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B4IXE0

- UBP36_DROGR

UniProt

B4IXE0 - UBP36_DROGR

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene
Usp36, scny, GH16215
Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei211 – 2111Nucleophile By similarity
Active sitei471 – 4711Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GH16215
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0123686. Dgri\GH16215.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12401240Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei715 – 7151Phosphothreonine By similarity
Modified residuei725 – 7251Phosphoserine By similarity
Modified residuei727 – 7271Phosphoserine By similarity
Modified residuei895 – 8951Phosphoserine By similarity
Modified residuei898 – 8981Phosphothreonine By similarity
Modified residuei901 – 9011Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Protein-protein interaction databases

STRINGi7222.FBpp0150121.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 512311USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiB4IXE0.
KOiK11855.
OMAiENEMDRG.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4IXE0.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IXE0-1 [UniParc]FASTAAdd to Basket

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MPVSLAVCET TANVVNAALR ESLGSCVARA ALSADEAKTS NGGGDGSSTS     50
GSSTDNLQSQ IVANAKRVLL AKIDYEEVDN YHESVLAKLK SKYIVIKPDS 100
NGGAASNGNG NYNGSNKTNG KFGAGNGHDN NGNGNGIVNG GTSALNGGNN 150
RKQIVVVDHQ SSNQHGSPSN PNELPKPKRV LYQREHIRIG WKQSERKWQV 200
GTGMLNVGNT CYLNSSLQAL FHIPSLANWL VSESAHLENC NISESCGSNG 250
CIICAMAKTL QSTQSNQSAV RPFLIYSKLR QICKHMVVGR QEDAHEFLRF 300
LIEAMEKAYL MRFRNYKELD QLVKETTPLN QIFGGYLRSE VRCLSCNHVS 350
ITFQHFQDLL LDIRKSDTLE DAFDGYFSRE RLEDMGYKCE GCKKKVSATK 400
QFSLERAPIT LCIQLKRFSM MGNKLTKQIS FKPRIDLSRF AARSPTAAAQ 450
PLSYRLVSMV THLGVSQHCG HYTAIGLTET GSYYNFDDSC VRPIAMQSVC 500
NTNAYIMFYE LDVNGNGHVV APKMNGMRLT TNGGQQHSSP VVATAPAAVV 550
SATATSTSAS VSAAAVTSPR FIGPQLPNGY GNSNGHALGG GAAKTAIQFK 600
TTPQKHQQQQ QAQTQYQLNG HINGAAKFQT GAANANANKS SCNTLNNSKQ 650
HQPQQQQQQP QHILPISSDE EEDSDDDNDN DNVKTNKAPQ LPSMPKMFEE 700
SSESVALTAK LKPKTALKSL VPYESASEEE EQQQQQQQQT LQQQAATNSR 750
KRRSGADSSD TDDDDDEEQQ QQQQQQPSLI LRNGHAKTNG NLLNSSSSKT 800
KSASNASSAN VNSSKQKTDA IDEIFKSLNN YKNKHRNDHN HVDDDDDDDE 850
DEDEDEDEAQ AQAEKKTVTK SSSSSSSTSL TNGWQQSQNG KATASPKTPP 900
SPAVIKTKTG IWQVTRNDED DDENVDGVAD ADDDDDNDEV AEPAVVTAKN 950
HKNPFAAGKA TATTDANPSA KRQKLLNGSS KSQQTTPRIG NGYQGESLPN 1000
GNAVVSELLK QNHRGYGSSV LSWNGKASEL DKETFDLVCA KRIAGYGAAA 1050
ADEHCCDVNS GHSSNYGTNY KSLNNDMSSS SSSSSSTNSS SNSSSRSNGN 1100
SSNCPPCDLL AEAREQRKRD DDDEEENEMD RGRQRKIKSA SVKCGSGATA 1150
APPGYNPFQE YESQKRWHSN KSGSYSRFYH HPNYRSNFQQ RNKFKHNRFA 1200
GGGGGAKFQQ QRALQRHLAS GGGFTRRQHH QSSGQQQQQS 1240
Length:1,240
Mass (Da):134,998
Last modified:September 23, 2008 - v1
Checksum:iD083740CBD133FF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916366 Genomic DNA. Translation: EDV96377.1.
RefSeqiXP_001984029.1. XM_001983993.1.

Genome annotation databases

EnsemblMetazoaiFBtr0151629; FBpp0150121; FBgn0123686.
GeneIDi6558136.
KEGGidgr:Dgri_GH16215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916366 Genomic DNA. Translation: EDV96377.1 .
RefSeqi XP_001984029.1. XM_001983993.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0150121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0151629 ; FBpp0150121 ; FBgn0123686 .
GeneIDi 6558136.
KEGGi dgr:Dgri_GH16215.

Organism-specific databases

FlyBasei FBgn0123686. Dgri\GH16215.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi B4IXE0.
KOi K11855.
OMAi ENEMDRG.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4IXE0.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00.

Entry informationi

Entry nameiUBP36_DROGR
AccessioniPrimary (citable) accession number: B4IXE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi