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Protein

Lateral signaling target protein 2 homolog

Gene

GM10129

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Negative regulator of epidermal growth factor receptor (EGFR) signaling.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri895 – 95561FYVE-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Lateral signaling target protein 2 homolog
Gene namesi
ORF Names:GM10129
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001292 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0165080. Dsec\GM10129.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 975975Lateral signaling target protein 2 homologPRO_0000378968Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei540 – 5401PhosphoserineBy similarity
Modified residuei541 – 5411PhosphoserineBy similarity
Modified residuei796 – 7961PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi302 – 422121Ser-richAdd
BLAST
Compositional biasi836 – 88853Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the lst-2 family.Curated
Contains 1 FYVE-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri895 – 95561FYVE-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

OMAiEDINTKV.
OrthoDBiEOG091G053Q.
PhylomeDBiB4IC49.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4IC49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQSADDKSLL ARFFHADRSL TAVASELDSF DGRAEPDRCT RLVSRLRQNQ
60 70 80 90 100
DKVLAITNLI MEELLGEDRD PRAFRAKFPE EVLQENLAGQ LWFGAECLAA
110 120 130 140 150
GSSIMNRESE SKEMRPLAQA VTKSLGNVRV LLRDQCLKNN VPNSKTLHLD
160 170 180 190 200
LNDSTTEQLY ESLKIFDRLF AEFELSYVSA MVQVKSRHEY EMQQWIGVLF
210 220 230 240 250
SETLQRALKI GLLDQEMVDA FDPGLMFSIP RLAIVAGLVV YAKGPLNMDM
260 270 280 290 300
PGDQLSEMFR PFRTILIKIR DLLRNLNNQE LYQLEKLLCT NEDINTKVPL
310 320 330 340 350
GSSSIEAPSP EHSSHPTTSS TQNNNNSSNN NHSSSSTNTT STTITTAGTT
360 370 380 390 400
NTHRTVERLV DQRNNNHNSN SNSSSNPTVE GATLRSPSML SLSTTSTPTA
410 420 430 440 450
SPTPSPTPSH SIASTSSAAT SSTNPPADWS DGDDEDEDDD DIDVDEEDPE
460 470 480 490 500
SSDDGTDEEQ LLKDIVAADC ASGYLIPNTN LGNLLQPQEV PLTDNFVASE
510 520 530 540 550
DDEYGTAEQQ GHQGLEEEEP STSAAMLAAT RTLQRLRLPS SDNEPLAEPT
560 570 580 590 600
TIKASEEHMQ QPSGRHHRHH QSHHHHHHHR HSHQHQHRQP HPHRTTRSGR
610 620 630 640 650
KRCSLEAADP ETIQPEREQN LASGDTSAAS SLSDDVSLAM RNTTARLKFK
660 670 680 690 700
STENLLHRLF VCIAGVADQL QTNFASDLRQ ILRSVFLMNM SAAQEDIDIP
710 720 730 740 750
EKTKESELFE FRASENDVIQ ESAGSNQSIY SAEEVNPELD NVFSAGGGNQ
760 770 780 790 800
ATGQRHSAGA SMQRNNTIDL ASQPGEGSPS GATTTTSRSH VTRSRSLGDQ
810 820 830 840 850
EAASSATSST AQLRQLEQQQ QQQQLQIQLQ RQRNNSVGSN TPSSASSTSS
860 870 880 890 900
SSEQNSPVSA RSGSRRRLQS NNETQMPSSA TSTSATLSPP AWIPDGKAPR
910 920 930 940 950
CMACQTPFTA FRRRHHCRNC GGVFCGVCSN ASAPLPKYGL TKAVRVCRDC
960 970
YVREVRSGMG VQGVQSVQSV QASAS
Length:975
Mass (Da):106,909
Last modified:September 23, 2008 - v1
Checksum:i240390DBDE6984D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480828 Genomic DNA. Translation: EDW45207.1.
RefSeqiXP_002041469.1. XM_002041433.1.

Genome annotation databases

EnsemblMetazoaiFBtr0193114; FBpp0191606; FBgn0165080.
GeneIDi6617142.
KEGGidse:Dsec_GM10129.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480828 Genomic DNA. Translation: EDW45207.1.
RefSeqiXP_002041469.1. XM_002041433.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0193114; FBpp0191606; FBgn0165080.
GeneIDi6617142.
KEGGidse:Dsec_GM10129.

Organism-specific databases

FlyBaseiFBgn0165080. Dsec\GM10129.

Phylogenomic databases

OMAiEDINTKV.
OrthoDBiEOG091G053Q.
PhylomeDBiB4IC49.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR000306. Znf_FYVE.
IPR017455. Znf_FYVE-rel.
IPR011011. Znf_FYVE_PHD.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF01363. FYVE. 1 hit.
[Graphical view]
SMARTiSM00064. FYVE. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 1 hit.
PROSITEiPS50178. ZF_FYVE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLST2_DROSE
AccessioniPrimary (citable) accession number: B4IC49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.