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B4IZF2

- B4IZF2_DROGR

UniProt

B4IZF2 - B4IZF2_DROGR

Protein

Isocitrate dehydrogenase [NADP]

Gene

Dgri\GH16411

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 47 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei109 – 1091Substrate
    Binding sitei114 – 1141NADPUniRule annotation
    Binding sitei141 – 1411Substrate
    Binding sitei164 – 1641SubstrateUniRule annotation
    Sitei171 – 1711Critical for catalysisUniRule annotation
    Sitei242 – 2421Critical for catalysisUniRule annotation
    Metal bindingi282 – 2821Magnesium or manganeseUniRule annotation
    Binding sitei290 – 2901NADPUniRule annotation
    Metal bindingi305 – 3051Magnesium or manganeseUniRule annotation
    Binding sitei358 – 3581NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi107 – 1093NADPUniRule annotation
    Nucleotide bindingi340 – 3456NADPUniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:Dgri\GH16411Imported
    ORF Names:Dgri_GH16411Imported, GH16411Imported
    OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)Imported
    Taxonomic identifieri7222 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
    ProteomesiUP000001070: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0123882. Dgri\GH16411.

    Interactioni

    Protein-protein interaction databases

    STRINGi7222.FBpp0150317.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni126 – 1327Substrate binding

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0538.
    InParanoidiB4IZF2.
    KOiK00031.
    OMAiSCGGVAM.
    OrthoDBiEOG7QNVKS.
    PhylomeDBiB4IZF2.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4IZF2-1 [UniParc]FASTAAdd to Basket

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    MFALRRTLKM ASQPQTLFLR APFKSNFGVC AAMAQKIRAG PVVDVLGDEM    50
    TRIIWQSIKD KLILPFLDIE LHTFDLGIEH RDKTEDQVTI DCSEAIKKYS 100
    VGIKCATITP DEKRVEEFKL KKMWKSPNGT IRNILGGTVF REAIICKNVP 150
    RLVTGWEKPI VIGRHANADQ YKAVDYVVPG PGKLTLTWKG NNGEVIEEVI 200
    NDFKGPGIAL GMYNTDDSIV DFAHASFKYA LERKMPLYMS TKNTILKRYD 250
    GRFKDIFEDI YGKEYKKQYE AAGIWYEHRL IDDMVAYCMK SEGGFVWACK 300
    NYDGDVQSDS VAQGYGSLGL MTSVLLCPDG KTVEAEAAHG TVTRHYRQYQ 350
    LGKETSTNPI ASIFAWTRGL LHRAKLDNNE PLKQFAETLE QVCIDTIEGG 400
    AMTKDLAICI KGSMAAVERK DYQETFEFMD TLAKNLQTAL ARSSHI 446
    Length:446
    Mass (Da):50,254
    Last modified:September 23, 2008 - v1
    Checksum:i5EF1F2792A78053D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916366 Genomic DNA. Translation: EDV96707.1.
    RefSeqiXP_001984359.1. XM_001984323.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0151825; FBpp0150317; FBgn0123882.
    GeneIDi6558822.
    KEGGidgr:Dgri_GH16411.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916366 Genomic DNA. Translation: EDV96707.1 .
    RefSeqi XP_001984359.1. XM_001984323.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7222.FBpp0150317.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0151825 ; FBpp0150317 ; FBgn0123882 .
    GeneIDi 6558822.
    KEGGi dgr:Dgri_GH16411.

    Organism-specific databases

    FlyBasei FBgn0123882. Dgri\GH16411.

    Phylogenomic databases

    eggNOGi COG0538.
    InParanoidi B4IZF2.
    KOi K00031.
    OMAi SCGGVAM.
    OrthoDBi EOG7QNVKS.
    PhylomeDBi B4IZF2.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15287-2541.00Imported.

    Entry informationi

    Entry nameiB4IZF2_DROGR
    AccessioniPrimary (citable) accession number: B4IZF2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3