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B4IL64

- SWS_DROSE

UniProt

B4IL64 - SWS_DROSE

Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity.By similarity

    Catalytic activityi

    2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei983 – 9831By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi174 – 301128cNMP 1Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi480 – 607128cNMP 2Sequence AnalysisAdd
    BLAST
    Nucleotide bindingi596 – 723128cNMP 3Sequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. lysophospholipase activity Source: UniProtKB

    GO - Biological processi

    1. glial cell apoptotic process Source: UniProtKB
    2. membrane lipid metabolic process Source: UniProtKB
    3. membrane organization Source: UniProtKB
    4. nervous system development Source: UniProtKB-KW
    5. neuron apoptotic process Source: UniProtKB
    6. phosphatidylcholine metabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein, Hydrolase

    Keywords - Biological processi

    Neurogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuropathy target esterase swsBy similarity
    Alternative name(s):
    Swiss cheeseBy similarity (EC:3.1.1.5)
    Gene namesi
    Name:swsBy similarity
    ORF Names:GM11957
    OrganismiDrosophila sechellia (Fruit fly)
    Taxonomic identifieri7238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001292: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0166898. Dsec\GM11957.

    Subcellular locationi

    Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
    Note: Sws tethers Pka-C3 to the membrane.By similarity

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14681468Neuropathy target esterase swsPRO_0000389226Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei442 – 4421PhosphoserineBy similarity
    Modified residuei451 – 4511PhosphoserineBy similarity
    Modified residuei1197 – 11971PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB4IL64.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3434LumenalSequence AnalysisAdd
    BLAST
    Topological domaini56 – 14681413CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei35 – 5521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini950 – 1116167PatatinSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1420 – 144627Gln-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NTE family.Sequence Analysis
    Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
    Contains 1 patatin domain.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK14676.
    OrthoDBiEOG7QRQT1.
    PhylomeDBiB4IL64.

    Family and domain databases

    Gene3Di2.60.120.10. 3 hits.
    InterProiIPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view]
    PfamiPF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view]
    SMARTiSM00100. cNMP. 3 hits.
    [Graphical view]
    SUPFAMiSSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4IL64-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYCA LVMMSLLFIA     50
    WFLYFKRMAR LRLRDELARS ISTATNSSGD LRGLRFRKRD KMLFYGRRML 100
    RKVKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY 150
    LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY 200
    LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID 250
    VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 300
    RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN 350
    GPPMVINQLN LMQSAASGTG SGVSVTVTRP PSSPSRHSRE EHTLSDPNPN 400
    PDGSFHGTTN LFTEVHGDAP NADLFQQQQQ PSVGNLSTRR SSITLMTPDG 450
    SHSCVQTPGV TTSIDMRLVQ SSAVDSLRKE LGLSEEDSHI IEPFVELREL 500
    EPNVTLITEG NADDVCVWFV MTGTLAVYQS NQDATRAKQD KSDMLIHFVH 550
    PGEIVGGLAM LTGEASAYTI RSRSYARIAF IRRAAIYQIM RQRPRIVLDL 600
    GNGVVRRLSP LVRQCDYALD WIFLESGRAV YRQDESSDST YIVLSGRMRS 650
    VITHPGGKKE IVGEYGKGDL VGIVEMITET SRTTTVMAVR DSELAKLPEG 700
    LFNAIKLRYP IVVTKLISFL SHRFLGSMQT RSGSGAPGAP VEANPVTHKY 750
    STVALVPITD EVPLTPFTYE LYHSLCAIGP VLRLTSDVVR KQLGSNIFEA 800
    ANEYRLTSWL AQQEDRNIIT LYQCDSSLSA WTQRCMRQAD VILIVGLGDR 850
    SHLVGKFERE IDRLAMRTQK ELVLLYPEAT NAKPANTLSW LNARPWVTKH 900
    HHVLCVKRIF TRKSQYRIND LYSRVLLSEP NMHSDFSRLA RWLTGNSIGL 950
    VLGGGGARGA AHIGMLKAIQ EAGIPVDMVG GVSIGALMGA LWCSDRNITT 1000
    VTQKAREWSK KMTKWFLQLL DLTYPITSMF SGREFNKTIH DTFGDVSIED 1050
    LWIPYFTLTT DITASCHRIH TNGSLWRYVR SSMSLSGYMP PLCDPKDGHL 1100
    LLDGGYVNNL PGHLWRYCRA SMSIAGVFPP FCDYRDGHLL LDGCYTNNVP 1150
    ADVMHNLGAA HIIAIDVGSQ DDTDLTNYGD DLSGWWLLYK KWNPFTSPVK 1200
    VPDLPDIQSR LAYVSCVRQL EEVKNSDYCE YIRPPIDKYK TLAFGSFDEI 1250
    RDVGYVFGKN YFENMAKAGR LGRFNQWFNK EPPKRVNHAS LNEYTFIDLA 1300
    QIVCRLPETY AVNTAELFSE DEDCDGYISE PTTLNTDRRR IQVSRAGNSL 1350
    SFSETEMDSD VELDLKLERK MDKSTQSSPP TSSRTDMRGK EEAKHMANWH 1400
    WGVKHKDETG SGATVATHTQ TGQEQELQQQ QKLQQLQQDQ GARAEQLVDK 1450
    DKEEDKENRS SPNNETKN 1468
    Length:1,468
    Mass (Da):165,401
    Last modified:September 23, 2008 - v1
    Checksum:iFA02ED9424EA49FF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480865 Genomic DNA. Translation: EDW53681.1.
    RefSeqiXP_002044474.1. XM_002044438.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0194942; FBpp0193434; FBgn0166898.
    GeneIDi6620266.
    KEGGidse:Dsec_GM11957.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480865 Genomic DNA. Translation: EDW53681.1 .
    RefSeqi XP_002044474.1. XM_002044438.1.

    3D structure databases

    ProteinModelPortali B4IL64.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0194942 ; FBpp0193434 ; FBgn0166898 .
    GeneIDi 6620266.
    KEGGi dse:Dsec_GM11957.

    Organism-specific databases

    FlyBasei FBgn0166898. Dsec\GM11957.

    Phylogenomic databases

    KOi K14676.
    OrthoDBi EOG7QRQT1.
    PhylomeDBi B4IL64.

    Family and domain databases

    Gene3Di 2.60.120.10. 3 hits.
    InterProi IPR016035. Acyl_Trfase/lysoPLipase.
    IPR018490. cNMP-bd-like.
    IPR000595. cNMP-bd_dom.
    IPR001423. LysoPLipase_patatin_CS.
    IPR002641. Patatin/PLipase_A2-rel.
    IPR014710. RmlC-like_jellyroll.
    [Graphical view ]
    Pfami PF00027. cNMP_binding. 3 hits.
    PF01734. Patatin. 1 hit.
    [Graphical view ]
    SMARTi SM00100. cNMP. 3 hits.
    [Graphical view ]
    SUPFAMi SSF51206. SSF51206. 3 hits.
    SSF52151. SSF52151. 2 hits.
    PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
    PS01237. UPF0028. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rob3c / Tucson 14021-0248.25Imported.

    Entry informationi

    Entry nameiSWS_DROSE
    AccessioniPrimary (citable) accession number: B4IL64
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 24, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3