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B4IXE0

- UBP36_DROGR

UniProt

B4IXE0 - UBP36_DROGR

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei211 – 2111NucleophilePROSITE-ProRule annotation
    Active sitei471 – 4711Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GH16215
    OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
    Taxonomic identifieri7222 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
    ProteomesiUP000001070: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0123686. Dgri\GH16215.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12401240Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378497Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei715 – 7151PhosphothreonineBy similarity
    Modified residuei725 – 7251PhosphoserineBy similarity
    Modified residuei727 – 7271PhosphoserineBy similarity
    Modified residuei895 – 8951PhosphoserineBy similarity
    Modified residuei898 – 8981PhosphothreonineBy similarity
    Modified residuei901 – 9011PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Protein-protein interaction databases

    STRINGi7222.FBpp0150121.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini202 – 512311USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5533.
    InParanoidiB4IXE0.
    KOiK11855.
    OMAiENEMDRG.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB4IXE0.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4IXE0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSLAVCET TANVVNAALR ESLGSCVARA ALSADEAKTS NGGGDGSSTS     50
    GSSTDNLQSQ IVANAKRVLL AKIDYEEVDN YHESVLAKLK SKYIVIKPDS 100
    NGGAASNGNG NYNGSNKTNG KFGAGNGHDN NGNGNGIVNG GTSALNGGNN 150
    RKQIVVVDHQ SSNQHGSPSN PNELPKPKRV LYQREHIRIG WKQSERKWQV 200
    GTGMLNVGNT CYLNSSLQAL FHIPSLANWL VSESAHLENC NISESCGSNG 250
    CIICAMAKTL QSTQSNQSAV RPFLIYSKLR QICKHMVVGR QEDAHEFLRF 300
    LIEAMEKAYL MRFRNYKELD QLVKETTPLN QIFGGYLRSE VRCLSCNHVS 350
    ITFQHFQDLL LDIRKSDTLE DAFDGYFSRE RLEDMGYKCE GCKKKVSATK 400
    QFSLERAPIT LCIQLKRFSM MGNKLTKQIS FKPRIDLSRF AARSPTAAAQ 450
    PLSYRLVSMV THLGVSQHCG HYTAIGLTET GSYYNFDDSC VRPIAMQSVC 500
    NTNAYIMFYE LDVNGNGHVV APKMNGMRLT TNGGQQHSSP VVATAPAAVV 550
    SATATSTSAS VSAAAVTSPR FIGPQLPNGY GNSNGHALGG GAAKTAIQFK 600
    TTPQKHQQQQ QAQTQYQLNG HINGAAKFQT GAANANANKS SCNTLNNSKQ 650
    HQPQQQQQQP QHILPISSDE EEDSDDDNDN DNVKTNKAPQ LPSMPKMFEE 700
    SSESVALTAK LKPKTALKSL VPYESASEEE EQQQQQQQQT LQQQAATNSR 750
    KRRSGADSSD TDDDDDEEQQ QQQQQQPSLI LRNGHAKTNG NLLNSSSSKT 800
    KSASNASSAN VNSSKQKTDA IDEIFKSLNN YKNKHRNDHN HVDDDDDDDE 850
    DEDEDEDEAQ AQAEKKTVTK SSSSSSSTSL TNGWQQSQNG KATASPKTPP 900
    SPAVIKTKTG IWQVTRNDED DDENVDGVAD ADDDDDNDEV AEPAVVTAKN 950
    HKNPFAAGKA TATTDANPSA KRQKLLNGSS KSQQTTPRIG NGYQGESLPN 1000
    GNAVVSELLK QNHRGYGSSV LSWNGKASEL DKETFDLVCA KRIAGYGAAA 1050
    ADEHCCDVNS GHSSNYGTNY KSLNNDMSSS SSSSSSTNSS SNSSSRSNGN 1100
    SSNCPPCDLL AEAREQRKRD DDDEEENEMD RGRQRKIKSA SVKCGSGATA 1150
    APPGYNPFQE YESQKRWHSN KSGSYSRFYH HPNYRSNFQQ RNKFKHNRFA 1200
    GGGGGAKFQQ QRALQRHLAS GGGFTRRQHH QSSGQQQQQS 1240
    Length:1,240
    Mass (Da):134,998
    Last modified:September 23, 2008 - v1
    Checksum:iD083740CBD133FF9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916366 Genomic DNA. Translation: EDV96377.1.
    RefSeqiXP_001984029.1. XM_001983993.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0151629; FBpp0150121; FBgn0123686.
    GeneIDi6558136.
    KEGGidgr:Dgri_GH16215.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH916366 Genomic DNA. Translation: EDV96377.1 .
    RefSeqi XP_001984029.1. XM_001983993.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 7222.FBpp0150121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0151629 ; FBpp0150121 ; FBgn0123686 .
    GeneIDi 6558136.
    KEGGi dgr:Dgri_GH16215.

    Organism-specific databases

    FlyBasei FBgn0123686. Dgri\GH16215.

    Phylogenomic databases

    eggNOGi COG5533.
    InParanoidi B4IXE0.
    KOi K11855.
    OMAi ENEMDRG.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B4IXE0.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Tucson 15287-2541.00.

    Entry informationi

    Entry nameiUBP36_DROGR
    AccessioniPrimary (citable) accession number: B4IXE0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3