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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Dgri\GH21756

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • [3Fe-4S] clusterUniRule annotationNote: Binds 1 [3Fe-4S] cluster.UniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathway:itricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dgri\GH22974), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dgri\GH21756), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dgri\GH24727), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (Dgri\GH10931), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (Dgri\GH16714)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Dgri\GH21756Imported
ORF Names:Dgri_GH21756Imported, GH21756Imported
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)Imported
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0129217. Dgri\GH21756.

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0155662.

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation
Contains 1 2Fe-2S ferredoxin-type domain.UniRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0479.
InParanoidiB4J6T2.
KOiK00235.
OMAiNTGDWFL.
OrthoDBiEOG7H4DTN.
PhylomeDBiB4J6T2.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4J6T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVNEARQIL SRASSLAARH QLRAISNSSQ LEQQAQPKES QAPQIKKFEI
60 70 80 90 100
YRWNPDNAGE KPYMQTYEIN MRECGPMVLD ALIKIKNEMD PTLTFRRSCR
110 120 130 140 150
EGICGSCAMN IGGTNTLACI SKIDATSSKP LKVYPLPHMY VVRDLVPDMN
160 170 180 190 200
NFYEQYKNIQ PWLQRKNEAG EKKGKAQYLQ SVEDRSKLDG LYECILCACC
210 220 230 240 250
STSCPSYWWN AEKYLGPAVL MQAYRWIIDS RDEMTVERLS KLKDPFSVYR
260 270 280 290
CHTIMNCTRT CPKGLNPGRA IAEIKKLLSG LASKPAPKLE TAALHK
Length:296
Mass (Da):33,640
Last modified:September 23, 2008 - v1
Checksum:i9BCCED7679324734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916367 Genomic DNA. Translation: EDW02013.1.
RefSeqiXP_001987146.1. XM_001987110.1.

Genome annotation databases

EnsemblMetazoaiFBtr0157170; FBpp0155662; FBgn0129217.
GeneIDi6559534.
KEGGidgr:Dgri_GH21756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916367 Genomic DNA. Translation: EDW02013.1.
RefSeqiXP_001987146.1. XM_001987110.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0155662.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0157170; FBpp0155662; FBgn0129217.
GeneIDi6559534.
KEGGidgr:Dgri_GH21756.

Organism-specific databases

FlyBaseiFBgn0129217. Dgri\GH21756.

Phylogenomic databases

eggNOGiCOG0479.
InParanoidiB4J6T2.
KOiK00235.
OMAiNTGDWFL.
OrthoDBiEOG7H4DTN.
PhylomeDBiB4J6T2.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiB4J6T2_DROGR
AccessioniPrimary (citable) accession number: B4J6T2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 22, 2015
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.