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Protein

Hexokinase

Gene

Dsec\GM10321

Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. hexokinase activity Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:Dsec\GM10321Imported
ORF Names:Dsec_GM10321Imported, GM10321Imported
OrganismiDrosophila sechellia (Fruit fly)Imported
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0165272. Dsec\GM10321.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation
Contains 1 hexokinase type-1 domain.UniRule annotation
Contains 1 hexokinase type-2 domain.UniRule annotation

Phylogenomic databases

KOiK00844.
OrthoDBiEOG7S21X5.
PhylomeDBiB4ICL8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4ICL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSLVHTEIE TAVKGFLIDQ EKMTEVVERM TKEIKMGLAK DTHARSVIKC
60 70 80 90 100
FVSHVQDLPT GKERGKYLAL DLGGSNFRVL LVNLISSSDV EIMSKGYNFP
110 120 130 140 150
LTLMSGSGNA LFDFLAESLS EFCHTHGLEN ESLPLGFTFS FPLQQQGLSK
160 170 180 190 200
GILVAWTKGF SCEGVVGKNV VSLLQEAIDR RGDIKINTVA ILNDTVGTLM
210 220 230 240 250
SCAFYHPNCR IGLIVGTGSN ACYVEKTVNA ECFEGYQTSP KPSMIINCEW
260 270 280 290 300
GAFGDNGVLE FVRTSYDKIV DKVTPNPGKQ TFEKCISGMY MGELVRLVII
310 320 330 340 350
DMIAKGFMFH GIISEKIQER WSFKTAYISD VESDAPGEYR NCNKVLSELG
360 370 380 390 400
ILGCQEPDKE ALRYICEAVS SRSAKLCACG LVTIINKMNI NEVVIGIDGS
410 420 430 440 450
VYRFHPKYHD MLQYHMKKLL KPGVKFELIV SEDGSGRGAA LVAATAVQAK

SKL
Length:453
Mass (Da):49,859
Last modified:September 23, 2008 - v1
Checksum:i886398B8B7876A43
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480828 Genomic DNA. Translation: EDW45114.1.
RefSeqiXP_002041376.1. XM_002041340.1.

Genome annotation databases

EnsemblMetazoaiFBtr0193306; FBpp0191798; FBgn0165272.
GeneIDi6617048.
KEGGidse:Dsec_GM10321.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480828 Genomic DNA. Translation: EDW45114.1.
RefSeqiXP_002041376.1. XM_002041340.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0193306; FBpp0191798; FBgn0165272.
GeneIDi6617048.
KEGGidse:Dsec_GM10321.

Organism-specific databases

FlyBaseiFBgn0165272. Dsec\GM10321.

Phylogenomic databases

KOiK00844.
OrthoDBiEOG7S21X5.
PhylomeDBiB4ICL8.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR022673. Hexokinase_C.
IPR019807. Hexokinase_CS.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 1 hit.
PF03727. Hexokinase_2. 1 hit.
[Graphical view]
PRINTSiPR00475. HEXOKINASE.
PROSITEiPS00378. HEXOKINASES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25Imported.

Entry informationi

Entry nameiB4ICL8_DROSE
AccessioniPrimary (citable) accession number: B4ICL8
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 4, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.