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B4HTK4 (B4HTK4_DROSE) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase RuleBase RU004435
EC=3.4.19.12 RuleBase RU004435
Gene names
Name:Dsec\GM14081 EMBL EDW50275.1
ORF Names:Dsec_GM14081 EMBL EDW50275.1, GM14081 FlyBase FBgn0169010
OrganismDrosophila sechellia (Fruit fly) [Complete proteome]
Taxonomic identifier7238 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›

Protein attributes

Sequence length826 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). RuleBase RU004435 SAAS SAAS001607

Sequence similarities

Belongs to the peptidase C19 family. RuleBase RU004434

Sequences

Sequence LengthMass (Da)Tools
B4HTK4 [UniParc].

Last modified September 23, 2008. Version 1.
Checksum: 2375A15632FC0B69

FASTA82692,078
        10         20         30         40         50         60 
MEELRKHLSK VNVPCVSGAG SPPIYKDECV YSYDNPETPT GLYVCLHSFL GFGEAYVREY 

        70         80         90        100        110        120 
ANKTGNRIFL HIQRVKTIKE GADMDADAES EAGPERKITR LAIGVEGGYN ESDMAKKYEI 

       130        140        150        160        170        180 
KDTYSIVVAP DLDKKLPYPD PELPMRVTQS VEAILAADSA IAKLEKATLM GTWDGEVRQA 

       190        200        210        220        230        240 
SKYAENLQQL DNGKRIPPSG WQCEKCDLTN NLWLNLTDGS IMCGRKFFDG SGGNDHAVEH 

       250        260        270        280        290        300 
YRVTGFPLAV KLGTITADGK SDVFSYPEDE MVLDPHLERH LSHFGINMAA MKKSEKSMVE 

       310        320        330        340        350        360 
LELDINHRIG EWSALTESES ELQPVAGPGY TGMRNLGNSC YINSVMQVLF IIPDFQQRFV 

       370        380        390        400        410        420 
GTGAERYFSE FPSDPANDFN IQMAKLGTGL QSGKYSSIAE NTLDTDHITG ISPAMFKNIV 

       430        440        450        460        470        480 
GKNHPDFSTK QQQDANDFYL HLLTLLDRNS RNQTNPADAL KFLLEDRVEC LASRKVKYRT 

       490        500        510        520        530        540 
REEYSFRLPV PLDKATNLDE VREFQERKKA ARETGQRLPD RDIVRHKVPL QACLERFFAP 

       550        560        570        580        590        600 
ELIEQFYSTA IDGKTNARKI TRLATMPDCL MIHVGKFTLG DDWVPKKLDV SVDMPDELDL 

       610        620        630        640        650        660 
SNWRSAGGLQ PGEEALPEPA AEEVKFAFDE AVMSELLTMG FPPEACKRAC YHTKNSGLEA 

       670        680        690        700        710        720 
ASNWLMEHIA DEDISEPFVV PNNSIGDCAA NQFVANPESL AMLMSMGFDE RQAVAALKAT 

       730        740        750        760        770        780 
DGNVERATDW IFSHADSISV EEAAPASNSS AAAASSAPNK TDYRDGRGKY RLVGFISHMG 

       790        800        810        820 
TSAQVGHYVC HIRKKGEWVI FNDSKVAKSQ NPPKDLGYLY LYMREQ

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References

[1]"Evolution of genes and genomes on the Drosophila phylogeny."
Drosophila 12 genomes consortium
Nature 450:203-218(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rob3c / Tucson 14021-0248.25.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CH480817 Genomic DNA. Translation: EDW50275.1.
RefSeqXP_002035139.1. XM_002035103.1.

3D structure databases

ProteinModelPortalB4HTK4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaFBtr0197066; FBpp0195558; FBgn0169010.
GeneID6610566.
KEGGdse:Dsec_GM14081.

Organism-specific databases

FlyBaseFBgn0169010. Dsec\GM14081.

Phylogenomic databases

KOK11836.
OrthoDBEOG4NGF2M.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19.
IPR009060. UBA-like.
IPR000449. UBA/transl_elong_EF1B_N.
IPR015940. UBA/transl_elong_EF1B_N_euk.
IPR016652. Ubiquitinyl_hydrolase.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamPF00627. UBA. 2 hits.
PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PIRSFPIRSF016308. UBP. 1 hit.
SMARTSM00165. UBA. 2 hits.
SM00290. ZnF_UBP. 1 hit.
[Graphical view]
SUPFAMSSF46934. UBA_like. 1 hit.
PROSITEPS50030. UBA. 2 hits.
PS00972. UCH_2_1. 1 hit.
PS00973. UCH_2_2. 1 hit.
PS50235. UCH_2_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB4HTK4_DROSE
AccessionPrimary (citable) accession number: B4HTK4
Entry history
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: May 29, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequences·References·Cross-refs·Entry info