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B4I9J6 (PGAM5_DROSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 23. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial

EC=3.1.3.16
Alternative name(s):
Phosphoglycerate mutase family member 5 homolog
Gene names
Name:Pgam5
ORF Names:GM18947
OrganismDrosophila sechellia (Fruit fly) [Complete proteome]
Taxonomic identifier7238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length289 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity. UniProtKB O46084

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Subunit structure

Interacts with Pk92B/ASK1 By similarity. UniProtKB O46084

Subcellular location

Mitochondrion outer membrane; Single-pass membrane protein By similarity.

Sequence similarities

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 289289Serine/threonine-protein phosphatase Pgam5, mitochondrial
PRO_0000390708

Regions

Transmembrane7 – 2317Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B4I9J6 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 7D74BD13C5187242

FASTA28933,142
        10         20         30         40         50         60 
MRKLTSFACG TGAGLAAYYL QRLRDPQTAV QNSWTHSDKP VDPWALWDTN WDCREPRALV 

        70         80         90        100        110        120 
RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV GDSDDTHHLT ERGRKQAEFT 

       130        140        150        160        170        180 
GKRLCELGIK WDKVVASTMM RAQETSDIIL KQIDFEKEKV VNCAFLREGA PIPPQPPVGH 

       190        200        210        220        230        240 
WKPEASQFLR DGSRIEAGFR RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW 

       250        260        270        280 
LRININHASI TWLTISPSGN VSIKYLGDSG FMPAELLTNR IPRDVKNVV 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rob3c / Tucson 14021-0248.25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH480825 Genomic DNA. Translation: EDW43877.1.
RefSeqXP_002040406.1. XM_002040370.1.

3D structure databases

ProteinModelPortalB4I9J6.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0201932; FBpp0200424; FBgn0173850.
GeneID6616040.
KEGGdse:Dsec_GM18947.

Organism-specific databases

FlyBaseFBgn0173850. Dsec\GM18947.

Phylogenomic databases

KOK15637.
OrthoDBEOG7966H1.

Family and domain databases

InterProIPR013078. His_Pase_superF_clade-1.
[Graphical view]
PfamPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTSM00855. PGAM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGAM5_DROSE
AccessionPrimary (citable) accession number: B4I9J6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase