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Protein

Delta-like protein

Gene

Dsec\GM10127

Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
Gene namesi
Name:Dsec\GM10127Imported
ORF Names:Dsec_GM10127Imported, GM10127Imported
OrganismiDrosophila sechellia (Fruit fly)Imported
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001292 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0165078. Dsec\GM10127.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1225 – 124824HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini241 – 28545DSLInterPro annotationAdd
BLAST
Domaini286 – 31934EGF-likeInterPro annotationAdd
BLAST
Domaini353 – 39139EGF-likeInterPro annotationAdd
BLAST
Domaini452 – 49140EGF-likeInterPro annotationAdd
BLAST
Domaini493 – 52937EGF-likeInterPro annotationAdd
BLAST
Domaini573 – 61139EGF-likeInterPro annotationAdd
BLAST
Domaini613 – 64836EGF-likeInterPro annotationAdd
BLAST
Domaini650 – 68637EGF-likeInterPro annotationAdd
BLAST
Domaini688 – 72336EGF-likeInterPro annotationAdd
BLAST
Domaini763 – 79937EGF-likeInterPro annotationAdd
BLAST
Domaini801 – 83737EGF-likeInterPro annotationAdd
BLAST
Domaini839 – 87941EGF-likeInterPro annotationAdd
BLAST
Domaini881 – 91737EGF-likeInterPro annotationAdd
BLAST
Domaini919 – 95537EGF-likeInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 DSL domain.UniRule annotation
Contains 14 EGF-like domains.UniRule annotation

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.
PhylomeDBiB4IC56.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 13 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IC56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYKMFRKHFR RKPATSTSLS SSESTIESPD SLGMSKKTAT KRQRPRHRAP
60 70 80 90 100
KIATLPSTIR DCRSLKSACN LIALILILLV HKISAAGNFE LEILEISNTN
110 120 130 140 150
SHLLNGYCCG MPAELRATKT IGCSPCTTAF RLCLKEYQTT EQGASISTGC
160 170 180 190 200
SFGNATTKIL GGSSFVLSDP GVGAIVLPFT FRWTKSFTLI LQALDMYNTS
210 220 230 240 250
YPDAERLIEE TSYSGVILPS PEWKTLDHIG RNARITYRVR VQCAVTYYNT
260 270 280 290 300
TCTTFCRPRD DQFGHYACGS EGQKLCLNGW QGVNCEEAIC KAGCDPVHGK
310 320 330 340 350
CDRPGECECR PGWRGPLCNE CMVYPGCKHG SCNGSAWKCV CDTNWGGILC
360 370 380 390 400
DQDLNFCGTH EPCKHGGTCE NTAPDKYRCT CAEGLSGEQC EIVEHPCATR
410 420 430 440 450
PCRNGGTCTL KTSNRTQVQV YRTSHGRSNM GRPVRRSSSM RSLDHLRPEG
460 470 480 490 500
QALNGSSSSA LVSLGSLQLQ QQLAPDFTCD CAAGWTGPTC EINIDECAGG
510 520 530 540 550
PCEHGGTCID LIGGFRCECP PEWHGDVCQV DVNECEAPHS AGIAANALLT
560 570 580 590 600
TTATAIIGSN LSSTALLAAL TSAVASTSMA IGPCINAKEC RNQPGSFACI
610 620 630 640 650
CKEGWGGVTC AENLDDCVGQ CRNGASCIDL VNDYRCACAA GFTGRDCETD
660 670 680 690 700
IDECATSPCR NGGECVDMVG KFNCICPLGY SGSLCEEAKE NCTPSPCLEG
710 720 730 740 750
HCLNTPEGYY CHCPPDRAGK HCEQLRPLCS QPPCNEGCFA NVSLATSATT
760 770 780 790 800
TTTTTTTATT TRKMAKPSGL PCSGHGSCEM SDVGTFCKCH VGHTGTFCEH
810 820 830 840 850
NLNECSPNPC RNGGICLDGD GDFTCECMSG WTGKRCSERA TGCYAGQCQN
860 870 880 890 900
GGTCMPGAPD KALQPHCRCA PGWTGLFCAE AIDQCRGQPC HNGGTCESGA
910 920 930 940 950
GWFRCVCAQG FSGPDCRINV NECSPQPCQG GATCIDGIGG YSCICPPGRH
960 970 980 990 1000
GLRCEILLSD PKSACQNASN TISPYTALNR SQNWLDIALT GRTEDDENCN
1010 1020 1030 1040 1050
ACVCENGTSR CTNLWCGLPN CYKVDPLSKS SNLSGVCKQH EVCVPALSET
1060 1070 1080 1090 1100
CLSSPCSVRG DCRALEPSRR VAPPRLPAKS SCWPNQAVVN ENCARLTILL
1110 1120 1130 1140 1150
ALERVGKGAS VEGLCSLVRV LLAAQLIKKP ASTFGQDPGM LMVLCDLKTG
1160 1170 1180 1190 1200
TNDTVELTVS SSKLNDPQLP VAVGLLGELL SSRQLTGNQR RKELELQHAK
1210 1220 1230 1240 1250
LAALTSIVEV KLETARVADG SGHSLLIGVL CGVFIVLVGF SVFISLYWKQ
1260 1270 1280 1290 1300
RLAYRTSSGM NLTPSLDALR HEEEKSNNLQ NEENLRRYTN PLKGSTSSLR
1310 1320 1330 1340 1350
AATGMELSLN PAPELAASAA SSSALHRSQP LFPPCDFERE LDSSTGLKQA
1360 1370 1380 1390 1400
HKRSSQILLH KTQNSDMRKN TVGSLDSPRK DFGKRSINCK SMPPSSGDEG
1410
SDVLATTVMV
Length:1,410
Mass (Da):150,933
Last modified:September 23, 2008 - v1
Checksum:i2EF1A4A25FF2BFD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480828 Genomic DNA. Translation: EDW45214.1.
RefSeqiXP_002041476.1. XM_002041440.1.

Genome annotation databases

EnsemblMetazoaiFBtr0193112; FBpp0191604; FBgn0165078.
GeneIDi6617149.
KEGGidse:Dsec_GM10127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480828 Genomic DNA. Translation: EDW45214.1.
RefSeqiXP_002041476.1. XM_002041440.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0193112; FBpp0191604; FBgn0165078.
GeneIDi6617149.
KEGGidse:Dsec_GM10127.

Organism-specific databases

FlyBaseiFBgn0165078. Dsec\GM10127.

Phylogenomic databases

KOiK06052.
OMAiMPGAPDK.
OrthoDBiEOG7BKCSS.
PhylomeDBiB4IC56.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_.
IPR026219. Jagged/Serrate.
IPR011651. Notch_ligand_N.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 6 hits.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
PRINTSiPR02059. JAGGEDFAMILY.
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 14 hits.
SM00179. EGF_CA. 9 hits.
SM00215. VWC_out. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 7 hits.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 14 hits.
PS01186. EGF_2. 8 hits.
PS50026. EGF_3. 13 hits.
PS01187. EGF_CA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 Genomes Consortium
    Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.
    , Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C., Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S., Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A., Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V., Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L., Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25Imported.

Entry informationi

Entry nameiB4IC56_DROSE
AccessioniPrimary (citable) accession number: B4IC56
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 8, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.