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B4IZF2

- B4IZF2_DROGR

UniProt

B4IZF2 - B4IZF2_DROGR

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Dgri\GH16411

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei114 – 1141NADPUniRule annotation
Binding sitei164 – 1641SubstrateUniRule annotation
Sitei171 – 1711Critical for catalysisUniRule annotation
Sitei242 – 2421Critical for catalysisUniRule annotation
Metal bindingi282 – 2821Magnesium or manganeseUniRule annotation
Binding sitei290 – 2901NADPUniRule annotation
Metal bindingi305 – 3051Magnesium or manganeseUniRule annotation
Binding sitei358 – 3581NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1093NADPUniRule annotation
Nucleotide bindingi340 – 3456NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:Dgri\GH16411Imported
ORF Names:Dgri_GH16411Imported, GH16411Imported
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)Imported
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0123882. Dgri\GH16411.

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0150317.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0538.
InParanoidiB4IZF2.
KOiK00031.
OMAiSCGGVAM.
OrthoDBiEOG7QNVKS.
PhylomeDBiB4IZF2.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IZF2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFALRRTLKM ASQPQTLFLR APFKSNFGVC AAMAQKIRAG PVVDVLGDEM
60 70 80 90 100
TRIIWQSIKD KLILPFLDIE LHTFDLGIEH RDKTEDQVTI DCSEAIKKYS
110 120 130 140 150
VGIKCATITP DEKRVEEFKL KKMWKSPNGT IRNILGGTVF REAIICKNVP
160 170 180 190 200
RLVTGWEKPI VIGRHANADQ YKAVDYVVPG PGKLTLTWKG NNGEVIEEVI
210 220 230 240 250
NDFKGPGIAL GMYNTDDSIV DFAHASFKYA LERKMPLYMS TKNTILKRYD
260 270 280 290 300
GRFKDIFEDI YGKEYKKQYE AAGIWYEHRL IDDMVAYCMK SEGGFVWACK
310 320 330 340 350
NYDGDVQSDS VAQGYGSLGL MTSVLLCPDG KTVEAEAAHG TVTRHYRQYQ
360 370 380 390 400
LGKETSTNPI ASIFAWTRGL LHRAKLDNNE PLKQFAETLE QVCIDTIEGG
410 420 430 440
AMTKDLAICI KGSMAAVERK DYQETFEFMD TLAKNLQTAL ARSSHI
Length:446
Mass (Da):50,254
Last modified:September 23, 2008 - v1
Checksum:i5EF1F2792A78053D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916366 Genomic DNA. Translation: EDV96707.1.
RefSeqiXP_001984359.1. XM_001984323.1.

Genome annotation databases

EnsemblMetazoaiFBtr0151825; FBpp0150317; FBgn0123882.
GeneIDi6558822.
KEGGidgr:Dgri_GH16411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH916366 Genomic DNA. Translation: EDV96707.1 .
RefSeqi XP_001984359.1. XM_001984323.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0150317.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0151825 ; FBpp0150317 ; FBgn0123882 .
GeneIDi 6558822.
KEGGi dgr:Dgri_GH16411.

Organism-specific databases

FlyBasei FBgn0123882. Dgri\GH16411.

Phylogenomic databases

eggNOGi COG0538.
InParanoidi B4IZF2.
KOi K00031.
OMAi SCGGVAM.
OrthoDBi EOG7QNVKS.
PhylomeDBi B4IZF2.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00Imported.

Entry informationi

Entry nameiB4IZF2_DROGR
AccessioniPrimary (citable) accession number: B4IZF2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: November 26, 2014
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3