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B4IXE0 (UBP36_DROGR) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GH16215
OrganismDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi) [Complete proteome]
Taxonomic identifier7222 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila

Protein attributes

Sequence length1240 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12401240Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378497

Regions

Domain202 – 512311USP

Sites

Active site2111Nucleophile By similarity
Active site4711Proton acceptor By similarity

Amino acid modifications

Modified residue7151Phosphothreonine By similarity
Modified residue7251Phosphoserine By similarity
Modified residue7271Phosphoserine By similarity
Modified residue8951Phosphoserine By similarity
Modified residue8981Phosphothreonine By similarity
Modified residue9011Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4IXE0 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: D083740CBD133FF9

FASTA1,240134,998
        10         20         30         40         50         60 
MPVSLAVCET TANVVNAALR ESLGSCVARA ALSADEAKTS NGGGDGSSTS GSSTDNLQSQ 

        70         80         90        100        110        120 
IVANAKRVLL AKIDYEEVDN YHESVLAKLK SKYIVIKPDS NGGAASNGNG NYNGSNKTNG 

       130        140        150        160        170        180 
KFGAGNGHDN NGNGNGIVNG GTSALNGGNN RKQIVVVDHQ SSNQHGSPSN PNELPKPKRV 

       190        200        210        220        230        240 
LYQREHIRIG WKQSERKWQV GTGMLNVGNT CYLNSSLQAL FHIPSLANWL VSESAHLENC 

       250        260        270        280        290        300 
NISESCGSNG CIICAMAKTL QSTQSNQSAV RPFLIYSKLR QICKHMVVGR QEDAHEFLRF 

       310        320        330        340        350        360 
LIEAMEKAYL MRFRNYKELD QLVKETTPLN QIFGGYLRSE VRCLSCNHVS ITFQHFQDLL 

       370        380        390        400        410        420 
LDIRKSDTLE DAFDGYFSRE RLEDMGYKCE GCKKKVSATK QFSLERAPIT LCIQLKRFSM 

       430        440        450        460        470        480 
MGNKLTKQIS FKPRIDLSRF AARSPTAAAQ PLSYRLVSMV THLGVSQHCG HYTAIGLTET 

       490        500        510        520        530        540 
GSYYNFDDSC VRPIAMQSVC NTNAYIMFYE LDVNGNGHVV APKMNGMRLT TNGGQQHSSP 

       550        560        570        580        590        600 
VVATAPAAVV SATATSTSAS VSAAAVTSPR FIGPQLPNGY GNSNGHALGG GAAKTAIQFK 

       610        620        630        640        650        660 
TTPQKHQQQQ QAQTQYQLNG HINGAAKFQT GAANANANKS SCNTLNNSKQ HQPQQQQQQP 

       670        680        690        700        710        720 
QHILPISSDE EEDSDDDNDN DNVKTNKAPQ LPSMPKMFEE SSESVALTAK LKPKTALKSL 

       730        740        750        760        770        780 
VPYESASEEE EQQQQQQQQT LQQQAATNSR KRRSGADSSD TDDDDDEEQQ QQQQQQPSLI 

       790        800        810        820        830        840 
LRNGHAKTNG NLLNSSSSKT KSASNASSAN VNSSKQKTDA IDEIFKSLNN YKNKHRNDHN 

       850        860        870        880        890        900 
HVDDDDDDDE DEDEDEDEAQ AQAEKKTVTK SSSSSSSTSL TNGWQQSQNG KATASPKTPP 

       910        920        930        940        950        960 
SPAVIKTKTG IWQVTRNDED DDENVDGVAD ADDDDDNDEV AEPAVVTAKN HKNPFAAGKA 

       970        980        990       1000       1010       1020 
TATTDANPSA KRQKLLNGSS KSQQTTPRIG NGYQGESLPN GNAVVSELLK QNHRGYGSSV 

      1030       1040       1050       1060       1070       1080 
LSWNGKASEL DKETFDLVCA KRIAGYGAAA ADEHCCDVNS GHSSNYGTNY KSLNNDMSSS 

      1090       1100       1110       1120       1130       1140 
SSSSSSTNSS SNSSSRSNGN SSNCPPCDLL AEAREQRKRD DDDEEENEMD RGRQRKIKSA 

      1150       1160       1170       1180       1190       1200 
SVKCGSGATA APPGYNPFQE YESQKRWHSN KSGSYSRFYH HPNYRSNFQQ RNKFKHNRFA 

      1210       1220       1230       1240 
GGGGGAKFQQ QRALQRHLAS GGGFTRRQHH QSSGQQQQQS 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Tucson 15287-2541.00.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH916366 Genomic DNA. Translation: EDV96377.1.
RefSeqXP_001984029.1. XM_001983993.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING7222.FBpp0150121.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0151629; FBpp0150121; FBgn0123686.
GeneID6558136.
KEGGdgr:Dgri_GH16215.

Organism-specific databases

FlyBaseFBgn0123686. Dgri\GH16215.

Phylogenomic databases

eggNOGCOG5533.
InParanoidB4IXE0.
KOK11855.
OMAENEMDRG.
OrthoDBEOG7XDBF6.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROGR
AccessionPrimary (citable) accession number: B4IXE0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase