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B4IZF2 (B4IZF2_DROGR) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding107 – 1093NADP By similarity
Nucleotide binding340 – 3456NADP By similarity
Region126 – 1327Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2821Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding3051Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1141NADP By similarity
Binding site1411Substrate By similarity PIRSR PIRSR000108-2
Binding site1641Substrate By similarity PIRSR PIRSR000108-2
Binding site2901NADP By similarity
Binding site3581NADP; via amide nitrogen and carbonyl oxygen By similarity
Site1711Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2421Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
B4IZF2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 5EF1F2792A78053D

FASTA44650,254
        10         20         30         40         50         60 
MFALRRTLKM ASQPQTLFLR APFKSNFGVC AAMAQKIRAG PVVDVLGDEM TRIIWQSIKD 

        70         80         90        100        110        120 
KLILPFLDIE LHTFDLGIEH RDKTEDQVTI DCSEAIKKYS VGIKCATITP DEKRVEEFKL 

       130        140        150        160        170        180 
KKMWKSPNGT IRNILGGTVF REAIICKNVP RLVTGWEKPI VIGRHANADQ YKAVDYVVPG 

       190        200        210        220        230        240 
PGKLTLTWKG NNGEVIEEVI NDFKGPGIAL GMYNTDDSIV DFAHASFKYA LERKMPLYMS 

       250        260        270        280        290        300 
TKNTILKRYD GRFKDIFEDI YGKEYKKQYE AAGIWYEHRL IDDMVAYCMK SEGGFVWACK 

       310        320        330        340        350        360 
NYDGDVQSDS VAQGYGSLGL MTSVLLCPDG KTVEAEAAHG TVTRHYRQYQ LGKETSTNPI 

       370        380        390        400        410        420 
ASIFAWTRGL LHRAKLDNNE PLKQFAETLE QVCIDTIEGG AMTKDLAICI KGSMAAVERK 

       430        440 
DYQETFEFMD TLAKNLQTAL ARSSHI 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15287-2541.00.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH916366 Genomic DNA. Translation: EDV96707.1.
RefSeqXP_001984359.1. XM_001984323.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7222.FBpp0150317.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0151825; FBpp0150317; FBgn0123882.
GeneID6558822.
KEGGdgr:Dgri_GH16411.

Organism-specific databases

FlyBaseFBgn0123882. Dgri\GH16411.

Phylogenomic databases

eggNOGCOG0538.
InParanoidB4IZF2.
KOK00031.
OMASCGGVAM.
OrthoDBEOG7QNVKS.
PhylomeDBB4IZF2.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4IZF2_DROGR
AccessionPrimary (citable) accession number: B4IZF2
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)