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B4HUI5

- UBP36_DROSE

UniProt

B4HUI5 - UBP36_DROSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 36

Gene

Usp36

Organism
Drosophila sechellia (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei177 – 1771NucleophilePROSITE-ProRule annotation
Active sitei416 – 4161Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. ubiquitin thiolesterase activity Source: UniProtKB

GO - Biological processi

  1. germ-line stem cell maintenance Source: UniProtKB
  2. protein deubiquitination Source: UniProtKB
  3. somatic stem cell maintenance Source: UniProtKB
  4. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 36 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene namesi
Name:Usp36
Synonyms:scny
ORF Names:GM14719
OrganismiDrosophila sechellia (Fruit fly)
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0169640. Dsec\GM14719.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10591059Ubiquitin carboxyl-terminal hydrolase 36PRO_0000378501Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei490 – 4901PhosphoserineBy similarity
Modified residuei492 – 4921PhosphoserineBy similarity
Modified residuei632 – 6321PhosphothreonineBy similarity
Modified residuei636 – 6361PhosphothreonineBy similarity
Modified residuei646 – 6461PhosphoserineBy similarity
Modified residuei648 – 6481PhosphoserineBy similarity
Modified residuei721 – 7211PhosphoserineBy similarity
Modified residuei753 – 7531PhosphoserineBy similarity
Modified residuei756 – 7561PhosphothreonineBy similarity
Modified residuei759 – 7591PhosphoserineBy similarity
Modified residuei799 – 7991PhosphothreonineBy similarity
Modified residuei817 – 8171PhosphoserineBy similarity
Modified residuei820 – 8201PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Interacts with atms/PAF1, but not with CycT.By similarity

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini168 – 457290USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

KOiK11855.
OrthoDBiEOG7XDBF6.
PhylomeDBiB4HUI5.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4HUI5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV
60 70 80 90 100
ANAKRILMAK IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN
110 120 130 140 150
TGKLVGANGH DNNGARKQAE HPNNQSHHNH PHPTSNPNEL PKPKRVLYPR
160 170 180 190 200
ENIRIGWKQS ERKWQVGTGM INVGNTCYLN STLQALLHIP ALANWLVSEQ
210 220 230 240 250
AHLADCNVAE PGSGCIICAM AKTLLATQSN QSAVRPFLIY SKLKQICKHM
260 270 280 290 300
VVGRQEDAHE FLRFLVEAME RAYLMRFRNY KELDQLVKET TPLGQIFGGY
310 320 330 340 350
LRSEVRCLSC NHVSITFQHF QDLLLDIRKA DSLEDAFEGH FSRERLEDMG
360 370 380 390 400
YKCEGCKKKL KRFSMIGNKL TKQISFKPRI DLSKYAARSP AAQAQPLTYR
410 420 430 440 450
LVSMVTHLGA SQHCGHYTAI GSTDTGSFYN FDDSYVRPIT MQNVCNTNAY
460 470 480 490 500
IMFFELDLSQ AASPPANRPN GVRLTNGHST TPVPAATVSS PSPTRFIGPQ
510 520 530 540 550
LPPGGANGYT NGNAQKTAIQ FKQQNQQNGL QLGTGKFQDT AKPPLVGAYA
560 570 580 590 600
KGEATSAPTA NGNKSSSPSS NSSSNHKSIN QQQYLPISSD DEDIDDEMKP
610 620 630 640 650
GPTTAQLPSM PNMTEDNTEP KAKSPVKIHL KTPVKTPLKS LVPYESASEE
660 670 680 690 700
EEAPLPNPRQ SPGGEDFSES DQESGQTNGH SKTNGSLTNG SASSSVHVNN
710 720 730 740 750
SKQKTDAIDE IFKSLKKSAD SEEDDDEEEP SIQLTNGWHP QKQSQSQSKA
760 770 780 790 800
PPSPKTPPSP AVIKSKTGIW KVTRKDEVDA IDDDDDAVVV EGAPVKIPTP
810 820 830 840 850
NKTHRNPFSS SKPSTDSPAT PGAKRQKLLN GSALKSHQQP RVGNGYQSNV
860 870 880 890 900
TSNGSTVNEL LKQSYRGYGA SVLSWNGKPA ELEKEPFELV CAKRIAGHGS
910 920 930 940 950
VEGSDIVEGS VAVDAAVTSS SNSNDVVVIA VALLVDAREQ RQRDLDDDEE
960 970 980 990 1000
NEMDRGRQRK VKSGSAKGNN ASNSTPGYNP FQEYEGQKRW NKNGGGGGFS
1010 1020 1030 1040 1050
RFYNQNYRQN FQQRNKFKFN RFGGAGSAKF QQQRALQRHL SAGGGFSRRQ

PSAQQQQQT
Length:1,059
Mass (Da):115,591
Last modified:September 23, 2008 - v1
Checksum:iEB4DAC63DA00063E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480817 Genomic DNA. Translation: EDW50606.1.
RefSeqiXP_002035470.1. XM_002035434.1.

Genome annotation databases

EnsemblMetazoaiFBtr0197704; FBpp0196196; FBgn0169640.
GeneIDi6610913.
KEGGidse:Dsec_GM14719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CH480817 Genomic DNA. Translation: EDW50606.1 .
RefSeqi XP_002035470.1. XM_002035434.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0197704 ; FBpp0196196 ; FBgn0169640 .
GeneIDi 6610913.
KEGGi dse:Dsec_GM14719.

Organism-specific databases

FlyBasei FBgn0169640. Dsec\GM14719.

Phylogenomic databases

KOi K11855.
OrthoDBi EOG7XDBF6.
PhylomeDBi B4HUI5.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25.

Entry informationi

Entry nameiUBP36_DROSE
AccessioniPrimary (citable) accession number: B4HUI5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: October 1, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3