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Protein

Dihydroorotate dehydrogenase (quinone), mitochondrial

Gene

Dsec\GM26331

Organism
Drosophila sechellia (Fruit fly)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-dihydroorotate + a quinone = orotate + a quinol.UniRule annotation

Cofactori

FMNUniRule annotationNote: Binds 1 FMN per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181NucleophileUniRule annotation

GO - Molecular functioni

  1. dihydroorotate dehydrogenase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Ligandi

Flavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroorotate dehydrogenase (quinone), mitochondrialUniRule annotation (EC:1.3.5.2UniRule annotation)
Short name:
DHOdehaseUniRule annotation
Gene namesi
Name:Dsec\GM26331Imported
ORF Names:Dsec_GM26331Imported, GM26331Imported
OrganismiDrosophila sechellia (Fruit fly)Imported
Taxonomic identifieri7238 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000001292 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0181184. Dsec\GM26331.

Subcellular locationi

Mitochondrion inner membrane UniRule annotation; Single-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 3919HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

KOiK00254.
OrthoDBiEOG7VHSXC.
PhylomeDBiB4HL42.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B4HL42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQDHLKNAK NATRRVGRLR SLGIVTVGGA ALVAGITAYK NQDQLFRTFV
60 70 80 90 100
MPAVRLLPAE ASHQLAVLAC KYRLCPVSQY HDDQNLHTPF FGRMLSNPIG
110 120 130 140 150
IAAGFDKNAE AVDGLQDLGF GFIEVGTVTP AAQEGNPKPR VFRLTDDKAI
160 170 180 190 200
INRYGFNSDG HQAVLQRLRL LRKKENFNGV VGVNLGRNKT TMSPIADYVQ
210 220 230 240 250
GVRVFGPVAD YLVINVSSPN TKGLRDMQSK EKLRELLEQV NDTKSSLDKN
260 270 280 290 300
KNVPILLKLS PDLSLDDMKD IVWVIKRKKS RVDGLIVSNT TVSRENLENK
310 320 330 340 350
KLAEETGGLS GPPLKARSTE MIAQMYQLTD GKIPIIGVGG VASGYDAYEK
360 370 380 390 400
IEAGASYVQI YTALVYEGPA LVEDIKAELS ALITRLGHTN VADVVGTNSK

FYLPK
Length:405
Mass (Da):44,338
Last modified:September 23, 2008 - v1
Checksum:iA51E72827D7E52DC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480815 Genomic DNA. Translation: EDW43006.1.
RefSeqiXP_002032020.1. XM_002031984.1.

Genome annotation databases

EnsemblMetazoaiFBtr0209316; FBpp0207808; FBgn0181184.
GeneIDi6607239.
KEGGidse:Dsec_GM26331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH480815 Genomic DNA. Translation: EDW43006.1.
RefSeqiXP_002032020.1. XM_002031984.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0209316; FBpp0207808; FBgn0181184.
GeneIDi6607239.
KEGGidse:Dsec_GM26331.

Organism-specific databases

FlyBaseiFBgn0181184. Dsec\GM26331.

Phylogenomic databases

KOiK00254.
OrthoDBiEOG7VHSXC.
PhylomeDBiB4HL42.

Enzyme and pathway databases

UniPathwayiUPA00070; UER00946.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR005719. Dihydroorotate_DH_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01036. pyrD_sub2. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Evolution of genes and genomes on the Drosophila phylogeny."
    Drosophila 12 genomes consortium
    Nature 450:203-218(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rob3c / Tucson 14021-0248.25Imported.

Entry informationi

Entry nameiB4HL42_DROSE
AccessioniPrimary (citable) accession number: B4HL42
Entry historyi
Integrated into UniProtKB/TrEMBL: September 23, 2008
Last sequence update: September 23, 2008
Last modified: April 1, 2015
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.