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B4HUI5 (UBP36_DROSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 26. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 36

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 36
Protein scrawny
Ubiquitin thioesterase 36
Ubiquitin-specific-processing protease 36
Gene names
Name:Usp36
Synonyms:scny
ORF Names:GM14719
OrganismDrosophila sechellia (Fruit fly) [Complete proteome]
Taxonomic identifier7238 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora

Protein attributes

Sequence length1059 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for maintaining multiple types of adult stem cells, including male and female germline, epithelial follicle cell and intestinal stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subunit structure

Interacts with atms/PAF1, but not with CycT By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10591059Ubiquitin carboxyl-terminal hydrolase 36
PRO_0000378501

Regions

Domain168 – 457290USP

Sites

Active site1771Nucleophile By similarity
Active site4161Proton acceptor By similarity

Amino acid modifications

Modified residue4901Phosphoserine By similarity
Modified residue4921Phosphoserine By similarity
Modified residue6321Phosphothreonine By similarity
Modified residue6361Phosphothreonine By similarity
Modified residue6461Phosphoserine By similarity
Modified residue6481Phosphoserine By similarity
Modified residue7211Phosphoserine By similarity
Modified residue7531Phosphoserine By similarity
Modified residue7561Phosphothreonine By similarity
Modified residue7591Phosphoserine By similarity
Modified residue7991Phosphothreonine By similarity
Modified residue8171Phosphoserine By similarity
Modified residue8201Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
B4HUI5 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: EB4DAC63DA00063E

FASTA1,059115,591
        10         20         30         40         50         60 
MPVSMAVCET ANVVNAALRE SLGGNSSAGS STDQAKSGED TNGSLQNHIV ANAKRILMAK 

        70         80         90        100        110        120 
IEYEEVPNYH ESVLENLKSK YIVIKPGNPG AINGFSGKNN TGKLVGANGH DNNGARKQAE 

       130        140        150        160        170        180 
HPNNQSHHNH PHPTSNPNEL PKPKRVLYPR ENIRIGWKQS ERKWQVGTGM INVGNTCYLN 

       190        200        210        220        230        240 
STLQALLHIP ALANWLVSEQ AHLADCNVAE PGSGCIICAM AKTLLATQSN QSAVRPFLIY 

       250        260        270        280        290        300 
SKLKQICKHM VVGRQEDAHE FLRFLVEAME RAYLMRFRNY KELDQLVKET TPLGQIFGGY 

       310        320        330        340        350        360 
LRSEVRCLSC NHVSITFQHF QDLLLDIRKA DSLEDAFEGH FSRERLEDMG YKCEGCKKKL 

       370        380        390        400        410        420 
KRFSMIGNKL TKQISFKPRI DLSKYAARSP AAQAQPLTYR LVSMVTHLGA SQHCGHYTAI 

       430        440        450        460        470        480 
GSTDTGSFYN FDDSYVRPIT MQNVCNTNAY IMFFELDLSQ AASPPANRPN GVRLTNGHST 

       490        500        510        520        530        540 
TPVPAATVSS PSPTRFIGPQ LPPGGANGYT NGNAQKTAIQ FKQQNQQNGL QLGTGKFQDT 

       550        560        570        580        590        600 
AKPPLVGAYA KGEATSAPTA NGNKSSSPSS NSSSNHKSIN QQQYLPISSD DEDIDDEMKP 

       610        620        630        640        650        660 
GPTTAQLPSM PNMTEDNTEP KAKSPVKIHL KTPVKTPLKS LVPYESASEE EEAPLPNPRQ 

       670        680        690        700        710        720 
SPGGEDFSES DQESGQTNGH SKTNGSLTNG SASSSVHVNN SKQKTDAIDE IFKSLKKSAD 

       730        740        750        760        770        780 
SEEDDDEEEP SIQLTNGWHP QKQSQSQSKA PPSPKTPPSP AVIKSKTGIW KVTRKDEVDA 

       790        800        810        820        830        840 
IDDDDDAVVV EGAPVKIPTP NKTHRNPFSS SKPSTDSPAT PGAKRQKLLN GSALKSHQQP 

       850        860        870        880        890        900 
RVGNGYQSNV TSNGSTVNEL LKQSYRGYGA SVLSWNGKPA ELEKEPFELV CAKRIAGHGS 

       910        920        930        940        950        960 
VEGSDIVEGS VAVDAAVTSS SNSNDVVVIA VALLVDAREQ RQRDLDDDEE NEMDRGRQRK 

       970        980        990       1000       1010       1020 
VKSGSAKGNN ASNSTPGYNP FQEYEGQKRW NKNGGGGGFS RFYNQNYRQN FQQRNKFKFN 

      1030       1040       1050 
RFGGAGSAKF QQQRALQRHL SAGGGFSRRQ PSAQQQQQT 

« Hide

References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rob3c / Tucson 14021-0248.25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CH480817 Genomic DNA. Translation: EDW50606.1.
RefSeqXP_002035470.1. XM_002035434.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0197704; FBpp0196196; FBgn0169640.
GeneID6610913.
KEGGdse:Dsec_GM14719.

Organism-specific databases

FlyBaseFBgn0169640. Dsec\GM14719.

Phylogenomic databases

KOK11855.
OrthoDBEOG7XDBF6.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP36_DROSE
AccessionPrimary (citable) accession number: B4HUI5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: September 23, 2008
Last modified: February 19, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Drosophila

Drosophila: entries, gene names and cross-references to FlyBase