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B4IL64

- SWS_DROSE

UniProt

B4IL64 - SWS_DROSE

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Protein

Neuropathy target esterase sws

Gene

sws

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity).By similarity

Catalytic activityi

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei983 – 9831By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi174 – 301128cNMP 1Sequence AnalysisAdd
BLAST
Nucleotide bindingi480 – 607128cNMP 2Sequence AnalysisAdd
BLAST
Nucleotide bindingi596 – 723128cNMP 3Sequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. lysophospholipase activity Source: UniProtKB

GO - Biological processi

  1. glial cell apoptotic process Source: UniProtKB
  2. membrane lipid metabolic process Source: UniProtKB
  3. membrane organization Source: UniProtKB
  4. nervous system development Source: UniProtKB-KW
  5. neuron apoptotic process Source: UniProtKB
  6. phosphatidylcholine metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase

Keywords - Biological processi

Neurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropathy target esterase swsBy similarity
Alternative name(s):
Swiss cheeseBy similarity (EC:3.1.1.5)
Gene namesi
Name:swsBy similarity
ORF Names:GM11957
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0166898. Dsec\GM11957.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass type I membrane protein By similarity
Note: Sws tethers Pka-C3 to the membrane.By similarity

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14681468Neuropathy target esterase swsPRO_0000389226Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei442 – 4421PhosphoserineBy similarity
Modified residuei451 – 4511PhosphoserineBy similarity
Modified residuei1197 – 11971PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4IL64.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3434LumenalSequence AnalysisAdd
BLAST
Topological domaini56 – 14681413CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini950 – 1116167PatatinSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1420 – 144627Gln-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the NTE family.Sequence Analysis
Contains 3 cyclic nucleotide-binding domains.PROSITE-ProRule annotation
Contains 1 patatin domain.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK14676.
OrthoDBiEOG7QRQT1.
PhylomeDBiB4IL64.

Family and domain databases

Gene3Di2.60.120.10. 3 hits.
InterProiIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamiPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTiSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEiPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IL64-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYCA LVMMSLLFIA
60 70 80 90 100
WFLYFKRMAR LRLRDELARS ISTATNSSGD LRGLRFRKRD KMLFYGRRML
110 120 130 140 150
RKVKNVSGQM YSSGKGYKRR AVMRFARRIL QLRRDNMPLE MRTVEPPAEY
160 170 180 190 200
LEETIEGSDR VPPDALYMLQ SIRIFGHFEK PVFLRLCKHT QLLELMAGDY
210 220 230 240 250
LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE SVTSLLSFID
260 270 280 290 300
VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI
310 320 330 340 350
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN
360 370 380 390 400
GPPMVINQLN LMQSAASGTG SGVSVTVTRP PSSPSRHSRE EHTLSDPNPN
410 420 430 440 450
PDGSFHGTTN LFTEVHGDAP NADLFQQQQQ PSVGNLSTRR SSITLMTPDG
460 470 480 490 500
SHSCVQTPGV TTSIDMRLVQ SSAVDSLRKE LGLSEEDSHI IEPFVELREL
510 520 530 540 550
EPNVTLITEG NADDVCVWFV MTGTLAVYQS NQDATRAKQD KSDMLIHFVH
560 570 580 590 600
PGEIVGGLAM LTGEASAYTI RSRSYARIAF IRRAAIYQIM RQRPRIVLDL
610 620 630 640 650
GNGVVRRLSP LVRQCDYALD WIFLESGRAV YRQDESSDST YIVLSGRMRS
660 670 680 690 700
VITHPGGKKE IVGEYGKGDL VGIVEMITET SRTTTVMAVR DSELAKLPEG
710 720 730 740 750
LFNAIKLRYP IVVTKLISFL SHRFLGSMQT RSGSGAPGAP VEANPVTHKY
760 770 780 790 800
STVALVPITD EVPLTPFTYE LYHSLCAIGP VLRLTSDVVR KQLGSNIFEA
810 820 830 840 850
ANEYRLTSWL AQQEDRNIIT LYQCDSSLSA WTQRCMRQAD VILIVGLGDR
860 870 880 890 900
SHLVGKFERE IDRLAMRTQK ELVLLYPEAT NAKPANTLSW LNARPWVTKH
910 920 930 940 950
HHVLCVKRIF TRKSQYRIND LYSRVLLSEP NMHSDFSRLA RWLTGNSIGL
960 970 980 990 1000
VLGGGGARGA AHIGMLKAIQ EAGIPVDMVG GVSIGALMGA LWCSDRNITT
1010 1020 1030 1040 1050
VTQKAREWSK KMTKWFLQLL DLTYPITSMF SGREFNKTIH DTFGDVSIED
1060 1070 1080 1090 1100
LWIPYFTLTT DITASCHRIH TNGSLWRYVR SSMSLSGYMP PLCDPKDGHL
1110 1120 1130 1140 1150
LLDGGYVNNL PGHLWRYCRA SMSIAGVFPP FCDYRDGHLL LDGCYTNNVP
1160 1170 1180 1190 1200
ADVMHNLGAA HIIAIDVGSQ DDTDLTNYGD DLSGWWLLYK KWNPFTSPVK
1210 1220 1230 1240 1250
VPDLPDIQSR LAYVSCVRQL EEVKNSDYCE YIRPPIDKYK TLAFGSFDEI
1260 1270 1280 1290 1300
RDVGYVFGKN YFENMAKAGR LGRFNQWFNK EPPKRVNHAS LNEYTFIDLA
1310 1320 1330 1340 1350
QIVCRLPETY AVNTAELFSE DEDCDGYISE PTTLNTDRRR IQVSRAGNSL
1360 1370 1380 1390 1400
SFSETEMDSD VELDLKLERK MDKSTQSSPP TSSRTDMRGK EEAKHMANWH
1410 1420 1430 1440 1450
WGVKHKDETG SGATVATHTQ TGQEQELQQQ QKLQQLQQDQ GARAEQLVDK
1460
DKEEDKENRS SPNNETKN
Length:1,468
Mass (Da):165,401
Last modified:September 23, 2008 - v1
Checksum:iFA02ED9424EA49FF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480865 Genomic DNA. Translation: EDW53681.1.
RefSeqiXP_002044474.1. XM_002044438.1.

Genome annotation databases

EnsemblMetazoaiFBtr0194942; FBpp0193434; FBgn0166898.
GeneIDi6620266.
KEGGidse:Dsec_GM11957.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480865 Genomic DNA. Translation: EDW53681.1 .
RefSeqi XP_002044474.1. XM_002044438.1.

3D structure databases

ProteinModelPortali B4IL64.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0194942 ; FBpp0193434 ; FBgn0166898 .
GeneIDi 6620266.
KEGGi dse:Dsec_GM11957.

Organism-specific databases

FlyBasei FBgn0166898. Dsec\GM11957.

Phylogenomic databases

KOi K14676.
OrthoDBi EOG7QRQT1.
PhylomeDBi B4IL64.

Family and domain databases

Gene3Di 2.60.120.10. 3 hits.
InterProi IPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view ]
Pfami PF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view ]
SMARTi SM00100. cNMP. 3 hits.
[Graphical view ]
SUPFAMi SSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEi PS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25Imported.

Entry informationi

Entry nameiSWS_DROSE
AccessioniPrimary (citable) accession number: B4IL64
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3