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B4I4Y1

- DGKH_DROSE

UniProt

B4I4Y1 - DGKH_DROSE

Protein

Diacylglycerol kinase eta

Gene

GM10981

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 2 (26 May 2009)
      Previous versions | rss
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    Functioni

    Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA).By similarity

    Catalytic activityi

    ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2-diacyl-sn-glycerol 3-phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. diacylglycerol kinase activity Source: UniProtKB
    3. metal ion binding Source: UniProtKB-KW
    4. NAD+ kinase activity Source: InterPro

    GO - Biological processi

    1. intracellular signal transduction Source: InterPro
    2. protein kinase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    3. protein oligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diacylglycerol kinase etaBy similarity (EC:2.7.1.107)
    Short name:
    DAG kinase etaBy similarity
    Gene namesi
    ORF Names:GM10981
    OrganismiDrosophila sechellia (Fruit fly)
    Taxonomic identifieri7238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001292: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0165926. Dsec\GM10981.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19141914Diacylglycerol kinase etaPRO_0000375989Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini82 – 17594PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini350 – 486137DAGKcPROSITE-ProRule annotationAdd
    BLAST
    Domaini1851 – 191464SAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the eukaryotic diacylglycerol kinase family.Sequence Analysis
    Contains 1 DAGKc domain.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 2 phorbol-ester/DAG-type zinc fingers.PROSITE-ProRule annotation
    Contains 1 SAM (sterile alpha motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri195 – 24551Phorbol-ester/DAG-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri268 – 31952Phorbol-ester/DAG-type 2PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    KOiK00901.
    OrthoDBiEOG7DVD9B.

    Family and domain databases

    Gene3Di1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProiIPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view]
    PfamiPF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view]
    SMARTiSM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEiPS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4I4Y1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHLKLDTLH VQRSPRGSRR SSRSSGRSSA CSSGSISPVP IIPIISISHD     50
    GDESESESEI ETEPARLFQR RMSIKCTNNL AAIIKEGFLL KHTWSFQRWR 100
    RRYFRLKRNM LFYAKDEKCD VFDDIDLSDL CYFECGIKNV NHSFQIITPT 150
    RSLVLCAESR REMEDWLGSL KTATAPQRPR GDSFLIEQHD ILSNHHHWYA 200
    TSHARPTYCN VCRDALSGVT SHGLSCEVCK CKVHKRCAAK SIANCKWTTL 250
    ASVGKDIIEQ ADGSIIMPHQ WMEGNLPVSS MCAVCKKTCG SVLRLQDWRC 300
    LWCRATVHVA CRPQMAVACP IGPAKLSVVP PTSVHSISTD DAWDVASPKG 350
    NFSPLLVFVN SKSGDNQGVK FLRRFKQLLN PAQVFDLIST GPSLGLRLFR 400
    HFEMFRILVC SGDGSVGWVL SEIDRFNMHK QCQVAVMPLG TGNDLARVLG 450
    WGSSCDDDTH LPQILERYES ASTKMLDRWS IMVFEKAIPV PKTPKMSIST 500
    EQEAMLTGMV TSANHHLRFI VETNDTQTLI SSTRNLCDTV DDLVCRISEH 550
    HKDDEQLAVK CDILRQKLNM LLDALQEEEI GAHSGDDLIA TIRSLIARSI 600
    PVTPGSNAYL LNPNISIEKT EKDQINSKER RNSRSLRSSE KEALQCRANS 650
    VKRAIYNVVE HSEPGRPKRY QRKLSITPFE ALKLPTNASG ESTPCTSPLP 700
    IIPPINIISP TMETSRLTCI SPLPDTRRDS VDENFFNSIN LPAPRQFADS 750
    RRSSGVPEVI QEIEEGANGE TVYRRSRMSL TGGANIDDAG NRLSPCSDGG 800
    ENTPTERKLD FLRVPIHTGE PIVDPLCDYR PHEVFERNYY MTREMDKDKE 850
    KDKEKDKPVE IDIEKDTCVE KEGSMPEEKL VHTCNLQVPG VVVTPNPQNV 900
    YSSASITIID TDAQTTTEQS SSDDLGGEAS DVLSAISNEE CSVASEIFDK 950
    QDAGQTVGDI IQNMDASNFT HIDSPETSDE TEAMPGESIM DDISSVLGHD 1000
    ITYALQDNTL TDDTTTLCSE HVGPPKPPRK KSLSALSRTQ AHPRRRNSSP 1050
    PRIARLARMD SDDNPQQFGF ENIVFEIDNR CDDQKMREPP RYCSLAQFVE 1100
    GNDIARQSFK QLMLEQHRGG DNDSEYPEHQ QTPTNKGANL LITTSEDELS 1150
    TQTAIKIEIQ DIDATVRNLN SSMKPNTILT TSTSPTKKSG HGQDISVVVR 1200
    PPTPLRGDST KPTVSLLPVS SGGAMAVSMT CSGMLGVRAM NASEIRRHSS 1250
    HAPGLAVREF DKDKDRRHSG FNPNQLTLDP EHARFLSSSP AASRRISCGS 1300
    LFKKKNKQIA TKRSYGLFSV RFFVVAEPDF RLATLALIRP LIPLNEALPN 1350
    LQTLKGSKSS LFMGSTLFGF DHLASAEKDK EEKGGKDKEK TPTEETNRKL 1400
    PIINPLVRLP NWPLANGGGF ISKCLLANAD TLCAAVSPLM DPDETLLAGY 1450
    HEKCVMNNYF GIGIDAKISL DFHNKREEHP EKCRSRARNY MWYGVLGSKQ 1500
    LLQKTCKNLE QRVQLECDGQ RIPLPELQGI VILNIPSFMG GTNFWGSSTK 1550
    KDDIFLPPSF DDRVLEVVAV FGSVQMAASR LINLQHHRIA QCQSVQINIL 1600
    GDEEIPIQVD GEAWLQPPGM IRILHKNRVQ MLCRNRSLEL SLKSWQEKQR 1650
    QHSISIQRDA SSTASEHANS TDEVISEREC YVLLNFIEAV SSLVKWVKFL 1700
    IISHPALQHD LYEVACRASE ALESIHPQGK LLEGPSLRTK LVEVIDSSRQ 1750
    LYDDACTLLR DRGHSLILRE DLETKLSAAL ANMEMELKKC SVQKCIDGKL 1800
    RAYFNVLAPN EESDGRRKSR PFWVRLRSGS TAGQQAFKPP LTNTREAPNN 1850
    WSVNEVVTWL ETMQLSEYVD SFLKNDIRGK ELLTLGRRDL KDLGVVKVGH 1900
    VKRILQAIKD LSEN 1914
    Length:1,914
    Mass (Da):213,869
    Last modified:May 26, 2009 - v2
    Checksum:i8F3D5EECF74C2777
    GO

