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B4I4G2

- B4I4G2_DROSE

UniProt

B4I4G2 - B4I4G2_DROSE

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Protein

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Gene

Dsec\GM10895

Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].UniRule annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specificUniRule annotation (EC:2.1.1.43UniRule annotation)
Alternative name(s):
Histone H3-K79 methyltransferaseUniRule annotation
Gene namesi
Name:Dsec\GM10895Imported
ORF Names:Dsec_GM10895Imported, GM10895Imported
OrganismiDrosophila sechellia (Fruit fly)Imported
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0165841. Dsec\GM10895.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.UniRule annotation
Contains 1 DOT1 domain.UniRule annotation

Phylogenomic databases

KOiK11427.
OrthoDBiEOG7W6WJV.
PhylomeDBiB4I4G2.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFiPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51569. DOT1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4I4G2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATPQVKDLV LRSPAGSSDV ISFAWPLQIG HGQDKHDNGI DIIDTIKFVC
60 70 80 90 100
DELPSMSSAF EETNLHQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP
110 120 130 140 150
AERLNKFAHP SLLRHILQLV YNAAVLDPDK LNQYEPFSPE VYGETSYELV
160 170 180 190 200
QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA GSFPLKTCIG IEKADTPARY
210 220 230 240 250
AERMDVIFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS STLVFVNNFA
260 270 280 290 300
FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS
310 320 330 340 350
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHESVGTVR
360 370 380 390 400
TTRDRAKREA NVGQHHHNNH HSNNHANSNN HQREREQSNG ATATAAHQQR
410 420 430 440 450
HQSQSPANVS GAGIAVAASG QQAASKTRQQ LQHQHNQQQR SLDMESSTES
460 470 480 490 500
DGEATNGNGG NTTTATNTTS ASNGPMTRKV WSDWCSSKGK SSQSDDEENN
510 520 530 540 550
NSNSNGGSNG GSIGGGSVGR QARATTQKKR KKLTRKAAIA SKSAAAAQRE
560 570 580 590 600
AEAAAVAASS VPSKESSSKE DPPRAASAGP GRKGRMKKGA RGRKSLKIVG
610 620 630 640 650
LEALHKQTVL STSLDTMTKK LPAAPGTVDQ QLTALLTENM SHAELDIPTA
660 670 680 690 700
PQDTPYALQI LLDVFRSQYT SMIEHMKSSA YVPQVQKQIA QEQERMARLK
710 720 730 740 750
NRANQLDKQI KVLIDDSVAL LKVRMNELGI HVNSPNDLIA QAKEIVGRHK
760 770 780 790 800
DLQHTASRMR NEVTFYEGEQ KLLLNKQLKN LPEYQKLCGT VNGKVKLEVP
810 820 830 840 850
PELSETTAQE LVLKEIANTL SQRKKLYAQV STIEQETSVL QKTAEERSTA
860 870 880 890 900
ATLLAQGTNM IVSTGSSSSS STTVCASAVT AQSNKLNSVK NSRRSREHRA
910 920 930 940 950
RSQEWPEVPE VGKIQESNPE VLAQKIVETC RQIEAGKFQG AAAPSLQVNG
960 970 980 990 1000
KNKAIIEVPP PPPTAPVSIK SSPGHHYKDT TLMPAPKQQQ QQQMTLSQLP
1010 1020 1030 1040 1050
KCELPGLSAS RKQESPKVAN FEDRLKSIIT TALNEDQEQR SKAVESSPSP
1060 1070 1080 1090 1100
SPLHSPAPKR SKQHPAGAIN PAQSLPNNLH NIITVSTQGL MHLNANTTIS
1110 1120 1130 1140 1150
PITPPLPGPG AGATASTAPP PPANLPYGAY GGAVAKTTVS GKYQAAKEPK
1160 1170 1180 1190 1200
YSPVRQAPLP PPPPSHMASL YPAGQQTTPA DLGYQRRRSS VSATSYEHYM
1210 1220 1230 1240 1250
VQQQQQLQQQ QLMLAAAAHA AQRQQMRVEE QQQQQHHQQQ QHHHHPQHRL
1260 1270 1280 1290 1300
PQHVQHQHTH HPNEFKAPPA DSHLQRSSSR EQLIVEPPQT QPLELLPRAS
1310 1320 1330 1340 1350
SANSDYSGYR IRPPSRPSSN SSQPDYTQVS PAKMALRRHL SQEKLSQHVT
1360 1370 1380 1390 1400
PQATPPLPGH GGAPTSGKTI GDLVNGEIER TLEISHQSII NAAVNMSTSG
1410 1420 1430 1440 1450
ASFMERAFLN ERSNDRLLIN LNAQRPERVH VRPLSEESQD PQPTSYAQER
1460 1470 1480 1490 1500
GPGVGAAGGN SNLATLAHVA YAQKAQGGAR ANAGTAPPAT HSSSARSGRD
1510 1520 1530 1540 1550
YQPVALPRAE LKGSIEAYFH EEQQQKQSKG AGSAGASSLR GPRLNGANPP
1560 1570 1580 1590 1600
LEGLAASLQD HVRARKYKEE TEERQRRAAA AASSSAGPPP GMELPTHYAH
1610 1620 1630 1640 1650
QAPPAHSYHH HGANINGTPH KVELGIKRSS PLAPHQQPPR PSKLAHYEPL
1660 1670 1680 1690 1700
TTQQQHAHAH LYANGQVLPP PPAHDATTPS PTPSSSSSSC GRRSNSNNGK
1710 1720 1730 1740 1750
LLVDPPLLMS PEINSLLGDE RPLQLSHHQQ QQQQMLHHHQ SQQQQHLQLT
1760 1770 1780 1790
QQQLRVAHLG HGHSTMPTLG VQRNGNGNAA DDVTIWHATY YN
Length:1,792
Mass (Da):195,544
Last modified:September 23, 2008 - v1
Checksum:iA9C2D06A3B479550
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480821 Genomic DNA. Translation: EDW55105.1.
RefSeqiXP_002038568.1. XM_002038532.1.

Genome annotation databases

EnsemblMetazoaiFBtr0193880; FBpp0192372; FBgn0165841.
GeneIDi6614114.
KEGGidse:Dsec_GM10895.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480821 Genomic DNA. Translation: EDW55105.1 .
RefSeqi XP_002038568.1. XM_002038532.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0193880 ; FBpp0192372 ; FBgn0165841 .
GeneIDi 6614114.
KEGGi dse:Dsec_GM10895.

Organism-specific databases

FlyBasei FBgn0165841. Dsec\GM10895.

Phylogenomic databases

KOi K11427.
OrthoDBi EOG7W6WJV.
PhylomeDBi B4I4G2.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF08123. DOT1. 1 hit.
[Graphical view ]
PIRSFi PIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51569. DOT1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25Imported.

Entry informationi

Entry nameiB4I4G2_DROSE
AccessioniPrimary (citable) accession number: B4I4G2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3