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Protein

Isocitrate dehydrogenase [NADP]

Gene

Dgri\GH16411

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg2+ or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109SubstrateUniRule annotation1
Binding sitei114NADPUniRule annotation1
Binding sitei141SubstrateUniRule annotation1
Binding sitei164SubstrateUniRule annotation1
Sitei171Critical for catalysisUniRule annotation1
Sitei242Critical for catalysisUniRule annotation1
Metal bindingi282Magnesium or manganeseUniRule annotation1
Binding sitei290NADPUniRule annotation1
Metal bindingi305Magnesium or manganeseUniRule annotation1
Binding sitei358NADP; via amide nitrogen and carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi107 – 109NADPUniRule annotation3
Nucleotide bindingi340 – 345NADPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:Dgri\GH16411Imported
ORF Names:Dgri_GH16411Imported, GH16411Imported
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)Imported
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
Proteomesi
  • UP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0123882. Dgri\GH16411.

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0150317.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 432Iso_dhInterPro annotationAdd BLAST392

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni126 – 132Substrate bindingUniRule annotation7

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
InParanoidiB4IZF2.
KOiK00031.
OMAiMFRANFA.
OrthoDBiEOG091G06IY.
PhylomeDBiB4IZF2.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IZF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFALRRTLKM ASQPQTLFLR APFKSNFGVC AAMAQKIRAG PVVDVLGDEM
60 70 80 90 100
TRIIWQSIKD KLILPFLDIE LHTFDLGIEH RDKTEDQVTI DCSEAIKKYS
110 120 130 140 150
VGIKCATITP DEKRVEEFKL KKMWKSPNGT IRNILGGTVF REAIICKNVP
160 170 180 190 200
RLVTGWEKPI VIGRHANADQ YKAVDYVVPG PGKLTLTWKG NNGEVIEEVI
210 220 230 240 250
NDFKGPGIAL GMYNTDDSIV DFAHASFKYA LERKMPLYMS TKNTILKRYD
260 270 280 290 300
GRFKDIFEDI YGKEYKKQYE AAGIWYEHRL IDDMVAYCMK SEGGFVWACK
310 320 330 340 350
NYDGDVQSDS VAQGYGSLGL MTSVLLCPDG KTVEAEAAHG TVTRHYRQYQ
360 370 380 390 400
LGKETSTNPI ASIFAWTRGL LHRAKLDNNE PLKQFAETLE QVCIDTIEGG
410 420 430 440
AMTKDLAICI KGSMAAVERK DYQETFEFMD TLAKNLQTAL ARSSHI
Length:446
Mass (Da):50,254
Last modified:September 23, 2008 - v1
Checksum:i5EF1F2792A78053D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916366 Genomic DNA. Translation: EDV96707.1.
RefSeqiXP_001984359.1. XM_001984323.1.

Genome annotation databases

EnsemblMetazoaiFBtr0151825; FBpp0150317; FBgn0123882.
GeneIDi6558822.
KEGGidgr:Dgri_GH16411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916366 Genomic DNA. Translation: EDV96707.1.
RefSeqiXP_001984359.1. XM_001984323.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0150317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0151825; FBpp0150317; FBgn0123882.
GeneIDi6558822.
KEGGidgr:Dgri_GH16411.

Organism-specific databases

FlyBaseiFBgn0123882. Dgri\GH16411.

Phylogenomic databases

eggNOGiKOG1526. Eukaryota.
COG0538. LUCA.
InParanoidiB4IZF2.
KOiK00031.
OMAiMFRANFA.
OrthoDBiEOG091G06IY.
PhylomeDBiB4IZF2.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
SMARTiSM01329. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB4IZF2_DROGR
AccessioniPrimary (citable) accession number: B4IZF2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.