    Sequence cautioni

    The sequence EDW55274.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480821 Genomic DNA. Translation: EDW55274.1. Sequence problems.
    RefSeqiXP_002038737.1. XM_002038701.1.

    Genome annotation databases

    GeneIDi6614297.
    KEGGidse:Dsec_GM10981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480821 Genomic DNA. Translation: EDW55274.1 . Sequence problems.
    RefSeqi XP_002038737.1. XM_002038701.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6614297.
    KEGGi dse:Dsec_GM10981.

    Organism-specific databases

    FlyBasei FBgn0165926. Dsec\GM10981.

    Phylogenomic databases

    KOi K00901.
    OrthoDBi EOG7DVD9B.

    Family and domain databases

    Gene3Di 1.10.150.50. 1 hit.
    2.30.29.30. 1 hit.
    InterProi IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR000756. Diacylglycerol_kin_accessory.
    IPR001206. Diacylglycerol_kinase_cat_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR002219. Prot_Kinase_C-like_PE/DAG-bd.
    IPR001660. SAM.
    IPR013761. SAM/pointed.
    IPR021129. SAM_type1.
    [Graphical view ]
    Pfami PF00130. C1_1. 2 hits.
    PF00609. DAGK_acc. 1 hit.
    PF00781. DAGK_cat. 1 hit.
    PF00169. PH. 1 hit.
    PF00536. SAM_1. 1 hit.
    [Graphical view ]
    SMARTi SM00109. C1. 2 hits.
    SM00045. DAGKa. 1 hit.
    SM00046. DAGKc. 1 hit.
    SM00233. PH. 1 hit.
    SM00454. SAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 2 hits.
    SSF47769. SSF47769. 1 hit.
    PROSITEi PS50146. DAGK. 1 hit.
    PS50003. PH_DOMAIN. 1 hit.
    PS50105. SAM_DOMAIN. 1 hit.
    PS00479. ZF_DAG_PE_1. 2 hits.
    PS50081. ZF_DAG_PE_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rob3c / Tucson 14021-0248.25Imported.

    Entry informationi

    Entry nameiDGKH_DROSE
    AccessioniPrimary (citable) accession number: B4I4Y1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 26, 2009
    Last sequence update: May 26, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3