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B4I4G2

- B4I4G2_DROSE

UniProt

B4I4G2 - B4I4G2_DROSE

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Protein
Histone-lysine N-methyltransferase, H3 lysine-79 specific
Gene
Dsec\GM10895, Dsec_GM10895, GM10895
Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionineUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
    Alternative name(s):
    Histone H3-K79 methyltransferase
    Gene namesi
    Name:Dsec\GM10895Imported
    ORF Names:Dsec_GM10895Imported, GM10895Imported
    OrganismiDrosophila sechellia (Fruit fly)
    Taxonomic identifieri7238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001292: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0165841. Dsec\GM10895.

    Subcellular locationi

    Nucleus By similarity UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    Complete GO annotation...

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 DOT1 domain.UniRule annotation

    Phylogenomic databases

    KOiK11427.
    OrthoDBiEOG7W6WJV.
    PhylomeDBiB4I4G2.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF08123. DOT1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51569. DOT1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4I4G2-1 [UniParc]FASTAAdd to Basket

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    MATPQVKDLV LRSPAGSSDV ISFAWPLQIG HGQDKHDNGI DIIDTIKFVC     50
    DELPSMSSAF EETNLHQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP 100
    AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV 150
    QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY 200
    AERMDVIFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS STLVFVNNFA 250
    FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 300
    EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHESVGTVR 350
    TTRDRAKREA NVGQHHHNNH HSNNHANSNN HQREREQSNG ATATAAHQQR 400
    HQSQSPANVS GAGIAVAASG QQAASKTRQQ LQHQHNQQQR SLDMESSTES 450
    DGEATNGNGG NTTTATNTTS ASNGPMTRKV WSDWCSSKGK SSQSDDEENN 500
    NSNSNGGSNG GSIGGGSVGR QARATTQKKR KKLTRKAAIA SKSAAAAQRE 550
    AEAAAVAASS VPSKESSSKE DPPRAASAGP GRKGRMKKGA RGRKSLKIVG 600
    LEALHKQTVL STSLDTMTKK LPAAPGTVDQ QLTALLTENM SHAELDIPTA 650
    PQDTPYALQI LLDVFRSQYT SMIEHMKSSA YVPQVQKQIA QEQERMARLK 700
    NRANQLDKQI KVLIDDSVAL LKVRMNELGI HVNSPNDLIA QAKEIVGRHK 750
    DLQHTASRMR NEVTFYEGEQ KLLLNKQLKN LPEYQKLCGT VNGKVKLEVP 800
    PELSETTAQE LVLKEIANTL SQRKKLYAQV STIEQETSVL QKTAEERSTA 850
    ATLLAQGTNM IVSTGSSSSS STTVCASAVT AQSNKLNSVK NSRRSREHRA 900
    RSQEWPEVPE VGKIQESNPE VLAQKIVETC RQIEAGKFQG AAAPSLQVNG 950
    KNKAIIEVPP PPPTAPVSIK SSPGHHYKDT TLMPAPKQQQ QQQMTLSQLP 1000
    KCELPGLSAS RKQESPKVAN FEDRLKSIIT TALNEDQEQR SKAVESSPSP 1050
    SPLHSPAPKR SKQHPAGAIN PAQSLPNNLH NIITVSTQGL MHLNANTTIS 1100
    PITPPLPGPG AGATASTAPP PPANLPYGAY GGAVAKTTVS GKYQAAKEPK 1150
    YSPVRQAPLP PPPPSHMASL YPAGQQTTPA DLGYQRRRSS VSATSYEHYM 1200
    VQQQQQLQQQ QLMLAAAAHA AQRQQMRVEE QQQQQHHQQQ QHHHHPQHRL 1250
    PQHVQHQHTH HPNEFKAPPA DSHLQRSSSR EQLIVEPPQT QPLELLPRAS 1300
    SANSDYSGYR IRPPSRPSSN SSQPDYTQVS PAKMALRRHL SQEKLSQHVT 1350
    PQATPPLPGH GGAPTSGKTI GDLVNGEIER TLEISHQSII NAAVNMSTSG 1400
    ASFMERAFLN ERSNDRLLIN LNAQRPERVH VRPLSEESQD PQPTSYAQER 1450
    GPGVGAAGGN SNLATLAHVA YAQKAQGGAR ANAGTAPPAT HSSSARSGRD 1500
    YQPVALPRAE LKGSIEAYFH EEQQQKQSKG AGSAGASSLR GPRLNGANPP 1550
    LEGLAASLQD HVRARKYKEE TEERQRRAAA AASSSAGPPP GMELPTHYAH 1600
    QAPPAHSYHH HGANINGTPH KVELGIKRSS PLAPHQQPPR PSKLAHYEPL 1650
    TTQQQHAHAH LYANGQVLPP PPAHDATTPS PTPSSSSSSC GRRSNSNNGK 1700
    LLVDPPLLMS PEINSLLGDE RPLQLSHHQQ QQQQMLHHHQ SQQQQHLQLT 1750
    QQQLRVAHLG HGHSTMPTLG VQRNGNGNAA DDVTIWHATY YN 1792
    Length:1,792
    Mass (Da):195,544
    Last modified:September 23, 2008 - v1
    Checksum:iA9C2D06A3B479550
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480821 Genomic DNA. Translation: EDW55105.1.
    RefSeqiXP_002038568.1. XM_002038532.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0193880; FBpp0192372; FBgn0165841.
    GeneIDi6614114.
    KEGGidse:Dsec_GM10895.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480821 Genomic DNA. Translation: EDW55105.1 .
    RefSeqi XP_002038568.1. XM_002038532.1.

    3D structure databases

    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0193880 ; FBpp0192372 ; FBgn0165841 .
    GeneIDi 6614114.
    KEGGi dse:Dsec_GM10895.

    Organism-specific databases

    FlyBasei FBgn0165841. Dsec\GM10895.

    Phylogenomic databases

    KOi K11427.
    OrthoDBi EOG7W6WJV.
    PhylomeDBi B4I4G2.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR013110. DOT1.
    IPR025789. Histone_H3-K79_MeTrfase.
    IPR021169. Histone_H3-K79_MeTrfase_met.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF08123. DOT1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51569. DOT1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rob3c / Tucson 14021-0248.25.

    Entry informationi

    Entry nameiB4I4G2_DROSE
    AccessioniPrimary (citable) accession number: B4I4G2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 23, 2008
    Last sequence update: September 23, 2008
    Last modified: June 11, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Miscellaneous

    In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    External Data

    Dasty 3

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