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B4IL64

- SWS_DROSE

UniProt

B4IL64 - SWS_DROSE

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Protein

Neuropathy target esterase sws

Gene
sws, GM11957
Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei983 – 9831 By similarityBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 301128cNMP 1Add
BLAST
Nucleotide bindingi480 – 607128cNMP 2Add
BLAST
Nucleotide bindingi596 – 723128cNMP 3Add
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese (EC:3.1.1.5)
Gene namesi
Name:sws
ORF Names:GM11957
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0166898. Dsec\GM11957.

Subcellular locationi

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane By similarity.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434Lumenal Reviewed predictionAdd
BLAST
Transmembranei35 – 5521Helical; Reviewed predictionAdd
BLAST
Topological domaini56 – 14681413Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14681468Neuropathy target esterase swsPRO_0000389226Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei442 – 4421Phosphoserine By similarityBy similarity
Modified residuei451 – 4511Phosphoserine By similarityBy similarity
Modified residuei1197 – 11971Phosphoserine By similarityBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4IL64.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini950 – 1116167PatatinAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1420 – 144627Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.
Contains 1 patatin domain.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4IL64.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IL64-1 [UniParc]FASTAAdd to Basket

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MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYCA LVMMSLLFIA     50
WFLYFKRMAR LRLRDELARS ISTATNSSGD LRGLRFRKRD KMLFYGRRML 100
RKVKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY 150
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY 200
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID 250
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN 350
GPPMVINQLN LMQSAASGTG SGVSVTVTRP PSSPSRHSRE EHTLSDPNPN 400
PDGSFHGTTN LFTEVHGDAP NADLFQQQQQ PSVGNLSTRR SSITLMTPDG 450
SHSCVQTPGV TTSIDMRLVQ SSAVDSLRKE LGLSEEDSHI IEPFVELREL 500
EPNVTLITEG NADDVCVWFV MTGTLAVYQS NQDATRAKQD KSDMLIHFVH 550
PGEIVGGLAM LTGEASAYTI RSRSYARIAF IRRAAIYQIM RQRPRIVLDL 600
GNGVVRRLSP LVRQCDYALD WIFLESGRAV YRQDESSDST YIVLSGRMRS 650
VITHPGGKKE IVGEYGKGDL VGIVEMITET SRTTTVMAVR DSELAKLPEG 700
LFNAIKLRYP IVVTKLISFL SHRFLGSMQT RSGSGAPGAP VEANPVTHKY 750
STVALVPITD EVPLTPFTYE LYHSLCAIGP VLRLTSDVVR KQLGSNIFEA 800
ANEYRLTSWL AQQEDRNIIT LYQCDSSLSA WTQRCMRQAD VILIVGLGDR 850
SHLVGKFERE IDRLAMRTQK ELVLLYPEAT NAKPANTLSW LNARPWVTKH 900
HHVLCVKRIF TRKSQYRIND LYSRVLLSEP NMHSDFSRLA RWLTGNSIGL 950
VLGGGGARGA AHIGMLKAIQ EAGIPVDMVG GVSIGALMGA LWCSDRNITT 1000
VTQKAREWSK KMTKWFLQLL DLTYPITSMF SGREFNKTIH DTFGDVSIED 1050
LWIPYFTLTT DITASCHRIH TNGSLWRYVR SSMSLSGYMP PLCDPKDGHL 1100
LLDGGYVNNL PGHLWRYCRA SMSIAGVFPP FCDYRDGHLL LDGCYTNNVP 1150
ADVMHNLGAA HIIAIDVGSQ DDTDLTNYGD DLSGWWLLYK KWNPFTSPVK 1200
VPDLPDIQSR LAYVSCVRQL EEVKNSDYCE YIRPPIDKYK TLAFGSFDEI 1250
RDVGYVFGKN YFENMAKAGR LGRFNQWFNK EPPKRVNHAS LNEYTFIDLA 1300
QIVCRLPETY AVNTAELFSE DEDCDGYISE PTTLNTDRRR IQVSRAGNSL 1350
SFSETEMDSD VELDLKLERK MDKSTQSSPP TSSRTDMRGK EEAKHMANWH 1400
WGVKHKDETG SGATVATHTQ TGQEQELQQQ QKLQQLQQDQ GARAEQLVDK 1450
DKEEDKENRS SPNNETKN 1468
Length:1,468
Mass (Da):165,401
Last modified:September 23, 2008 - v1
Checksum:iFA02ED9424EA49FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480865 Genomic DNA. Translation: EDW53681.1.
RefSeqiXP_002044474.1. XM_002044438.1.

Genome annotation databases

EnsemblMetazoaiFBtr0194942; FBpp0193434; FBgn0166898.
GeneIDi6620266.
KEGGidse:Dsec_GM11957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480865 Genomic DNA. Translation: EDW53681.1 .
RefSeqi XP_002044474.1. XM_002044438.1.

3D structure databases

ProteinModelPortali B4IL64.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0194942 ; FBpp0193434 ; FBgn0166898 .
GeneIDi 6620266.
KEGGi dse:Dsec_GM11957.

Organism-specific databases

FlyBasei FBgn0166898. Dsec\GM11957.

Phylogenomic databases

KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4IL64.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25.

Entry informationi

Entry nameiSWS_DROSE
AccessioniPrimary (citable) accession number: B4IL64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi