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B4IXE0

- UBP36_DROGR

UniProt

B4IXE0 - UBP36_DROGR

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei211 – 2111NucleophilePROSITE-ProRule annotation
Active sitei471 – 4711Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.097.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GH16215
OrganismiDrosophila grimshawi (Fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
ProteomesiUP000001070: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0123686. Dgri\GH16215.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12401240Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378497Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei715 – 7151PhosphothreonineBy similarity
Modified residuei725 – 7251PhosphoserineBy similarity
Modified residuei727 – 7271PhosphoserineBy similarity
Modified residuei895 – 8951PhosphoserineBy similarity
Modified residuei898 – 8981PhosphothreonineBy similarity
Modified residuei901 – 9011PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Protein-protein interaction databases

STRINGi7222.FBpp0150121.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini202 – 512311USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5533.
InParanoidiB4IXE0.
KOiK11855.
OMAiENEMDRG.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4IXE0.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IXE0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSLAVCET TANVVNAALR ESLGSCVARA ALSADEAKTS NGGGDGSSTS
60 70 80 90 100
GSSTDNLQSQ IVANAKRVLL AKIDYEEVDN YHESVLAKLK SKYIVIKPDS
110 120 130 140 150
NGGAASNGNG NYNGSNKTNG KFGAGNGHDN NGNGNGIVNG GTSALNGGNN
160 170 180 190 200
RKQIVVVDHQ SSNQHGSPSN PNELPKPKRV LYQREHIRIG WKQSERKWQV
210 220 230 240 250
GTGMLNVGNT CYLNSSLQAL FHIPSLANWL VSESAHLENC NISESCGSNG
260 270 280 290 300
CIICAMAKTL QSTQSNQSAV RPFLIYSKLR QICKHMVVGR QEDAHEFLRF
310 320 330 340 350
LIEAMEKAYL MRFRNYKELD QLVKETTPLN QIFGGYLRSE VRCLSCNHVS
360 370 380 390 400
ITFQHFQDLL LDIRKSDTLE DAFDGYFSRE RLEDMGYKCE GCKKKVSATK
410 420 430 440 450
QFSLERAPIT LCIQLKRFSM MGNKLTKQIS FKPRIDLSRF AARSPTAAAQ
460 470 480 490 500
PLSYRLVSMV THLGVSQHCG HYTAIGLTET GSYYNFDDSC VRPIAMQSVC
510 520 530 540 550
NTNAYIMFYE LDVNGNGHVV APKMNGMRLT TNGGQQHSSP VVATAPAAVV
560 570 580 590 600
SATATSTSAS VSAAAVTSPR FIGPQLPNGY GNSNGHALGG GAAKTAIQFK
610 620 630 640 650
TTPQKHQQQQ QAQTQYQLNG HINGAAKFQT GAANANANKS SCNTLNNSKQ
660 670 680 690 700
HQPQQQQQQP QHILPISSDE EEDSDDDNDN DNVKTNKAPQ LPSMPKMFEE
710 720 730 740 750
SSESVALTAK LKPKTALKSL VPYESASEEE EQQQQQQQQT LQQQAATNSR
760 770 780 790 800
KRRSGADSSD TDDDDDEEQQ QQQQQQPSLI LRNGHAKTNG NLLNSSSSKT
810 820 830 840 850
KSASNASSAN VNSSKQKTDA IDEIFKSLNN YKNKHRNDHN HVDDDDDDDE
860 870 880 890 900
DEDEDEDEAQ AQAEKKTVTK SSSSSSSTSL TNGWQQSQNG KATASPKTPP
910 920 930 940 950
SPAVIKTKTG IWQVTRNDED DDENVDGVAD ADDDDDNDEV AEPAVVTAKN
960 970 980 990 1000
HKNPFAAGKA TATTDANPSA KRQKLLNGSS KSQQTTPRIG NGYQGESLPN
1010 1020 1030 1040 1050
GNAVVSELLK QNHRGYGSSV LSWNGKASEL DKETFDLVCA KRIAGYGAAA
1060 1070 1080 1090 1100
ADEHCCDVNS GHSSNYGTNY KSLNNDMSSS SSSSSSTNSS SNSSSRSNGN
1110 1120 1130 1140 1150
SSNCPPCDLL AEAREQRKRD DDDEEENEMD RGRQRKIKSA SVKCGSGATA
1160 1170 1180 1190 1200
APPGYNPFQE YESQKRWHSN KSGSYSRFYH HPNYRSNFQQ RNKFKHNRFA
1210 1220 1230 1240
GGGGGAKFQQ QRALQRHLAS GGGFTRRQHH QSSGQQQQQS
Length:1,240
Mass (Da):134,998
Last modified:September 23, 2008 - v1
Checksum:iD083740CBD133FF9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916366 Genomic DNA. Translation: EDV96377.1.
RefSeqiXP_001984029.1. XM_001983993.1.

Genome annotation databases

EnsemblMetazoaiFBtr0151629; FBpp0150121; FBgn0123686.
GeneIDi6558136.
KEGGidgr:Dgri_GH16215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH916366 Genomic DNA. Translation: EDV96377.1 .
RefSeqi XP_001984029.1. XM_001983993.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 7222.FBpp0150121.

Protein family/group databases

MEROPSi C19.097.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0151629 ; FBpp0150121 ; FBgn0123686 .
GeneIDi 6558136.
KEGGi dgr:Dgri_GH16215.

Organism-specific databases

FlyBasei FBgn0123686. Dgri\GH16215.

Phylogenomic databases

eggNOGi COG5533.
InParanoidi B4IXE0.
KOi K11855.
OMAi ENEMDRG.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4IXE0.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tucson 15287-2541.00.

Entry informationi

Entry nameiUBP36_DROGR
AccessioniPrimary (citable) accession number: B4IXE0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3