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B4IZF2

- B4IZF2_DROGR

UniProt

B4IZF2 - B4IZF2_DROGR

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Protein

Isocitrate dehydrogenase [NADP]

Gene
Dgri\GH16411, Dgri_GH16411, GH16411
Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei109 – 1091Substrate By similarityUniRule annotation
Binding sitei114 – 1141NADP By similarity
Binding sitei141 – 1411Substrate By similarityUniRule annotation
Binding sitei164 – 1641Substrate By similarityUniRule annotation
Sitei171 – 1711Critical for catalysis By similarityUniRule annotation
Sitei242 – 2421Critical for catalysis By similarityUniRule annotation
Metal bindingi282 – 2821Magnesium or manganese By similarityUniRule annotation
Binding sitei290 – 2901NADP By similarity
Metal bindingi305 – 3051Magnesium or manganese By similarityUniRule annotation
Binding sitei358 – 3581NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi107 – 1093NADP By similarity
Nucleotide bindingi340 – 3456NADP By similarity

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:Dgri\GH16411Imported
ORF Names:Dgri_GH16411Imported, GH16411Imported
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0123882. Dgri\GH16411.

Interactioni

Protein-protein interaction databases

STRINGi7222.FBpp0150317.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni126 – 1327Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0538.
InParanoidiB4IZF2.
KOiK00031.
OMAiSCGGVAM.
OrthoDBiEOG7QNVKS.
PhylomeDBiB4IZF2.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IZF2-1 [UniParc]FASTAAdd to Basket

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MFALRRTLKM ASQPQTLFLR APFKSNFGVC AAMAQKIRAG PVVDVLGDEM    50
TRIIWQSIKD KLILPFLDIE LHTFDLGIEH RDKTEDQVTI DCSEAIKKYS 100
VGIKCATITP DEKRVEEFKL KKMWKSPNGT IRNILGGTVF REAIICKNVP 150
RLVTGWEKPI VIGRHANADQ YKAVDYVVPG PGKLTLTWKG NNGEVIEEVI 200
NDFKGPGIAL GMYNTDDSIV DFAHASFKYA LERKMPLYMS TKNTILKRYD 250
GRFKDIFEDI YGKEYKKQYE AAGIWYEHRL IDDMVAYCMK SEGGFVWACK 300
NYDGDVQSDS VAQGYGSLGL MTSVLLCPDG KTVEAEAAHG TVTRHYRQYQ 350
LGKETSTNPI ASIFAWTRGL LHRAKLDNNE PLKQFAETLE QVCIDTIEGG 400
AMTKDLAICI KGSMAAVERK DYQETFEFMD TLAKNLQTAL ARSSHI 446
Length:446
Mass (Da):50,254
Last modified:September 23, 2008 - v1
Checksum:i5EF1F2792A78053D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916366 Genomic DNA. Translation: EDV96707.1.
RefSeqiXP_001984359.1. XM_001984323.1.

Genome annotation databases

EnsemblMetazoaiFBtr0151825; FBpp0150317; FBgn0123882.
GeneIDi6558822.
KEGGidgr:Dgri_GH16411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916366 Genomic DNA. Translation: EDV96707.1 .
RefSeqi XP_001984359.1. XM_001984323.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0150317.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0151825 ; FBpp0150317 ; FBgn0123882 .
GeneIDi 6558822.
KEGGi dgr:Dgri_GH16411.

Organism-specific databases

FlyBasei FBgn0123882. Dgri\GH16411.

Phylogenomic databases

eggNOGi COG0538.
InParanoidi B4IZF2.
KOi K00031.
OMAi SCGGVAM.
OrthoDBi EOG7QNVKS.
PhylomeDBi B4IZF2.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00.

Entry informationi

Entry nameiB4IZF2_DROGR
AccessioniPrimary (citable) accession number: B4IZF2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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