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B4IL64 (SWS_DROSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 31. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuropathy target esterase sws
Alternative name(s):
Swiss cheese
EC=3.1.1.5
Gene names
Name:sws
ORF Names:GM11957
OrganismDrosophila sechellia (Fruit fly) [Complete proteome]
Taxonomic identifier7238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1468 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain By similarity. UniProtKB Q9U969

Catalytic activity

2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate. UniProtKB Q9U969

Subunit structure

Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws By similarity. UniProtKB Q9U969

Subcellular location

Endoplasmic reticulum membrane; Single-pass type I membrane protein By similarity. Note: Sws tethers Pka-C3 to the membrane By similarity. UniProtKB Q9U969

Sequence similarities

Belongs to the NTE family.

Contains 3 cyclic nucleotide-binding domains.

Contains 1 patatin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14681468Neuropathy target esterase sws
PRO_0000389226

Regions

Topological domain1 – 3434Lumenal Potential
Transmembrane35 – 5521Helical; Potential
Topological domain56 – 14681413Cytoplasmic Potential
Domain950 – 1116167Patatin
Nucleotide binding174 – 301128cNMP 1
Nucleotide binding480 – 607128cNMP 2
Nucleotide binding596 – 723128cNMP 3
Compositional bias1420 – 144627Gln-rich

Sites

Active site9831 By similarity UniProtKB Q9U969

Amino acid modifications

Modified residue4421Phosphoserine By similarity UniProtKB Q9U969
Modified residue4511Phosphoserine By similarity UniProtKB Q9U969
Modified residue11971Phosphoserine By similarity UniProtKB Q9U969

Sequences

Sequence LengthMass (Da)Tools
B4IL64 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: FA02ED9424EA49FF

FASTA1,468165,401
        10         20         30         40         50         60 
MDVLEMLRAS ASGSYNTIFS DAWCQYVSKQ ITATVYMYCA LVMMSLLFIA WFLYFKRMAR 

        70         80         90        100        110        120 
LRLRDELARS ISTATNSSGD LRGLRFRKRD KMLFYGRRML RKVKNVSGQM YSSGKGYKRR 

       130        140        150        160        170        180 
AVMRFARRIL QLRRDNMPLE MRTVEPPAEY LEETIEGSDR VPPDALYMLQ SIRIFGHFEK 

       190        200        210        220        230        240 
PVFLRLCKHT QLLELMAGDY LFKITDPDDS VYIVQSGMIN VYISNADGST LSLKTVRKGE 

       250        260        270        280        290        300 
SVTSLLSFID VLSGNPSYYK TVTAKAIEKS VVIRLPMQAF EEVFQDNPDV MIRVIQVIMI 

       310        320        330        340        350        360 
RLQRVLFTAL RNYLGLNAEL VQNHMRYKSV STMSGPINSQ TSQSSRQAPN GPPMVINQLN 

       370        380        390        400        410        420 
LMQSAASGTG SGVSVTVTRP PSSPSRHSRE EHTLSDPNPN PDGSFHGTTN LFTEVHGDAP 

       430        440        450        460        470        480 
NADLFQQQQQ PSVGNLSTRR SSITLMTPDG SHSCVQTPGV TTSIDMRLVQ SSAVDSLRKE 

       490        500        510        520        530        540 
LGLSEEDSHI IEPFVELREL EPNVTLITEG NADDVCVWFV MTGTLAVYQS NQDATRAKQD 

       550        560        570        580        590        600 
KSDMLIHFVH PGEIVGGLAM LTGEASAYTI RSRSYARIAF IRRAAIYQIM RQRPRIVLDL 

       610        620        630        640        650        660 
GNGVVRRLSP LVRQCDYALD WIFLESGRAV YRQDESSDST YIVLSGRMRS VITHPGGKKE 

       670        680        690        700        710        720 
IVGEYGKGDL VGIVEMITET SRTTTVMAVR DSELAKLPEG LFNAIKLRYP IVVTKLISFL 

