDPLSDYR PIEVFERTYY
860 870 880 890 900
MARELDKDKD KERKQDVVLD GEKEEDAGVN EKCEEQTLHP QNTLVHTCNL
910 920 930 940 950
QVPGIVVTPQ SQNVYTSDSI TIIDTDQQSN TLQEQSSSEE LGCDASDVLS
960 970 980 990 1000
AISNEECSVA SEIFDKAETG HTLGDIIQNL DASNFTHIDS PETSDETEAM
1010 1020 1030 1040 1050
PGESLMDDIS SVLGHDITNA LQDNTITDDT TTLCSEHMGP PKPPRKKSMS
1060 1070 1080 1090 1100
ALSKSQIHPR RRNSSPPRMA RLARMDSDDN PQQFGFENIV FEIDNRCDDQ
1110 1120 1130 1140 1150
KMREPPRYCS LAQFVEGNDI ARQSFKQLML ECNSNNNSNN NSNSNSNNNN
1160 1170 1180 1190 1200
HNDGNSNDEP ETPTNTVITL AHSQLTTTST SDELDELSTQ TAIKIEIHDA
1210 1220 1230 1240 1250
DSSTMCTTTA TTKPLESAMA SSTSPTKRSG LGQDISVVVR PPTPLRGDSI
1260 1270 1280 1290 1300
KPTPSSSSIL SSSLLGVRSL NSSEIRRHSS HAPSLAVREY DKDKDRRHSG
1310 1320 1330 1340 1350
FNPNYLALDP EHARFLSSSP AASRRISCGS LFKKNQKYYT KRTYGLFRVR
1360 1370 1380 1390 1400
FFVVAEPDIR LATLALIRPL IPLPNEALPN LQTLKGSKSS LFMGSTLFGF
1410 1420 1430 1440 1450
EHFSDKEERQ GKDKERTPPE ETSRKMPIIN PIVRLPNWPN LANGTGFISK
1460 1470 1480 1490 1500
CLLANADTLC AAVSPLMDPD ETLLAGYHEK CVMNNYFGIG IDAKISLDFH
1510 1520 1530 1540 1550
NKREEHPEKC RSRARNYMWY GVLGSKQLLQ KTCKNLEQRV QLECDGQRIP
1560 1570 1580 1590 1600
LPELQGIVIL NIPSFMGGTN FWGSSTKKDD IFLPPSFDDR VLEVVAVFGS
1610 1620 1630 1640 1650
VQMAASRLIN LQHHRIAQCQ SVQINILGDE EIPIQVDGEA WLQPPGMIRI
1660 1670 1680 1690 1700
LHKNRVQMLC RNRSLEVSLK SWQEKQRQHS ISIQRDASST ASEHAVSTDD
1710 1720 1730 1740 1750
VISERECYVL LNFIEAVSSL VKWVKFLIIS HPALQHDLYE VACRASEALE
1760 1770 1780 1790 1800
SIHPQGKLLE GPSLRTKLVE VIDSSRQLYD DACTLLRDRG HSLILREDLE
1810 1820 1830 1840 1850
TKLSAALANM EMELKKCSVQ KCIDGKLRAY FNVLAPNEES DGRRKSRPFW
1860 1870 1880 1890 1900
VRLRSGSTAG QQQFKPPMTN TREAANNWSV NEVVTWLETM QLSEYVDSFL
1910 1920 1930 1940
KNDIRGKELL TLGRRDLKDL GVVKVGHVKR ILQAIKDLSE N
Length:1,941
Mass (Da):216,882
Last modified:September 23, 2008 - v1
Checksum:i3BA4E29CAD1430F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916369 Genomic DNA. Translation: EDV92824.1.
RefSeqiXP_001989762.1. XM_001989726.1.

Genome annotation databases

EnsemblMetazoaiFBtr0154387; FBpp0152879; FBgn0126440.
GeneIDi6563274.
KEGGidgr:Dgri_GH18973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916369 Genomic DNA. Translation: EDV92824.1 .
RefSeqi XP_001989762.1. XM_001989726.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0152879.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0154387 ; FBpp0152879 ; FBgn0126440 .
GeneIDi 6563274.
KEGGi dgr:Dgri_GH18973.

Organism-specific databases

FlyBasei FBgn0126440. Dgri\GH18973.

Phylogenomic databases

eggNOGi NOG328046.
InParanoidi B4JHJ7.
KOi K00901.
OMAi DPFRILV.
OrthoDBi EOG7DVD9B.
PhylomeDBi B4JHJ7.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiDGKH_DROGR
AccessioniPrimary (citable) accession number: B4JHJ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3