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Protein

Superoxide dismutase [Cu-Zn]

Gene

Dsec\GM20432

Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • Cu cationUniRule annotationNote: Binds 1 copper ion per subunit.UniRule annotation
  • Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandCopperUniRule annotation, Metal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Cu-Zn]UniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:Dsec\GM20432Imported
ORF Names:Dsec_GM20432Imported, GM20432Imported
OrganismiDrosophila sechellia (Fruit fly)Imported
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000001292 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0175314 Dsec\GM20432

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_500280913319 – 181Superoxide dismutase [Cu-Zn]Sequence analysisAdd BLAST163

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 178Sod_CuInterPro annotationAdd BLAST139

Sequence similaritiesi

Belongs to the Cu-Zn superoxide dismutase family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

KOiK04565
OMAiDITYTDP
OrthoDBiEOG091G0OG2
PhylomeDBiB4HNH5

Family and domain databases

CDDicd00305 Cu-Zn_Superoxide_Dismutase, 1 hit
Gene3Di2.60.40.200, 1 hit
InterProiView protein in InterPro
IPR036423 SOD-like_Cu/Zn_dom_sf
IPR024134 SOD_Cu/Zn_/chaperone
IPR018152 SOD_Cu/Zn_BS
IPR001424 SOD_Cu_Zn_dom
PANTHERiPTHR10003 PTHR10003, 1 hit
PfamiView protein in Pfam
PF00080 Sod_Cu, 1 hit
PRINTSiPR00068 CUZNDISMTASE
SUPFAMiSSF49329 SSF49329, 1 hit
PROSITEiView protein in PROSITE
PS00087 SOD_CU_ZN_1, 1 hit
PS00332 SOD_CU_ZN_2, 1 hit

Sequencei

Sequence statusi: Complete.

B4HNH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQYLVVSLA LCATICSAAQ TRNMPIQAIA YLIGPVQSDN TQVKGNVTFT
60 70 80 90 100
QNDCGQNVHV RVQLEGLKEG KHGFHVHEKG DLTNGCLSMG GHYNPDKVDH
110 120 130 140 150
GGPDHEVRHV GDLGNLEANS TGIIDITYTD QVITLTGKLG IIGRGVVVHE
160 170 180
LEDDLGLGNH TDSKKTGNAG GRIACGVIGV K
Length:181
Mass (Da):19,193
Last modified:September 23, 2008 - v1
Checksum:iFE9606C7D662B5D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480816 Genomic DNA Translation: EDW47411.1
RefSeqiXP_002033398.1, XM_002033362.1

Genome annotation databases

EnsemblMetazoaiFBtr0203417; FBpp0201909; FBgn0175314
GeneIDi6608665
KEGGidse:Dsec_GM20432

Similar proteinsi

Entry informationi

Entry nameiB4HNH5_DROSE
AccessioniPrimary (citable) accession number: B4HNH5
Entry historyiIntegrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: March 28, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health