       730        740        750        760        770        780 
SHRFLGSMQT RSGSGAPGAP VEANPVTHKY STVALVPITD EVPLTPFTYE LYHSLCAIGP 

       790        800        810        820        830        840 
VLRLTSDVVR KQLGSNIFEA ANEYRLTSWL AQQEDRNIIT LYQCDSSLSA WTQRCMRQAD 

       850        860        870        880        890        900 
VILIVGLGDR SHLVGKFERE IDRLAMRTQK ELVLLYPEAT NAKPANTLSW LNARPWVTKH 

       910        920        930        940        950        960 
HHVLCVKRIF TRKSQYRIND LYSRVLLSEP NMHSDFSRLA RWLTGNSIGL VLGGGGARGA 

       970        980        990       1000       1010       1020 
AHIGMLKAIQ EAGIPVDMVG GVSIGALMGA LWCSDRNITT VTQKAREWSK KMTKWFLQLL 

      1030       1040       1050       1060       1070       1080 
DLTYPITSMF SGREFNKTIH DTFGDVSIED LWIPYFTLTT DITASCHRIH TNGSLWRYVR 

      1090       1100       1110       1120       1130       1140 
SSMSLSGYMP PLCDPKDGHL LLDGGYVNNL PGHLWRYCRA SMSIAGVFPP FCDYRDGHLL 

      1150       1160       1170       1180       1190       1200 
LDGCYTNNVP ADVMHNLGAA HIIAIDVGSQ DDTDLTNYGD DLSGWWLLYK KWNPFTSPVK 

      1210       1220       1230       1240       1250       1260 
VPDLPDIQSR LAYVSCVRQL EEVKNSDYCE YIRPPIDKYK TLAFGSFDEI RDVGYVFGKN 

      1270       1280       1290       1300       1310       1320 
YFENMAKAGR LGRFNQWFNK EPPKRVNHAS LNEYTFIDLA QIVCRLPETY AVNTAELFSE 

      1330       1340       1350       1360       1370       1380 
DEDCDGYISE PTTLNTDRRR IQVSRAGNSL SFSETEMDSD VELDLKLERK MDKSTQSSPP 

      1390       1400       1410       1420       1430       1440 
TSSRTDMRGK EEAKHMANWH WGVKHKDETG SGATVATHTQ TGQEQELQQQ QKLQQLQQDQ 

      1450       1460 
GARAEQLVDK DKEEDKENRS SPNNETKN 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rob3c / Tucson 14021-0248.25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH480865 Genomic DNA. Translation: EDW53681.1.
RefSeqXP_002044474.1. XM_002044438.1.

3D structure databases

ProteinModelPortalB4IL64.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0194942; FBpp0193434; FBgn0166898.
GeneID6620266.
KEGGdse:Dsec_GM11957.

Organism-specific databases

FlyBaseFBgn0166898. Dsec\GM11957.

Phylogenomic databases

KOK14676.
OrthoDBEOG7QRQT1.

Family and domain databases

Gene3D2.60.120.10. 3 hits.
InterProIPR016035. Acyl_Trfase/lysoPLipase.
IPR018490. cNMP-bd-like.
IPR000595. cNMP-bd_dom.
IPR001423. LysoPLipase_patatin_CS.
IPR002641. Patatin/PLipase_A2-rel.
IPR014710. RmlC-like_jellyroll.
[Graphical view]
PfamPF00027. cNMP_binding. 3 hits.
PF01734. Patatin. 1 hit.
[Graphical view]
SMARTSM00100. cNMP. 3 hits.
[Graphical view]
SUPFAMSSF51206. SSF51206. 3 hits.
SSF52151. SSF52151. 2 hits.
PROSITEPS50042. CNMP_BINDING_3. 3 hits.
PS01237. UPF0028. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSWS_DROSE
AccessionPrimary (citable) accession number: B4IL64
Entry history
Integrated into UniProtKB/Swiss-Prot: November 24, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase