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B4I9J6

- PGAM5_DROSE

UniProt

B4I9J6 - PGAM5_DROSE

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Protein
Serine/threonine-protein phosphatase Pgam5, mitochondrial
Gene
Pgam5, GM18947
Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity.By similarity

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: UniProtKB

GO - Biological processi

  1. protein dephosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial (EC:3.1.3.16)
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene namesi
Name:Pgam5
ORF Names:GM18947
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0173850. Dsec\GM18947.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial outer membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000390708Add
BLAST

Interactioni

Subunit structurei

Interacts with Pk92B/ASK1 By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliB4I9J6.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK15637.
OrthoDBiEOG7966H1.
PhylomeDBiB4I9J6.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view]
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.

Sequencei

Sequence statusi: Complete.

B4I9J6-1 [UniParc]FASTAAdd to Basket

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MRKLTSFACG TGAGLAAYYL QRLRDPQTAV QNSWTHSDKP VDPWALWDTN    50
WDCREPRALV RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV 100
GDSDDTHHLT ERGRKQAEFT GKRLCELGIK WDKVVASTMM RAQETSDIIL 150
KQIDFEKEKV VNCAFLREGA PIPPQPPVGH WKPEASQFLR DGSRIEAGFR 200
RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW LRININHASI 250
TWLTISPSGN VSIKYLGDSG FMPAELLTNR IPRDVKNVV 289
Length:289
Mass (Da):33,142
Last modified:September 23, 2008 - v1
Checksum:i7D74BD13C5187242
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480825 Genomic DNA. Translation: EDW43877.1.
RefSeqiXP_002040406.1. XM_002040370.1.

Genome annotation databases

EnsemblMetazoaiFBtr0201932; FBpp0200424; FBgn0173850.
GeneIDi6616040.
KEGGidse:Dsec_GM18947.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480825 Genomic DNA. Translation: EDW43877.1 .
RefSeqi XP_002040406.1. XM_002040370.1.

3D structure databases

ProteinModelPortali B4I9J6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0201932 ; FBpp0200424 ; FBgn0173850 .
GeneIDi 6616040.
KEGGi dse:Dsec_GM18947.

Organism-specific databases

FlyBasei FBgn0173850. Dsec\GM18947.

Phylogenomic databases

KOi K15637.
OrthoDBi EOG7966H1.
PhylomeDBi B4I9J6.

Family and domain databases

Gene3Di 3.40.50.1240. 1 hit.
InterProi IPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
[Graphical view ]
Pfami PF00300. His_Phos_1. 1 hit.
[Graphical view ]
SMARTi SM00855. PGAM. 1 hit.
[Graphical view ]
SUPFAMi SSF53254. SSF53254. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25.

Entry informationi

Entry nameiPGAM5_DROSE
AccessioniPrimary (citable) accession number: B4I9J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi