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B4I4Y1

- DGKH_DROSE

UniProt

B4I4Y1 - DGKH_DROSE

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Protein

Diacylglycerol kinase eta

Gene

GM10981

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

Catalytic activityi

ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. diacylglycerol kinase activity Source: UniProtKB
  3. metal ion binding Source: UniProtKB-KW
  4. NAD+ kinase activity Source: InterPro

GO - Biological processi

  1. intracellular signal transduction Source: InterPro
  2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
  3. protein oligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
Short name:
DAG kinase etaBy similarity
Gene namesi
ORF Names:GM10981
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0165926. Dsec\GM10981.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19141914Diacylglycerol kinase etaPRO_0000375989Add
BLAST

Keywords - PTMi

Phosphoprotein

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini82 – 17594PHPROSITE-ProRule annotationAdd
BLAST
Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
BLAST
Domaini1851 – 191464SAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
Contains 1 DAGKc domain.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

KOiK00901.
OrthoDBiEOG7DVD9B.

Family and domain databases

Gene3Di1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view]
PfamiPF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEiPS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4I4Y1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHLKLDTLH VQRSPRGSRR SSRSSGRSSA CSSGSISPVP IIPIISISHD
60 70 80 90 100
GDESESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR
110 120 130 140 150
RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT
160 170 180 190 200
RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA
210 220 230 240 250
TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL
260 270 280 290 300
ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC
310 320 330 340 350
LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG
360 370 380 390 400
NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR
410 420 430 440 450
HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG
460 470 480 490 500
WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST
510 520 530 540 550
EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH
560 570 580 590 600
HKDDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLIARSI
610 620 630 640 650
PVTPGSNAYL LNPNISIEKT EKDQINSKER RNSRSLRSSE KEALQCRANS
660 670 680 690 700
VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTNASG ESTPCTSPLP
710 720 730 740 750
IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS
760 770 780 790 800
RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG
810 820 830 840 850
ENTPTERKLD FLRVPIHTGE PIVDPLCDYR PHEVFERNYY MTREMDKDKE
860 870 880 890 900
KDKEKDKPVE IDIEKDTCVE KEGSMPEEKL VHTCNLQVPG VVVTPNPQNV
910 920 930 940 950
YSSASITIID TDAQTTTEQS SSDDLGGEAS DVLSAISNEE CSVASEIFDK
960 970 980 990 1000
QDAGQTVGDI IQNMDASNFT HIDSPETSDE TEAMPGESIM DDISSVLGHD
1010 1020 1030 1040 1050
ITYALQDNTL TDDTTTLCSE HVGPPKPPRK KSLSALSRTQ AHPRRRNSSP
1060 1070 1080 1090 1100
PRIARLARMD SDDNPQQFGF ENIVFEIDNR CDDQKMREPP RYCSLAQFVE
1110 1120 1130 1140 1150
GNDIARQSFK QLMLEQHRGG DNDSEYPEHQ QTPTNKGANL LITTSEDELS
1160 1170 1180 1190 1200
TQTAIKIEIQ DIDATVRNLN SSMKPNTILT TSTSPTKKSG HGQDISVVVR
1210 1220 1230 1240 1250
PPTPLRGDST KPTVSLLPVS SGGAMAVSMT CSGMLGVRAM NASEIRRHSS
1260 1270 1280 1290 1300
HAPGLAVREF DKDKDRRHSG FNPNQLTLDP EHARFLSSSP AASRRISCGS
1310 1320 1330 1340 1350
LFKKKNKQIA TKRSYGLFSV RFFVVAEPDF RLATLALIRP LIPLNEALPN
1360 1370 1380 1390 1400
LQTLKGSKSS LFMGSTLFGF DHLASAEKDK EEKGGKDKEK TPTEETNRKL
1410 1420 1430 1440 1450
PIINPLVRLP NWPLANGGGF ISKCLLANAD TLCAAVSPLM DPDETLLAGY
1460 1470 1480 1490 1500
HEKCVMNNYF GIGIDAKISL DFHNKREEHP EKCRSRARNY MWYGVLGSKQ
1510 1520 1530 1540 1550
LLQKTCKNLE QRVQLECDGQ RIPLPELQGI VILNIPSFMG GTNFWGSSTK
1560 1570 1580 1590 1600
KDDIFLPPSF DDRVLEVVAV FGSVQMAASR LINLQHHRIA QCQSVQINIL
1610 1620 1630 1640 1650
GDEEIPIQVD GEAWLQPPGM IRILHKNRVQ MLCRNRSLEL SLKSWQEKQR
1660 1670 1680 1690 1700
QHSISIQRDA SSTASEHANS TDEVISEREC YVLLNFIEAV SSLVKWVKFL
1710 1720 1730 1740 1750
IISHPALQHD LYEVACRASE ALESIHPQGK LLEGPSLRTK LVEVIDSSRQ
1760 1770 1780 1790 1800
LYDDACTLLR DRGHSLILRE DLETKLSAAL ANMEMELKKC SVQKCIDGKL
1810 1820 1830 1840 1850
RAYFNVLAPN EESDGRRKSR PFWVRLRSGS TAGQQAFKPP LTNTREAPNN
1860 1870 1880 1890 1900
WSVNEVVTWL ETMQLSEYVD SFLKNDIRGK ELLTLGRRDL KDLGVVKVGH
1910
VKRILQAIKD LSEN
Length:1,914
Mass (Da):213,869
Last modified:May 26, 2009 - v2
Checksum:i8F3D5EECF74C2777
GO

Sequence cautioni

The sequence EDW55274.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480821 Genomic DNA. Translation: EDW55274.1. Sequence problems.
RefSeqiXP_002038737.1. XM_002038701.1.

Genome annotation databases

GeneIDi6614297.
KEGGidse:Dsec_GM10981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480821 Genomic DNA. Translation: EDW55274.1 . Sequence problems.
RefSeqi XP_002038737.1. XM_002038701.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6614297.
KEGGi dse:Dsec_GM10981.

Organism-specific databases

FlyBasei FBgn0165926. Dsec\GM10981.

Phylogenomic databases

KOi K00901.
OrthoDBi EOG7DVD9B.

Family and domain databases

Gene3Di 1.10.150.50. 1 hit.
2.30.29.30. 1 hit.
InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR000756. Diacylglycerol_kin_accessory.
IPR001206. Diacylglycerol_kinase_cat_dom.
IPR002219. PE/DAG-bd.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR021129. SAM_type1.
[Graphical view ]
Pfami PF00130. C1_1. 2 hits.
PF00609. DAGK_acc. 1 hit.
PF00781. DAGK_cat. 1 hit.
PF00169. PH. 1 hit.
PF00536. SAM_1. 1 hit.
[Graphical view ]
SMARTi SM00109. C1. 2 hits.
SM00045. DAGKa. 1 hit.
SM00046. DAGKc. 1 hit.
SM00233. PH. 1 hit.
SM00454. SAM. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 2 hits.
SSF47769. SSF47769. 1 hit.
PROSITEi PS50146. DAGK. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50105. SAM_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 2 hits.
PS50081. ZF_DAG_PE_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25Imported.

Entry informationi

Entry nameiDGKH_DROSE
AccessioniPrimary (citable) accession number: B4I4Y1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 26, 2009
Last modified: October 29, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3