B4I9J6 (PGAM5_DROSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase Pgam5, mitochondrial
EC=3.1.3.16

Alternative name(s):
Phosphoglycerate mutase family member 5 homolog

Gene names

Name:	Pgam5
ORF Names:	GM18947

Organism

Drosophila sechellia (Fruit fly) [Complete proteome]

Taxonomic identifier

7238 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Eremoneura › Cyclorrhapha › Schizophora › Acalyptratae › Ephydroidea › Drosophilidae › Drosophilinae › Drosophilini › Drosophilina › Drosophiliti › Drosophila › Sophophora › melanogaster group › melanogaster subgroup

Protein attributes

Sequence length	289 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Displays phosphatase activity for serine/threonine residues, and dephosphorylates and activates Pk92B kinase. Has apparently no phosphoglycerate mutase activity By similarity. UniProtKB O46084
Catalytic activity	A phosphoprotein + H2O = a protein + phosphate. UniProtKB O46084
Subunit structure	Interacts with Pk92B/ASK1 By similarity. UniProtKB O46084
Subcellular location	Mitochondrion outer membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion outer membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein dephosphorylation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphoprotein phosphatase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 289	289	Serine/threonine-protein phosphatase Pgam5, mitochondrial		PRO_0000390708
Regions
	Transmembrane	7 – 23	17	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B4I9J6 [UniParc]. Last modified September 23, 2008. Version 1. Checksum: 7D74BD13C5187242	FASTA	289	33,142
	10 20 30 40 50 60 MRKLTSFACG TGAGLAAYYL QRLRDPQTAV QNSWTHSDKP VDPWALWDTN WDCREPRALV 70 80 90 100 110 120 RPLRNSQPEE ENRYNAELEK AKAKKARHII LVRHGEYLDV GDSDDTHHLT ERGRKQAEFT 130 140 150 160 170 180 GKRLCELGIK WDKVVASTMM RAQETSDIIL KQIDFEKEKV VNCAFLREGA PIPPQPPVGH 190 200 210 220 230 240 WKPEASQFLR DGSRIEAGFR RYFHRAYPDQ EKESYTLIVG HGNVIRYFVC RALQFPAEGW 250 260 270 280 LRININHASI TWLTISPSGN VSIKYLGDSG FMPAELLTNR IPRDVKNVV

References

[1]	"Evolution of genes and genomes on the Drosophila phylogeny." Drosophila 12 genomes consortium Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rob3c / Tucson 14021-0248.25.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH480825 Genomic DNA. Translation: EDW43877.1.
RefSeq	XP_002040406.1. XM_002040370.1.
3D structure databases
ProteinModelPortal	B4I9J6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0201932; FBpp0200424; FBgn0173850.
GeneID	6616040.
KEGG	dse:Dsec_GM18947.
Organism-specific databases
FlyBase	FBgn0173850. Dsec\GM18947.
Phylogenomic databases
KO	K15637.
OrthoDB	EOG447D98.
Family and domain databases
InterPro	IPR013078. His_Pase_superF_clade-1. [Graphical view]
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
PROSITE	PS00175. PG_MUTASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGAM5_DROSE

Accession

Primary (citable) accession number: B4I9J6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 19, 2010
Last sequence update:	September 23, 2008
Last modified:	February 6, 2013
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Drosophila annotation project