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B4I4G2 (B4I4G2_DROSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histone-lysine N-methyltransferase, H3 lysine-79 specific RuleBase RU271113

EC=2.1.1.43 RuleBase RU271113
Alternative name(s):
Histone H3-K79 methyltransferase RuleBase RU271113
Gene names
Name:Dsec\GM10895 EMBL EDW55105.1
ORF Names:Dsec_GM10895 EMBL EDW55105.1, GM10895 FlyBase FBgn0165841
OrganismDrosophila sechellia (Fruit fly) [Complete proteome]
Taxonomic identifier7238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1792 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. RuleBase RU271113

Subcellular location

Nucleus By similarity RuleBase RU271113.

Miscellaneous

In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones By similarity. RuleBase RU271113

Sequence similarities

Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family. RuleBase RU271113

Contains 1 DOT1 domain. RuleBase RU271113

Ontologies

Keywords
   Cellular componentNucleus RuleBase RU271113
   LigandS-adenosyl-L-methionine RuleBase RU271113
   Molecular functionChromatin regulator RuleBase RU271113
Methyltransferase RuleBase RU271113
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhistone-lysine N-methyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
B4I4G2 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: A9C2D06A3B479550

FASTA1,792195,544
        10         20         30         40         50         60 
MATPQVKDLV LRSPAGSSDV ISFAWPLQIG HGQDKHDNGI DIIDTIKFVC DELPSMSSAF 

        70         80         90        100        110        120 
EETNLHQIDT ACYKTMTGLV DRFNKAVDSI VALEKGTSLP AERLNKFAHP SLLRHILQLV 

       130        140        150        160        170        180 
YNAAVLDPDK LNQYEPFSPE VYGETSYELV QQMLKHVTVS KEDTFIDLGS GVGQVVLQMA 

       190        200        210        220        230        240 
GSFPLKTCIG IEKADTPARY AERMDVIFRQ YMGWFGKRFC EYKLIKGDFL VDEHREKITS 

       250        260        270        280        290        300 
STLVFVNNFA FGPTVDHQLK ERFADLRDGA RVVSSKSFCP LNFRITDRNL SDIGTIMHVS 

       310        320        330        340        350        360 
EIPPLKGSVS WTCKPVSYYL HVIDRTILER YFQRLKTKGG NDHESVGTVR TTRDRAKREA 

       370        380        390        400        410        420 
NVGQHHHNNH HSNNHANSNN HQREREQSNG ATATAAHQQR HQSQSPANVS GAGIAVAASG 

       430        440        450        460        470        480 
QQAASKTRQQ LQHQHNQQQR SLDMESSTES DGEATNGNGG NTTTATNTTS ASNGPMTRKV 

       490        500        510        520        530        540 
WSDWCSSKGK SSQSDDEENN NSNSNGGSNG GSIGGGSVGR QARATTQKKR KKLTRKAAIA 

       550        560        570        580        590        600 
SKSAAAAQRE AEAAAVAASS VPSKESSSKE DPPRAASAGP GRKGRMKKGA RGRKSLKIVG 

       610        620        630        640        650        660 
LEALHKQTVL STSLDTMTKK LPAAPGTVDQ QLTALLTENM SHAELDIPTA PQDTPYALQI 

       670        680        690        700        710        720 
LLDVFRSQYT SMIEHMKSSA YVPQVQKQIA QEQERMARLK NRANQLDKQI KVLIDDSVAL 

       730        740        750        760        770        780 
LKVRMNELGI HVNSPNDLIA QAKEIVGRHK DLQHTASRMR NEVTFYEGEQ KLLLNKQLKN 

       790        800        810        820        830        840 
LPEYQKLCGT VNGKVKLEVP PELSETTAQE LVLKEIANTL SQRKKLYAQV STIEQETSVL 

       850        860        870        880        890        900 
QKTAEERSTA ATLLAQGTNM IVSTGSSSSS STTVCASAVT AQSNKLNSVK NSRRSREHRA 

