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B4J6T2

- B4J6T2_DROGR

UniProt

B4J6T2 - B4J6T2_DROGR

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

Dgri\GH21756

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 2Fe-2S cluster.UniRule annotation
  • Note: Binds 1 3Fe-4S cluster.UniRule annotation
  • Note: Binds 1 4Fe-4S cluster.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: InterPro
  2. electron carrier activity Source: InterPro
  3. oxidoreductase activity Source: InterPro

GO - Biological processi

  1. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Ligandi

2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
Name:Dgri\GH21756Imported
ORF Names:Dgri_GH21756Imported, GH21756Imported
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)Imported
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0129217. Dgri\GH21756.

Subcellular locationi

Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0155662.

Family & Domainsi

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation
Contains 1 2Fe-2S ferredoxin-type domain.UniRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0479.
InParanoidiB4J6T2.
KOiK00235.
OMAiHARDPIS.
OrthoDBiEOG7H4DTN.
PhylomeDBiB4J6T2.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4J6T2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLVNEARQIL SRASSLAARH QLRAISNSSQ LEQQAQPKES QAPQIKKFEI
60 70 80 90 100
YRWNPDNAGE KPYMQTYEIN MRECGPMVLD ALIKIKNEMD PTLTFRRSCR
110 120 130 140 150
EGICGSCAMN IGGTNTLACI SKIDATSSKP LKVYPLPHMY VVRDLVPDMN
160 170 180 190 200
NFYEQYKNIQ PWLQRKNEAG EKKGKAQYLQ SVEDRSKLDG LYECILCACC
210 220 230 240 250
STSCPSYWWN AEKYLGPAVL MQAYRWIIDS RDEMTVERLS KLKDPFSVYR
260 270 280 290
CHTIMNCTRT CPKGLNPGRA IAEIKKLLSG LASKPAPKLE TAALHK
Length:296
Mass (Da):33,640
Last modified:September 23, 2008 - v1
Checksum:i9BCCED7679324734
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916367 Genomic DNA. Translation: EDW02013.1.
RefSeqiXP_001987146.1. XM_001987110.1.

Genome annotation databases

EnsemblMetazoaiFBtr0157170; FBpp0155662; FBgn0129217.
GeneIDi6559534.
KEGGidgr:Dgri_GH21756.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916367 Genomic DNA. Translation: EDW02013.1 .
RefSeqi XP_001987146.1. XM_001987110.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0155662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0157170 ; FBpp0155662 ; FBgn0129217 .
GeneIDi 6559534.
KEGGi dgr:Dgri_GH21756.

Organism-specific databases

FlyBasei FBgn0129217. Dgri\GH21756.

Phylogenomic databases

eggNOGi COG0479.
InParanoidi B4J6T2.
KOi K00235.
OMAi HARDPIS.
OrthoDBi EOG7H4DTN.
PhylomeDBi B4J6T2.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiB4J6T2_DROGR
AccessioniPrimary (citable) accession number: B4J6T2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3