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Protein

Histone-lysine N-methyltransferase

Gene

Dsec\GM11794

Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:Dsec\GM11794Imported
ORF Names:Dsec_GM11794Imported, GM11794Imported
OrganismiDrosophila sechellia (Fruit fly)Imported
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0166737. Dsec\GM11794.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation

Phylogenomic databases

KOiK11421.
OrthoDBiEOG7ZD1TG.
PhylomeDBiB4IH79.

Family and domain databases

Gene3Di3.30.890.10. 1 hit.
InterProiIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IH79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKQPLLLKD FHQDHADFVA LDSSDEEEEE KQPEKSDFSK EKLQLIEDEL
60 70 80 90 100
DDAIKNVLNK VDFTAQMAWS KTILQAKADH LERQFALADV ELEKVQTTAD
110 120 130 140 150
KMHCALYNSC PVAHKHLPIL DIEPSDYVHE VPPAGEIVRP PIQLGETYYA
160 170 180 190 200
VKNKAIASWV SIKVIEFTES TAINGNTMKS YKIRYLNTPY QMIKTVTAKH
210 220 230 240 250
IAYFEPPPVR LTIGTRVIAY FDGTTLSRGK DKGVVQSAFY PGIIAEPLKQ
260 270 280 290 300
ANRYRYLIFY DDGYTQYVPH RDVRLVCQAS EKVWEDVHAA SRDFIQKYVE
310 320 330 340 350
KYSVDRPMVQ CTRGQSMNTE SNGTWLYARV MDIDCSLVLM QFEGDKNHTE
360 370 380 390 400
WIYRGSLRLG PVFRETQNNM NSSSAQQLRV PRRTEPFIRY TKEMESSSKV
410 420 430 440 450
NQQMRAFARK SSASAQNNAL AAASSAATSA GGRTNAGGAS TSNSSSAVRH
460 470 480 490 500
LNNSTIYVDD ENRPKGHVVY FTAKRNLPPK MYKRHECSPN CLFKIVHRLD
510 520 530 540 550
SYSPLAKPLL SGWERLVMRQ KTKKSVVYKG PCGKSLRNLA EVHRYLRATE
560 570 580 590 600
NVLNVDNFDF TPDLKCLAEY SIDPSIVKDT DISKGQEKMA IPLVNYYDNT
610 620 630 640 650
LPPPCTYAKQ RIPTEGVHLN LDEEFLLCCD CEDDCSDKSK CACWQLTVAG
660 670 680 690 700
VRYCNPKKPI EEIGYQYKRL HEHVPTGIYE CNSRCKCKKN CLNRVVQFSL
710 720 730 740 750
EMKLQVFKTS NRGWGLRCVN DIPKGAFICI YAGHLLTETM ANEGGQDAGD
760 770 780 790 800
EYFADLDYIE VAEQLKEGYE SEVDHSDPDA EEDNGGPDAE DDDDFRPNYH
810 820 830 840 850
YQRKIKRSSR SSSTQSCSTQ SSELDSQERA VINFNPNADL DETVRENSVR
860 870 880 890 900
RLFGKDEAPY IMDAKTTGNL GRYFNHSCNP NLFVQNVFVD THDLRFPWVA
910 920 930 940
FFSAAHIRSG TELTWNYNYE VGVVPGKVLY CQCGAPNCRI RLL
Length:943
Mass (Da):107,184
Last modified:September 22, 2008 - v1
Checksum:iCB664AB18E779497
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480838 Genomic DNA. Translation: EDW49255.1.
RefSeqiXP_002043124.1. XM_002043088.1.

Genome annotation databases

EnsemblMetazoaiFBtr0194779; FBpp0193271; FBgn0166737.
GeneIDi6618876.
KEGGidse:Dsec_GM11794.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480838 Genomic DNA. Translation: EDW49255.1.
RefSeqiXP_002043124.1. XM_002043088.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0194779; FBpp0193271; FBgn0166737.
GeneIDi6618876.
KEGGidse:Dsec_GM11794.

Organism-specific databases

FlyBaseiFBgn0166737. Dsec\GM11794.

Phylogenomic databases

KOiK11421.
OrthoDBiEOG7ZD1TG.
PhylomeDBiB4IH79.

Family and domain databases

Gene3Di3.30.890.10. 1 hit.
InterProiIPR016177. DNA-bd_dom.
IPR001739. Methyl_CpG_DNA-bd.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF01429. MBD. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS50982. MBD. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25Imported.

Entry informationi

Entry nameiB4IH79_DROSE
AccessioniPrimary (citable) accession number: B4IH79
Entry historyi
Integrated into UniProtKB/TrEMBL: September 22, 2008
Last sequence update: September 22, 2008
Last modified: March 3, 2015
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.