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B4HUI5

- UBP36_DROSE

UniProt

B4HUI5 - UBP36_DROSE

Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (23 Sep 2008)
      Previous versions | rss
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    Functioni

    Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei177 – 1771NucleophilePROSITE-ProRule annotation
    Active sitei416 – 4161Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitin thiolesterase activity Source: UniProtKB

    GO - Biological processi

    1. germ-line stem cell maintenance Source: UniProtKB
    2. protein deubiquitination Source: UniProtKB
    3. somatic stem cell maintenance Source: UniProtKB
    4. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 36
    Protein scrawny
    Ubiquitin thioesterase 36
    Ubiquitin-specific-processing protease 36
    Gene namesi
    Name:Usp36
    Synonyms:scny
    ORF Names:GM14719
    OrganismiDrosophila sechellia (Fruit fly)
    Taxonomic identifieri7238 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000001292: Unassembled WGS sequence

    Organism-specific databases

    FlyBaseiFBgn0169640. Dsec\GM14719.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10591059Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378501Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei490 – 4901PhosphoserineBy similarity
    Modified residuei492 – 4921PhosphoserineBy similarity
    Modified residuei632 – 6321PhosphothreonineBy similarity
    Modified residuei636 – 6361PhosphothreonineBy similarity
    Modified residuei646 – 6461PhosphoserineBy similarity
    Modified residuei648 – 6481PhosphoserineBy similarity
    Modified residuei721 – 7211PhosphoserineBy similarity
    Modified residuei753 – 7531PhosphoserineBy similarity
    Modified residuei756 – 7561PhosphothreonineBy similarity
    Modified residuei759 – 7591PhosphoserineBy similarity
    Modified residuei799 – 7991PhosphothreonineBy similarity
    Modified residuei817 – 8171PhosphoserineBy similarity
    Modified residuei820 – 8201PhosphothreonineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Interactioni

    Subunit structurei

    Interacts with atms/PAF1, but not with CycT.By similarity

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini168 – 457290USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    KOiK11855.
    OrthoDBiEOG7XDBF6.
    PhylomeDBiB4HUI5.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B4HUI5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV     50
    ANAKRILMAK IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN 100
    TGKLVGANGH DNNGARKQAE HPNNQSHHNH PHPTSNPNEL PKPKRVLYPR 150
    ENIRIGWKQS ERKWQVGTGM INVGNTCYLN STLQALLHIP ALANWLVSEQ 200
    AHLADCNVAE PGSGCIICAM AKTLLATQSN QSAVRPFLIY SKLKQICKHM 250
    VVGRQEDAHE FLRFLVEAME RAYLMRFRNY KELDQLVKET TPLGQIFGGY 300
    LRSEVRCLSC NHVSITFQHF QDLLLDIRKA DSLEDAFEGH FSRERLEDMG 350
    YKCEGCKKKL KRFSMIGNKL TKQISFKPRI DLSKYAARSP AAQAQPLTYR 400
    LVSMVTHLGA SQHCGHYTAI GSTDTGSFYN FDDSYVRPIT MQNVCNTNAY 450
    IMFFELDLSQ AASPPANRPN GVRLTNGHST TPVPAATVSS PSPTRFIGPQ 500
    LPPGGANGYT NGNAQKTAIQ FKQQNQQNGL QLGTGKFQDT AKPPLVGAYA 550
    KGEATSAPTA NGNKSSSPSS NSSSNHKSIN QQQYLPISSD DEDIDDEMKP 600
    GPTTAQLPSM PNMTEDNTEP KAKSPVKIHL KTPVKTPLKS LVPYESASEE 650
    EEAPLPNPRQ SPGGEDFSES DQESGQTNGH SKTNGSLTNG SASSSVHVNN 700
    SKQKTDAIDE IFKSLKKSAD SEEDDDEEEP SIQLTNGWHP QKQSQSQSKA 750
    PPSPKTPPSP AVIKSKTGIW KVTRKDEVDA IDDDDDAVVV EGAPVKIPTP 800
    NKTHRNPFSS SKPSTDSPAT PGAKRQKLLN GSALKSHQQP RVGNGYQSNV 850
    TSNGSTVNEL LKQSYRGYGA SVLSWNGKPA ELEKEPFELV CAKRIAGHGS 900
    VEGSDIVEGS VAVDAAVTSS SNSNDVVVIA VALLVDAREQ RQRDLDDDEE 950
    NEMDRGRQRK VKSGSAKGNN ASNSTPGYNP FQEYEGQKRW NKNGGGGGFS 1000
    RFYNQNYRQN FQQRNKFKFN RFGGAGSAKF QQQRALQRHL SAGGGFSRRQ 1050
    PSAQQQQQT 1059
    Length:1,059
    Mass (Da):115,591
    Last modified:September 23, 2008 - v1
    Checksum:iEB4DAC63DA00063E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480817 Genomic DNA. Translation: EDW50606.1.
    RefSeqiXP_002035470.1. XM_002035434.1.

    Genome annotation databases

    EnsemblMetazoaiFBtr0197704; FBpp0196196; FBgn0169640.
    GeneIDi6610913.
    KEGGidse:Dsec_GM14719.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CH480817 Genomic DNA. Translation: EDW50606.1 .
    RefSeqi XP_002035470.1. XM_002035434.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0197704 ; FBpp0196196 ; FBgn0169640 .
    GeneIDi 6610913.
    KEGGi dse:Dsec_GM14719.

    Organism-specific databases

    FlyBasei FBgn0169640. Dsec\GM14719.

    Phylogenomic databases

    KOi K11855.
    OrthoDBi EOG7XDBF6.
    PhylomeDBi B4HUI5.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of genes and genomes on the Drosophila phylogeny."
      Drosophila 12 genomes consortium
      Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rob3c / Tucson 14021-0248.25.

    Entry informationi

    Entry nameiUBP36_DROSE
    AccessioniPrimary (citable) accession number: B4HUI5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 7, 2009
    Last sequence update: September 23, 2008
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3