       910        920        930        940        950        960 
RSQEWPEVPE VGKIQESNPE VLAQKIVETC RQIEAGKFQG AAAPSLQVNG KNKAIIEVPP 

       970        980        990       1000       1010       1020 
PPPTAPVSIK SSPGHHYKDT TLMPAPKQQQ QQQMTLSQLP KCELPGLSAS RKQESPKVAN 

      1030       1040       1050       1060       1070       1080 
FEDRLKSIIT TALNEDQEQR SKAVESSPSP SPLHSPAPKR SKQHPAGAIN PAQSLPNNLH 

      1090       1100       1110       1120       1130       1140 
NIITVSTQGL MHLNANTTIS PITPPLPGPG AGATASTAPP PPANLPYGAY GGAVAKTTVS 

      1150       1160       1170       1180       1190       1200 
GKYQAAKEPK YSPVRQAPLP PPPPSHMASL YPAGQQTTPA DLGYQRRRSS VSATSYEHYM 

      1210       1220       1230       1240       1250       1260 
VQQQQQLQQQ QLMLAAAAHA AQRQQMRVEE QQQQQHHQQQ QHHHHPQHRL PQHVQHQHTH 

      1270       1280       1290       1300       1310       1320 
HPNEFKAPPA DSHLQRSSSR EQLIVEPPQT QPLELLPRAS SANSDYSGYR IRPPSRPSSN 

      1330       1340       1350       1360       1370       1380 
SSQPDYTQVS PAKMALRRHL SQEKLSQHVT PQATPPLPGH GGAPTSGKTI GDLVNGEIER 

      1390       1400       1410       1420       1430       1440 
TLEISHQSII NAAVNMSTSG ASFMERAFLN ERSNDRLLIN LNAQRPERVH VRPLSEESQD 

      1450       1460       1470       1480       1490       1500 
PQPTSYAQER GPGVGAAGGN SNLATLAHVA YAQKAQGGAR ANAGTAPPAT HSSSARSGRD 

      1510       1520       1530       1540       1550       1560 
YQPVALPRAE LKGSIEAYFH EEQQQKQSKG AGSAGASSLR GPRLNGANPP LEGLAASLQD 

      1570       1580       1590       1600       1610       1620 
HVRARKYKEE TEERQRRAAA AASSSAGPPP GMELPTHYAH QAPPAHSYHH HGANINGTPH 

      1630       1640       1650       1660       1670       1680 
KVELGIKRSS PLAPHQQPPR PSKLAHYEPL TTQQQHAHAH LYANGQVLPP PPAHDATTPS 

      1690       1700       1710       1720       1730       1740 
PTPSSSSSSC GRRSNSNNGK LLVDPPLLMS PEINSLLGDE RPLQLSHHQQ QQQQMLHHHQ 

      1750       1760       1770       1780       1790 
SQQQQHLQLT QQQLRVAHLG HGHSTMPTLG VQRNGNGNAA DDVTIWHATY YN 

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rob3c / Tucson 14021-0248.25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH480821 Genomic DNA. Translation: EDW55105.1.
RefSeqXP_002038568.1. XM_002038532.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0193880; FBpp0192372; FBgn0165841.
GeneID6614114.
KEGGdse:Dsec_GM10895.

Organism-specific databases

FlyBaseFBgn0165841. Dsec\GM10895.

Phylogenomic databases

KOK11427.
OrthoDBEOG7W6WJV.
PhylomeDBB4I4G2.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
InterProIPR013110. DOT1.
IPR025789. Histone_H3-K79_MeTrfase.
IPR021169. Histone_H3-K79_MeTrfase_met.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamPF08123. DOT1. 1 hit.
[Graphical view]
PIRSFPIRSF037123. Histone_H3-K79_MeTrfase_met. 1 hit.
SUPFAMSSF53335. SSF53335. 1 hit.
PROSITEPS51569. DOT1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4I4G2_DROSE
AccessionPrimary (citable) accession number: B4I4G2
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: June 11, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)