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B4HUI5

- UBP36_DROSE

UniProt

B4HUI5 - UBP36_DROSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene
Usp36, scny, GM14719
Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771Nucleophile By similarity
Active sitei416 – 4161Proton acceptor By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GM14719
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0169640. Dsec\GM14719.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei490 – 4901Phosphoserine By similarity
Modified residuei492 – 4921Phosphoserine By similarity
Modified residuei632 – 6321Phosphothreonine By similarity
Modified residuei636 – 6361Phosphothreonine By similarity
Modified residuei646 – 6461Phosphoserine By similarity
Modified residuei648 – 6481Phosphoserine By similarity
Modified residuei721 – 7211Phosphoserine By similarity
Modified residuei753 – 7531Phosphoserine By similarity
Modified residuei756 – 7561Phosphothreonine By similarity
Modified residuei759 – 7591Phosphoserine By similarity
Modified residuei799 – 7991Phosphothreonine By similarity
Modified residuei817 – 8171Phosphoserine By similarity
Modified residuei820 – 8201Phosphothreonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT By similarity.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 457290USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Phylogenomic databases

KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4HUI5.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4HUI5-1 [UniParc]FASTAAdd to Basket

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MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV     50
ANAKRILMAK IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN 100
TGKLVGANGH DNNGARKQAE HPNNQSHHNH PHPTSNPNEL PKPKRVLYPR 150
ENIRIGWKQS ERKWQVGTGM INVGNTCYLN STLQALLHIP ALANWLVSEQ 200
AHLADCNVAE PGSGCIICAM AKTLLATQSN QSAVRPFLIY SKLKQICKHM 250
VVGRQEDAHE FLRFLVEAME RAYLMRFRNY KELDQLVKET TPLGQIFGGY 300
LRSEVRCLSC NHVSITFQHF QDLLLDIRKA DSLEDAFEGH FSRERLEDMG 350
YKCEGCKKKL KRFSMIGNKL TKQISFKPRI DLSKYAARSP AAQAQPLTYR 400
LVSMVTHLGA SQHCGHYTAI GSTDTGSFYN FDDSYVRPIT MQNVCNTNAY 450
IMFFELDLSQ AASPPANRPN GVRLTNGHST TPVPAATVSS PSPTRFIGPQ 500
LPPGGANGYT NGNAQKTAIQ FKQQNQQNGL QLGTGKFQDT AKPPLVGAYA 550
KGEATSAPTA NGNKSSSPSS NSSSNHKSIN QQQYLPISSD DEDIDDEMKP 600
GPTTAQLPSM PNMTEDNTEP KAKSPVKIHL KTPVKTPLKS LVPYESASEE 650
EEAPLPNPRQ SPGGEDFSES DQESGQTNGH SKTNGSLTNG SASSSVHVNN 700
SKQKTDAIDE IFKSLKKSAD SEEDDDEEEP SIQLTNGWHP QKQSQSQSKA 750
PPSPKTPPSP AVIKSKTGIW KVTRKDEVDA IDDDDDAVVV EGAPVKIPTP 800
NKTHRNPFSS SKPSTDSPAT PGAKRQKLLN GSALKSHQQP RVGNGYQSNV 850
TSNGSTVNEL LKQSYRGYGA SVLSWNGKPA ELEKEPFELV CAKRIAGHGS 900
VEGSDIVEGS VAVDAAVTSS SNSNDVVVIA VALLVDAREQ RQRDLDDDEE 950
NEMDRGRQRK VKSGSAKGNN ASNSTPGYNP FQEYEGQKRW NKNGGGGGFS 1000
RFYNQNYRQN FQQRNKFKFN RFGGAGSAKF QQQRALQRHL SAGGGFSRRQ 1050
PSAQQQQQT 1059
Length:1,059
Mass (Da):115,591
Last modified:September 23, 2008 - v1
Checksum:iEB4DAC63DA00063E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480817 Genomic DNA. Translation: EDW50606.1.
RefSeqiXP_002035470.1. XM_002035434.1.

Genome annotation databases

EnsemblMetazoaiFBtr0197704; FBpp0196196; FBgn0169640.
GeneIDi6610913.
KEGGidse:Dsec_GM14719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480817 Genomic DNA. Translation: EDW50606.1 .
RefSeqi XP_002035470.1. XM_002035434.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0197704 ; FBpp0196196 ; FBgn0169640 .
GeneIDi 6610913.
KEGGi dse:Dsec_GM14719.

Organism-specific databases

FlyBasei FBgn0169640. Dsec\GM14719.

Phylogenomic databases

KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4HUI5.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25.

Entry informationi

Entry nameiUBP36_DROSE
AccessioniPrimary (citable) accession number: B4HUI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: July 9, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi